Installation of New CSD (Carbonated Soft Drink) RGB (Returnable Glass Bottle) Line with Food Safety Comply and Final Validation

The basic of this project was installation of new CSD (carbonated soft drink) RGB (returnable glass bottle) line with comply food safety and final validation of line. New manufacturing line installation deals with installation of all equipment and machine require for smooth running and producing CSD for COCA-COLA company (Coca-Cola, Thums UP, Limca) such as conveyer belt, uncasing machine, light inspection station, bottle washer EBI (electronic bottle inspection ) machine, Paramix, Filler, Sealer, Date coding machine, caser etc. During installation of machine we have fulfill requirement related to machine, work space, hygienic condition so that machine can work smoothly and deliver safe food product The main concern of doing this project was deliver a safe product to the consumer by applying HACCP and ISO22K. I have done hazard analysis and validation of this new installed line and identify CCP and OPRP which need to control by applying control measure

Barium & related stars and their white-dwarf companions II. Main-sequence and subgiant stars

Barium (Ba) dwarfs and CH subgiants are the less-evolved analogues of Ba and CH giants. They are F- to G-type main-sequence stars polluted with heavy elements by a binary companion when the latter was on the Asymptotic Giant Branch (AGB). This companion is now a white dwarf that in most cases cannot be directly detected. We present a large systematic study of 60 objects classified as Ba dwarfs or CH subgiants. Combining radial-velocity measurements from HERMES and SALT high-resolution spectra with radial-velocity data from CORAVEL and CORALIE, we determine the orbital parameters of 27 systems. We also derive their masses by comparing their location in the Hertzsprung-Russell diagram with evolutionary models. We confirm that Ba dwarfs and CH subgiants are not at different evolutionary stages and have similar metallicities, despite their different names. Additionally, Ba giants appear significantly more massive than their main-sequence analogues. This is likely due to observational biases against the detection of hotter main-sequence post-mass-transfer objects. Combining our spectroscopic orbits with the Hipparcos astrometric data, we derive the orbital inclinations and the mass of the WD companion for four systems. Since this cannot be done for all systems in our sample yet (but should be with upcoming Gaia data releases), we also analyse the mass-function distribution of our binaries. We can model this distribution with very narrow mass distributions for the two components and random orbital orientation on the sky. Finally, based on BINSTAR evolutionary models, we suggest that the orbital evolution of low-mass Ba systems can be affected by a second phase of interaction along the Red Giant Branch of the Ba star, impacting on the eccentricities and periods of the giants.Comment: Accepted for publication in A&A on the 5th of April, 201

Human Arm simulation for interactive constrained environment design

During the conceptual and prototype design stage of an industrial product, it is crucial to take assembly/disassembly and maintenance operations in advance. A well-designed system should enable relatively easy access of operating manipulators in the constrained environment and reduce musculoskeletal disorder risks for those manual handling operations. Trajectory planning comes up as an important issue for those assembly and maintenance operations under a constrained environment, since it determines the accessibility and the other ergonomics issues, such as muscle effort and its related fatigue. In this paper, a customer-oriented interactive approach is proposed to partially solve ergonomic related issues encountered during the design stage under a constrained system for the operator's convenience. Based on a single objective optimization method, trajectory planning for different operators could be generated automatically. Meanwhile, a motion capture based method assists the operator to guide the trajectory planning interactively when either a local minimum is encountered within the single objective optimization or the operator prefers guiding the virtual human manually. Besides that, a physical engine is integrated into this approach to provide physically realistic simulation in real time manner, so that collision free path and related dynamic information could be computed to determine further muscle fatigue and accessibility of a product designComment: International Journal on Interactive Design and Manufacturing (IJIDeM) (2012) 1-12. arXiv admin note: substantial text overlap with arXiv:1012.432

Effect of Fasciola gigantica excretory secretory antigen on rat hematological indices

