Space Weather Effects on Mid-Latitude HF Propagation Paths: Observations and a Data-Driven D-Region Model

A two-pronged study is under way to improve understanding of the D region response to space weather and its effects on HF propagation. One part, the HF Investigation of D region Ionospheric Variation Experiment (HIDIVE), is designed to obtain simultaneous, quantitative propagation and absorption data from an HF signal monitoring network along with solar X-ray flux from the NOAA GOES satellites. Observations have been made continuously since late December 2002 and include the severe disturbances of October–November 2003. GOES satellite X-ray observations and geophysical indices are assimilated into the Data-Driven D Region (DDDR) electron density model developed as the second part of this project. ACE satellite proton observations, the HIDIVE HF observations, and possibly other real-time space weather data will be assimilated into DDDR in the future. Together with the Ionospheric Forecast Model developed by the Space Environment Corporation, DDDR will provide improved specification of HF propagation and absorption characteristics when supplemented by near-real-time propagation observations from HIDIVE

Adenosine A2A receptors: localization and function

Adenosine is an endogenous purine nucleoside present in all mammalian tissues, that originates from the breakdown of ATP. By binding to its four receptor subtypes (A1, A2A, A2B, and A3), adenosine regulates several important physiological functions at both the central and peripheral levels. Therefore, ligands for the different adenosine receptors are attracting increasing attention as new potential drugs to be used in the treatment of several diseases. This chapter is aimed at providing an overview of adenosine metabolism, adenosine receptors localization and their signal transduction pathways. Particular attention will be paid to the biochemistry and pharmacology of A2A receptors, since antagonists of these receptors have emerged as promising new drugs for the treatment of Parkinson's disease. The interactions of A2A receptors with other nonadenosinergic receptors, and the effects of the pharmacological manipulation of A2A receptors on different body organs will be discussed, together with the usefulness of A2A receptor antagonists for the treatment of Parkinson's disease and the potential adverse effects of these drugs

Power spectrum analysis of ionospheric fluctuations with the Murchison Widefield Array

Low-frequency, wide field-of-view (FOV) radio telescopes such as the Murchison Widefield Array (MWA) enable the ionosphere to be sampled at high spatial completeness. We present the results of the first power spectrum analysis of ionospheric fluctuations in MWA data, where we examined the position offsets of radio sources appearing in two data sets. The refractive shifts in the positions of celestial sources are proportional to spatial gradients in the electron column density transverse to the line of sight. These can be used to probe plasma structures and waves in the ionosphere. The regional (10–100 km) scales probed by the MWA, determined by the size of its FOV and the spatial density of radio sources (typically thousands in a single FOV), complement the global (100–1000 km) scales of GPS studies and local (0.01–1 km) scales of radar scattering measurements. Our data exhibit a range of complex structures and waves. Some fluctuations have the characteristics of traveling ionospheric disturbances, while others take the form of narrow, slowly drifting bands aligned along the Earth's magnetic field

Microsporidia::Why Make Nucleotides if You Can Steal Them?

Microsporidia are strict obligate intracellular parasites that infect a wide range of eukaryotes including humans and economically important fish and insects. Surviving and flourishing inside another eukaryotic cell is a very specialised lifestyle that requires evolutionary innovation. Genome sequence analyses show that microsporidia have lost most of the genes needed for making primary metabolites, such as amino acids and nucleotides, and also that they have only a limited capacity for making adenosine triphosphate (ATP). Since microsporidia cannot grow and replicate without the enormous amounts of energy and nucleotide building blocks needed for protein, DNA, and RNA biosynthesis, they must have evolved ways of stealing these substrates from the infected host cell. Providing they can do this, genome analyses suggest that microsporidia have the enzyme repertoire needed to use and regenerate the imported nucleotides efficiently. Recent functional studies suggest that a critical innovation for adapting to intracellular life was the acquisition by lateral gene transfer of nucleotide transport (NTT) proteins that are now present in multiple copies in all microsporidian genomes. These proteins are expressed on the parasite surface and allow microsporidia to steal ATP and other purine nucleotides for energy and biosynthesis from their host. However, it remains unclear how other essential metabolites, such as pyrimidine nucleotides, are acquired. Transcriptomic and experimental studies suggest that microsporidia might manipulate host cell metabolism and cell biological processes to promote nucleotide synthesis and to maximise the potential for ATP and nucleotide import. In this review, we summarise recent genomic and functional data relating to how microsporidia exploit their hosts for energy and building blocks needed for growth and nucleic acid metabolism and we identify some remaining outstanding questions

Physiological roles for ecto-5’-nucleotidase (CD73)

Nucleotides and nucleosides influence nearly every aspect of physiology and pathophysiology. Extracellular nucleotides are metabolized through regulated phosphohydrolysis by a series of ecto-nucleotidases. The formation of extracellular adenosine from adenosine 5’-monophosphate is accomplished primarily through ecto-5’-nucleotidase (CD73), a glycosyl phosphatidylinositol-linked membrane protein found on the surface of a variety of cell types. Recent in vivo studies implicating CD73 in a number of tissue protective mechanisms have provided new insight into its regulation and function and have generated considerable interest. Here, we review contributions of CD73 to cell and tissue stress responses, with a particular emphasis on physiologic responses to regulated CD73 expression and function, as well as new findings utilizing Cd73-deficient animals

Development of Space Weather Reasonable Worst-Case Scenarios for the UK National Risk Assessment

Severe space weather was identified as a risk to the UK in 2010 as part of a wider review of natural hazards triggered by the societal disruption caused by the eruption of the Eyjafjallajökull volcano in April of that year. To support further risk assessment by government officials, and at their request, we developed a set of reasonable worst-casescenarios and first published them as a technical report in 2012(current version published in 2020). Each scenario focused on a space weather environment that could disrupt a particular national infrastructure such as electric power or satellites, thus enabling officials to explore the resilience of that infrastructure against severe space weather through discussions with relevant experts from other parts of government and with the operators of that infrastructure. This approach also encouraged us to focus on the environmental features that are key to generating adverse impacts. In this paper,we outline the scientific evidence that we have used to develop these scenarios,and therefinements made to them as new evidence emerged. We show how these scenarios are also considered as an ensemble so that government officials can prepare for a severe space weather event, during which many or all of the different scenarios will materialise. Finally,we note that this ensemble also needs to include insights into how public behaviour will play out during a severe space weather event and hence the importance of providing robust, evidence-basedinformation on space weather and its adverse impacts