Prévalence des accommodements pour l’examen d’aptitude du Conseil médical du Canada, partie I, 2013-2021

Introduction: Previous articles have highlighted the laborious process of acquiring disability accommodations in medical education. We endeavoured to characterize the trends of test accommodations on the MCCQE Part I. Methods: Data was obtained from the Medical Council of Canada on the number of applicants who attained test accommodations on the MCCQE Part I between 2013 and 2021. The number of test takers for the same period was obtained from the Medical Council of Canada’s Annual Technical Reports; this data was not publicly available for 2013, 2014, or 2021. Prevalence rates and graphs were produced. Results: The number of test takers who attained test accommodations ranged from 35 to 126 between 2013 and 2021. The percentage of test takers who attained test accommodations ranged from 0.89% to 2.01% between 2015 and 2020. Per correspondence with the Medical Council of Canada, no applicant who provided all required documentation was denied test accommodations during this period. Discussion: The number and rate of test takers attaining test accommodations on the MCCQE Part I have increased substantially during this period. It is unclear whether this increase is due to greater rates of students with disabilities, or a reduction in stigma around using test accommodations.Introduction : Des articles publiés antérieurement ont mis en évidence le processus laborieux d’obtention d’accommodements pour les personnes handicapées dans le cadre de la formation en médecine. Nous explorons les tendances en matière d’accommodements pour l’examen d’aptitude du Conseil médical du Canada (EACMC), partie I. Méthodes : Le Conseil médical du Canada nous a communiqué le nombre de candidats qui ont obtenu des accommodements pour l’EACMC, partie I, entre 2013 et 2021. Le nombre de candidats ayant passé l’examen au cours de la même période a été obtenu en consultant les rapports techniques annuels du Conseil médical du Canada; les données pour 2013, 2014 et 2021 n’étaient pas accessibles au public. Nous présentons des taux de prévalence et des graphiques. Résultats : Le nombre de candidats ayant bénéficié d’accommodements a varié de 35 à 126 entre 2013 et 2021. Le pourcentage de ces candidats a varié de 0,89 % à 2,01 % entre 2015 et 2020. Selon la correspondance du Conseil médical du Canada, aucun candidat ayant fourni les documents requis ne s’est vu refuser l’accommodement d’examen au cours de cette période. Discussion : Le nombre et le taux de candidats bénéficiant d’accommodements pour l’EACMC, partie I, ont considérablement augmenté au cours de la période visée. On ne sait pas si cette hausse est due à une augmentation du nombre d’étudiants handicapés ou à une réduction de la stigmatisation liée au recours aux accommodements d’examen

Исследование соударения шаров

Методические указания к лабораторной работе № 1.4 «Исследование соуда- рения шаров» по разделу «Физические основы механики» общего курса фи- зики для студентов всех специальносте

Coherent magnetic plasmon modes in a contacting gold nano-sphere chain on a gold Slab

A coupled magnetic resonator waveguide, composed of a contacting gold nanosphere chain on a gold slab, is proposed and investigated. A broadband coherent magnetic plasmon mode can be excited in this one dimensional nanostructure. By employing the Lagrangian formalism and the Fourier transform method, the dispersion properties of the wave vector and group velocity of the magnetic plasmon mode are investigated. Small group velocity can be obtained from this system which can be applied as subwavelength slow wave waveguides.Comment: 11pages, 5 figures, This work is published at Optics Express 19, 23782 (2011

The efficacy and tolerability of latency-reversing agents in reactivating the HIV-1 reservoir in clinical studies:a systematic review

