1,035 research outputs found
AGN counts at 15um. XMM observations of the ELAIS-S1-5 sample
Context: The counts of galaxies and AGN in the mid infra-red (MIR) bands are
important instruments for studying their cosmological evolution. However, the
classic spectral line ratios techniques can become misleading when trying to
properly separate AGN from starbursts or even from apparently normal galaxies.
Aims: We use X-ray band observations to discriminate AGN activity in
previously classified MIR-selected starburst galaxies and to derive updated
AGN1 and (Compton thin) AGN2 counts at 15 um.
Methods: XMM observations of the ELAIS-S1 15um sample down to flux limits
~2x10^-15 erg cm^-2 s^-1 (2-10 keV band) were used. We classified as AGN all
those MIR sources with a unabsorbed 2-10 keV X-ray luminosity higher that
~10^42 erg/s.
Results: We find that at least about 13(+/-6) per cent of the previously
classified starburst galaxies harbor an AGN. According to these figures, we
provide an updated estimate of the counts of AGN1 and (Compton thin) AGN2 at 15
um. It turns out that at least 24% of the extragalactic sources brighter than
0.6 my at 15 um are AGN (~13% contribution to the extragalactic background
produced at fluxes brighter than 0.6 mJy).Comment: Accepted for publication on A&
The Nustar Extragalactic Surveys: Overview and Catalog from the Cosmos Field
To provide the census of the sources contributing to the X-ray background peak above 10 keV, NuSTAR is performing extragalactic surveys using a three-tier wedding cake approach. We present the NuSTAR survey of the COSMOS field, the medium sensitivity and medium area tier, covering 1.7 deg2 and overlapping with both Chandra and XMM-Newton data. This survey consists of 121 observations for a total exposure of ~3 Ms. To fully exploit these data, we developed a new detection strategy, carefully tested through extensive simulations. The survey sensitivity at 20% completeness is 5.9, 2.9 and 6.4 x 10^-14 erg/cm2/s in the 3-24 keV, 3-8 keV and 8-24 keV bands, respectively. By combining detections in 3 bands, we have a sample of 91 NuSTAR sources with 10^42 -10^45.5 erg/s luminosities and redshift z=0.04-2.5. Thirty two sources are detected in the 8-24 keV band with fluxes ~100 times fainter than sources detected by Swift-BAT. Of the 91 detections, all but four are associated with a Chandra and/or XMM-Newton point-like counterpart. One source is associated with an extended lower energy X-ray source. We present the X-ray (hardness ratio and luminosity) and optical-to-X-ray properties. The observed fraction of candidate Compton-thick AGN measured from the hardness ratio is between 13-20%. We discuss the spectral properties of NuSTAR J100259+0220.6 (ID 330) at z=0.044, with the highest hardness ratio in the entire sample. The measured column density exceeds 10^24 /cm2, implying the source is Compton-thick. This source was not previously recognized as such without the \u3e10 keV data
The multi-phase winds of Markarian 231: from the hot, nuclear, ultra-fast wind to the galaxy-scale, molecular outflow
We present the best sensitivity and angular resolution maps of the molecular
disk and outflow of Mrk 231, as traced by CO observations obtained with
IRAM/PdBI, and we analyze archival Chandra and NuSTAR observations. We
constrain the physical properties of both the molecular disk and outflow, the
presence of a highly-ionized ultra-fast nuclear wind, and their connection. The
molecular outflow has a size of ~1 kpc, and extends in all directions around
the nucleus, being more prominent along the south-west to north-east direction,
suggesting a wide-angle biconical geometry. The maximum projected velocity of
the outflow is nearly constant out to ~1 kpc, thus implying that the density of
the outflowing material decreases from the nucleus outwards as . This
suggests that either a large part of the gas leaves the flow during its
expansion or that the bulk of the outflow has not yet reached out to ~1 kpc,
thus implying a limit on its age of ~1 Myr. We find and erg s.
Remarkably, our analysis of the X-ray data reveals a nuclear ultra-fast outflow
(UFO) with velocity -20000 km s, , and momentum load .We find as predicted for outflows undergoing an energy
conserving expansion. This suggests that most of the UFO kinetic energy is
transferred to mechanical energy of the kpc-scale outflow, strongly supporting
that the energy released during accretion of matter onto super-massive black
holes is the ultimate driver of giant massive outflows. We estimate a momentum
boost . The ratios and agree
with the requirements of the most popular models of AGN feedback.Comment: 16 pages, 17 figures. Accepted for publication in A&
Preclinical discovery and development of fingolimod for the treatment of multiple sclerosis
ABSTRACTIntroduction: Fingolimod, the first oral disease-modifying treatment (DMT) in multiple sclerosis (MS), is a sphingosine 1-phosphate receptor (S1PR) ligand. Approved in 2010, fingolimod has ..