The present study was undertaken to investigate the effect of Fasciola gigantica excretory secretory antigen (Fg-ESA) on rat hematological indices. Fg-ESA was prepared by keeping thoroughly washed 40 F. gigantica flukes in 100 ml phosphate buffer saline (PBS) for 2 h at 37℃, and centrifuging the supernatant at 12,000 g at 4℃ for 30 min. The protein content of Fg-ESA was adjusted to 1.8 mg/ml. The rats were randomly divided into two groups of six rats each. Rats in group A received 0.5 ml of Fg-ESA intraperitoneally (i.p.) for 7 days, whereas control rats in group B received 0.5 ml of PBS i.p. for 7 days. Hemograms of both groups were studied initially and on days 0, 2, 4, 14 and 21 after the final injection of Fg-ESA or PBS. Progressive and significant (p < 0.01) declines in the values of hemoglobin, hematocrit, and total erythrocyte count were observed without significant (p > 0.05) changes in the values of mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, or mean corpuscular volume in group A. Thus, we conclude that Fg-ESA induces normocytic normochromic anemia in rats

Diabetes conversation map - A novel tool for diabetes management self-efficacy among type 2 diabetes patients in Pakistan: A randomized controlled trial

Background: This study aimed to measure the effect of diabetes education using the novel method of "diabetes conversation map (DCM)"as compared to routine counselling (RC) on diabetes management self-efficacy (DMSE) among patients living with type 2 diabetes in Karachi, Pakistan. Methods: A parallel arm randomized controlled trial among patients with type 2 diabetes aged 30-60 years, with HbA1c > 7%, diagnosed for at least 5 yrs., was conducted at the national institute of diabetes and endocrinology in Karachi, Pakistan. A total 123 type 2 diabetes patients were randomized into DCM (n = 62) or RC (n = 61). Four weekly diabetes control sessions of 40 min each using the DCM or RC was provided. DMSE was measured using a validated Urdu language DMSE tool at baseline and after three months of the randomization. Change in DMSE and HbA1c levels within groups (pre-post) and between the groups after 3 months of enrollment was compared. Results: Baseline characteristics except HbA1c were similar between the two arms. After 3 months of enrollment, there was no change in the DMSE score in the RC arm however, significant increase in DMSE score was noted in the DCM arm (P = < 0.001). The average difference (95% confidence interval) in DMSE score between the DCM and RC arm was 33.7(27.3, 40.0; p = < 0.001) after 3 months of the enrollment. Difference in HbA1c within groups was not significant. Conclusions: DCM significantly improved DMSE among type 2 diabetes patients in a developing country setting like Pakistan. Healthcare workers caring for type 2 diabetes patients need to be trained on DCM to effectively utilize this novel tool for educating diabetes patients. Trial registration: This trial was prospectively registered. ClinicalTrials.gov Identifier: NCT03747471. Date of registration: Nov 20. 2018

Health hazards of pesticides in Pakistan

Public health / Risks / Pesticide residues / Pest control / Plant protection / Surveys / Pakistan / Sindh

A META-ANALYSIS OF THE EFFICACY AND SAFETY OF ADJUNCTIVE PERAMPANEL FOR THE TREATMENT OF REFRACTORY FOCAL-ONSET SEIZURES IN EPILEPTIC PATIENTS

The usage of anti-seizure medications (ASMs) has increased over the previous decade, yet the burden of treating drug-resistant epilepsy has not decreased. This meta-analysis was carried out to determine the best dose of Perampanel (PER) as a new adjunctive treatment for drug-resistant seizures. Method We examined through ScienceDirect, PubMed, and the Central Register of Controlled Trials (CENTRAL) for research that had been published between their start and February 1, 2021. characteristics of the research, patients, and treatment regimen, concurrent ASMs, and clinical results were taken out. The practical result was a 50%, 75%, or 100% decrease in the frequency of convulsive seizures, and the safety result was the percentage of drug withdrawal and negative side effects. The inverse variance approach was used to estimate odds ratios (OR) for 95% confidence intervals (CI). Result Four trials totalled 2187 people (1569 in the PER group and 618 in the placebo group). Results revealed that 8 or 12 mg per day had the greatest impact on all three outcomes, with no statistically significant difference between 8 and 12 mg per day (seizure-free, 3.5% vs. 3.7%, P =.85); 50% reduction, 35.5% vs. 36.1%; 75% reduction, 17.8% vs. 19.1%). Additionally, a larger percentage of treatment-emergent adverse events (TEAE) that led to dosage reduction or discontinuation occurred with 12-mg PER compared to 8-mg (8.7% vs. 17.0%; P .00001). Dizziness, somnolence, weariness, and irritability were the reported adverse events (AEs) (significantly linked with adjunctive PER). Significance In patients with refractory epilepsy, adjunctive treatment with PER was related to a greater reduction in seizure frequency than placebo and a higher frequency of adverse events (AEs). For the majorityof research participants, PER at a dose of 8 mg per day appeared to have the best efficacy-to-tolerance ratio

