560 research outputs found

    Teachers teaching teachers : a case study of the 2011 ProEd professional learning community and its influence on creating a culture for organizational learning in schools in the Republic of Panama

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    Title from PDF of title page (University of Missouri--Columbia, viewed on August 30, 2012).The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file.Dissertation advisor: Dr. Phillip MessnerIncludes bibliographical references.Vita.Ed. D. University of Missouri-Columbia 2012."May 2012"While evidence of organizational learning through empowered teacher collaboration has been established in many international school studies, no such relationship has been investigated in public and/or low-middle socioeconomic private schools in the Republic of Panama. This observation provides a framework for exploring how schools in Panama learn. This qualitative ethnomethodological case study was driven by the void in empirical knowledge and the guiding question that asked: How and to what extent does participation in the monthly 2011 ProEd Professional Learning Community influence a culture for organizational learning in schools in Panama. Data were collected in a three-step interview process conducted with a sample of 25 randomly selected 2011 ProEd PLC teachers from 5 low-middle socioeconomic public and/or private schools in Panama. Data analysis included open coding of emerging themes from the interviews and field notes. Walkthrough observations of ProEd PLC teachers and focus groups with non-2011 ProEd PLC members were conducted to triangulate for trustworthiness of this study. The participant researcher of this study was involved as lead facilitator and coach of all monthly PLC workshops and in data collection during the interview process. Emerging themes surfaced from conversations with teachers who created meanings from stories shared about their roles as educators in a developing nation.Includes bibliographical reference

    Assay for Neural Induction in the Chick Embryo

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    The chick embryo is a valuable tool in the study of early embryonic development. Its transparency, accessibility and ease of manipulation, make it an ideal tool for studying the formation and initial patterning of the nervous system. This video demonstrates how to graft organizer tissue into a host, a method by which Hensen s node (the organizer in the chick embryo) is grafted to a host competent ectoderm. The organizer graft instructs overlying na ve tissue to adopt a neural fate via neural inducing signals. This mechanism is referred to as neural induction, and constitutes the initial step in the formation of brain and spinal cord in amniotes. This method is essentially used for the characterization of putative neural inducing molecules in chick. This video demonstrates the different steps in the assay for neural induction; First, the donnor embryo is explanted and pinned on a dish. Then, the host embryo is prepared for New culture. The graft is excised and transplanted to the host area pellucida margin. The host is cultured for 18-22 hrs. The assembly is fixed and processed for further applications (e.g. in situ hybridization). This method was originally devised by Waddington 1,2 and Gallera 3,4

    The early stages of heart development: insights from chicken embryos

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    The heart is the first functioning organ in the developing embryo and the detailed understanding of the molecular and cellular mechanisms involved in its formation provides insights into congenital malformations affecting its function and therefore the survival of the organism. Because many developmental mechanisms are highly conserved, it is possible to extrapolate from observations made in invertebrate and vertebrate model organisms to human. This review will highlight the contributions made through studying heart development in avian embryos, particularly the chicken. The major advantage of chick embryos is their accessibility for surgical manipulations and functional interference approaches, both gain- and loss-of-function. In addition to experiments performed in ovo, the dissection of tissues for ex vivo culture, genomic or biochemical approaches, is straightforward. Furthermore, embryos can be cultured for time-lapse imaging, which enables tracking of fluorescently labeled cells and detailed analyses of tissue morphogenesis. Owing to these features, investigations in chick embryos have led to important discoveries, often complementing genetic studies in mouse and zebrafish. As well as including some historical aspects, we cover here some of the crucial advances made in understanding of early heart development using the chicken model

    Stability and Formation of the Resonant System HD 73526

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    Based on radial velocity measurements it has been found recently that the two giant planets detected around the star HD 73526 are in 2:1 resonance. However, as our numerical integration shows, the derived orbital data for this system result in chaotic behavior of the giant planets, which is uncommon among the resonant extrasolar planetary systems. We intend to present regular (non-chaotic) orbital solutions for the giant planets in the system HD 73526 and offer formation scenarios based on combining planetary migration and sudden perturbative effects such as planet-planet scattering or rapid dispersal of the protoplanetary disk. A comparison with the already studied resonant system HD 128311, exhibiting similar behavior, is also done. The new sets of orbital solutions have been derived by the Systemic Console (www.oklo.org). The stability of these solutions has been investigated by the Relative Lyapunov indicator, while the migration and scattering effects are studied by gravitational N-body simulations applying non-conservative forces as well. Additionally, hydrodynamic simulations of embedded planets in protoplanetary disks are performed to follow the capture into resonance. For the system HD 73526 we demonstrate that the observational radial velocity data are consistent with a coplanar planetary system engaged in a stable 2:1 resonance exhibiting apsidal corotation. We have shown that, similarly to the system HD 128311, the present dynamical state of HD 73526 could be the result of a mixed evolutionary process melting together planetary migration and a perturbative event.Comment: 12 pages, 14 figures, accepted in A&A, v2: technical change

