DNA Technology: Are We Ready?

It is a common practice to identify certain historical periods with the name of the most significant technological invention of the time. Thus, we have had an Industrial Revolution, an Age of Steam, the Automotive Age, and so on, up to the Atomic Age. We are now at the crossroads of a new age; the Age of Biology. This new age promises to be every bit as influential in terms of broad social impact as any of its predecessors, and may ultimately profoundly modify the way in which we define our lives. The hallmark of this new age is DNA technology, the ability to manipulate the genetic make-up of living organisms; and like most new techologies, this one must be treated with respect in order to maximize the benefits while minimizing the attendant disruptions and risks. The purpose of this article is to explore alternative ways of dealing with DNA technology, and to recommend a safe as well as workable course of action

Fast two-dimensional model

A two dimensional (altitude and latitude) model of the atmosphere is used to investigate problems relating to the variability of the dynamics and temperature of the atmosphere on the ozone distribution, solar cycle variations of atmospheric constituents, the sensitivity of model results to tropospheric trace gas sources, and assessment computations of changes in ozone related to manmade influences. In a comparison between two dimensional model results in which the odd nitrogen family was transported together and model results in which the odd nitrogen species was transported separately, it was found that the family approximations are adequate for perturbation scenario calculations

Relationships Between Physical Measurements and Calving Difficulty in Two-Year-Old Santa Gertrudis Heifers

Last updated: 6/1/200

The disastrous 17 February 2006 rockslide-debris avalanche on Leyte Island, Philippines: a catastrophic landslide in tropical mountain terrain

International audienceIn February 2006, a disastrous rockslide-debris avalanche occurred in tropical mountain terrain, on Leyte Island, Central Philippines. Over 1100 people perished when the village of Guinsaugon was overwhelmed directly in the path of the landslide. The landslide was initiated by the failure of a 450 m high rock slope within the damage zone of the Philippine Fault where the rock mass consisted of sheared and brecciated volcanic, sedimentary and volcaniclastic rocks. Tectonic weakening of the failed rock mass had resulted from active strike-slip movements along the Philippine Fault which have been estimated by other workers at 2.5 cm/year. The landslide involved a total volume of 15 Mm3, including significant entrainment from its path, and ran out a horizontal distance of 3800 m over a vertical distance of 810 m, equivalent to a fahrböschung of 12°. Run-out distance was enhanced by friction reduction due to undrained loading when the debris encountered flooded paddy fields in the valley bottom at a path distance of 2600 m. A simulation of the event using the dynamic analysis model DAN indicated a mean velocity of 35 m/s and demonstrated the contribution of the paddy field effect to total run-out distance. There was no direct trigger for the landslide but the landslide did follow a period of very heavy rainfall with a lag time of four days. The rockslide-debris avalanche is one of several disastrous landslides to have occurred in the Philippines in the last twenty years. In terms of loss of life, the Guinsaugon event is the most devastating single-event landslide to have occurred worldwide since the Casita Volcano rock avalanche-debris flow which was triggered by Hurricane Mitch in Nicaragua in 1998

[Editorial] Accounting scholarship and management by numbers

There is a plethora of indices ranking universities, departments, and individual researchers based on a variety of indices. These invariably include a measurement of research, usually based on a combination of quantity and quality of journal publications. Informal discussions with accounting researchers invariably turns to the question of journal rankings and performance management indicators. Why is this so

Helium, Oxygen, Proton, and Electron (HOPE) Mass Spectrometer for the Radiation Belt Storm Probes Mission

The HOPE mass spectrometer of the Radiation Belt Storm Probes (RBSP) mission (renamed the Van Allen Probes) is designed to measure the in situ plasma ion and electron fluxes over 4π sr at each RBSP spacecraft within the terrestrial radiation belts. The scientific goal is to understand the underlying physical processes that govern the radiation belt structure and dynamics. Spectral measurements for both ions and electrons are acquired over 1 eV to 50 keV in 36 log-spaced steps at an energy resolution ΔE FWHM/E≈15 %. The dominant ion species (H+, He+, and O+) of the magnetosphere are identified using foil-based time-of-flight (TOF) mass spectrometry with channel electron multiplier (CEM) detectors. Angular measurements are derived using five polar pixels coplanar with the spacecraft spin axis, and up to 16 azimuthal bins are acquired for each polar pixel over time as the spacecraft spins. Ion and electron measurements are acquired on alternate spacecraft spins. HOPE incorporates several new methods to minimize and monitor the background induced by penetrating particles in the harsh environment of the radiation belts. The absolute efficiencies of detection are continuously monitored, enabling precise, quantitative measurements of electron and ion fluxes and ion species abundances throughout the mission. We describe the engineering approaches for plasma measurements in the radiation belts and present summaries of HOPE measurement strategy and performance

The Hand of Cercopithecoides williamsi (Mammalia, Primates): Earliest Evidence for Thumb Reduction among Colobine Monkeys

Thumb reduction is among the most important features distinguishing the African and Asian colobines from each other and from other Old World monkeys. In this study we demonstrate that the partial skeleton KNM-ER 4420 from Koobi Fora, Kenya, dated to 1.9 Ma and assigned to the Plio-Pleistocene colobine species Cercopithecoides williamsi, shows marked reduction of its first metacarpal relative to the medial metacarpals. Thus, KNM-ER 4420 is the first documented occurrence of cercopithecid pollical reduction in the fossil record. In the size of its first metacarpal relative to the medial metacarpals, C. williamsi is similar to extant African colobines, but different from cercopithecines, extant Asian colobines and the Late Miocene colobines Microcolobus and Mesopithecus. This feature clearly links the genus Cercopithecoides with the extant African colobine clade and makes it the first definitive African colobine in the fossil record. The postcranial adaptations to terrestriality in Cercopithecoides are most likely secondary, while ancestral colobinans (and colobines) were arboreal. Finally, the absence of any evidence for pollical reduction in Mesopithecus implies either independent thumb reduction in African and Asian colobines or multiple colobine dispersal events out of Africa. Based on the available evidence, we consider the first scenario more likely

Reimagining the Path of an Unmatched Orthopaedic Residency Application: A Survey of Program Directors

BACKGROUND: Few evidence-based suggestions are available to help applicants and mentors improve reapplication outcomes. We sought to provide program directors\u27 (PDs) perspectives on actionable steps to improve reapplicants\u27 chances for a match. METHODS: The PDs were asked to rank positions unmatched applicants can pursue, steps these applicants can take for the next application cycle, and reasons why reapplicants do not match. RESULTS: Responses from 66 of 123 PDs were received (53.6% response rate). Obtaining new recommendation letters and rotating with orthopaedics were the highest 20 ranked steps unmatched applicants can take. No curriculum vitae (CV) improvement, poor interview, and poor letters of recommendation were the most important reasons hindering applicants from matching when reapplying. CONCLUSIONS: Steps reapplicants could prioritize include obtaining new recommendation letters, rotating in orthopaedics, and producing new research items. CV strengthening and improving interview skills address the 2 main reasons why unmatched applicants failed in subsequent attempts. LEVEL OF EVIDENCE: Level IV