Repenser la didactique du français dans sa mission d'intégration en classe d'initiation (CLIN)

National audienceIn the French educational system for primary school, the special classroom that welcomes immigrant children is called CLIN. It occurred to us that CLIN needs to consider and make the most of the different languages spoken by these immigrant children. This article aims at redefining the specificity of this classroom whose purpose is to help the children to reach a certain level of fluency in French and thus follow an ordinary education with French children.La classe d'initiation a besoin de se doter d'une didactique en faveur des élèves dont les appartenances langagières sont multiples . Cet article se propose de redéfinir la spécificité de cette classe dont la vocation est de dispenser un enseignement du français dans la perspective d'une intégration scolaire. C'est en réinterrogeant les différentes didactiques constituées du français (FLM/FLS/FLE) que seront esquissées les limites d'une didactique composite pour ouvrir sur une piste transversale, fondée sur un courant de recherche canadien d'une part et sur la démarche d'observation réfléchie de la langue à l'école d'autre part, dans la perspective d'établir une didactique du français à l'école élémentaire qui soit cohérente par rapport aux objectifs définis dans les programmes

Multi-temporal speckle reduction with self-supervised deep neural networks

Speckle filtering is generally a prerequisite to the analysis of synthetic aperture radar (SAR) images. Tremendous progress has been achieved in the domain of single-image despeckling. Latest techniques rely on deep neural networks to restore the various structures and textures peculiar to SAR images. The availability of time series of SAR images offers the possibility of improving speckle filtering by combining different speckle realizations over the same area. The supervised training of deep neural networks requires ground-truth speckle-free images. Such images can only be obtained indirectly through some form of averaging, by spatial or temporal integration, and are imperfect. Given the potential of very high quality restoration reachable by multi-temporal speckle filtering, the limitations of ground-truth images need to be circumvented. We extend a recent self-supervised training strategy for single-look complex SAR images, called MERLIN, to the case of multi-temporal filtering. This requires modeling the sources of statistical dependencies in the spatial and temporal dimensions as well as between the real and imaginary components of the complex amplitudes. Quantitative analysis on datasets with simulated speckle indicates a clear improvement of speckle reduction when additional SAR images are included. Our method is then applied to stacks of TerraSAR-X images and shown to outperform competing multi-temporal speckle filtering approaches. The code of the trained models is made freely available on the Gitlab of the IMAGES team of the LTCI Lab, T\'el\'ecom Paris Institut Polytechnique de Paris (https://gitlab.telecom-paris.fr/ring/multi-temporal-merlin/)

Effect of oxidoreduction potential and of gas bubbling on rheological properties and microstructure of acid skim milk gels acidified with glucono-delta-lactone

Milk oxidoreduction potential was modified using gases during the production of a model dairy product and its effect on gel setting was studied. Acidification by glucono-δ-lactone was used to examine the physicochemistry of gelation and to avoid variations due to microorganisms sensitive to oxidoreduction potential.Four conditions of oxidoreduction potential were appliedto milk: milk was gassed with air, nongassed, gassed with N2, or gassed with N2H2. The rheologicalproperties and microstructure of these gels were determined using viscoelasticimetry, measurement of whey separation, and confocal laser scanning microscopy. It appeared that a reducing environment led to less-aggregated proteins within the matrix and consequently decreased whey separation significantly. The use of gas to modify oxidoreduction potential is a possible way to improve the quality of dairy products

RemoteAR : Reconstruction d'environnement pour la collaboration en Réalité Augmentée

NE PAS DEPOSER SUR HAL (déjà déposé par ailleurs)La restitution d’environnements réels au sein d’un espace virtuel partagé est un enjeu majeur pour la collaboration en réalité étendue. L’objectif de cette recherche est de proposer un système de captation d’un environnement réel grâce aux seuls capteurs d’un casque de réalité augmentée, afin de le transmettre et de le restituer au sein d’un espace virtuel partagé. Dans cet article, nous explorons différentes méthodes de captation et de restitution de l’environnement, afin d’établir un système simple, mais de qualité suffisante pour faciliter les échanges. Nous avons réalisé une pré-expérience dans le but d’identifier les axes d’amélioration importants, avec pour objectif une future expérience utilisateur centrée sur les interactions entre les collaborateurs

