Synchronization in all-digital QAM receivers

The recent advance in Field Programmable Gate Array (FPGA) technology has been largely embraced by the communication industry, which views this technology as an effective and economical alternative to the design of Application Specific Integrated Circuits (ASICs). The primary reasons for switching to FPGAs are lower development and non-recurring engineering costs, the flexibility to design to a preliminary standard and adapt the design as the standard evolves, as well as the option of performing software updates in the field. A sector with strong interest in FPGAs is the coaxial cable TV/Internet distribution industry. The creation of soft preliminary standards by the standards organization governing the industry has been the main catalyst for the massive adoption of FPGAs by small to medium size companies, which see this technology as an opportunity to compete in this open market. Both the circuit speed and the economy of FPGA technology depend upon using algorithms that map efficiently into its fabric. Often it is prudent to sacrifice performance to improve either clock speed or economy when developing with FPGAs. The purpose of this research is to both revise and devise synchronization algorithms / structures for cable digital receivers that are to be implemented in FPGA. The main communication scheme used by the coaxial cable distribution industry is digital Quadrature Amplitude Modulation (QAM). The problem of synchronizing to the QAM signal in the receiver is not a new topic and several synchronization-related circuits, which were devised with ASICs implementation in mind, can be found in the open literature. Of interest in this thesis is the non-data-aided digital timing synchronizer that was proposed by D'Andrea to recover timing with no knowledge of the transmitted data. Accurate timing estimation was achieved by reshaping the received signal with a prefilter prior to estimating the timing. A problem with D'Andrea's synchronizer is that the prefilter for reshaping the signal is a relatively long Finite Impulse Response (FIR) filter, whose implementation requires a large number of multipliers. This may not have been an issue with ASICs in as much as the number of hardwired multipliers on a chip is not limited as it is in an FPGA chip. One contribution in this research is to propose an alternative to D'Andrea's synchronizer by replacing the long FIR filter with two single-pole Infinite Impulse Response (IIR) filters that are directly placed inside the timing recovery loop. This novel architecture, which drastically reduces the number of multipliers, is well suited for FPGA implementation. Non-data-aided feedforward synchronizers, which use the same prefilter as D'Andrea's synchronizer, have been receiving significant attention in recent years. Detailed performance analysis for these synchronizers can be found in the open literature. These synchronizers have the advantage of using a feedfordward structure rather than a feedback structure, as it is the case in D'Andrea's synchronizer, to estimate the timing. While D'Andrea's synchronizer has an advantage in performance over a non-data-aided feedforward synchronizer, this has not been reported in the literature. In this thesis a second contribution consists of thoroughly analyzing the steady state timing jitter in D'Andrea synchronizer by deriving a closed-form expression for the noise power spectrum and a simple equation to estimate the timing jitter variance. A third contribution is a novel low-complexity and fast acquisition coherent detector for the detection of Quadrature Phase Shift Keying (QPSK) (i.e., 4-QAM) symbols. This detector performs carrier phase synchronization much faster than a conventional coherent detector. The acquisition time is comparable to that of a differential detector. The fast acquisition comes at the expense of phase jitter, and the end result is a 1 dB performance loss over theoretical coherent detection. This detector can be used in place of the differential detector with no economic penalty. Doing so yields a performance advantage of about 2 dB over differential detection

Possibilités et limites de la sélection visuelle dans la lutte contre les viroses de la vigne: une expérience avec quelques cépages rouges en Suisse romande

Un travail de sélection portant sur 8 cépages rouges, entrepris en 1954 à la Station Fédérale d'Essars Agricoles de Lausanne (Suisse) et basé sur le seul examen visuel des symptômes a donné des résultats très satisfaisants. Les auteurs soulignent l'intérêt que cette méthode simple et peu coûteuse de sélection présente encore, malgré l'existence de techniques plus raffinées, telles que l'indexage, la sérologie 2t la thermothérapie. Ils décrivent les conditions dans lesquelles elle est susceptible de donner les meilleuns résultats et montrent ses limites: bien qu'elle ne suffise en général pas pour éliminer tous les virus, elle permet d'obtenir à peu de frais une amélioration très sensible du rendement des cépages sélectionnés

