Literature review of physical and chemical pretreatment processes for lignocellulosic biomass

Different pretreatment technologies published in public literature are described in terms of the mechanisms involved, advantages and disadvantages, and economic assessment. Pretreatment technologies for lignocellulosic biomass include biological, mechanical, chemical methods and various combinations thereof. The choice of the optimum pretreatment process depends very much on the objective of the biomass pretreatment, its economic assessment and environmental impact. Only a small number of pretreatment methods has been reported as being potentially cost-effective thus far. These include steam explosion, liquid hot water, concentrated acid hydrolysis and dilute acid pretreatments

Pilotstudie voortijdig schoolverlaters 1995/1996

Dit werkdocument doet verslag van het onderzoek onder voortijdig schoolverlaters van het Algemeen Voortgezet Onderwijs (AVO), het Voortgezet Beroepsonderwijs (VBO) en de Beroepsopleidende Leerweg (BOL niveaus 1 tot en met 4) uit het schooljaar 1995/1996. Doel van het onderzoek was om door middel van een pilot-studie de positie van deze groep schoolverlaters in het vervolgonderwijs en op de arbeidsmarkt in kaart te brengen en daar waar mogelijk een vergelijking te maken met de reguliere gediplomeerde schoolverlaters. Daarnaast is getracht om tot een duidelijke en hanteerbare definitie te komen van het begrip ''voortijdig schoolverlater . Het onderzoek is intern begeleid door dr. J. Allen en het verslag is geschreven door drs. T. Huijgen. Een eerste aanzet voor het werkdocument is gemaakt door drs. R. Welters. De enquêtering van de respondenten heeft telefonisch plaatsgevonden en is uitgevoerd door DESAN Marktonderzoek BV.labour market entry;

Measuring Agility in Tennis, Badminton, and Squash:A Systematic Review

A systematic review in PubMed, Web of Science, SPORTDiscus, PsycINFO, and Google Scholar was conducted to provide a state-of-the-science overview of agility tests in the racquet sports tennis, badminton, and squash while evaluating their measurement properties. Twenty articles were included covering 28 agility tests. Results showed 10 sport-specific agility tests of which 5 were assessed on reliability and 6 on validity. Both the Badcamp and the badminton-specific speed ("agility") test were identified as suitable agility tests available for badminton. For tennis and squash, there were no sport-specific agility tests identified in the literature showing both reliable and valid results. Future research should focus on developing sport-specific agility tests for tennis and squash, including assessment of the reliability and validity of the tests.</p

Technisch rapport WO-Monitor 1998

In 1998 is onder auspiciën van de VSNU de WO-Monitor van start gegaan. Aanleiding hiervoor was de behoefte om over landelijke gegevens te beschikken met betrekking tot de arbeidsmarktintrede van afgestudeerden. Weliswaar werd op diverse plaatsen reeds onderzoek verricht naar de overgang van het WO naar de arbeidsmarkt, maar door de uiteenlopende designs en vraagstellingen leverde dit geen onderling vergelijkbare gegevens op. Het Algemeen Bestuur van de VSNU heeft daarom besloten tot invoering van een landelijke WO-Monitor, waarin alle universiteiten participeren.labour market entry and occupational careers;

Founder mutations in the Netherlands: geographical distribution of the most prevalent mutations in the low-density lipoprotein receptor and apolipoprotein B genes

Background In the Netherlands, a screening programme was set up in 1994 in order to identify all patients with familial hypercholesterolaemia (FH). After 15 years of screening, we evaluated the geographical distribution, possible founder effects and clinical phenotype of the 12 most prevalent FH gene mutations. Methods Patients who carried one of the 12 most prevalent mutations, index cases and those identified between 1994 and 2009 through the screening programme and whose postal code was known were included in the study. Low-density lipoprotein cholesterol (LDL-C) levels at the time of screening were retrieved. The prevalence of identified patients in each postal code area was calculated and visualised in different maps. Results A total of 10,889 patients were included in the study. Mean untreated LDL-C levels ranged from 4.4 to 6.4 mmol/l. For almost all mutations, a region of high prevalence could be observed. In total, 51 homozygous patients were identified in the Netherlands, of which 13 true homozygous for one of the 12 most prevalent mutations. The majority of them were living in high-prevalence areas for that specific mutation. Conclusions Phenotypes with regard to LDL-C levels varied between the 12 most prevalent FH mutations. For most of these mutations, a founder effect was observed. Our observations can have implications with regard to the efficiency of molecular screening and physician's perception of FH and to the understanding of the prevalence and distribution of homozygous patients in the Netherland

