Pattern formation by lateral inhibition with feedback: a mathematical model of Delta-Notch intercellular signalling

In many developing tissues, adjacent cells diverge in character so as to create a fine-grained pattern of cells in contrasting states of differentiation. It has been proposed that such patterns can be generated through lateral inhibition—a type cells–cell interaction whereby a cell that adopts a particular fate inhibits its immediate neighbours from doing likewise. Lateral inhibition is well documented in flies, worms and vertebrates. In all of these organisms, the transmembrane proteins Notch and Delta (or their homologues) have been identified as mediators of the interaction—Notch as receptor, Delta as its ligand on adjacent cells. However, it is not clear under precisely what conditions the Delta-Notch mechanism of lateral inhibition can generate the observed types of pattern, or indeed whether this mechanism is capable of generating such patterns by itself. Here we construct and analyse a simple and general mathematical model of such contact-mediated lateral inhibition. In accordance with experimental data, the model postulates that receipt of inhibition (i.e. activation of Notch) diminishes the ability to deliver inhibition (i.e. to produce active Delta). This gives rise to a feedback loop that can amplify differences between adjacent cells. We investigate the pattern-forming potential and temporal behavior of this model both analytically and through numerical simulation. Inhomogeneities are self-amplifying and develop without need of any other machinery, provided the feedback is sufficiently strong. For a wide range of initial and boundary conditions, the model generates fine-grained patterns similar to those observed in living systems

Bistable molecular conductors with a field-switchable dipole group

A class of bistable "stator-rotor" molecules is proposed, where a stationary bridge (stator) connects the two electrodes and facilitates electron transport between them. The rotor part, which has a large dipole moment, is attached to an atom of the stator via a single sigma bond. Hydrogen bonds formed between the rotor and stator make the symmetric orientation of the dipole unstable. The rotor has two potential minima with equal energy for rotation about the sigma bond. The dipole orientation, which determines the conduction state of the molecule, can be switched by an external electric field that changes the relative energy of the two potential minima. Both orientation of the rotor correspond to asymmetric current-voltage characteristics that are the reverse of each other, so they are distinguishable electrically. Such bistable stator-rotor molecules could potentially be used as parts of molecular electronic devices.Comment: 8 pages, 7 figure

Instrumentation for hydrogen slush storage containers

Hydrogen liquid and slush tank continuous inventory during ground storag

Lunar Surface Potential Changes Possible Associated with Traversals of the Bow Shock

We report an analysis of seven Apollo 14 Apollo Lunar Surface Experiments Package (ALSEP) Suprathermal Ion Detector Experiment (SIDE) "resonance" events from January 1972 through January 1973. The events appear to be associated with traversals of the Moon through the terrestrial bow shock

The On/Off Nature of Star-Planet Interactions

Evidence suggesting an observable magnetic interaction between a star and its hot Jupiter appears as a cyclic variation of stellar activity synchronized to the planet's orbit. In this study, we monitored the chromospheric activity of 7 stars with hot Jupiters using new high-resolution echelle spectra collected with ESPaDOnS over a few nights in 2005 and 2006 from the CFHT. We searched for variability in several stellar activity indicators (Ca II H, K, the Ca II infrared triplet, Halpha, and He I). HD 179949 has been observed almost every year since 2001. Synchronicity of the Ca II H & K emission with the orbit is clearly seen in four out of six epochs, while rotational modulation with P_rot=7 days is apparent in the other two seasons. We observe a similar phenomenon on upsilon And, which displays rotational modulation (P_rot=12 days) in September 2005, in 2002 and 2003 variations appear to correlate with the planet's orbital period. This on/off nature of star-planet interaction (SPI) in the two systems is likely a function of the changing stellar magnetic field structure throughout its activity cycle. Variability in the transiting system HD 189733 is likely associated with an active region rotating with the star, however, the flaring in excess of the rotational modulation may be associated with its hot Jupiter. As for HD 179949, the peak variability as measured by the mean absolute deviation for both HD 189733 and tau Boo leads the sub-planetary longitude by 70 degrees. The tentative correlation between this activity and the ratio of Mpsini to the planet's rotation period, a quantity proportional to the hot Jupiter's magnetic moment, first presented in Shkolnik et al. 2005 remains viable. This work furthers the characterization of SPI, improving its potential as a probe of extrasolar planetary magnetic fields.Comment: Accepted for publication in the Astrophysical Journa

Fast spectroscopic variations on rapidly-rotating, cool dwarfs. 3: Masses of circumstellar absorbing clouds on AB Doradus

