Pasitos seguros: un juego serio para la educación vial en niños de primaria

En México, el Instituto Nacional de Estadística y Geografía reportó 4,168 accidentes fatales en el 2014, entre las principales víctimas se encontraron peatones entre un rango de 5 a 34 años. Es necesario que la ciudadanía acepte su responsabilidad y asuma una conducta segura al transitar en la vía pública. Para evitar los accidentes de tránsito existen soluciones, que van desde comerciales en radio y televisión hasta campañas de concientización, información y prevención. Una alternativa es el uso de los juegos serios, que son juegos con un objetivo de aprendizaje, la parte más notoria es que quienes los juegan no saben que están aprendiendo. En este artículo, se presenta el desarrollo de Pasitos seguros, un juego serio para la educación vial dirigido a niños de 8 a 11 años para que adquieran jugando una cultura vial de la prevención, centrándose en saber cómo cruzar las calles de forma segura. Se realizó una prueba piloto con un grupo de 4° año de primaria, obteniéndose resultados prometedores

Análisis de la cartera de crédito de la Microfinanciera Pro mujer durante el período 2020- 2021

El siguiente seminario de graduación tiene como objetivo principal analizar la cartera de crédito de la Microfinanciera Pro Mujer dentro de los periodos 2020-2021. La elaboración del diagnóstico financiero permitió evaluar la institución y de esta manera conocer la verdadera situación financiera a través de estudios realizados como análisis vertical y horizontal e indicadores financieros a la información presentada durante este periodo. Al realizar los análisis financieros se obtuvo la siguiente información de que la Microfinanciera presento una diferencia de liquidez del 8.73% que bajo en el periodo 2021 y nos indica que la institución disminuyo para hacerle frente a sus obligaciones, de igual manera se observa que la rentabilidad de las inversiones presentaron un aumento del 2.7% esto nos indica la ganancia que se obtuvo al final del cierre del periodo 2021, y con respecto de la solvencia que presenta dicha institución observamos que disminuyo en un 15.34% en el periodo 2021 el cual nos indica que la Microfinanciera estaba bajando su habilidad de hacerle frente a sus obligaciones con los accionistas y público en general. Por otro lado, si la Microfinanciera Pro mujer presento disminución en la capacidad de liquidez y solvencia durante el periodo 2021, debe aplicar nuevos métodos en la prestación de los servicios financieros y de recuperación de cartera de crédito con el fin de mejorar su economía institucional, que por lo consiguiente se presentara como uno de nuestros objetivos realizar nuevas políticas para la recuperación de la cartera de la Microfinanciera y así poder dar una solución a nuestro caso práctic

My migraine voice survey. aA global study of disease burden among individuals with migraine for whom preventive treatments have failed

Background: Migraine is associated with many debilitating symptoms that affect daily functioning. My Migraine Voice is a large global cross-sectional study aimed at understanding the full burden and impact of migraine directly from patients suffering from ≥4 monthly migraine days (MMDs) with a history of prophylactic treatment failure. Methods: This study was conducted worldwide (31 countries across North and South Americas, Europe, the Middle East and Northern Africa, and the Asia-Pacific region) using an online survey administered to adults with migraine who reported ≥4 MMDs in the 3 months preceding survey administration, with pre-specified criteria of 90% having used preventive migraine treatment (80% with history of ≥1 treatment failure). Prophylactic treatment failure was defined as a reported change in preventive medication by individuals with migraine for any reason, at least once. Results: In total, 11,266 individuals participated in the survey. Seventy-four percent of the participants reported spending time in darkness/isolation due to migraine (average: 19 h/month). While 85% of all respondents reported negative aspects of living with migraine (feeling helpless, depressed, not understood), sleeping difficulties (83%), and fear of the next attack (55%), 57% shared ≥1 positive aspect (learning to cope, becoming a stronger person). Forty-nine percent reported feeling limited in daily activities throughout all migraine phases. Migraine impact on professional, private, or social domains was reported by 87% of respondents (51% in all domains). In the previous 12 months, 38% of respondents had visited the emergency department (average: 3.3 visits), whereas 23% stayed in hospital overnight (average: 3.2 nights) due to migraine. Conclusions: The burden of migraine is substantial among this cohort of individuals with at least 4 migraine days per month and for whom at least 1 preventive migraine treatment had failed. Interestingly, respondents reported some positive aspects in their migraine journey; the greater resilience and strength brought on by coping with migraine suggests that if future treatments could address existing unmet needs, these individuals with migraine will be able to maximize their contribution to society

