764 research outputs found
Evolution of size-dependent flowering in a variable environment: construction and analysis of a stochastic integral projection model
Understanding why individuals delay reproduction is a classic problem in evolutionary biology. In plants, the study of reproductive delays is complicated because growth and survival can be size and age dependent, individuals of the same size can grow by different amounts and there is temporal variation in the environment. We extend the recently developed integral projection approach to include size- and age-dependent demography and temporal variation. The technique is then applied to a long-term individually structured dataset for Carlina vulgaris, a monocarpic thistle. The parameterized model has excellent descriptive properties in terms of both the population size and the distributions of sizes within each age class. In Carlina, the probability of flowering depends on both plant size and age. We use the parameterized model to predict this relationship, using the evolutionarily stable strategy approach. Considering each year separately, we show that both the direction and the magnitude of selection on the flowering strategy vary from year to year. Provided the flowering strategy is constrained, so it cannot be a step function, the model accurately predicts the average size at flowering. Elasticity analysis is used to partition the size- and age-specific contributions to the stochastic growth rate, λs. We use λs to construct fitness landscapes and show how different forms of stochasticity influence its topography. We prove the existence of a unique stochastic growth rate, λs, which is independent of the initial population vector, and show that Tuljapurkar's perturbation analysis for log(λs) can be used to calculate elasticities
From scaling up to sustainability in HIV: potential lessons for moving forward
Background: In 30 years of experience in responding to the HIV epidemic, critical decisions and program characteristics for successful scale-up have been studied. Now leaders face a new challenge: sustaining large-scale HIV prevention programs. Implementers, funders, and the communities served need to assess what strategies and practices of scaling up are also relevant for sustaining delivery at scale. Methods: We reviewed white and gray literature to identify domains central to scaling-up programs and reviewed HIV case studies to identify how these domains might relate to sustaining delivery at scale. Results: We found 10 domains identified as important for successfully scaling up programs that have potential relevance for sustaining delivery at scale: fiscal support; political support; community involvement, integration, buy-in, and depth; partnerships; balancing flexibility/adaptability and standardization; supportive policy, regulatory, and legal environment; building and sustaining strong organizational capacity; transferring ownership; decentralization; and ongoing focus on sustainability. We identified one additional potential domain important for programs sustaining delivery at scale: emphasizing equity. Conclusions: Today, the public and private sector are examining their ability to generate value for populations. All stakeholders are aiming to stem the tide of the HIV epidemic. Implementers need a framework to guide the evolution of their strategies and management practices. Greater research is needed to refine the domains for policy and program implementers working to sustain HIV program delivery at scale
Noise and Nonlinearity in Measles Epidemics: Combining Mechanistic and Statistical Approaches to Population Modeling
We present and evaluate an approach to analyzing population dynamics data using semimechanistic models. These models incorporate reliable information on population structure and underlying dynamic mechanisms but use nonparametric surface-fitting methods to avoid unsupported assumptions about the precise form of rate equations. Using historical data on measles epidemics as a case study, we show how this approach can lead to better forecasts, better characterizations of the dynamics, and better understanding of the factors causing complex population dynamics relative to either mechanistic models or purely descriptive statistical time-series models. The semimechanistic models are found to have better forecasting accuracy than either of the model types used in previous analyses when tested on data not used to fit the models. The dynamics are characterized as being both nonlinear and noisy, and the global dynamics are clustered very tightly near the border of stability (dominant Lyapunov exponent λ < 0). However, locally in state space the dynamics oscillate between strong short-term stability and strong short-term chaos (i.e., between negative and positive local Lyapunov exponents). There is statistically significant evidence for short-term chaos in all data sets examined. Thus the nonlinearity in these systems is characterized by the variance over state space in local measures of chaos versus stability rather than a single summary measure of the overall dynamics as either chaotic or nonchaotic
Understanding Terrorist Organizations with a Dynamic Model
Terrorist organizations change over time because of processes such as
recruitment and training as well as counter-terrorism (CT) measures, but the
effects of these processes are typically studied qualitatively and in
separation from each other. Seeking a more quantitative and integrated
understanding, we constructed a simple dynamic model where equations describe
how these processes change an organization's membership. Analysis of the model
yields a number of intuitive as well as novel findings. Most importantly it
becomes possible to predict whether counter-terrorism measures would be
sufficient to defeat the organization. Furthermore, we can prove in general
that an organization would collapse if its strength and its pool of foot
soldiers decline simultaneously. In contrast, a simultaneous decline in its
strength and its pool of leaders is often insufficient and short-termed. These
results and other like them demonstrate the great potential of dynamic models
for informing terrorism scholarship and counter-terrorism policy making.Comment: To appear as Springer Lecture Notes in Computer Science v2:
vectorized 4 figures, fixed two typos, more detailed bibliograph
Rapid contemporary evolution and clonal food web dynamics
Character evolution that affects ecological community interactions often
occurs contemporaneously with temporal changes in population size, potentially
altering the very nature of those dynamics. Such eco-evolutionary processes may
be most readily explored in systems with short generations and simple genetics.
