Transitional Interface: Concept, Issues and Framework

Transitional Interfaces have emerged as a new way to interact and collaborate between different interaction spaces such as Reality, Virtual Reality and Augmented Reality. In this paper we explore this concept further. We introduce a descriptive model of the concept, its collaborative aspect and how it can be generalized to describe natural and continuous transitions between contexts (e.g. across space, scale, viewpoint, and representation)

The evolution of drug-activated nuclear receptors: one ancestral gene diverged into two xenosensor genes in mammals

BACKGROUND: Drugs and other xenobiotics alter gene expression of cytochromes P450 (CYP) by activating the pregnane X receptor (PXR) and constitutive androstane receptor (CAR) in mammals. In non-mammalian species, only one xenosensor gene has been found. Using chicken as a model organism, the aim of our study was to elucidate whether non-mammalian species only have one or two xenosensors like mammals. RESULTS: To explore the evolutionary aspect of this divergence, we tried to identify additional xenobiotic sensing nuclear receptors in chicken using various experimental approaches. However, none of those revealed novel candidates. Ablation of chicken xenobiotic receptor (CXR) function by RNAi or dominant-negative alleles drastically reduced drug-induction in a chicken hepatoma cell line. Subsequently, we functionally and structurally characterized CXR and compared our results to PXR and CAR. Despite the high similarity in their amino acid sequence, PXR and CAR have very distinct modes of activation. Some aspects of CXR function, e.g. direct ligand activation and high promiscuity are very reminiscent of PXR. On the other hand, cellular localization studies revealed common characteristics of CXR and CAR in terms of cytoplasmic-nuclear distribution. Finally, CXR has unique properties regarding its regulation in comparison to PXR and CAR. CONCLUSION: Our finding thus strongly suggest that CXR constitutes an ancestral gene which has evolved into PXR and CAR in mammals. Future studies should elucidate the reason for this divergence in mammalian versus non-mammalian species

First insights into the ISM at z > 8 with JWST: Possible physical implications of a high [O iii] λ4363/[O iii] λ5007

We present a detailed analysis of the rest-frame optical emission line ratios for three spectroscopically confirmed galaxies at z > 7.5. The galaxies were identified in the James Webb Space Telescope (JWST) Early Release Observations field SMACS J0723.3 - 7327. By quantitatively comparing Balmer and oxygen line ratios of these galaxies with various low-redshift 'analogue' populations (e.g. Green Peas, Blueberries, etc.), we show that no single analogue population captures the diversity of line ratios of all three galaxies observed at z > 7.5. We find that S06355 at z = 7.67 and S10612 at z = 7.66 are similar to local Green Peas and Blueberries. In contrast, S04590 at z = 8.50 appears to be significantly different from the other two galaxies, most resembling extremely low-metallicity systems in the local Universe. Perhaps the most striking spectral feature in S04590 is the curiously high [O iii] λ4363/[O iii] λ5007 ratio (RO3) of 0.048 (or 0.055 when dust-corrected), implying either extremely high electron temperatures, >3 × 104 K, or gas densities >104 cm-3. Observed line ratios indicate that this galaxy is unlikely to host an AGN. Using photoionization modelling, we show that the inclusion of high-mass X-ray binaries or a high cosmic ray background in addition to a young, low-metallicity stellar population can provide the additional heating necessary to explain the observed high RO3 while remaining consistent with other observed line ratios. Our models represent a first step at accurately characterizing the dominant sources of photoionization and heating at very high redshifts, demonstrating that non-thermal processes may become important as we probe deeper into the Epoch of Reionization

Cone-Rod Dystrophy Due to Mutations in a Novel Photoreceptor-Specific Homeobox Gene (CRX) Essential for Maintenance of the Photoreceptor

