Development of TPS flight test and operational instrumentation

Thermal and flow sensor instrumentation was developed for use as an integral part of the space shuttle orbiter reusable thermal protection system. The effort was performed in three tasks: a study to determine the optimum instruments and instrument installations for the space shuttle orbiter RSI and RCC TPS; tests and/or analysis to determine the instrument installations to minimize measurement errors; and analysis using data from the test program for comparison to analytical methods. A detailed review of existing state of the art instrumentation in industry was performed to determine the baseline for the departure of the research effort. From this information, detailed criteria for thermal protection system instrumentation were developed

Hydroprocessing and Blending of a Biomass-Based DTG-Gasoline

The number of annually registered internal-combustion vehicles still exceeds electric-driven ones in most regions, e.g., Germany. Ambitious goals are disclosed with the European Green Deal, which calls for new technical approaches and greenhouse gas neutral transition technologies. Such bridging technologies are synthetic fuels for the transportation sector, e.g., using the bioliq® process for a CO2-neutral gasoline supply. Fuels must meet the applicable national standards to be used in existing engines. Petrochemical parameters can be variably adapted to their requirements by hydroprocessing. In this work, we considered the upgrading of aromatic-rich DTG gasoline from the bioliq® process. The heavy gasoline was therefore separated from the light one by rectification. We investigated how to selectively modify the petrochemical parameters of the heavy gasoline, especially the boiling characteristics, to make the product suitable as a high-quality blending component. Three commercially available Pt/zeolite catalysts were tested over a wide range of temperature and space velocity. We achieved high gasoline yields, while the content of light end compounds up to a boiling temperature of 150°C could be increased significantly. In contrast to the high naphthenic content of the gasoline, the obtained octane numbers were satisfactory. Especially the Motor Octane Number turned out unexpectedly high and showed a dependency on the isomerization of the naphthenic rings. By blending the upgraded heavy gasoline with the previously separated light gasoline, we could finally show that hydroprocessing is suitable for adjusting petrochemical parameters. The aromatic concentration was 37.5% lower than that in the original raw gasoline, while the boiling characteristics improved significantly. Additionally, the final boiling point was 82°C lower, which is beneficial for the emission behavior

Predictors of septic shock in patients with methicillin-resistant Staphylococcus aureus bacteremia

SummaryObjectivesRisk factors for septic shock associated with methicillin-resistant Staphylococcus aureus (MRSA) bacteremia are not well described. We designed this study to assess the independent predictors of septic shock in patients with MRSA bacteremia.MethodsThis retrospective chart review included 234 patients with MRSA bacteremia admitted to a tertiary care academic medical center. Cases of septic shock and non-septic shock MRSA bacteremia were compared in terms of patient baseline characteristics and co-morbidities, modes of acquisition, and MRSA genotyping. Independent risk factors were determined by multivariable analysis.ResultsOn univariate analysis the presence of chronic kidney disease, respiratory failure, acute renal failure, staphylococcal cassette chromosome (SCCmec) type II, and higher APACHE II scores were significantly correlated with the presence of septic shock. On multivariate analysis, baseline APACHE II score (adjusted odds ratio (AOR) for 1-point increase 1.13, 95% confidence interval (CI) 1.04–1.22, p=0.005), acute renal failure (AOR 2.57, 95% CI 1.02–6.48, p=0.045), and SCCmec type II (AOR 2.60, 95% CI 1.01–6.75, p=0.049) were independently associated with MRSA bacteremic septic shock.ConclusionsThe development of septic shock associated with MRSA bacteremia was independently correlated with baseline severity of illness, presence of acute renal failure, and an MRSA genotyping consistent with nosocomially acquired MRSA infection

Genetic background modifies CNS-mediated sensorimotor decline in the AD-BXD mouse model of genetic diversity in Alzheimer\u27s disease.

