Selecting mixed-effects models based on a generalized information criterion

The generalized information criterion (GIC) proposed by Rao and Wu [A strongly consistent procedure for model selection in a regression problem, Biometrika 76 (1989) 369-374] is a generalization of Akaike's information criterion (AIC) and the Bayesian information criterion (BIC). In this paper, we extend the GIC to select linear mixed-effects models that are widely applied in analyzing longitudinal data. The procedure for selecting fixed effects and random effects based on the extended GIC is provided. The asymptotic behavior of the extended GIC method for selecting fixed effects is studied. We prove that, under mild conditions, the selection procedure is asymptotically loss efficient regardless of the existence of a true model and consistent if a true model exists. A simulation study is carried out to empirically evaluate the performance of the extended GIC procedure. The results from the simulation show that if the signal-to-noise ratio is moderate or high, the percentages of choosing the correct fixed effects by the GIC procedure are close to one for finite samples, while the procedure performs relatively poorly when it is used to select random effects.Inter-subject variation Within-subject variation Model selection Penalty functions

Above-Bottom Biomass Retrieval of Aquatic Plants with Regression Models and SfM Data acquired by a UAV Platform – A Case Study in Wild Duck Lake Wetland, Beijing, China

Above-bottom biomass (ABB) is considered as an important parameter for measuring the growth status of aquatic plants, and is of great significance for assessing health status of wetland ecosystems. In this study, Structure from Motion (SfM) technique was used to rebuild the study area with high overlapped images acquired by an unmanned aerial vehicle (UAV). We generated orthoimages and SfM dense point cloud data, from which vegetation indices (VIs) and SfM point cloud variables including average height (HAVG), standard deviation of height (HSD) and coefficient of variation of height (HCV) were extracted. These VIs and SfM point cloud variables could effectively characterize the growth status of aquatic plants, and thus they could be used to develop a simple linear regression model (SLR) and a stepwise linear regression model (SWL) with field measured ABB samples of aquatic plants. We also utilized a decision tree method to discriminate different types of aquatic plants. The experimental results indicated that (1) the SfM technique could effectively process high overlapped UAV images and thus be suitable for the reconstruction of fine texture feature of aquatic plant canopy structure; and (2) an SWL model based on point cloud variables: HAVG, HSD, HCV and two VIs: NGRDI, ExGR as independent variables has produced the best predictive result of ABB of aquatic plants in the study area, with a coefficient of determination of 0.84 and a relative root mean square error of 7.13%. In this analysis, a novel method for the quantitative inversion of a growth parameter (i.e., ABB) of aquatic plants in wetlands was demonstrated

Estimating Wetland Vegetation Abundance from Landsat-8 Operational Land Imager Imagery: A Comparison between Linear Spectral Mixture Analysis and Multinomial Logit Modeling Methods

Mapping vegetation abundance by using remote sensing data is an efficient means for detecting changes of an eco-environment. With Landsat-8 operational land imager (OLI) imagery acquired on July 31, 2013, both linear spectral mixture analysis (LSMA) and multinomial logit model (MNLM) methods were applied to estimate and assess the vegetation abundance in the Wild Duck Lake Wetland in Beijing, China. To improve mapping vegetation abundance and increase the number of endmembers in spectral mixture analysis, normalized difference vegetation index was extracted from OLI imagery along with the seven reflective bands of OLI data for estimating the vegetation abundance. Five endmembers were selected, which include terrestrial plants, aquatic plants, bare soil, high albedo, and low albedo. The vegetation abundance mapping results from Landsat OLI data were finally evaluated by utilizing a WorldView-2 multispectral imagery. Similar spatial patterns of vegetation abundance produced by both fully constrained LSMA algorithm and MNLM methods were observed: higher vegetation abundance levels were distributed in agricultural and riparian areas while lower levels in urban/built-up areas. The experimental results also indicate that the MNLM model outperformed the LSMA algorithm with smaller root mean square error (0.0152 versus 0.0252) and higher coefficient of determination (0.7856 versus 0.7214) as the MNLM model could handle the nonlinear reflection phenomenon better than the LSMA with mixed pixels

