Heart Rate Control in Non-Paroxysmal Atrial Fibrillation. A New Indication for Ivabradine?

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Terremoto Italia centrale 2016 : microzonazione sismica acquisizione dati geofisici Down-Hole

In riferimento alla Ripartizione delle Attività e competenze tra CNR-IGAG e CNR-IAMC nell’ambito della convenzione stipulata tra il Commissario Straordinario del Governo per la Ricostruzione Sisma 2016 e l’Istituto di Geologia Ambientale e Geoingegneria del Consiglio Nazionale delle Ricerche (per il Centro per la Microzonazione Sismica e le sue applicazioni), il Gruppo di Geofisica dell’ISMAR (precedentemente IAMC, afferente al Centro per la Microzonazione Sismica e sue applicazioni ed attualmente ISPC) è stato incaricato per l'esecuzione di indagini geofisiche di tipo Down-Hole (DH) ai fini di studi di Microzonazione Sismica (MS) di livello 3

Decreased Rhes mRNA levels in the brain of patients with Parkinson's disease and MPTP-treated macaques

In rodent and human brains, the small GTP-binding protein Rhes is highly expressed in virtually all dopaminoceptive striatal GABAergic medium spiny neurons, as well as in large aspiny cholinergic interneurons, where it is thought to modulate dopamine-dependent signaling. Consistent with this knowledge, and considering that dopaminergic neurotransmission is altered in neurological and psychiatric disorders, here we sought to investigate whether Rhes mRNA expression is altered in brain regions of patients with Parkinsonâ\u80\u99s disease (PD), Schizophrenia (SCZ), and Bipolar Disorder (BD), when compared to healthy controls (about 200 post-mortem samples). Moreover, we performed the same analysis in the putamen of non-human primate Macaca Mulatta, lesioned with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Overall, our data indicated comparable Rhes mRNA levels in the brain of patients with SCZ and BD, and their respective healthy controls. In sharp contrast, the putamen of patients suffering from PD showed a significant 35% reduction of this transcript, compared to healthy subjects. Interestingly, in line with observations obtained in humans, we found 27% decrease in Rhes mRNA levels in the putamen of MPTP-treated primates. Based on the established inhibitory influence of Rhes on dopamine-related responses, we hypothesize that its striatal downregulation in PD patients and animal models of PD might represent an adaptive event of the dopaminergic system to functionally counteract the reduced nigrostriatal innervation

Tomografia Geoelettrica 3D ad alta risoluzione nell’area di San Gregorio Magno (SA)

Nell’ambito delle attività di ricerca del progetto “TESIRA”, in cui partecipano il Dipartimento di Scienze della Terra dell’Ambiente e delle Risorse (DISTAR) dell’Università degli Studi di Napoli “Federico II”, l’Istituto di Scienze del Patrimonio Culturale del Consiglio Nazionale delle Ricerche CNR – ISPC e l'Istituto Nazionale di Geofisica e Vulcanologia sede di Roma (INGV), il gruppo di geofisica di Napoli dell’ISPC,ha condotto nell’area test del comune di San Gregorio Magno, SGM, (SA) un’indagine di tomografia geoelettrica 3D (ERT), per l’individuazione e la ricostruzione tridimensionale delle strutture presenti nel sottosuolo connesse con la faglia di SGM. In particolare in questo rapporto tecnico si riportano le procedure di acquisizione ed elaborazione di dati di tomografia geoelettrica 3D

Application of X-Band Wave Radar for Coastal Dynamic Analysis: Case Test of Bagnara Calabra (South Tyrrhenian Sea, Italy)

Sea state knowledge has a key role in evaluation of coastal erosion, the assessment of vulnerability and potential in coastal zone utilization, and development of numerical models to predict its evolution. X-band radar measurements were conducted to observe the spatial and temporal variation of the sea-state parameters along a 3 km long sandy-gravelly pocket beaches forming a littoral cell on Bagnara Calabra. We produced a sequence of 1000 images of the sea state extending offshore up to 1 mile. The survey has allowed monitoring the coastline, the directional wave spectra, the sea surface current fields, and the significant wave heights and detecting strong rip currents which cause scours around the open inlets and affect the stability of the submerged reef-type breakwaters. The possibility to validate the data acquired with other datasets (e.g., LaMMA Consortium) demonstrates the potential of the X-band radar technology as a monitoring tool to advance the understanding of the linkages between sea conditions, nearshore sediment dynamics, and coastal change. This work proves the possibility to obtain relevant information (e.g., wave number, period, and direction) for evaluation of local erosion phenomena and of morphological changes in the nearshore and surf zone

The Brain’s Reward System in Health and Disease

Rhythmic gene expression is found throughout the central nervous system. This harmonized regulation can be dependent on- and independent of- the master regulator of biological clocks, the suprachiasmatic nucleus (SCN). Substantial oscillatory activity in the brain's reward system is regulated by dopamine. While light serves as a primary time-giver (zeitgeber) of physiological clocks and synchronizes biological rhythms in 24-h cycles, nonphotic stimuli have a profound influence over circadian biology. Indeed, reward-related activities (e.g., feeding, exercise, sex, substance use, and social interactions), which lead to an elevated level of dopamine, alters rhythms in the SCN and the brain's reward system. In this chapter, we will discuss the influence of the dopaminergic reward pathways on circadian system and the implication of this interplay on human health

Application of geophysical tests for the detection of buried subsoil geometry in a cultural heritage site in Naples (Italy): the Fontanelle Cemetery

The paper presents recent examples of application of near-surface geophysical techniques, such as Ground Penetrating Radar (GPR) and Electrical Resistivity Tomography (ERT), in order to show their effectiveness in reconstructing buried subsoil in historical site located in Naples, the Fontanelle Cemetery. In fact, such non-invasive methods can assist the geotechnical engineers in the detection of complex subsoil conditions when cultural heritage needs to be preserved and penetrating investigation tools (such as boreholes) must be avoided or, at least, their impact reduced to the minimum