Exact propagators for SUSY partners

Pairs of SUSY partner Hamiltonians are studied which are interrelated by usual (linear) or polynomial supersymmetry. Assuming the model of one of the Hamiltonians as exactly solvable with known propagator, expressions for propagators of partner models are derived. The corresponding general results are applied to "a particle in a box", the Harmonic oscillator and a free particle (i.e. to transparent potentials).Comment: 31 page

Astenic syndrome in you students with different online-behaviors during the pandemic of new coronavirus infection COVID-19

Introduction. An urgent problem in many countries of the world is the growth of comorbid diseases and conditions associated with the pathological use of the Internet, including functional somatic disorders, which include asthenic syndrome.Purpose of the study. To study the frequency of occurrence of asthenic syndrome schoolchildren with different online behavior during the coronavirus pandemic.Materials and methods. The method of random sampling was used to examine 1 148 adolescents at the age of 11–18 years, of which 535 (46.6%) were boys and 613 (53.4%) were girls. The frequency of occurrence was analyzed in the entire sample of the surveyed, as well as in the comparison groups, formed by gender: 1 gr. – boys (n = 535), 2 gr. – girls (n = 613), age: 1 gr. – 11–14 years old (m + d) (n = 837) and 2 gr. – 15–18 years old (m + d) (n = 311), type of online behavior: 1 gr. – with adaptive use of the Internet, 2 gr. – with maladaptive internet use, 3 gr. – with pathological use of the Internet and type of Internet addiction.Results. The frequency of adaptive use of the Internet was 37.0%, with maladaptive – 49.9% and with pathological – 13.1% of the total sample of  the surveyed. The content structure of  the online behavior of  Tuvan schoolchildren includes the  presence of a game Internet addiction in 4.4% of the surveyed, dependence on social networks – in 12.5%, mixed IА – in 2.4% and undifferentiated IА – in 5.0%. The frequency of asthenic syndrome is 12.2% of all surveyed.Conclusion. A more pronounced association of asthenic syndrome in schoolchildren with maladaptive online behavior indicates the negative impact of the computer and the Internet on the body and justifies the need for a personalized approach to these contingents

СОВРЕМЕННЫЕ ПОДХОДЫ К ЛУЧЕВОМУ ЛЕЧЕНИЮ МЕТАСТАТИЧЕСКОГО ПОРАЖЕНИЯ ГОЛОВНОГО МОЗГА

The development of chemotherapy led to significant advances in cancer treatment, but its efficacy in treatment of brain metastases is insufficient. Fractionated whole brain irradiation has been the standard treatment for brain metastases, but provides limited local control and as a result, poor clinical results. Radiosurgery using "Gamma Knife" and "Cyber Knife" significantly changed the results of treatment of patients with metastatic brain lesions, which allowed to formulate new standards in the therapy of this group of patients. This review summarizes the current literature data on radiosurgical treatment of metastatic brain lesions with an emphasis on survival and quality of life, tumor response and potential combinations of treatments.Развитие  химиотерапии привело к существенному прогрессу  в терапии злокачественных опухолей, но ее эффек-тивность в отношении метастазов в головной  мозг (МГМ) является недостаточной. Фракционированное облучение всего головного мозга (ОВГМ) было стандартным методом  лечения  МГМ, но обеспечивает  ограниченный  локальный контроль и, как следствие,  неудовлетворительные  клинические результаты. Радиохирургия с использованием аппа-ратов «Гамма Нож», «Кибер Нож» существенно  изменила  результаты  лечения  пациентов с МГМ, что позволило сформулировать новые стандарты лечения этой группы больных.Настоящий обзор подводит итог текущих литературных данных радиохирургического  лечения МГМ с акцентом на выживаемость и качество жизни, ответа опухоли на лечение и потенциальных комбинациях методов лечения МГМ