New time-resolved H alpha, Ca II H and K and Mg II h and k spectra of the rapidly-rotating K0 dwarf star AB Doradus (= HD 36705). The transient absorption features seen in the H alpha line are also present in the Ca II and Mg II resonance lines. New techniques are developed for measuring the average strength of the line absorption along lines of sight intersecting the cloud. These techniques also give a measure of the projected cloud area. The strength of the resonance line absorption provides useful new constraints on the column densities, projected surface areas, temperatures and internal turbulent velocity dispersions of the circumstellar clouds producing the absorption features. At any given time the star appears to be surrounded by at least 6 to 10 clouds with masses in the range 2 to 6 x 10(exp 17) g. The clouds appear to have turbulent internal velocity dispersions of order 3 to 20 km/s, comparable with the random velocities of discrete filamentary structures in solar quiescent prominences. Night-to-night changes in the amount of Ca II resonance line absorption can be explained by changes in the amplitude of turbulent motions in the clouds. The corresponding changes in the total energy of the internal motions are of order 10(exp 29) erg per cloud. Changes of this magnitude could easily be activated by the frequent energetic (approximately 10(exp 34) erg) x ray flares seen on this star

The Angular Momentum Evolution of Very Low Mass Stars

We present theoretical models of the angular momentum evolution of very low mass stars (0.1 - 0.5 M_sun) and solar analogues (0.6 - 1.1 M_sun). We investigate the effect of rotation on the effective temperature and luminosity of these stars. We find that the decrease in T_eff and L can be significant at the higher end of our mass range, but becomes negligible below 0.4 M_sun. Formulae for relating T_eff to mass and v_rot are presented. We compare our models to rotational data from young open clusters of different ages to infer the rotational history of low mass stars, and the dependence of initial conditions and rotational evolution on mass. We find that the qualitative conclusions for stars below 0.6 M_sun do not depend on the assumptions about internal angular momentum transport, which makes these low mass stars ideal candidates for the study of the angular momentum loss law and distribution of initial conditions. We find that neither models with solid body nor differential rotation can simultaneously reproduce the observed stellar spin down in the 0.6 to 1.1 M_sun mass range and for stars between 0.1 and 0.6 M_sun. The most likely explanation is that the saturation threshold drops more steeply at low masses than would be predicted with a simple Rossby scaling. In young clusters there is a systematic increase in the mean rotation rate with decreased temperature below 3500 K (0.4 M_sun). This suggests either inefficient angular momentum loss or mass-dependent initial conditions for stars near the fully convective boundary. (abridged)Comment: To appear in the May 10, 2000 Ap

The Doppler Shadow of WASP-3b: A tomographic analysis of Rossiter-McLaughlin observations

Hot-Jupiter planets must form at large separations from their host stars where the temperatures are cool enough for their cores to condense. They then migrate inwards to their current observed orbital separations. Different theories of how this migration occurs lead to varying distributions of orbital eccentricity and the alignment between the rotation axis of the star and the orbital axis of the planet. The spin-orbit alignment of a transiting system is revealed via the Rossiter-McLaughlin effect, which is the anomaly present in the radial velocity measurements of the rotating star during transit due to the planet blocking some of the starlight. In this paper we aim to measure the spin-orbit alignment of the WASP-3 system via a new way of analysing the Rossiter-McLaughlin observations. We apply a new tomographic method for analysing the time variable asymmetry of stellar line profiles caused by the Rossiter-McLaughlin effect. This new method eliminates the systematic error inherent in previous methods used to analyse the effect. We find a value for the projected stellar spin rate of v sin i = 13.9 \pm 0.03 km/s which is in agreement with previous measurements but has a much higher precision. The system is found to be well aligned which favours an evolutionary history for WASP-3b involving migration through tidal interactions with a protoplanetary disc. Using gyrochronology we estimate the age of the star to be ~300 Myr with an upper limit of 2 Gyr from comparison with isochrones.Comment: Accepted for publication in A&A, 8 pages, 4 figures, 2 table

AGN behind the SMC selected from radio and X-ray surveys

The XMM-Newton survey of the Small Magellanic Cloud (SMC) revealed 3053 X-ray sources with the majority expected to be active galactic nuclei (AGN) behind the SMC. However, the high stellar density in this field often does not allow assigning unique optical counterparts and hinders source classification. On the other hand, the association of X-ray point sources with radio emission can be used to select background AGN with high confidence, and to constrain other object classes like pulsar wind nebula. To classify X-ray and radio sources, we use clear correlations of X-ray sources found in the XMM-Newton survey with radio-continuum sources detected with ATCA and MOST. Deep radio-continuum images were searched for correlations with X-ray sources of the XMM-Newton SMC-survey point-source catalogue as well as galaxy clusters seen with extended X-ray emission. Eighty eight discrete radio sources were found in common with the X-ray point-source catalogue in addition to six correlations with extended X-ray sources. One source is identified as a Galactic star and eight as galaxies. Eight radio sources likely originate in AGN that are associated with clusters of galaxies seen in X-rays. One source is a PWN candidate. We obtain 43 new candidates for background sources located behind the SMC. A total of 24 X-ray sources show jet-like radio structures.Comment: 9 pages, 6 figures, accepted for publication in A&