Straightforward Assembly of Benzoxepines by Means of a Rhodium(III)-Catalyzed C–H Functionalization of o-Vinylphenols

This document is the Accepted Manuscript version of a Published Work that appeared in final form in ACS Chemical Biology, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see: https://pubs.acs.org/doi/10.1021/ja410538wReadily available o-vinylphenols undergo a formal (5 + 2) cycloaddition to alkynes when treated with catalytic amounts of [Cp*RhCl2]2 and Cu(OAc)2. The reaction, which involves the cleavage of the terminal C–H bond of the alkenyl moiety, generates highly valuable benzoxepine skeletons in a practical, versatile, and atom-economical manner. Using carbon monoxide instead of an alkyne as reaction partner leads to coumarin products which formally result from a (5 + 1) cycloadditionWe are thankful for the financial support provided by the Spanish Grants (SAF2010-20822-C02 and CSD2007-00006 Consolider Ingenio 2010), the ERDF and the Xunta de Galicia Grants GRC2010/12, GR2013-041, INCITE09 209084PR and EM2013/036. M.G thanks Xunta de Galicia for a Parga Pondal contractS

Rhodium(III)-catalyzed intramolecular annulations involving amide-directed C–H activations: synthetic scope and mechanistic studies

Alkyne tethered benzamides undergo rhodium(III)-catalyzed intramolecular annulations to give tricyclic isoquinoline derivatives in good yields. DFT calculations suggest that the reaction mechanism involves a migratory insertion of the alkyne into the rhodium–nitrogen bond of the rhodacycle intermediate that results from the initial C–H activation. This contrasts with the pathway proposed for intermolecular cases, which considers an insertion into the rhodium–carbon instead of the rhodium–nitrogen bond. The annulation is also effective with acrylamides; and, while anilides fail to participate in the process, naphthylamides do undergo the intramolecular annulation, albeit the chemoselectivity is different than for the intermolecular reactionsS

Docentes por un Mundo Mejor : Fomentando espacios escolares libres de discriminación por diversidad sexual

La discriminación por orientación sexual en las escuelas es un problema que afecta la autoestima, el desarrollo integral y el proceso de aprendizaje, ya que no hay un ambiente de respeto ni de valoración. Es por eso que, se presenta el trabajo de investigación denominado “Docentes por un Mundo Mejor: Fomentando espacios escolares libres de discriminación por diversidad sexual”. Para este trabajo, se planteó la siguiente problemática comunicacional: el miedo de los docentes de secundaria del colegio Mundo Mejor de Chimbote a abordar temas relacionados a la diversidad sexual en las aulas, debido a que se sienten poco preparados para mediar espacios libres de violencia contra discriminación sexual en los que se pueda hablar con respeto, empatía y asertividad de estos temas. El objetivo principal fortalecer las competencias y seguridad de los docentes para propiciar y generar espacios respetuosos, empáticos, asertivos y libres de violencia contra la diversidad sexual. Asimismo, se propuso trabajar a través de dos enfoques: Género, que se basa en la necesidad de reflexionar sobre las identidades masculinas y femeninas como constructos sociales, y, Derechos Humanos, relacionado al reconocimiento de los estudiantes como sujetos de derechos y no como objetos de cuidado. El recojo de información utiliza una metodología cualitativa y cuantitativa, y se propone la ejecución de nueve actividades que cumplen con los objetivos específicos del proyecto. Por su parte, las estrategias utilizadas tienen una metodología dialógica y participativa, testimonial, edu-entretenimiento y comunicación comunitaria; por ello, el proyecto está diseñado para ser implementado de manera presencial. Finalmente, se rescata que la comunicación para el desarrollo es clave pues permite cambiar las actitudes y comportamientos de los docentes para convertirlos en agentes de cambio.Discrimination based on sexual orientation in schools affects self-esteem, integral development and, above all, the learning process of students, since there is no environment of respected or appreciation. For this reason, the research work called "Docentes por un Mundo Mejor: Fomentando espacios escolares libres de discriminación por diversidad sexual " is presented. For this work, the following communication problem was raised: the fear of secondary school teachers of the Mundo Mejor school in Chimbote to address issues related to sexual diversity in the classroom because they feel unprepared to mediate spaces free of violence against sexual discrimination in which they can talk about these issues with respect, empathy and assertiveness. The main objective is to strengthen the competencies and security of teachers to promote and generate respectful, empathetic, assertive and violence-free spaces against sexual diversity. It was also proposed to work through two approaches: Gender, which is based on the need to reflect on masculine and feminine identities as social constructs, and Human Rights, related to the recognition of students as subjects of rights and not as objects of care. The collection of information uses a qualitative and quantitative methodology, and nine activities are proposed that meet the specific objectives of the project . The strategies used have a dialogic and participatory methodology, testimonial, edutainment and community communication; therefore, the project is designed to be implemented in a face-to-face manner. Finally, it should be noted that communication for development is key because it allows us to change the attitudes and behaviors of teachers in order to turn them into agents of change

Rhodium(III)-Catalyzed Dearomatizing (3+2) Annulation of 2-Alkenylphenols and Alkynes