Factors associated with the continuum of care of HIV infected patients in Belgium

BREACHinfo:eu-repo/semantics/nonPublishe

The Gut Microbiota Regulates Intestinal CD4 T Cells Expressing RORγt and Controls Metabolic Disease

SummaryA high-fat diet (HFD) induces metabolic disease and low-grade metabolic inflammation in response to changes in the intestinal microbiota through as-yet-unknown mechanisms. Here, we show that a HFD-derived ileum microbiota is responsible for a decrease in Th17 cells of the lamina propria in axenic colonized mice. The HFD also changed the expression profiles of intestinal antigen-presenting cells and their ability to generate Th17 cells in vitro. Consistent with these data, the metabolic phenotype was mimicked in RORγt-deficient mice, which lack IL17 and IL22 function, and in the adoptive transfer experiment of T cells from RORγt-deficient mice into Rag1-deficient mice. We conclude that the microbiota of the ileum regulates Th17 cell homeostasis in the small intestine and determines the outcome of metabolic disease

Identification of a novel BET bromodomain inhibitor-sensitive, gene regulatory circuit that controls Rituximab response and tumour growth in aggressive lymphoid cancers.: CYCLON-induced Rituximab resistance

International audienceImmuno-chemotherapy elicit high response rates in B-cell non-Hodgkin lymphoma but heterogeneity in response duration is observed, with some patients achieving cure and others showing refractory disease or relapse. Using a transcriptome-powered targeted proteomics screen, we discovered a gene regulatory circuit involving the nuclear factor CYCLON which characterizes aggressive disease and resistance to the anti-CD20 monoclonal antibody, Rituximab, in high-risk B-cell lymphoma. CYCLON knockdown was found to inhibit the aggressivity of MYC-overexpressing tumours in mice and to modulate gene expression programs of biological relevance to lymphoma. Furthermore, CYCLON knockdown increased the sensitivity of human lymphoma B cells to Rituximab in vitro and in vivo. Strikingly, this effect could be mimicked by in vitro treatment of lymphoma B cells with a small molecule inhibitor for BET bromodomain proteins (JQ1). In summary, this work has identified CYCLON as a new MYC cooperating factor that autonomously drives aggressive tumour growth and Rituximab resistance in lymphoma. This resistance mechanism is amenable to next-generation epigenetic therapy by BET bromodomain inhibition, thereby providing a new combination therapy rationale for high-risk lymphoma

Efficacy, durability, and tolerability of bictegravir/emtricitabine/tenofovir alafenamide for the treatment of HIV in a real-world setting in Belgium.

peer reviewed[en] OBJECTIVES: Our objective was to evaluate the efficacy, durability, and tolerability of bictegravir/emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) in a real-world setting in Belgium. METHODS: This was a retrospective, multicentre cohort study involving adult treatment-naïve (TN) and treatment-experienced (TE) people living with HIV receiving BIC/FTC/TAF between 1 January 2019 and 30 September 2020. The primary outcome was rate of virological suppression (plasma HIV-1 viral load 200 copies/mL after being virologically suppressed) by week 48 and analysis of resistance-associated mutations at time of LVS; tolerability of BIC/FTC/TAF over the 48-week study period; and change in weight and proportion of participants reporting a >10% weight gain at week 48. RESULTS: Overall, 2001 participants were included. Through 48 weeks, overall rate of virological suppression was 93.5%, with similar results observed in the following subgroups: age ≥50 years (92.7%), women (92.8%), Black sub-Saharan African (91%), TN (94%), TE (93.2%), and non-suppressed at baseline (86.6%). LVS was observed in 0.7% (n = 14) of participants, with one participant developing resistance-associated mutations to nucleoside reverse transcriptase inhibitors (184 V) and integrase strand transfer inhibitors (263KR). Of the 131 (6.5%) treatment discontinuations, the most common reason was an adverse event (2.4%), with the most frequent being central nervous system/psychiatric (0.4%) and gastrointestinal (0.4%) toxicity. Median weight gain at week 48 was 2 kg (interquartile range -1 to 5), and a >10% weight increase was observed in 11.6% of participants. CONCLUSION: In this large real-world cohort, BIC/FTC/TAF showed excellent virological efficacy in a diverse population of patients with HIV. Rare occurrence of emergent drug resistance was observed, and treatment was well tolerated