Morphogenesis of the T4 tail and tail fibers

Remarkable progress has been made during the past ten years in elucidating the structure of the bacteriophage T4 tail by a combination of three-dimensional image reconstruction from electron micrographs and X-ray crystallography of the components. Partial and complete structures of nine out of twenty tail structural proteins have been determined by X-ray crystallography and have been fitted into the 3D-reconstituted structure of the "extended" tail. The 3D structure of the "contracted" tail was also determined and interpreted in terms of component proteins. Given the pseudo-atomic tail structures both before and after contraction, it is now possible to understand the gross conformational change of the baseplate in terms of the change in the relative positions of the subunit proteins. These studies have explained how the conformational change of the baseplate and contraction of the tail are related to the tail's host cell recognition and membrane penetration function. On the other hand, the baseplate assembly process has been recently reexamined in detail in a precise system involving recombinant proteins (unlike the earlier studies with phage mutants). These experiments showed that the sequential association of the subunits of the baseplate wedge is based on the induced-fit upon association of each subunit. It was also found that, upon association of gp53 (gene product 53), the penultimate subunit of the wedge, six of the wedge intermediates spontaneously associate to form a baseplate-like structure in the absence of the central hub. Structure determination of the rest of the subunits and intermediate complexes and the assembly of the hub still require further study

A potent anti-dengue human antibody preferentially recognizes the conformation of E protein monomers assembled on the virus surface

Dengue virus (DENV), which consists of four serotypes (DENV1-4), infects over 400million people annually. Previous studies have indicated most human monoclonal antibodies (HMAbs) from dengue patients are cross-reactive and poorly neutralizing. Rare neutralizing HMAbs are usually serotype-specific and bind to quaternary structure-dependent epitopes. We determined the structure of DENV1 complexed with Fab fragments of a highly potent HMAb 1F4 to 6Å resolution by cryo-EM. Although HMAb 1F4 appeared to bind to virus and not E proteins in ELISAs in the previous study, our structure showed that the epitope is located within an envelope (E) protein monomer, and not across neighboring E proteins. The Fab molecules bind to domain I (DI), and DI-DII hinge of the E protein. We also showed that HMAb 1F4 can neutralize DENV at different stages of viral entry in a cell type and receptor dependent manner. The structure reveals the mechanism by which this potent and specific antibody blocks viral infection.Subject Categories Microbiology, Virology & Host Pathogen Interaction; Immunolog

Рецидивы метастазов в головном мозге после радиохирургического лечения. Существуют ли возможности стереотаксического лучевого лечения?

Цель исследования. Провести анализ результатов повторного радиохирургического (РХ) лечения пациентов с интракраниальными рецидивами метастазов в головной мозг (МГМ), после ранее проведенной РХ первично выявленных церебральных метастазов.Материалы и методы. Были изучены общая и безрецидивная выживаемость у 290 пациентов, получивших радиохирургическое лечение по поводу первично выявленных МГМ. Из них у 153 пациентов развились интракраниальные рецидивы, а 73 -проведено повторное радиохирургическое лечение по поводу новых (дистантных) метастазов.Результаты. Медиана общей выживаемости (ОВ) пациентов с дистантными метастазами (ДМ) составила 9,0 месяцев, а в группе без ДМ – 10,2 мес. (p = 0,3556). Статистически значимыми факторами прогноза развития ДМ (на момент проведения первой радиохирургии) являются: множественное (>3) метастатическое поражение головного мозга, плохой функциональный статус (индекс Карновского ≤70) и наличие меланомы как первоисточника метастазирования. Наличие ДМ, в целом по группе, не ухудшает общую выживаемость, а ОВ в группе пациентов с повторной РХ существенно выше (22,4 месяца,95% ДИ 14,8–38,6). Поэтому прогноз пациента с ДМ не является однозначно плохим, как это предполагалось ранее.Выводы. Повторная РХ дистантных метастазов увеличивает время жизни по сравнению с группой пациентов без локального лечения ДМ. Следовательно, повторная радиохирургия интракраниальных рецидивов приводит к улучшению выживаемости у части пациентов. Классификация интракраниальных рецидивов на основе ожидаемых результатов лечения в различных клинических ситуациях позволяет оптимизировать тактику лечения пациентов этой группы

Population-level consequences of seismic surveys on fishes : an interdisciplinary challenge