Potential Involvement of NSD1, KRT24 and ACACA in the Genetic Predisposition to Colorectal Cancer

The ALFRED (Allelic Loss Featuring Rare Damaging) in silico method was developed to identify cancer predisposition genes through the identification of somatic second hits. By applying ALFRED to ~10,000 tumor exomes, 49 candidate genes were identified. We aimed to assess the causal association of the identified genes with colorectal cancer (CRC) predisposition. Of the 49 genes, NSD1, HDAC10, KRT24, ACACA and TP63 were selected based on specific criteria relevant for hereditary CRC genes. Gene sequencing was performed in 736 patients with familial/early onset CRC or polyposis without germline pathogenic variants in known genes. Twelve (predicted) damaging variants in 18 patients were identified. A gene-based burden test in 1596 familial/early-onset CRC patients, 271 polyposis patients, 543 TCGA CRC patients and >134,000 controls (gnomAD, non-cancer), revealed no clear association with CRC for any of the studied genes. Nevertheless, (non-significant) over-representation of disruptive variants in NSD1, KRT24 and ACACA in CRC patients compared to controls was observed. A somatic second hit was identified in one of 20 tumors tested, corresponding to an NSD1 carrier. In conclusion, most genes identified through the ALFRED in silico method were not relevant for CRC predisposition, although a possible association was detected for NSD1, KRT24 and ACACA

Natural estrogens enhance the engraftment of human hematopoietic stem and progenitor cells in immunodeficient mice

Hematopoietic Stem and Progenitor Cells are crucial in the maintenance of lifelong production of all blood cells. These Stem Cells are highly regulated to maintain homeostasis through a delicate balance between quiescence, self-renewal and differentiation. However, this balance is altered during the hematopoietic recovery after Hematopoietic Stem and Progenitor Cell Transplantation. Transplantation efficacy can be limited by inadequate Hematopoietic Stem Cells number, poor homing, low level of engraftment, or limited self-renewal. As recent evidences indicate that estrogens are involved in regulating the hematopoiesis, we sought to examine whether natural estrogens (estrone or E1, estradiol or E2, estriol or E3 and estetrol or E4) modulate human Hematopoietic Stem and Progenitor Cells. Our results show that human Hematopoietic Stem and Progenitor Cell subsets express estrogen receptors, and whose signaling is activated by E2 and E4 on these cells. Additionally, these natural estrogens cause different effects on human Progenitors in vitro. We found that both E2 and E4 expand human Hematopoietic Stem and Progenitor Cells. However, E4 was the best tolerated estrogen and promoted cell cycle of human Hematopoietic Progenitors. Furthermore, we identified that E2 and, more significantly, E4 doubled human hematopoietic engraftment in immunodeficient mice without altering other Hematopoietic Stem and Progenitor Cells properties. Finally, the impact of E4 on promoting human hematopoietic engraftment in immunodeficient mice might be mediated through the regulation of mesenchymal stromal cells in the bone marrow niche. Together, our data demonstrate that E4 is well tolerated and enhances human reconstitution in immunodeficient mice, directly by modulating human Hematopoietic Progenitor properties and indirectly by interacting with the bone marrow niche. This application might have particular relevance to ameliorate the hematopoietic recovery 3 after myeloablative conditioning, especially when limiting numbers of Hematopoietic Stem and Progenitor Cells are available