Kepler eclipsing binary stars. VII. the catalogue of eclipsing binaries found in the entire Kepler data set

The primary Kepler Mission provided nearly continuous monitoring of ~200,000 objects with unprecedented photometric precision. We present the final catalog of eclipsing binary systems within the 105 deg2 Kepler field of view. This release incorporates the full extent of the data from the primary mission (Q0-Q17 Data Release). As a result, new systems have been added, additional false positives have been removed, ephemerides and principal parameters have been recomputed, classifications have been revised to rely on analytical models, and eclipse timing variations have been computed for each system. We identify several classes of systems including those that exhibit tertiary eclipse events, systems that show clear evidence of additional bodies, heartbeat systems, systems with changing eclipse depths, and systems exhibiting only one eclipse event over the duration of the mission. We have updated the period and galactic latitude distribution diagrams and included a catalog completeness evaluation. The total number of identified eclipsing and ellipsoidal binary systems in the Kepler field of view has increased to 2878, 1.3% of all observed Kepler targets

The Tarantula massive binary monitoring: III. Atmosphere analysis of double-lined spectroscopic systems

Context. Accurate stellar parameters of individual objects in binary systems are essential to constrain the effects of binarity on stellar evolution. These parameters serve as a prerequisite to probing existing and future theoretical evolutionary models. Aims. We aim to derive the atmospheric parameters of the 31 double-lined spectroscopic binaries in the Tarantula Massive Binary Monitoring sample. This sample, composed of detached, semi-detached and contact systems with at least one of the components classified as an O-type star, is an excellent test-bed to study how binarity can impact our knowledge of the evolution of massive stars. Methods. In the present paper, 32 epochs of FLAMES/GIRAFFE spectra are analysed by using spectral disentangling to construct the individual spectra of 62 components. We then apply the CMFGEN atmosphere code to determine their stellar parameters and their helium, carbon, and nitrogen surface abundances. Results. Among the 31 systems that we study in the present paper, we identify between 48 and 77% of them as detached, likely pre-interacting systems, 16% as semi-detached systems, and between 5 and 35% as systems in or close to contact phase. Based on the properties of their components, we show that the effects of tides on chemical mixing are limited. Components on longer-period orbits show higher nitrogen enrichment at their surface than those on shorter-period orbits, in contrast to expectations of rotational or tidal mixing, implying that other mechanisms play a role in this process. For semi-detached systems, components that fill their Roche lobe are mass donors. They exhibit higher nitrogen content at their surface and rotate more slowly than their companions. By accreting new material, their companions spin faster and are likely rejuvenated. Their locations in the N − v sin i diagram tend to show that binary products are good candidates to populate the two groups of stars (slowly rotating, nitrogen-enriched objects and rapidly rotating non-enriched objects) that cannot be reproduced through single-star population synthesis. Finally, we find no peculiar surface abundances for the components in (over-)contact systems, as has been suggested by evolutionary models for tidal mixing. Conclusions. This sample, consisting of 31 massive binary systems, is the largest sample of binaries composed of at least one O-type star to be studied in such a homogeneous way by applying spectral disentangling and atmosphere modelling. The study of these objects gives us strong observational constraints to test theoretical binary evolutionary tracks