Safety and immunogenicity of a ChAd155-vectored respiratory syncytial virus vaccine in infants 6–7 months of age: a phase 1/2 randomized trial

Background: respiratory syncytial virus (RSV) is a common cause of lower respiratory tract infections in infants. This phase 1/2, observer-blind, randomized, controlled study assessed the safety and immunogenicity of an investigational chimpanzee-derived adenoviral vector RSV vaccine (ChAd155-RSV, expressing RSV F, N, and M2-1) in infants.Methods: healthy 6- to 7-month-olds were 1:1:1-randomized to receive 1 low ChAd155-RSV dose (1.5 × 1010 viral particles) followed by placebo (RSV_1D); 2 high ChAd155-RSV doses (5 × 1010 viral particles) (RSV_2D); or active comparator vaccines/placebo (comparator) on days 1 and 31. Follow-up lasted approximately 2 years.Results: two hundred one infants were vaccinated (RSV_1D: 65; RSV_2D: 71; comparator: 65); 159 were RSV-seronaive at baseline. Most solicited and unsolicited adverse events after ChAd155-RSV occurred at similar or lower rates than after active comparators. In infants who developed RSV infection, there was no evidence of vaccine-associated enhanced respiratory disease (VAERD). RSV-A neutralizing titers and RSV F-binding antibody concentrations were higher post–ChAd155-RSV than postcomparator at days 31, 61, and end of RSV season 1 (mean follow-up, 7 months). High-dose ChAd155-RSV induced stronger responses than low-dose, with further increases post–dose 2.Conclusions: ChAd155-RSV administered to 6- to 7-month-olds had a reactogenicity/safety profile like other childhood vaccines, showed no evidence of VAERD, and induced a humoral immune response.Clinical trials registration: NCT03636906

Mechanical thrombectomy with combined stent retriever and contact aspiration versus stent retriever alone for acute large vessel occlusion: data from ANGEL-ACT registry

Background and purpose An analysis of the ASTER 2 trial revealed similar final recanalisation levels and clinical outcomes in acute large vessel occlusion (LVO) stroke between stent retrieval (SR) alone as a first-line mechanical thrombectomy (MT) technique (SR alone first-line) and concomitant use of contact aspiration (CA) plus SR as a first-line MT technique (SR+CA first-line). The purpose of the present study was to compare the safety and efficacy of SR+CA first-line with those of SR alone first-line for patients with LVO in China.Methods We conducted the present study by using the data from the ANGEL-ACT registry. We divided the selected patients into SR+CA first-line and SR alone first-line groups. We performed logistic regression and generalised linear models with adjustments to compare the angiographic and clinical outcomes, including successful/complete recanalisation after the first technique alone and all procedures, first-pass successful/complete recanalisation, number of passes, 90-day modified Rankin Scale, procedure duration, rescue treatment and intracranial haemorrhage within 24 hours.Results Of the 1233 enrolled patients, 1069 (86.7%) received SR alone first-line, and 164 (13.3%) received SR+CA first-line. SR+CA first-line was associated with more thrombectomy passes (3 (2–4) vs 2 (1–2); β=1.77, 95% CI=1.55 to 1.99, p<0.001), and longer procedure duration (86 (60–129) min vs 80 (50–122) min; β=10.76, 95% CI=1.08 to 20.43, p=0.029) than SR alone first-line group. Other outcomes were comparable (all p>0.05) between the two groups.Conclusions Patients undergoing SR+CA first-line had more thrombectomy passes and longer procedure duration than patients undergoing SR alone first-line. Additionally, we suggested that SR+CA first-line was not superior to SR alone first-line in final recanalisation level, first-pass recanalisation level and 90-day clinical outcomes in the Chinese population