Genes associated with inherited retinal degeneration have been found to encode proteins required for phototransduction, metabolism, or structural support of photoreceptors. Here we show that mutations in a novel photoreceptor-specific homeodomain transcription factor gene (CRX) cause an autosomal dominant form of cone-rod dystrophy (adCRD) at the CORD2 locus on chromosome 19q13. In affected members of a CORD2-linked family, the highly conserved glutamic acid at the first position of the recognition helix is replaced by alanine (E80A). In another CRD family, a 1 bp deletion (E168 [delta1 bp]) within a novel sequence, the WSP motif, predicts truncation of the C-terminal 132 residues of CRX. Mutations in the CRX gene cause adCRD either by haploinsufficiency or by a dominant negative effect and demonstrate that CRX is essential for the maintenance of mammalian photoreceptorsThis work was supported by the RP Foundation of Canada (R. R. M.), the Foundation Fighting Blindness (R. R. M. and S. G. J.), the Canadian Genetic Disease Network (R. R. M. and A. D.), the Medical Research Council of Canada (R. R. M.), The Wellcome Trust (043825/Z/95) and the Human Genome Mapping Resource Centre (C. Y. G.-E. and S. S. B.), the Howard Hughes Medical Institute and NIH R01 EY0 8064 (C. L. C.), the Canadian Genome Analysis and Technology Genome Resource Facility (S. W. S. and L.-C. T.), the NIH/NEI (EY05627) (S. G. J.), and the Greek National Scholarship Foundation (M. P.). R. R. M. and L.-C. T. are International Research Scholars of the Howard Hughes Medical Institute

Exploring embodiment through martial arts and combat sports: a review of empirical research

Since the late 1970s, social scientists have turned considerable attention to investigating martial arts and combat sports (MACS). In particular, this broad range of fighting disciplines has been shown to offer numerous avenues for scholarly enquiry into social change and personal transformation via processes of embodiment. Adopting a thematic structure, we assess the empirical literature in this area via four interconnecting categories pertaining to MACS and embodiment: (1) body cultures; (2) body pedagogies; (3) the embodiment of gender; and (4) bodily harm. Following this review, we identify several gaps in the existing literature, suggesting potential new topics and strategies for research connecting to the social world of physical culture more generally

How well do computer-generated faces tap face expertise?

The use of computer-generated (CG) stimuli in face processing research is proliferating due to the ease with which faces can be generated, standardised and manipulated. However there has been surprisingly little research into whether CG faces are processed in the same way as photographs of real faces. The present study assessed how well CG faces tap face identity expertise by investigating whether two indicators of face expertise are reduced for CG faces when compared to face photographs. These indicators were accuracy for identification of own-race faces and the other-race effect (ORE)-the well-established finding that own-race faces are recognised more accurately than other-race faces. In Experiment 1 Caucasian and Asian participants completed a recognition memory task for own- and other-race real and CG faces. Overall accuracy for own-race faces was dramatically reduced for CG compared to real faces and the ORE was significantly and substantially attenuated for CG faces. Experiment 2 investigated perceptual discrimination for own- and other-race real and CG faces with Caucasian and Asian participants. Here again, accuracy for own-race faces was significantly reduced for CG compared to real faces. However the ORE was not affected by format. Together these results signal that CG faces of the type tested here do not fully tap face expertise. Technological advancement may, in the future, produce CG faces that are equivalent to real photographs. Until then caution is advised when interpreting results obtained using CG faces

JADES : the emergence and evolution of Ly α emission and constraints on the intergalactic medium neutral fraction

