Clinical characterization, diagnosis and surgical treatment of endometrial cancer in patients from the national cancer institute in the year 2020

El cáncer de endometrio es la enfermedad maligna del tracto genital femenino, es el cuarto cáncer más común, representa el 6% de los tumores malignos en la mujer después del cáncer de mama, pulmón y colorrectal. Penosamente su incidencia aumenta ligado a los cambios epidemiológicos y medioambientales que afectan a la población femenina. Objetivo: Determinar el tratamiento prevalente en pacientes con cáncer de endometrio en pacientes atendidos en el Instituto Nacional del Cáncer de Enero a Diciembre 2020. Metodología: Se realizó un estudio observacional, descriptivo, retrospectivo de corte transversal. Resultados: En nuestra investigación la incidencia de cáncer de endometrio fue de 24,6%, la edad de las pacientes, la edad frecuente fue de 61 a 70 años en 10 (30,3%), con una media de 57,5 años. El sangrado vaginal postmenopáusico fue la manifestación clínica más frecuente en 48,4%. La obesidad en las pacientes fue en 39% con un IMC mayor a 30. La diabetes se presentó en 18% de las pacientes y 5 de ellas presentaron obesidad. La HTA fue 58% de los pacientes. El tipo histológico más frecuente fue el Adenocarcinoma moderadamente diferenciado endometroide en un 56%. El tratamiento fue la histerectomía en todos los casos siendo la más frecuente la histerectomía total en 21 (63,6%), 6 (18,1%) requirió de Quimioterapia y 10(30,3%) de Radioterapia. La tipificación del cáncer con mayor frecuencia fue el tipo T1cN0Mx en 17 (52%) casos. Conclusiones: En nuestra investigación la incidencia de cáncer de endometrio fue de 24,6%, la edad media fue de 57,5 años. La manifestación clínica más frecuente fue el sangrado irregular, las patologías asociadas fueron sobrepeso, la obesidad, la diabetes y la HTA. En la mayoría, el tratamiento fue la histerectomía total, la tipificación fue T1cN0Mx y el grado fue IIEndometrial cancer is the malignant disease of the female genital tract, it is the fourth most common cancer, accounting for 6% of malignant tumors in women after breast, lung and colorectal cancer. Sadly, its incidence increases linked to epidemiological and environmental changes that affect the female population. Objective: To determine the prevalent treatment in patients with endometrial cancer in patients treated at the National Cancer Institute from January to December 2020. Methodology: An observational, descriptive, retrospective cross-sectional study was carried out. Results: In our research, the incidence of endometrial cancer was 24.6%, the age of the patients, the frequent age was 61 to 70 years in 10 (30.3%), with a mean of 57.5 years. Postmenopausal vaginal bleeding was the most frequent clinical manifestation in 48.4%. Obesity in the patients was in 39%, who presented a BMI greater than 30. Diabetes appeared in 18% of the patients and 5 of them presented obesity. HT was 58% of the patients. The most frequent histological type was moderately differentiated endometroid adenocarcinoma in 56%. Treatment was hysterectomy in all cases, the most frequent being total hysterectomy in 21 (63.6%), 6 (18.1%) required chemotherapy and 10 (30.3%) required radiotherapy. The most frequent type of cancer was the T1cN0Mx type in 17 (52%) cases. Conclusions: In our research, the incidence of endometrial cancer was 24.6%, the mean age was 57.5 years. The most frequent clinical manifestation was irregular bleeding, the associated pathologies were overweight, obesity, diabetes and hypertension. In the majority, the treatment was total hysterectomy, the typing was T1cN0Mx and the grade was I

DFT Electronic Properties and Synthesis Thermodynamics of LixLa1-xTiO3Electrolytes for Li-Ion Batteries

Lithium lanthanum titanate perovskites Li x La1-x TiO3 (LLTO) are promising solid-electrolytes for Li-ion batteries. We studied, in the Density-Functional-Theory framework, the thermodynamic stability and the electronic and magnetic properties of LLTO, as bulk materials and as thin slabs with (001) exposed surfaces. Results show that LaTiO3 (LTO) exhibits semiconductor behavior and G-type antiferromagnetic order (AFMG), whereas the TiO2-terminated LTO slab is a semiconductor with ferromagnetic (FM) order. Contrasting, the LTO slab exposing a LaO-terminated surface is a conductor with AFMG ordered Ti cations' magnetic moments (MMs), but at the surface there are some FM ordered MMs (La atoms). LLTO bulk electrolyte is a semiconductor (x = 0.25) or insulator (x = 0.50). The LLTO slab is a FM (non-magnetic) conductor (TiO2 (LiO)-terminated surface) or a FM semiconductor (LaO-terminated). Besides, the stability of the LLTO bulk and slabs structures was analyzed, as well as the slabs' preferences for LiO, LaO or TiO2 ends.This work was partially supported by the projects IPN-SIP 20196659, 20201114 and 20210203. J. M. Cervantes, J. E. Antonio and H. Muñoz want to acknowledge the scholarship granted by the CONACyT and support from BEIFI-IPN. J. Pilo acknowledges the postdoctoral scholarship granted by CONACyT. J. L. Rosas-Huerta wants to acknowledge the postdoctoral-scholarship granted by DGAPA-UNAM

Mortality after surgery in Europe: a 7 day cohort study

Background: Clinical outcomes after major surgery are poorly described at the national level. Evidence of heterogeneity between hospitals and health-care systems suggests potential to improve care for patients but this potential remains unconfirmed. The European Surgical Outcomes Study was an international study designed to assess outcomes after non-cardiac surgery in Europe.Methods: We did this 7 day cohort study between April 4 and April 11, 2011. We collected data describing consecutive patients aged 16 years and older undergoing inpatient non-cardiac surgery in 498 hospitals across 28 European nations. Patients were followed up for a maximum of 60 days. The primary endpoint was in-hospital mortality. Secondary outcome measures were duration of hospital stay and admission to critical care. We used χ² and Fisher’s exact tests to compare categorical variables and the t test or the Mann-Whitney U test to compare continuous variables. Significance was set at p<0·05. We constructed multilevel logistic regression models to adjust for the differences in mortality rates between countries.Findings: We included 46 539 patients, of whom 1855 (4%) died before hospital discharge. 3599 (8%) patients were admitted to critical care after surgery with a median length of stay of 1·2 days (IQR 0·9–3·6). 1358 (73%) patients who died were not admitted to critical care at any stage after surgery. Crude mortality rates varied widely between countries (from 1·2% [95% CI 0·0–3·0] for Iceland to 21·5% [16·9–26·2] for Latvia). After adjustment for confounding variables, important differences remained between countries when compared with the UK, the country with the largest dataset (OR range from 0·44 [95% CI 0·19 1·05; p=0·06] for Finland to 6·92 [2·37–20·27; p=0·0004] for Poland).Interpretation: The mortality rate for patients undergoing inpatient non-cardiac surgery was higher than anticipated. Variations in mortality between countries suggest the need for national and international strategies to improve care for this group of patients.Funding: European Society of Intensive Care Medicine, European Society of Anaesthesiology