464 research outputs found
Scanning probe recognition microscopy investigation of tissue scaffold properties
Scanning probe recognition microscopy is a new scanning probe microscopy technique which enables selective scanning along individual nanofibers within a tissue scaffold. Statistically significant data for multiple properties can be collected by repetitively fine-scanning an identical region of interest. The results of a scanning probe recognition microscopy investigation of the surface roughness and elasticity of a series of tissue scaffolds are presented. Deconvolution and statistical methods were developed and used for data accuracy along curved nanofiber surfaces. Nanofiber features were also independently analyzed using transmission electron microscopy, with results that supported the scanning probe recognition microscopy-based analysis
Fake CPT Violation in Disappearance Neutrino Oscillations
We make an analysis of the fake CPT-violating asymmetries between the
survival probabilities of neutrinos and antineutrinos, induced by the
terrestrial matter effects, in three different scenarios of long-baseline
neutrino oscillation experiments with L=730 km, L=2100 km and L=3200 km. In
particular, the dependence of those asymmetries on the Dirac-type CP-violating
phase of the lepton flavor mixing matrix is examined.Comment: RevTex 8 pages (including 3 PS figures). To be publishe
Cell Response and Tissue Scaffold Triggers Investigated by Scanning Probe Recognition Microscopy
ABSTRACT Recent efforts in the field of regenerative medicine have focused on the fabrication of scaffolds capable of promoting a repertoire of cellular responses. These scaffolds are designed to be mimetic in structure and function to the extracellular matrix/basement membrane, which serves as the physiological support for cells within tissues. Understanding the nature of the physical interactions of cells within these biomimetic structures and deriving information that would correlate geometric properties of the scaffolds with the promotion of specific cellular responses would have a major impact on their design and utility. In this paper, we introduce the use of a new and powerful form of atomic force microscopy developed by our group, termed Scanning Probe Recognition Microscopy (SPRM). SPRM is used to examine the physical interactions of protrusions emanating from NIH 3T3 fibroblasts with the surfaces of both 2D planar and 3D nanofibrillar cell culture surfaces. This technique provides the means to maintain focus on user defined regions of contact (in the nanometer range) between the cell protrusions and the 2D and 3D surfaces. Differences in the number and shape of contact regions between the cell protrusions and the two types of surface were observed using SPRM. These observations were supported by similar imaging results obtained, albeit at significantly lower resolution, using phase contrast and bright field microscopy
Neutrino Masses and Mixing: Evidence and Implications
Measurements of various features of the fluxes of atmospheric and solar
neutrinos have provided evidence for neutrino oscillations and therefore for
neutrino masses and mixing. We review the phenomenology of neutrino
oscillations in vacuum and in matter. We present the existing evidence from
solar and atmospheric neutrinos as well as the results from laboratory
searches, including the final status of the LSND experiment. We describe the
theoretical inputs that are used to interpret the experimental results in terms
of neutrino oscillations. We derive the allowed ranges for the mass and mixing
parameters in three frameworks: First, each set of observations is analyzed
separately in a two-neutrino framework; Second, the data from solar and
atmospheric neutrinos are analyzed in a three active neutrino framework; Third,
the LSND results are added, and the status of accommodating all three signals
in the framework of three active and one sterile light neutrinos is presented.
We review the theoretical implications of these results: the existence of new
physics, the estimate of the scale of this new physics and the lessons for
grand unified theories, for supersymmetric models with R-parity violation, for
models of extra dimensions and singlet fermions in the bulk, and for flavor
models.Comment: Added note on the effects of KamLAND results. Two new figure
Physical Stress, Not Biotic Interactions, Preclude an Invasive Grass from Establishing in Forb-Dominated Salt Marshes
Biological invasions have become the focus of considerable concern and ecological research, yet the relative importance of abiotic and biotic factors in controlling the invasibility of habitats to exotic species is not well understood. Spartina species are highly invasive plants in coastal wetlands; however, studies on the factors that control the success or failure of Spartina invasions across multiple habitat types are rare and inconclusive.We examined the roles of physical stress and plant interactions in mediating the establishment of the smooth cordgrass, Spartina alterniflora, in a variety of coastal habitats in northern China. Field transplant experiments showed that cordgrass can invade mudflats and low estuarine marshes with low salinity and frequent flooding, but cannot survive in salt marshes and high estuarine marshes with hypersaline soils and infrequent flooding. The dominant native plant Suaeda salsa had neither competitive nor facilitative effects on cordgrass. A common garden experiment revealed that cordgrass performed significantly better when flooded every other day than when flooded weekly. These results suggest that physical stress rather than plant interactions limits cordgrass invasions in northern China.We conclude that Spartina invasions are likely to be constrained to tidal flats and low estuarine marshes in the Yellow River Delta. Due to harsh physical conditions, salt marshes and high estuarine marshes are unlikely to be invaded. These findings have implications for understanding Spartina invasions in northern China and on other coasts with similar biotic and abiotic environments