The rest-frame UV recombination emission line Lyα can be powered by ionising photons from young massive stars in star-forming galaxies, but the fact that it can be resonantly scattered by neutral gas complicates its interpretation. For reionisation-era galaxies, a neutral intergalactic medium will scatter Lyα from the line of sight, making Lyα a useful probe of the neutral fraction evolution. Here, we explore Lyα in JWST/NIRSpec spectra from the ongoing JADES programme, which targets hundreds of galaxies in the well-studied GOODS-S and GOODS-N fields. These sources are UV-faint (-20.4 < MUV <-16.4) and thus represent a poorly explored class of galaxy. We fitted the low spectral resolution spectra (R ∼ 100) of a subset of 84 galaxies in GOODS-S with zspec > 5.6 (as derived with optical lines) with line and continuum models to search for significant line emission. Through exploration of the R100 data, we find evidence for Lyα in 17 sources. This sample allowed us to place observational constraints on the fraction of galaxies with Lyα emission in the redshift range 5.6 < z < 7.5, with a decrease from z = 6 to z = 7. We also find a positive correlation between the Lyα equivalent width and MUV, as seen in other samples. We used these results to estimate the neutral gas fraction at z ∼ 7, and our estimates are in agreement with previous results (XHI ∼ 0.5-0.9)

JADES: Insights into the low-mass end of the mass-metallicity-SFR relation at 3 < z < 10 from deep JWST/NIRSpec spectroscopy

We analysed the gas-phase metallicity properties of a sample of low-stellar-mass (log M?/M. 9) galaxies at 3 &lt; z &lt; 10 observed with JWST/NIRSpec as part of the JADES programme in its deep GOODS-S tier. By combining this sample with more massive galaxies at similar redshifts from other programmes, we study the scaling relations between stellar mass (M?), oxygen abundance (O/H), and star-formation rate (SFR) for 146 galaxies spanning three orders of magnitude in stellar mass and out to the epoch of early galaxy assembly. We find evidence for a shallower slope at the low-mass end of the mass-metallicity relation (MZR), with 12+log(O/H) = (7.72 ± 0.02) + (0.17 ± 0.03) log(M?/108 M ), in good agreement with the MZR probed by local analogues of high-redshift systems, such as the 'Green Pea' and 'Blueberry' galaxies. The inferred slope is well matched by models including 'momentum-driven' supernova (SN) winds, suggesting that feedback mechanisms in dwarf galaxies (and at high z) might be different from those in place at higher masses. The evolution in the normalisation is observed to be relatively mild compared to previous determinations of the MZR at z ∼ 3 (∼0.1−0.2 dex across the explored mass regime). We observe a deviation from the local fundamental metallicity relation (FMR) for our sample at high redshift, especially at z &gt; 6, with galaxies significantly less enriched than predicted given their M? and SFR (with a median offset in log(O/H) of ∼0.5 dex, significant at ∼5σ). These observations are consistent with an enhanced stochasticity in the gas accretion and star-formation history of high-redshift systems, prompting us to reconsider the nature of the relationship between M?, O/H, and SFR in the early Universe

The chemical enrichment in the early Universe as probed by JWST via direct metallicity measurements at z ∼ 8

We analyse the chemical properties of three z∼ 8 galaxies behind the galaxy cluster SMACS J0723.3-7327, observed as part of the Early Release Observations programme of the James Webb Space Telescope. Exploiting [O III]λ4363 auroral line detections in NIRSpec spectra, we robustly apply the direct Te method for the very first time at such high redshift, measuring metallicities ranging from extremely metal poor (12 + log(O/H)≈ 7) to about one-third solar. We also discuss the excitation properties of these sources, and compare them with local strong-line metallicity calibrations. We find that none of the considered diagnostics match simultaneously the observed relations between metallicity and strong-line ratios for the three sources, implying that a proper re-assessment of the calibrations may be needed at these redshifts. On the mass-metallicity plane, the two galaxies at z ∼ 7.6 (log(M∗/M☉) = 8.1, 8.7) have metallicities that are consistent with the extrapolation of the mass-metallicity relation at z∼2-3, while the least massive galaxy at z ∼ 8.5 (log(M∗/M☉) = 7.8) shows instead a significantly lower metallicity. The three galaxies show different level of offset relative to the Fundamental Metallicity Relation, with two of them (at z∼ 7.6) being marginally consistent, while the z∼ 8.5 source deviating significantly, being probably far from the smooth equilibrium between gas flows, star formation, and metal enrichment in place at later epochs