Asynchronous Sampling Rate Conversions in Digital Communications Systems

The problem of resampling digital signals at an output sampling rate that is incommensurate with the input sampling rate is the topic of this paper. This problem is often encountered in practice, as for example in the multiplexing of video signals from different sources for the purpose of distribution. There are basically two approaches to resample the signals. Both approaches are thoroughly described and practical circuits for hardware implementation are provided. A comparison of the two circuits presented in the paper shows that one circuit requires a division to compute the new sampling times. This time scaling operation adds complexity to the implementation with no performance advantage over the other circuit, and makes the “division free” circuit the preferred one for resampling

Hirschsprung disease, associated syndromes and genetics: A review

Hirschsprung disease (HSCR, aganglionic megacolon) represents the main genetic cause of functional intestinal obstruction with an incidence of 1/5000 live births. This developmental disorder is a neurocristopathy and is characterised by the absence of the enteric ganglia along a variable length of the intestine. In the last decades, the development of surgical approaches has importantly decreased mortality and morbidity which allowed the emergence of familial cases. Isolated HSCR appears to be a non-Mendelian malformation with low, sex-dependent penetrance, and variable expression according to the length of the aganglionic segment. While all Mendelian modes of inheritance have been described in syndromic HSCR, isolated HSCR stands as a model for genetic disorders with complex patterns of inheritance. The tyrosine kinase receptor RET is the major gene with both rare coding sequence mutations and/or a frequent variant located in an enhancer element predisposing to the disease. Hitherto, 10 genes and five loci have been found to be involved in HSCR development.published_or_final_versio

ALADIN is Required for the Production of Fertile Mouse Oocytes

Asymmetric cell divisions depend on the precise placement of the spindle apparatus. In mammalian oocytes, spindles assemble close to the cell's center, but chromosome segregation takes place at the cell periphery where half of the chromosomes are expelled into small, nondeveloping polar bodies at anaphase. By dividing so asymmetrically, most of the cytoplasmic content within the oocyte is preserved, which is critical for successful fertilization and early development. Recently we determined that the nucleoporin ALADIN participates in spindle assembly in somatic cells, and we have also shown that female mice homozygously null for ALADIN are sterile. In this study we show that this protein is involved in specific meiotic stages, including meiotic resumption, spindle assembly, and spindle positioning. In the absence of ALADIN, polar body extrusion is compromised due to problems in spindle orientation and anchoring at the first meiotic anaphase. ALADIN null oocytes that mature far enough to be fertilized in vitro are unable to support embryonic development beyond the two-cell stage. Overall, we find that ALADIN is critical for oocyte maturation and appears to be far more essential for this process than for somatic cell divisions

Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use.

Genetic decoding is not 'frozen' as was earlier thought, but dynamic. One facet of this is frameshifting that often results in synthesis of a C-terminal region encoded by a new frame. Ribosomal frameshifting is utilized for the synthesis of additional products, for regulatory purposes and for translational 'correction' of problem or 'savior' indels. Utilization for synthesis of additional products occurs prominently in the decoding of mobile chromosomal element and viral genomes. One class of regulatory frameshifting of stable chromosomal genes governs cellular polyamine levels from yeasts to humans. In many cases of productively utilized frameshifting, the proportion of ribosomes that frameshift at a shift-prone site is enhanced by specific nascent peptide or mRNA context features. Such mRNA signals, which can be 5' or 3' of the shift site or both, can act by pairing with ribosomal RNA or as stem loops or pseudoknots even with one component being 4 kb 3' from the shift site. Transcriptional realignment at slippage-prone sequences also generates productively utilized products encoded trans-frame with respect to the genomic sequence. This too can be enhanced by nucleic acid structure. Together with dynamic codon redefinition, frameshifting is one of the forms of recoding that enriches gene expression.This work was supported by grants from Science Foundation Ireland [12/IP/1492 and 13/1A/1853 to J.F.A; 12/IA/1335 to P.V.B.], US. National Institutes of Health [RO3 MH098688 to J.F.A.], the Wellcome Trust [106207 to A.E.F and 094423 to P.V.B.] and the European Research Council (ERC) grant No. 646891 to A.E.F.]This is the final version of the article. It first appeared from Oxford University Press via https://doi.org/10.1093/nar/gkw53

The Bankart repair versus the Putti-Platt procedure: A randomized study with WOSI score at 10-year follow-up in 62 patients

Background and purpose This randomized study compared clinical results after surgery for posttraumatic shoulder instability with either an anatomical repair or an older, less anatomical but commonly used method. The less anatomical procedure has been considered quicker and less demanding, but it has been questioned regarding the clinical result. We therefore wanted to compare the clinical outcome of the two different procedures. Our hypothesis was that the anatomical repair would give less residual impairment postoperatively