The XMM-Newton survey of the ELAIS-S1 field II: optical identifications and multiwavelength catalogue of X-ray sources
We present optical identifications and a multi-band catalogue of a sample of
478 X-ray sources in the XMM and Chandra surveys of the central 0.6 deg^2 of
the ELAIS-S1 field. The optical/infrared counterpart of each X-ray source was
identified using R and IRAC 3.6 um bands. This method was complemented by the
precise positions obtained through Chandra observations. Approximately 94% of
the counterparts are detected in the R band, while the remaining are blank
fields in the optical down to R~24.5, but have a near-infrared counterpart
detected by IRAC within 6 arcsec from the XMM centroid. The multi-band
catalogue contains photometry in ten photometric bands (B to the MIPS 24 um).
We determined redshift and classification for 237 sources (~50% of the sample)
brighter than R=24. We classified 47% of the sources with spectroscopic
redshift as broad-line active galactic nuclei (BL AGNs) with z=0.1-3.5, while
sources without broad-lines are about 46% of the spectroscopic sample and are
found up to z=2.6. We identified 11 type 2 QSOs among the sources with X/O>8,
with z=0.9-2.6, high 2-10 keV luminosity (log(L2-10keV)>=43.8 erg/s) and hard
X-ray colors suggesting large absorbing columns at the rest frame (logN_H up to
23.6 cm^-2). BL AGNs show on average blue optical-to-near-infrared colors,
softer X-ray colors and X-ray-to-optical colors typical of optically selected
AGNs. Conversely, narrow-line sources show redder optical colors, harder X-ray
flux ratio and span a wider range of X-ray-to-optical colors. On average the
SEDs of high-luminosity BL AGNs resemble the power-law typical of unobscured
AGNs. The SEDs of NOT BL AGNs are dominated by the galaxy emission in the
optical/near-infrared, and show a rise in the mid-infrared which suggests the
presence of an obscured active nucleus.Comment: 15 pages, A&A accepted, affiliations correcte
Unveiling obscured accretion in the Chandra Deep Field South
A large population of heavily obscured, Compton Thick AGNs is predicted by
models of galaxy formation, models of Cosmic X-ray Background and by the
``relic'' super-massive black-hole mass function measured from local bulges.
However, so far only a handful of Compton thick AGNs have been possibly
detected using even the deepest Chandra and XMM surveys. Compton-thick AGNs can
be recovered thanks to the reprocessing of the AGN UV emission in the infrared
by selecting sources with AGN luminosity's in the mid-infrared and faint
near-infrared and optical emission. To this purpose, we make use of deep HST,
VLT, Spitzer and Chandra data on the Chandra Deep Field South to constrain the
number of Compton thick AGN in this field. We show that sources with high
24m to optical flux ratios and red colors form a distinct source
population, and that their infrared luminosity is dominated by AGN emission.
Analysis of the X-ray properties of these extreme sources shows that most of
them (80) are indeed likely to be highly obscured, Compton thick AGNs.
The number of infrared selected, Compton thick AGNs with 5.8m luminosity
higher than erg s turns out to be similar to that of X-ray
selected, unobscured and moderately obscured AGNs with 2-10 keV luminosity
higher than erg s in the redshift bin 1.2-2.6. This ``factor
of 2'' source population is exactly what it is needed to solve the
discrepancies between model predictions and X-ray AGN selection.Comment: Revised version, to be published by The Astrophysical Journa
The HELLAS2XMM survey. IX. Spectroscopic identification of super-EROs hosting AGNs
We present VLT near-IR spectroscopic observations of three X-ray sources
characterized by extremely high X-ray-to-optical ratios (X/O>40), extremely red
colors (6.3<R-K<7.4, i.e. EROs) and bright infrared magnitudes (17.6<K<18.3).