Unha enxeñeira ou científica en cada cole

Póster presentado na V XORNADA UNIVERSITARIA GALEGA EN XÉNERO. TRANSFORMANDO DENDE A UNIVERSIDADE. Vigo, 7 Xullo 2017Nesta comunicación, presentamos o proxecto Unha enxeñeira ou científica en cada cole organizado pola Oficina de Igualdade de Xénero da Universidade de Santiago de Compostela (USC) en colaboración co Concello de Santiago de Compostela. Esta iniciativa pretende incentivar a presenza de rapazas en carreiras relacionadas coas disciplinas STEM (ciencia, enxeñería, tecnoloxía e matemáticas), mediante actividades didácticas nos centros educativos que rachen cos estereotipos sexistas da nosa sociedade. A actividade didáctica consistiu na realización de dezanove obradoiros, dirixidos a nenas e nenos de 5º ou 6º de primaria e realizados nos meses de setembro e outubro de 2016. Os obradoiros foron impartidos por profesoras ou investigadoras da USC e do Centro de Supercomputación de Galicia (CESGA) para crear referentes femininos e incentivar a presenza de rapazas no ámbito científico tecnolóxico. Ademais, estes obradoiros amosaron a relación da ciencia e da tecnoloxía coa nosa vida cotiá e serviron para achegar ao alumnado a estas disciplinas dun xeito lúdicoConcello de Santiago de Compostel

Autoantibodies against type I IFNs in patients with critical influenza pneumonia

In an international cohort of 279 patients with hypoxemic influenza pneumonia, we identified 13 patients (4.6%) with autoantibodies neutralizing IFN-alpha and/or -omega, which were previously reported to underlie 15% cases of life-threatening COVID-19 pneumonia and one third of severe adverse reactions to live-attenuated yellow fever vaccine. Autoantibodies neutralizing type I interferons (IFNs) can underlie critical COVID-19 pneumonia and yellow fever vaccine disease. We report here on 13 patients harboring autoantibodies neutralizing IFN-alpha 2 alone (five patients) or with IFN-omega (eight patients) from a cohort of 279 patients (4.7%) aged 6-73 yr with critical influenza pneumonia. Nine and four patients had antibodies neutralizing high and low concentrations, respectively, of IFN-alpha 2, and six and two patients had antibodies neutralizing high and low concentrations, respectively, of IFN-omega. The patients' autoantibodies increased influenza A virus replication in both A549 cells and reconstituted human airway epithelia. The prevalence of these antibodies was significantly higher than that in the general population for patients 70 yr of age (3.1 vs. 4.4%, P = 0.68). The risk of critical influenza was highest in patients with antibodies neutralizing high concentrations of both IFN-alpha 2 and IFN-omega (OR = 11.7, P = 1.3 x 10(-5)), especially those <70 yr old (OR = 139.9, P = 3.1 x 10(-10)). We also identified 10 patients in additional influenza patient cohorts. Autoantibodies neutralizing type I IFNs account for similar to 5% of cases of life-threatening influenza pneumonia in patients <70 yr old

Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children

We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-alpha 2 in 10 patients: IFN-alpha 2 only in three, IFN-alpha 2 plus IFN-omega in five, and IFN-alpha 2, IFN-omega plus IFN-beta in two; IFN-omega only in nine patients). Seven children (3.8%) had Abs neutralizing at least 10 ng/ml of one IFN, whereas the other 12 (6.6%) had Abs neutralizing only 100 pg/ml. The auto-Abs neutralized both unglycosylated and glycosylated IFNs. We also detected auto-Abs neutralizing 100 pg/ml IFN-alpha 2 in 4 of 2,267 uninfected children (0.2%) and auto-Abs neutralizing IFN-omega in 45 children (2%). The odds ratios (ORs) for life-threatening COVID-19 pneumonia were, therefore, higher for auto-Abs neutralizing IFN-alpha 2 only (OR [95% CI] = 67.6 [5.7-9,196.6]) than for auto-Abs neutralizing IFN-. only (OR [95% CI] = 2.6 [1.2-5.3]). ORs were also higher for auto-Abs neutralizing high concentrations (OR [95% CI] = 12.9 [4.6-35.9]) than for those neutralizing low concentrations (OR [95% CI] = 5.5 [3.1-9.6]) of IFN-omega and/or IFN-alpha 2