Asexual and cyclically parthenogenetic organisms such as microalgae,
cladocerans, and rotifers, which frequently dominate freshwater plankton
communities, meet these requirements. Multiple clonal lines can coexist within
each species over extended periods, until either fixation occurs or a sexual
phase reshuffles the genetic material. When clones differ in traits affecting
interspecific interactions, within-species clonal dynamics can have major
effects on the population dynamics. We first consider a simple predator-prey
system with two prey genotypes, parameterized with data on a well-studied
experimental system, and explore how the extent of differences in defense
against predation within the prey population determine dynamic stability versus
instability of the system. We then explore how increased potential for
evolution affects the community dynamics in a more general community model with
multiple predator and multiple prey genotypes. These examples illustrate how
microevolutionary "details" that enhance or limit the potential for heritable
phenotypic change can have significant effects on contemporaneous
community-level dynamics and the persistence and coexistence of species.Comment: 30 pages, 6 Figure
The demographic consequences of growing older and bigger in oyster populations
Structured population models, particularly size-or age-structured, have a long history of informing conservation and natural resource management. While size is often easier to measure than age and is the focus of many management strategies, age-structure can have important effects on population dynamics that are not captured in size-only models. However, relatively few studies have included the simultaneous effects of both age-and size-structure. To better understand how population structure, particularly that of age and size, impacts restoration and management decisions, we developed and compared a size-structured integral projection model (IPM) and an age-and size-structured IPM, using a population of Crassostrea gigas oysters in the northeastern Pacific Ocean. We analyzed sensitivity of model results across values of local retention that give populations decreasing in size to populations increasing in size. We found that age-and size-structured models yielded the best fit to the demographic data and provided more reliable results about long-term demography. Elasticity analysis showed that population growth rate was most sensitive to changes in the survival of both large (\u3e175 mm shell length) and small (length) oysters, indicating that a maximum size limit, in addition to a minimum size limit, could be an effective strategy for maintaining a sustainable population. In contrast, the purely size-structured model did not detect the importance of large individuals. Finally, patterns in stable age and stable size distributions differed between populations decreasing in size due to limited local retention and populations increasing in size due to high local retention. These patterns can be used to determine population status and restoration success. The methodology described here provides general insight into the necessity of including both age-and size-structure into modeling frameworks when using population models to inform restoration and management decisions
Mathematical Biology at an Undergraduate Liberal Arts College
Since 2002 we have offered an undergraduate major in Mathematical Biology at Harvey Mudd College. The major was developed and is administered jointly by the mathematics and biology faculty. In this paper we describe the major, courses, and faculty and student research and discuss some of the challenges and opportunities we have experienced
Integrating evolution into ecological modelling: accommodating phenotypic changes in agent based models.
PMCID: PMC3733718This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.Evolutionary change is a characteristic of living organisms and forms one of the ways in which species adapt to changed conditions. However, most ecological models do not incorporate this ubiquitous phenomenon. We have developed a model that takes a 'phenotypic gambit' approach and focuses on changes in the frequency of phenotypes (which differ in timing of breeding and fecundity) within a population, using, as an example, seasonal breeding. Fitness per phenotype calculated as the individual's contribution to population growth on an annual basis coincide with the population dynamics per phenotype. Simplified model variants were explored to examine whether the complexity included in the model is justified. Outputs from the spatially implicit model underestimated the number of individuals across all phenotypes. When no phenotype transitions are included (i.e. offspring always inherit their parent's phenotype) numbers of all individuals are always underestimated. We conclude that by using a phenotypic gambit approach evolutionary dynamics can be incorporated into individual based models, and that all that is required is an understanding of the probability of offspring inheriting the parental phenotype
Early alveolar macrophage response and IL-1R-dependent T cell priming determine transmissibility of Mycobacterium tuberculosis strains
Funding Information: The work was funded by the National Institute of Allergy and Infectious Diseases, National Institutes of Health grants U19AI111276 and U01AI065663 to R.R.R., R.D., J.J.E. and P.S., and NIAID training grant T32AI125185 to A.L. The study sponsors were not involved in the study design, in the collection, analysis, and interpretation of data; in the writing of the manuscript; or in the decision to submit the manuscript for publication. Publisher Copyright: © 2022, The Author(s).Mechanisms underlying variability in transmission of Mycobacterium tuberculosis strains remain undefined. By characterizing high and low transmission strains of M.tuberculosis in mice, we show here that high transmission M.tuberculosis strain induce rapid IL-1R-dependent alveolar macrophage migration from the alveolar space into the interstitium and that this action is key to subsequent temporal events of early dissemination of bacteria to the lymph nodes, Th1 priming, granulomatous response and bacterial control. In contrast, IL-1R-dependent alveolar macrophage migration and early dissemination of bacteria to lymph nodes is significantly impeded in infection with low transmission M.tuberculosis strain; these events promote the development of Th17 immunity, fostering neutrophilic inflammation and increased bacterial replication. Our results suggest that by inducing granulomas with the potential to develop into cavitary lesions that aids bacterial escape into the airways, high transmission M.tuberculosis strain is poised for greater transmissibility. These findings implicate bacterial heterogeneity as an important modifier of TB disease manifestations and transmission.publishersversionpublishe
Homophily and Contagion Are Generically Confounded in Observational Social Network Studies
We consider processes on social networks that can potentially involve three
factors: homophily, or the formation of social ties due to matching individual
traits; social contagion, also known as social influence; and the causal effect
of an individual's covariates on their behavior or other measurable responses.
We show that, generically, all of these are confounded with each other.
Distinguishing them from one another requires strong assumptions on the
parametrization of the social process or on the adequacy of the covariates used
(or both). In particular we demonstrate, with simple examples, that asymmetries
in regression coefficients cannot identify causal effects, and that very simple
models of imitation (a form of social contagion) can produce substantial
correlations between an individual's enduring traits and their choices, even
when there is no intrinsic affinity between them. We also suggest some possible
constructive responses to these results.Comment: 27 pages, 9 figures. V2: Revised in response to referees. V3: Ditt
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