Implantación de la vacuna frente al meningococo B en el calendario vacunal. Revisión bibliográfica

La enfermedad meningocócica producida por el serogrupo B es una patología grave y potencialmente mortal, ocasionándose la mayoría de casos a edad infantil. Actualmente disponemos de una eficaz arma terapéutica frente a la enfermedad, la vacuna tetravalente (4CMenB), también conocida como Bexsero®, disponible en farmacias pero no incluida en el calendario de vacunaciones financiado por la sanidad pública. Distintos organismos como la Asociación Española de Pediatría recomiendan la vacunación sistemática como única medida de prevención primaria. En este trabajo hemos querido hacer una revisión bibliográfica acerca de los estudios disponibles en relación con la vacuna y describir el escenario actual de la enfermedad y la vacuna en España, que puedan justificar una hipotética inclusión en el calendario vacunal.Grado en Medicin

Grabadores rupestres inéditos en el Cerro del Riscal (El Madroño, Sevilla)

El objetivo de este artículo es presentar unos grabados rupestres hallados en el Cerro del Riscal, un afloramiento rocoso de esquistos sito en las proximidades de El Madroño, pequeña localidad del Noroeste de la provincia de Sevilla. El hecho de que sean los primeros de estas características localizados en dicha provincia permite suponer su interés, al tiempo que aporta nueva luz a esta problemática en el Suroeste peninsular, abriendo nuevas perspectivas a la búsqueda y estudio de otras localizaciones. En una primera aproximación han sido datados en el Bronce MedioThe reason for this article is to introduce some rock carvings found on Cerro del Riscal, a rocky shale outcrop nearby the small village of El Madroño, in the Northwest of the province of Sevilla. The interest on these carvings rest on their newness as they are the first ones of the type traced in the province, so they enlighten the polemics about the Peninsular Southwest, opening new perspectives to the search and study of other locations. On a preliminary aproach, they date from the Middle Bronze Ag

Noticia de los principales sucesos ocurridos en el gobierno de España : desde el momento de la insurrección en 1808, hasta la disolución de las Cortes ordinarias en 1814

Autor tomado de Palau y del CCP

Historia del levantamiento, guerra y revolución de España

Copia digital : Biblioteca de Asturias "Ramón Pérez de Ayala" : Biblioteca Pública Estatal de Oviedo, 2010Mención de impresor en el tomo V: Oficina de Don Tomás Jordán. -- Los cuatro primeros tomos, de 183

Discursos pronunciados en el Congreso de los Diputados por los señores Conde de Toreno, Alcalá Galiano, Martínez de la Rosa, Gispert, y Rey, en las sesiones de los días 27, 28 y 29 de enero de 1838

Copia digital : Biblioteca de Asturias "Ramón Pérez de Ayala" : Biblioteca Pública Estatal de Oviedo, 201

Memoria sobre la deuda interior

Texto firmado por el Conde de TorenoTexto fechado en Madrid el 30 de diciembre de 1834Signaturizad

Real-life outcomes in biotypes of psychotic disorders based on neurocognitive performance

Producción CientíficaAiming at discerning potential biotypes within the psychotic syndrome, we have recently reported the possible existence of two clusters or biotypes across schizophrenia and bipolar disorder characterized by their cognitive performance using the Brief Assessment of Cognition in Schizophrenia (BACS) instrument and validated with independent biological and clinical indexes (Fernández-Linsenbarth et al. in Schizophr Res 229:102–111, 2021). In this previous work, the group with larger cognitive deficits (N = 93, including 69 chronic schizophrenia, 17 first episodes (FE) of schizophrenia and 7 bipolar disorder patients) showed smaller thalamus and hippocampus volume and hyper-synchronic electroencephalogram than the group with milder deficits (N = 105, including 58 chronic schizophrenia, 25 FE and 22 bipolar disorder patients). We predicted that if these biotypes indeed corresponded to different cognitive and biological substrates, their adaptation to real life would be different. To this end, in the present work we have followed up the patients’ population included in that work at 1st and 3rd years after the date of inclusion in the 2021 study and we report on the statistical comparisons of each clinical and real-life outcomes between them. The first cluster, with larger cognitive deficits and more severe biological alterations, showed during that period a decreased capacity for job tenure (1st and 3rd years), more admissions to a psychiatric ward (1st year) and a higher likelihood for quitting psychiatric follow-up (3rd year). Patients in the second cluster, with moderate cognitive deficits, were less compliant with prescribed treatment at the 3rd year. The differences in real-life outcomes may give additional external validity to that yielded by biological measurements to the described biotypes based on neurocognition.Instituto de Salud Carlos III (grant ID PI18/00178)Dirección Regional de Salud de Castilla y León (grant ID GRS 2121/A/2020)Junta de Castilla y León - predoctoral grants from the Consejería de Educación and the European Social Fund (grant IDs VA-183-18 to IFL and VA- 223-19 to RMBRS)Publicación en abierto financiada por el Consorcio de Bibliotecas Universitarias de Castilla y León (BUCLE), con cargo al Programa Operativo 2014ES16RFOP009 FEDER 2014-2020 DE CASTILLA Y LEÓN, Actuación:20007-CL - Apoyo Consorcio BUCL