Many patients with Alzheimer\u27s dementia (AD) also exhibit noncognitive symptoms such as sensorimotor deficits, which can precede the hallmark cognitive deficits and significantly impact daily activities and an individual\u27s ability to live independently. However, the mechanisms underlying sensorimotor dysfunction in AD and their relationship with cognitive decline remains poorly understood, due in part to a lack of translationally relevant animal models. To address this, we recently developed a novel model of genetic diversity in Alzheimer\u27s disease, the AD-BXD genetic reference panel. In this study, we investigated sensorimotor deficits in the AD-BXDs and the relationship to cognitive decline in these mice. We found that age- and AD-related declines in coordination, balance and vestibular function vary significantly across the panel, indicating genetic background strongly influences the expressivity of the familial AD mutations used in the AD-BXD panel and their impact on motor function. Although young males and females perform comparably regardless of genotype on narrow beam and inclined screen tasks, there were significant sex differences in aging- and AD-related decline, with females exhibiting worse decline than males of the same age and transgene status. Finally, we found that AD motor decline is not correlated with cognitive decline, suggesting that sensorimotor deficits in AD may occur through distinct mechanisms. Overall, our results suggest that AD-related sensorimotor decline is strongly dependent on background genetics and is independent of dementia and cognitive deficits, suggesting that effective therapeutics for the entire spectrum of AD symptoms will likely require interventions targeting each distinct domain involved in the disease

Protein spot arrays on graphene oxide coatings for efficient single-cell capture

Biomedical applications such as cell screening or cell–cell interaction studies require placement and adhesion of cells on surfaces with controlled numbers and location. In particular, single-cell arraying and positioning has come into focus as a basis of such applications. An ideal substrate would combine biocompatibility with favorable attributes such as pattern stability and easy processing. Here, we present a simple yet effective approach to single-cell arraying based on a graphene oxide (GO) surface carrying protein (fibronectin) microarrays to define cell adhesion points. These capture NIH-3T3 cells, resulting in cell arrays, which are benchmarked against analogous arrays on silanized glass samples. We reveal significant improvement in cell-capture performance by the GO coating with regards to overall cell adhesion and single-cell feature occupancy. This overall improvement of cell-arraying combined with retained transparency of substrate for microscopy and good biocompatibility makes this graphene-based approach attractive for single-cell experiments

Coulomb plasmas in outer envelopes of neutron stars

Outer envelopes of neutron stars consist mostly of fully ionized, strongly coupled Coulomb plasmas characterized by typical densities about 10^4-10^{11} g/cc and temperatures about 10^4-10^9 K. Many neutron stars possess magnetic fields about 10^{11}-10^{14} G. Here we briefly review recent theoretical advances which allow one to calculate thermodynamic functions and electron transport coefficients for such plasmas with an accuracy required for theoretical interpretation of observations.Comment: 4 pages, 2 figures, latex2e using cpp2e.cls (included). Proc. PNP-10 Workshop, Greifswald, Germany, 4-9 Sept. 2000. Accepted for publication in Contrib. Plasma Phys. 41 (2001) no. 2-

Conseil-santé dans la médecine de premier recours, partie 2

Les maladies non transmissibles (MNT, en anglais «non-communicable diseases») ont gagné du terrain dans le monde entier. Les approches de conseil fourni au cabinet médical ont déjà été présentées dans un premier article. Le présent article se consacre aux conditions permettant à ces approches de déployer leur efficacité au niveau de la population. Ceci est illustré sur la base des programmes suisses actuels «Vivre sans tabac», PAPRICA et «Coaching Santé» ainsi que de l’exemple historique «Ça débouche sur quoi?»

Trauma, poverty and mental health among Somali and Rwandese refugees living in an African refugee settlement – an epidemiological study

Onyut LP, Neuner F, Ertl V, Schauer E, Odenwald M, Elbert T. Trauma, poverty and mental health among Somali and Rwandese refugees living in an African refugee settlement – an epidemiological study. Conflict and Health. 2009;3(1):6.Background: The aim of this study was to establish the prevalence of posttraumatic stress disorder (PTSD) and depression among Rwandese and Somali refugees resident in a Ugandan refugee settlement, as a measure of the mental health consequences of armed conflict, as well as to inform a subsequent mental health outreach program. The study population comprised a sample from 14400 (n = 519 Somali and n = 906 Rwandese) refugees resident in Nakivale refugee settlement in South Western Uganda during the year 2003. Methods: The Posttraumatic Diagnostic Scale (PDS) and the Hopkins Symptom Checklist 25 were used to screen for posttraumatic stress disorder and depression. Results: Thirty two percent of the Rwandese and 48.1% of the Somali refugees were found to suffer from PTSD. The Somalis refugees had a mean of 11.95 (SD = 6.17) separate traumatic event types while the Rwandese had 8.86 (SD = 5.05). The Somalis scored a mean sum score of 21.17 (SD = 16.19) on the PDS while the Rwandese had a mean sum score of 10.05 (SD = 9.7). Conclusion: Mental health consequences of conflict remain long after the events are over, and therefore mental health intervention is as urgent for post-conflict migrant populations as physical health and other emergency interventions. A mental health outreach program was initiated based on this study