Design of a Tennis-Specific Agility Test (TAT) for Monitoring Tennis Players

Agility is an important ability for tennis players. To be successful in the rallies, players must perform rapid, multidirectional movements in response to the ball and/or the position of the opponent. For a test to be representative in monitoring agility performance, it should capture a combination of the physical and cognitive agility performance. Considering that literature reports no reliable and valid sport-specific agility test for tennis, the aim of this article was to design and evaluate the measurement properties of a Tennis-specific Agility Test (TAT). To evaluate the TAT, test-retest reliability, concurrent validity, and feasibility were assessed. For reproducibility, a two-way mixed ANOVA was performed. Concurrent validity was assessed using Pearson correlations. A total of 69 tennis players participated in this study of whom 16 competed at the international (22 ± 3.7 years, playing level (Dynamic Rating System): .8 ± .3), 43 at the national (14 ± 1.4 years, playing level: 4.6 ± 1.4), and 10 at the regional level (15 ± 0.8 years, playing level: 4.9 ± 1.1). Test-retest reliability was found to be moderate with an Intra-Class Correlation coefficient (ICC) of .74 (p < .01) and a percentual minimal detectable change (%MDC) of 6.2%. Concurrent validity was found to be moderate by comparison with a recognised agility test, the Spider Drill, which measures only the physical component (.70; p < .01), and by comparison with tennis performance for both boys (r = .67; p < .01) and girls (r = .72; p < .01). The feasibility was high with short time for preparation (five to ten minutes) and time per participant (<5 minutes). In conclusion, the TAT shows promising results for assessing sport-specific agility performance in tennis making it likely to be used in the practical setting

Targeted genetic testing for familial hypercholesterolaemia using next generation sequencing:a population-based study

Background&lt;p&gt;&lt;/p&gt; Familial hypercholesterolaemia (FH) is a common Mendelian condition which, untreated, results in premature coronary heart disease. An estimated 88% of FH cases are undiagnosed in the UK. We previously validated a method for FH mutation detection in a lipid clinic population using next generation sequencing (NGS), but this did not address the challenge of identifying index cases in primary care where most undiagnosed patients receive healthcare. Here, we evaluate the targeted use of NGS as a potential route to diagnosis of FH in a primary care population subset selected for hypercholesterolaemia.&lt;p&gt;&lt;/p&gt; Methods&lt;p&gt;&lt;/p&gt; We used microfluidics-based PCR amplification coupled with NGS and multiplex ligation-dependent probe amplification (MLPA) to detect mutations in LDLR, APOB and PCSK9 in three phenotypic groups within the Generation Scotland: Scottish Family Health Study including 193 individuals with high total cholesterol, 232 with moderately high total cholesterol despite cholesterol-lowering therapy, and 192 normocholesterolaemic controls.&lt;p&gt;&lt;/p&gt; Results&lt;p&gt;&lt;/p&gt; Pathogenic mutations were found in 2.1% of hypercholesterolaemic individuals, in 2.2% of subjects on cholesterol-lowering therapy and in 42% of their available first-degree relatives. In addition, variants of uncertain clinical significance (VUCS) were detected in 1.4% of the hypercholesterolaemic and cholesterol-lowering therapy groups. No pathogenic variants or VUCS were detected in controls.&lt;p&gt;&lt;/p&gt; Conclusions&lt;p&gt;&lt;/p&gt; We demonstrated that population-based genetic testing using these protocols is able to deliver definitive molecular diagnoses of FH in individuals with high cholesterol or on cholesterol-lowering therapy. The lower cost and labour associated with NGS-based testing may increase the attractiveness of a population-based approach to FH detection compared to genetic testing with conventional sequencing. This could provide one route to increasing the present low percentage of FH cases with a genetic diagnosis