Mejora de estabilidad vertical con fijador externo pre-tensado: un estudio biomecánico en modelo sintético con fractura pélvica inestable tipo Tile C

En el tratamiento de emergencia de las fracturas del anillo pélvico, los fijadores externos convencionales no consiguen producir compresión en los elementos óseos posteriores ni dar estabilidad suficiente en fracturas verticalmente inestables. El fijador externo pretensado diseñado por nuestro equipo produce compresión en todo el anillo pélvico, dotándolo de potencial para mejorar el cierre del anillo fracturado y su estabilidad vertical. El objetivo de este trabajo es comprobar si la aplicación de fijación externa mediante barra curva de fibra de carbono conectada a clavos de Schanz supra-acetabulares mejora la estabilidad del anillo pélvico con lesión tipo Tile C1.2 cuando se realiza el montaje con la barra pretensada que con el montaje estándar.Sociedad Española de Cirugía Ortopédica y Traumatología (SECOT). Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

The lincRNA HOTAIRM1, located in the HOXA genomic region, is expressed in acute myeloid leukemia, impacts prognosis in patients in the intermediate-risk cytogenetic category, and is associated with a distinctive microRNA signature

Altres ajuts: SDCSD from School of Medicine, University of BarcelonaLong non-coding RNAs (lncRNAs) are deregulated in several tumors, although their role in acute myeloid leukemia (AML) is mostly unknown.We have examined the expression of the lncRNA HOX antisense intergenic RNA myeloid 1 (HOTAIRM1) in 241 AML patients. We have correlated HOTAIRM1 expression with a miRNA expression profile. We have also analyzed the prognostic value of HOTAIRM1 expression in 215 intermediate-risk AML (IR-AML) patients.The lowest expression level was observed in acute promyelocytic leukemia (P < 0.001) and the highest in t(6;9) AML (P = 0.005). In 215 IR-AML patients, high HOTAIRM1 expression was independently associated with shorter overall survival (OR:2.04;P = 0.001), shorter leukemia-free survival (OR:2.56; P < 0.001) and a higher cumulative incidence of relapse (OR:1.67; P = 0.046). Moreover, HOTAIRM1 maintained its independent prognostic value within the favorable molecular subgroup (OR: 3.43; P = 0.009). Interestingly, HOTAIRM1 was overexpressed in NPM1-mutated AML (P < 0.001) and within this group retained its prognostic value (OR: 2.21; P = 0.01). Moreover, HOTAIRM1 expression was associated with a specific 33-microRNA signature that included miR-196b (P < 0.001). miR-196b is located in the HOX genomic region and has previously been reported to have an independent prognostic value in AML. miR-196b and HOTAIRM1 in combination as a prognostic factor can classify patients as high-, intermediate-, or low-risk (5-year OS: 24% vs 42% vs 70%; P = 0.004).Determination of HOTAIRM1 level at diagnosis provided relevant prognostic information in IR-AML and allowed refinement of risk stratification based on common molecular markers. The prognostic information provided by HOTAIRM1 was strengthened when combined with miR-196b expression. Furthermore, HOTAIRM1 correlated with a 33-miRNA signatur

The expression level of BAALC-associated microRNA miR-3151 is an independent prognostic factor in younger patients with cytogenetic intermediate-risk acute myeloid leukemia

Acute myeloid leukemia (AML) is a heterogeneous disease whose prognosis is mainly related to the biological risk conferred by cytogenetics and molecular profiling. In elderly patients (>= 60 years) with normal karyotype AML miR-3151 have been identified as a prognostic factor. However, miR-3151 prognostic value has not been examined in younger AML patients. In the present work, we have studied miR-3151 alone and in combination with BAALC, its host gene, in a cohort of 181 younger intermediate-risk AML (IR-AML) patients. Patients with higher expression of miR-3151 had shorter overall survival (P = 0.0025), shorter leukemia-free survival (P = 0.026) and higher cumulative incidence of relapse (P = 0.082). Moreover, in the multivariate analysis miR-3151 emerged as independent prognostic marker in both the overall series and within the unfavorable molecular prognostic category. Interestingly, the combined determination of both miR-3151 and BAALC improved this prognostic stratification, with patients with low levels of both parameters showing a better outcome compared with those patients harboring increased levels of one or both markers (P = 0.003). In addition, we studied the microRNA expression profile associated with miR-3151 identifying a six-microRNA signature. In conclusion, the analysis of miR-3151 and BAALC expression may well contribute to an improved prognostic stratification of younger patients with IR-AML