These objects are very faint in the optical, making their spectroscopic
identification extremely challenging. Instead, our near-IR spectroscopic
observations have been successful in identifying the redshift of two of them
(z=2.08 and z=1.35), and tentatively even of the third one (z=2.13). When
combined with the X-ray properties, our results clearly indicate that all these
objects host obscured QSOs (4e44 < L(2-10keV) < 1.5e45 erg/s, 2e22 < N_H < 4e23
cm-2) at high redshift. The only object with unresolved morphology in the K
band shows broad Halpha emission, but not broad Hbeta, implying a type 1.9 AGN
classification. The other two objects are resolved and dominated by the host
galaxy light in the K band, and appear relatively quiescent: one of them has a
LINER-like emission line spectrum and the other presents only a single, weak
emission line which we tentatively identify with Halpha. The galaxy
luminosities for the latter two objects are an order of magnitude brighter than
typical local L* galaxies and the derived stellar masses are well in excess of
10^11 Msun. For these objects we estimate black hole masses higher than 10^9
Msun and we infer that they are radiating at Eddington ratios L/L_Edd < 0.1. We
discuss the implications of these findings for the coevolution of galaxies and
black hole growth. Our results provide further support that X-ray sources with
high X/O ratios and very red colors tend to host obscured QSO in very massive
galaxies at high redshift.Comment: 7 pages, 5 figures, accepted for publication in A&
Long non-coding RNAs play a role in the pathogenesis of psoriatic arthritis by regulating microRNAs and genes involved in inflammation and metabolic syndrome
Psoriatic arthritis (PsA) is an inflammatory arthritis, characterized by inflammation of entheses and synovium, leading to joint erosions and new bone formation. It affects 10-30% of patients with psoriasis, and has an estimated prevalence of approximately 1%. PsA is considered to be primarily an autoimmune disease, driven by autoreactive T cells directed against autoantigens present in the skin and in the joints. However, an autoinflammatory origin has recently been proposed. Long noncoding RNAs (lncRNAs) are RNAs more than 200 nucleotides in length that do not encode proteins. LncRNAs play important roles in several biological processes, including chromatin remodeling, transcription control, and post-transcriptional processing. Several studies have shown that lncRNAs are expressed in a stage-specific or lineage-specific manner in immune cells that have a role in the development, activation, and effector functions of immune cells. LncRNAs are thought to play a role in several diseases, including autoimmune disorders. Indeed, a few lncRNAs have been identified in systemic lupus erythematosus, rheumatoid arthritis, and psoriasis. Although several high-throughput studies have been performed to identify lncRNAs, their biological and pathological relevance are still unknown, and most transcriptome studies in autoimmune diseases have only assessed protein-coding transcripts. No data are currently available on lncRNAs in PsA. Therefore, by microarray analysis, we have investigated the expression profiles of more than 50,000 human lncRNAs in blood samples from PsA patients and healthy controls using Human Clariom D Affymetrix chips, suitable to detect rare and low-expressing transcripts otherwise unnoticed by common sequencing methodologies. Network analysis identified lncRNAs targeting highly connected genes in the PsA transcriptome. Such genes are involved in molecular pathways crucial for PsA pathogenesis, including immune response, glycolipid metabolism, bone remodeling, type 1 interferon, wingless related integration site, and tumor necrosis factor signaling. Selected lncRNAs were validated by RT-PCR in an expanded cohort of patients. Moreover, modulated genes belonging to meaningful pathways were validated by RT-PCR in PsA PBMCs and/or by ELISA in PsA sera. The findings indicate that lncRNAs are involved in PsA pathogenesis by regulating both microRNAs and genes and open new avenues for the identification of new biomarkers and therapeutical targets
Relativistic iron K X-ray Reverberation in NGC 4151
Recent X-ray observations have enabled the study of reverberation delays in
AGN for the first time. All the detections so far are in sources with a strong
soft excess, and the measured delay is between the hard (1-3 keV) direct
continuum and the soft excess (0.5-1 keV), interpreted as the reflection
continuum smeared by relativistic effects. There is however an inherent
ambiguity in identifying and studying the details of the lines in the soft
excess. Here we report the first detection of reverberation in the iron K band
in any AGN. Using XMM-Newton observations of NGC 4151, we find delays of order
2000 s on time-scales of 10e5 s between the 5-6 keV band and 2-3 and 7-8 keV
bands, with a broad lag profile resembling a relativistically-broadened iron
line. The peak of the lag spectra shifts to lower energies at higher
frequencies, consistent with the red wing of the line being emitted at smaller
radii, as expected from reflection off the inner accretion disk. This is a
first detection of a broad iron line using timing studies.Comment: final version, corrected small typo
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