Offshore activities elevate ambient sound levels at sea, which may affect marine fauna. We reviewed the literature about impact of airgun acoustic exposure on fish in terms of damage, disturbance and detection and explored the nature of impact assessment at population level. We provided a conceptual framework for how to address this interdisciplinary challenge, and we listed potential tools for investigation. We focused on limitations in data currently available, and we stressed the potential benefits from cross‐species comparisons. Well‐replicated and controlled studies do not exist for hearing thresholds and dose–response curves for airgun acoustic exposure. We especially lack insight into behavioural changes for free‐ranging fish to actual seismic surveys and on lasting effects of behavioural changes in terms of time and energy budgets, missed feeding or mating opportunities, decreased performance in predator‐prey interactions, and chronic stress effects on growth, development and reproduction. We also lack insight into whether any of these effects could have population‐level consequences. General “population consequences of acoustic disturbance” (PCAD) models have been developed for marine mammals, but there has been little progress so far in other taxa. The acoustic world of fishes is quite different from human perception and imagination as fish perceive particle motion and sound pressure. Progress is therefore also required in understanding the nature and extent to which fishes extract acoustic information from their environment. We addressed the challenges and opportunities for upscaling individual impact to the population, community and ecosystem level and provided a guide to critical gaps in our knowledge.Publisher PDFPeer reviewe

Immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children: a propensity-weighted cohort study

Background: Multisystem inflammatory syndrome in children (MIS-C), a hyperinflammatory condition associated with SARS-CoV-2 infection, has emerged as a serious illness in children worldwide. Immunoglobulin or glucocorticoids, or both, are currently recommended treatments. Methods: The Best Available Treatment Study evaluated immunomodulatory treatments for MIS-C in an international observational cohort. Analysis of the first 614 patients was previously reported. In this propensity-weighted cohort study, clinical and outcome data from children with suspected or proven MIS-C were collected onto a web-based Research Electronic Data Capture database. After excluding neonates and incomplete or duplicate records, inverse probability weighting was used to compare primary treatments with intravenous immunoglobulin, intravenous immunoglobulin plus glucocorticoids, or glucocorticoids alone, using intravenous immunoglobulin as the reference treatment. Primary outcomes were a composite of inotropic or ventilator support from the second day after treatment initiation, or death, and time to improvement on an ordinal clinical severity scale. Secondary outcomes included treatment escalation, clinical deterioration, fever, and coronary artery aneurysm occurrence and resolution. This study is registered with the ISRCTN registry, ISRCTN69546370. Findings: We enrolled 2101 children (aged 0 months to 19 years) with clinically diagnosed MIS-C from 39 countries between June 14, 2020, and April 25, 2022, and, following exclusions, 2009 patients were included for analysis (median age 8·0 years [IQR 4·2–11·4], 1191 [59·3%] male and 818 [40·7%] female, and 825 [41·1%] White). 680 (33·8%) patients received primary treatment with intravenous immunoglobulin, 698 (34·7%) with intravenous immunoglobulin plus glucocorticoids, 487 (24·2%) with glucocorticoids alone; 59 (2·9%) patients received other combinations, including biologicals, and 85 (4·2%) patients received no immunomodulators. There were no significant differences between treatments for primary outcomes for the 1586 patients with complete baseline and outcome data that were considered for primary analysis. Adjusted odds ratios for ventilation, inotropic support, or death were 1·09 (95% CI 0·75–1·58; corrected p value=1·00) for intravenous immunoglobulin plus glucocorticoids and 0·93 (0·58–1·47; corrected p value=1·00) for glucocorticoids alone, versus intravenous immunoglobulin alone. Adjusted average hazard ratios for time to improvement were 1·04 (95% CI 0·91–1·20; corrected p value=1·00) for intravenous immunoglobulin plus glucocorticoids, and 0·84 (0·70–1·00; corrected p value=0·22) for glucocorticoids alone, versus intravenous immunoglobulin alone. Treatment escalation was less frequent for intravenous immunoglobulin plus glucocorticoids (OR 0·15 [95% CI 0·11–0·20]; p<0·0001) and glucocorticoids alone (0·68 [0·50–0·93]; p=0·014) versus intravenous immunoglobulin alone. Persistent fever (from day 2 onward) was less common with intravenous immunoglobulin plus glucocorticoids compared with either intravenous immunoglobulin alone (OR 0·50 [95% CI 0·38–0·67]; p<0·0001) or glucocorticoids alone (0·63 [0·45–0·88]; p=0·0058). Coronary artery aneurysm occurrence and resolution did not differ significantly between treatment groups. Interpretation: Recovery rates, including occurrence and resolution of coronary artery aneurysms, were similar for primary treatment with intravenous immunoglobulin when compared to glucocorticoids or intravenous immunoglobulin plus glucocorticoids. Initial treatment with glucocorticoids appears to be a safe alternative to immunoglobulin or combined therapy, and might be advantageous in view of the cost and limited availability of intravenous immunoglobulin in many countries. Funding: Imperial College London, the European Union's Horizon 2020, Wellcome Trust, the Medical Research Foundation, UK National Institute for Health and Care Research, and National Institutes of Health