Introduction: Understanding the clinical potency of latency-reversing agents (LRAs) on the HIV-1 reservoir is useful to deploy future strategies. This systematic review evaluated the effects of LRAs in human intervention studies. Methods: A literature search was performed using medical databases focusing on studies with adults living with HIV-1 receiving LRAs. Eligibility criteria required participants from prospective clinical studies, a studied compound hypothesised as LRA, and reactivation or tolerability assessments. Relevant demographical data, LRA reactivation capacity, reservoir size, and adverse events were extracted. A study quality assessment with analysis of bias was performed by RoB 2 and ROBINS-I tools. The primary endpoints were HIV-1 reservoir reactivation after LRA treatment quantified by cell-associated unspliced HIV-1 RNA, and LRA tolerability defined by adverse events. Secondary outcomes were reservoir size and the effect of LRAs on analytical treatment interruption (ATI) duration. Results: After excluding duplicates, 5182 publications were screened. In total 45 publications fulfilled eligibility criteria including 26 intervention studies and 16 randomised trials. The risk of bias was evaluated as high. Chromatin modulators were the main investigated LRA class in 24 studies. Participants were mostly males (90.1%). Where reported, HIV-1 subtype B was most frequently observed. Reactivation after LRA treatment occurred in 78% of studies and was observed with nearly all chromatin modulators. When measured, reactivation mostly occurred within 24 h after treatment initiation. Combination LRA strategies have been infrequently studied and were without synergistic reactivation. Adverse events, where reported, were mostly low grade, yet occurred frequently. Seven studies had individuals who discontinued LRAs for related adverse events. The reservoir size was assessed by HIV-1 DNA in 80% of studies. A small decrease in reservoir was observed in three studies on immune checkpoint inhibitors and the histone deacetylase inhibitors romidepsin and chidamide. No clear effect of LRAs on ATI duration was observed. Conclusion: This systematic review provides a summary of the reactivation of LRAs used in current clinical trials whilst highlighting the importance of pharmacovigilance. Highly heterogeneous study designs and underrepresentation of relevant patient groups are to be considered when interpreting these results. The observed reactivation did not lead to cure or a significant reduction in the size of the reservoir. Finding more effective LRAs by including well-designed studies are needed to define the required reactivation level to reduce the HIV-1 reservoir.</p

Photonic bandgaps for grating-coupled waveguide modes with a silver tunnel barrier

Copyright © 2007 IOP Publishing Ltd and Deutsche Physikalische Gesellschaft. This is the published version of an article published in New Journal of Physics Vol. 9, article 251. DOI: 10.1088/1367-2630/9/8/251The optical properties of a periodically modulated photoresist waveguide structure has been explored using the Kretschmann–Raether configuration with a thin silver tunnel barrier. A detailed experimental study of how wavelength-scale periodic texture modifies the dispersion of the guided modes in the visible range for a wide range of azimuthal angles is presented. Fitting the observed in-plane momenta of the modes to predictions from a multilayer, multishape differential grating theory model allows the identities of each of the modes to be confirmed. In addition, the intensities obtained experimentally are compared favourably with those predicted from a theoretical model. Such a waveguide structure can produce not only the photonic bandgaps at the Brillouin zone boundary, but also bandgaps within the Brillouin zone caused by the Bragg scattered guided modes anti-crossing with the unscattered modes. All of these photonic bandgaps have potential applications controlling spontaneous emission in devices

Transcriptomic evidence for modulation of host inflammatory responses during febrile Plasmodium falciparum malaria

Identifying molecular predictors and mechanisms of malaria disease is important for understanding how Plasmodium falciparum malaria is controlled. Transcriptomic studies in humans have so far been limited to retrospective analysis of blood samples from clinical cases. In this prospective, proof-of-principle study, we compared whole-blood RNA-seq profiles at pre-and post-infection time points from Malian adults who were either asymptomatic (n = 5) or febrile (n = 3) during their first seasonal PCR-positive P. falciparum infection with those from malaria-naïve Dutch adults after a single controlled human malaria infection (n = 5). Our data show a graded activation of pathways downstream of pro-inflammatory cytokines, with the highest activation in malaria-naïve Dutch individuals and significantly reduced activation in malaria-experienced Malians. Newly febrile and asymptomatic infections in Malians were statistically indistinguishable except for genes activated by pro-inflammatory cytokines. The combined data provide a molecular basis for the development of a pyrogenic threshold as individuals acquire immunity to clinical malaria