Appropriately substituted 2-alkenylphenols undergo a mild formal [3C+2C] cycloaddition with alkynes when treated with a Rh(III) catalyst and an oxidant. The reaction, which involves the cleavage of the terminal C–H bond of the alkenyl moiety and the dearomatization of the phenol ring, provides a versatile and efficient approach to highly appealing spirocyclic skeletons and occurs with high selectivityWe thank the financial support provided by the Spanish Grants SAF2010-20822-C02 and CSD2007-00006 Consolider Ingenio 2010, the Xunta de Galicia Grants GR2013-041 and EM2013/036, the ERDF, and the European Research Council (Advanced Grant No. 340055). M.G. thanks Xunta de Galicia for a Parga Pondal contractS

Handbook of Active Ageing and Quality of Life: From Concepts to Applications

La edición de este libro estuvo a cargo de Fermina Rojo-Pérez y Gloria Fernández-Mayoralas.El documento adjunto contiene la cubierta, portada e índice del libro.This handbook presents an overview of studies on the relationship of active ageing and quality of life. It addresses the new challenges of ageing from the paradigm of positive ageing (active, healthy and successful) for a better quality of life. It provides theoretical perspectives and empirical studies, including scientific knowledge as well as practical experiences about the good ageing and the quality of later life around the world, in order to respond to the challenges of an aged population. The handbook is structured in 4 sections covering theoretical and conceptual perspectives, social policy issues and research agenda, methods, measurement instrument-scales and evaluations, and lastly application studies including domains and geographical contexts.Peer reviewe

Diseño de un carro-tienda

[ES] El presente trabajo consiste en el diseño de un carro que será utilizado como una pequeña tienda móvil, así como su desarrollo técnico y estético. El diseño del carro-tienda está pensado y diseñado para poder exponer y vender los productos de un hotel, la propuesta pretende cubrir las necesidades del cliente además de analizar las posibles modificaciones o mejoras en un futuro.[EN] The project consists in the design of a trolley that will be used as a small mobile store, and also its technical and esthetic development. The design of the trolley-store is ready to show and sell the products of the hotel, the proposal is designed to meet the demand of the customer and to analyze possibles modifications or improvements in the future.Quiñones Sanchis, N. (2018). Diseño de un carro-tienda. http://hdl.handle.net/10251/112543TFG

Discovery of Three Eclipsing Binaries in the field of AW Cru

We present the light elements of three newly discovered eclipsing binaries. Their variability was detected during our observations of the variable AW Cru in 2013.Fil: Quiñones, Cecilia. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba; ArgentinaFil: Mina, Federico Daniel. Universidad Nacional de Córdoba. Facultad de Filosofía y Humanidades; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Humanidades. Universidad Nacional de Córdoba. Instituto de Humanidades; ArgentinaFil: Suarez, Noelia. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba; Argentin

Análisis jurídico de la reproducción asistida en seres humanos

Tesis (Lic. en Derecho)-Universidad Nacional Autónoma de Nicaragua, LeónUNAN-Leó

Estudio de polimorfismos genéticos en CYP3A4 y CYP2D6, y su papel en la susceptibilidad a cáncer de mama

Background: Breast cancer is the first cause of death in women in Chile and worldwide. One of the causing factors is the exposition to endogenous and exogenous estrogens which stimulate cell proliferation. Estrogens are metabolized by cytochrome P450 enzymes, mainly CYP3A4 and CYP2D6, which participate in estradiol hydroxylation to 2-hydroxyestradiol and/ or 4-hydroxyestradiol, facilitating their excretion from the body. Thus, polymorphisms in these enzymes alter the plasma estrogen concentration and its excretion rate. Moreover, CYP3A4*1B polymorphism have been associated to breast cancer risk and also with early menarche. Goal: To establish potential associations between breast cancer risk and CYP3A4*1B and CYP2D6*4 genetic variants in patients compared with healthy volunteers. Methods: The Research was authorized by the Ethical Comitee of Military Hospital of Santiago, Chile. Patients signed an informed consent and genomic DNA was obtained for genotyping of CYP3A4 and CYP2D6 through PCR-RFLP. Results: Obtained genotype frequencies in patients for CYP3A4*1B were: 0.821 for CYP3A4*1/*1; 0.184 for CYP3A4*1/*1B; 0.789 for CYP2D6*1/*1 and 0.211 for CYP2D6*1/*4. No recessive homozygote mutant genotypes were detected in patients (CYP3A4*1B/*1B or CYP2D6*4/*4). enotype frequencies for healthy volunteers were 0.890 for CYP3A4*1/*1; 0.110 for CYP3A4*1/*1B; 0.735 for CYP2D6*1/*1; 0.245 for CYP2D6*1/*4 and 0.019 for CYP2D6*4/*4. It was observed a higher frequency of CYP3A4*1/*1B in patients in relation to healthy volunteers, however the difference was not statistically significant. Conclusions: This research is a first approach to the study of breast cancer susceptibility associated to CYP3A4 and CYP2D6 variants in Chilean patients. Even though we do not find an statistically significant association, the potential relationship observed for CYP3A4*1B (OR=1,83, IC=0,63-5,22, p= 0,212) should be confirmed in a bigger study, so that these findings could be extrapolated to clinical therapeutics in breast cancer patients in order to favor early detection of the risk to acquire the pathology