Cross-national epidemiology of DSM-IV major depressive episode

Background: Major depression is one of the leading causes of disability worldwide, yet epidemiologic data are not available for many countries, particularly low- to middle-income countries. In this paper, we present data on the prevalence, impairment and demographic correlates of depression from 18 high and low-to middle-income countries in the World Mental Health Survey Initiative. Methods: Major depressive episodes (MDE) as defined by the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DMS-IV) were evaluated in face-to-face interviews using the World Health Organization Composite International Diagnostic Interview (CIDI). Data from 18 countries were analyzed in this report (n = 89,037). All countries surveyed representative, population-based samples of adults. Results: The average lifetime and 12-month prevalence estimates of DSM-IV MDE were 14.6% and 5.5% in the ten high-income and 11.1% and 5.9% in the eight low- to middle-income countries. The average age of onset ascertained retrospectively was 25.7 in the high-income and 24.0 in low- to middle-income countries. Functional impairment was associated with recency of MDE. The female: male ratio was about 2: 1. In high-income countries, younger age was associated with higher 12-month prevalence; by contrast, in several low-to middle-income countries, older age was associated with greater likelihood of MDE. The strongest demographic correlate in high-income countries was being separated from a partner, and in low- to middle-income countries, was being divorced or widowed. Conclusions: MDE is a significant public-health concern across all regions of the world and is strongly linked to social conditions. Future research is needed to investigate the combination of demographic risk factors that are most strongly associated with MDE in the specific countries included in the WMH.(NIH/NIMH) United States National Institute of Mental Health[R01MH070884]John D. and Catherine T. MacArthur FoundationPfizer FoundationUSA Public Health Service[R13-MH066849]USA Public Health Service[R01-MH069864]USA Public Health Service[R01 DA016558](NIH) Fogarty International Center[FIRCA R03-TW006481]PAHO Pan American Health OrganizationEli Lilly & Company FoundationOrtho-McNeil Pharmaceutical, Inc.GlaxoSmithKlineSanofi-AventisBristol-Myers SquibbState of Brazil Research Foundation (FAPESP)[03/00204-3]Ministry of Social ProtectionEuropean Commission[QLG5-1999-01042]European Commission[SANCO 2004123]Piedmont Region (Italy)Fondo de Investigacion Sanitaria, Instituto de Salud Carlos III, Spain[FIS 00/0028]Spanish Ministerio de Ciencia y Tecnologia[SAF 2000-158-CE]Departament de Salut, Generalitat de Catalunya, SpainInstituto de Salud Carlos III[CIBER CB06/02/0046]Instituto de Salud Carlos III[RETICS RD06/0011 REM-TAP]Government of IndiaWHOMinistry of HealthIsrael National Institute for Health Policy and Health Services ResearchNational Insurance Institute of IsraelJapan Ministry of Health, Labour and Welfare[H13-Shogai-023]Japan Ministry of Health, Labour and Welfare[H14-Tokubetsu-026]Japan Ministry of Health, Labour and Welfare[H16-Kokoro-013]Lebanese Ministry of Public HealthWHO (Lebanon)(NIH) Fogarty International, anonymous private donations to IDRAAC, LebanonJanssen CilagEli LillyRocheNovartisNational Institute of Psychiatry Ramon de la Fuente[INPRFMDIES 4280]CNPq National Council on Science and Technology[CONACyT-G30544-H]PanAmerican Health Organization (PAHO)New Zealand Ministry of Health, Alcohol Advisory CouncilHealth Research Council(NIH/NIMH) USA National Institute of Mental Health[R01-MH059575](NIH/NIMH) USA National Institute of Mental Health[RO1-MH61905]National Institute of Drug AbuseSouth African Department of HealthUniversity of MichiganNational Institute of Mental Health (NIH/NIMH)[U01-MH60220]National Institute of Drug Abuse (NIDA)Substance Abuse and Mental Health Services Administration (SAMHSA)Robert Wood Johnson Foundation (RWJF)[044708]John W. Alden TrustsAnalysis Group Inc.Eli Lilly CompanyEPI-QJohnson & Johnson PharmaceuticalsOrtho-McNeil Janssen Scientific AffairsPfizer Inc.Shire USA, Inc