Compensating Commitments: The Law and Economics of Commitment Bonds That Compensate for the Possibility of Forfeiture
This Article introduces compensating commitment bonds, which make it more affordable for a government, entity, or individual to commit to some course of action. These bonds, like traditional government or corporate bonds, can generate revenue for committing parties. A bond seller makes a commitment and promises to pay a forfeit if the seller fails to meet the bond conditions. The bond buyer pays the seller to be contractually designated as the recipient of any amounts the bond seller forfeits. This approach has potential application in a range of legal situations. Governments and other parties may use such bonds to facilitate commitments to principles from which they later may face temptation to deviate. Such bonds also can facilitate legislative compromise or the settlement of private legal disputes. The Article identifies a variety of incentive-equivalent commitment bond structures as well as the circumstances under which a particular implementation is likely to be most effective. It also explores hurdles to the use of such bonds, including the concerns that the courts might find a legislature’s use of such bonds to entrench its preferences unconstitutional and that a legislature might issue such bonds but cancel them after failing to maintain a commitment
A Precise Measurement of the Muon Neutrino-Nucleon Inclusive Charged Current Cross-Section off an Isoscalar Target in the Energy Range 2.5 < E_\nu < 40 GeV by NOMAD
We present a measurement of the muon neutrino-nucleon inclusive charged
current cross-section, off an isoscalar target, in the neutrino energy range
GeV. The significance of this measurement is its
precision, % in GeV, and % in GeV regions, where significant uncertainties in previous
experiments still exist, and its importance to the current and proposed long
baseline neutrino oscillation experiments.Comment: 14 pages, 3 figures, submitted to Phys.Lett.
X-Ray Spectroscopy of Stars
(abridged) Non-degenerate stars of essentially all spectral classes are soft
X-ray sources. Low-mass stars on the cooler part of the main sequence and their
pre-main sequence predecessors define the dominant stellar population in the
galaxy by number. Their X-ray spectra are reminiscent, in the broadest sense,
of X-ray spectra from the solar corona. X-ray emission from cool stars is
indeed ascribed to magnetically trapped hot gas analogous to the solar coronal
plasma. Coronal structure, its thermal stratification and geometric extent can
be interpreted based on various spectral diagnostics. New features have been
identified in pre-main sequence stars; some of these may be related to
accretion shocks on the stellar surface, fluorescence on circumstellar disks
due to X-ray irradiation, or shock heating in stellar outflows. Massive, hot
stars clearly dominate the interaction with the galactic interstellar medium:
they are the main sources of ionizing radiation, mechanical energy and chemical
enrichment in galaxies. High-energy emission permits to probe some of the most
important processes at work in these stars, and put constraints on their most
peculiar feature: the stellar wind. Here, we review recent advances in our
understanding of cool and hot stars through the study of X-ray spectra, in
particular high-resolution spectra now available from XMM-Newton and Chandra.
We address issues related to coronal structure, flares, the composition of
coronal plasma, X-ray production in accretion streams and outflows, X-rays from
single OB-type stars, massive binaries, magnetic hot objects and evolved WR
stars.Comment: accepted for Astron. Astrophys. Rev., 98 journal pages, 30 figures
(partly multiple); some corrections made after proof stag
Measurement of the Atmospheric Muon Charge Ratio at TeV Energies with MINOS
The 5.4 kton MINOS far detector has been taking charge-separated cosmic ray
muon data since the beginning of August, 2003 at a depth of 2070
meters-water-equivalent in the Soudan Underground Laboratory, Minnesota, USA.
The data with both forward and reversed magnetic field running configurations
were combined to minimize systematic errors in the determination of the
underground muon charge ratio. When averaged, two independent analyses find the
charge ratio underground to be 1.374 +/- 0.004 (stat.) +0.012 -0.010(sys.).
Using the map of the Soudan rock overburden, the muon momenta as measured
underground were projected to the corresponding values at the surface in the
energy range 1-7 TeV. Within this range of energies at the surface, the MINOS
data are consistent with the charge ratio being energy independent at the two
standard deviation level. When the MINOS results are compared with measurements
at lower energies, a clear rise in the charge ratio in the energy range 0.3 --
1.0 TeV is apparent. A qualitative model shows that the rise is consistent with
an increasing contribution of kaon decays to the muon charge ratio.Comment: 16 pages, 17 figure
Measurement of neutrino velocity with the MINOS detectors and NuMI neutrino beam
The velocity of a ~3 GeV neutrino beam is measured by comparing detection times at the near and far detectors of the MINOS experiment, separated by 734 km. A total of 473 far detector neutrino events was used to measure (v-c)/c=5.12.910-5 (at 68% C.L.). By correlating the measured energies of 258 charged-current neutrino events to their arrival times at the far detector, a limit is imposed on the neutrino mass of mnu<50 MeV/c2 (99% C.L.)
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