    CB1R-Mediated Activation of Caspase-3 Causes Epigenetic and Neurobehavioral Abnormalities in Postnatal Ethanol-Exposed Mice

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    Alcohol exposure can affect brain development, leading to long-lasting behavioral problems, including cognitive impairment, which together is defined as fetal alcohol spectrum disorder (FASD). However, the fundamental mechanisms through which this occurs are largely unknown. In this study, we report that the exposure of postnatal day 7 (P7) mice to ethanol activates caspase-3 via cannabinoid receptor type-1 (CB1R) in neonatal mice and causes a reduction in methylated DNA binding protein (MeCP2) levels. The developmental expression of MeCP2 in mice is closely correlated with synaptogenesis and neuronal maturation. It was shown that ethanol treatment of P7 mice enhanced Mecp2 mRNA levels but reduced protein levels. The genetic deletion of CB1R prevented, and administration of a CB1R antagonist before ethanol treatment of P7 mice inhibited caspase-3 activation. Additionally, it reversed the loss of MeCP2 protein, cAMP response element binding protein (CREB) activation, and activity-regulated cytoskeleton-associated protein (Arc) expression. The inhibition of caspase-3 activity prior to ethanol administration prevented ethanol-induced loss of MeCP2, CREB activation, epigenetic regulation of Arc expression, long-term potentiation (LTP), spatial memory deficits and activity-dependent impairment of several signaling molecules, including MeCP2, in adult mice. Collectively, these results reveal that the ethanol-induced CB1R-mediated activation of caspase-3 degrades the MeCP2 protein in the P7 mouse brain and causes long-lasting neurobehavioral deficits in adult mice. This CB1R-mediated instability of MeCP2 during active synaptic maturation may disrupt synaptic circuit maturation and lead to neurobehavioral abnormalities, as observed in this animal model of FASD

    On the dynamics of Extrasolar Planetary Systems under dissipation. Migration of planets

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    We study the dynamics of planetary systems with two planets moving in the same plane, when frictional forces act on the two planets, in addition to the gravitational forces. The model of the general three-body problem is used. Different laws of friction are considered. The topology of the phase space is essential in understanding the evolution of the system. The topology is determined by the families of stable and unstable periodic orbits, both symmetric and non symmetric. It is along the stable families, or close to them, that the planets migrate when dissipative forces act. At the critical points where the stability along the family changes, there is a bifurcation of a new family of stable periodic orbits and the migration process changes route and follows the new stable family up to large eccentricities or to a chaotic region. We consider both resonant and non resonant planetary systems. The 2/1, 3/1 and 3/2 resonances are studied. The migration to larger or smaller eccentricities depends on the particular law of friction. Also, in some cases the semimajor axes increase and in other cases they are stabilized. For particular laws of friction and for special values of the parameters of the frictional forces, it is possible to have partially stationary solutions, where the eccentricities and the semimajor axes are fixed.Comment: Accepted in Celestial Mechanics and Dynamical Astronom

    Cell Movement patterns during gastrulation in the chick are controlled by positive and negative chemotaxis mediated by FGF4 and FGF8

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    AbstractDuring gastrulation in amniotes, epiblast cells ingress through the primitive streak and migrate away to form endodermal, mesodermal, and extraembryonic structures. Here we analyze the detailed movement trajectories of cells emerging at different anterior-posterior positions from the primitive streak, using in vivo imaging of the movement of GFP-tagged streak cells. Cells emerging at different anterior-posterior positions from the streak show characteristic cell migration patterns, in response to guidance signals from neighboring tissues. Streak cells are attracted by sources of FGF4 and repelled by sources of FGF8. The observed movement patterns of anterior streak cells can be explained by an FGF8-mediated chemorepulsion of cells away from the streak followed by chemoattraction toward an FGF4 signal produced by the forming notochord

    WhatsApp Remote Reading Recovery: Using Mobile Technology to Promote Literacy during COVID-19

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    School closures because of the COVID-19 pandemic affected over a billion young people worldwide and presented a threat to long-term learning, particularly for public school students in low socioeconomic situations. This article offers quasi-experimental evidence on a low-cost strategy for distance learning applied in the Republic of Panama to minimize the negative consequences of the pandemic on public elementary school children’s reading levels. We conducted a 12-week intervention that utilized mobile phone technology and dissemination of reading material through WhatsApp, a cross-platform messaging freeware service, to maintain and improve children’s reading levels during the pandemic school shutdown. The objective was to determine the feasibility of using WhatsApp as a digital tool to facilitate education and inform evolving practice and policy responses. Results among 292 students between the second and sixth grades indicated overall mean gains of up to 10.3% in the number of words read per minute, with statistically significant improvements overall and higher gains among the second and third grades. In addition, the adoption rate was high, with a reported average of 84% completion of the daily readings. The results of this low-tech intervention have immediate and longer-term implications for using mobile technology as a supplemental or complementary learning tool, especially for developing regions and during school closures or school vacations
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