5,571 research outputs found
The hypertoric intersection cohomology ring
We present a functorial computation of the equivariant intersection
cohomology of a hypertoric variety, and endow it with a natural ring structure.
When the hyperplane arrangement associated with the hypertoric variety is
unimodular, we show that this ring structure is induced by a ring structure on
the equivariant intersection cohomology sheaf in the equivariant derived
category. The computation is given in terms of a localization functor which
takes equivariant sheaves on a sufficiently nice stratified space to sheaves on
a poset.Comment: Significant revisions in Section 5, with several corrected proof
Poisson-de Rham homology of hypertoric varieties and nilpotent cones
We prove a conjecture of Etingof and the second author for hypertoric
varieties, that the Poisson-de Rham homology of a unimodular hypertoric cone is
isomorphic to the de Rham cohomology of its hypertoric resolution. More
generally, we prove that this conjecture holds for an arbitrary conical variety
admitting a symplectic resolution if and only if it holds in degree zero for
all normal slices to symplectic leaves.
The Poisson-de Rham homology of a Poisson cone inherits a second grading. In
the hypertoric case, we compute the resulting 2-variable Poisson-de
Rham-Poincare polynomial, and prove that it is equal to a specialization of an
enrichment of the Tutte polynomial of a matroid that was introduced by Denham.
We also compute this polynomial for S3-varieties of type A in terms of Kostka
polynomials, modulo a previous conjecture of the first author, and we give a
conjectural answer for nilpotent cones in arbitrary type, which we prove in
rank less than or equal to 2.Comment: 25 page
Noninvasive vagus nerve stimulation alters neural response and physiological autonomic tone to noxious thermal challenge.
The mechanisms by which noninvasive vagal nerve stimulation (nVNS) affect central and peripheral neural circuits that subserve pain and autonomic physiology are not clear, and thus remain an area of intense investigation. Effects of nVNS vs sham stimulation on subject responses to five noxious thermal stimuli (applied to left lower extremity), were measured in 30 healthy subjects (n = 15 sham and n = 15 nVNS), with fMRI and physiological galvanic skin response (GSR). With repeated noxious thermal stimuli a group × time analysis showed a significantly (p < .001) decreased response with nVNS in bilateral primary and secondary somatosensory cortices (SI and SII), left dorsoposterior insular cortex, bilateral paracentral lobule, bilateral medial dorsal thalamus, right anterior cingulate cortex, and right orbitofrontal cortex. A group × time × GSR analysis showed a significantly decreased response in the nVNS group (p < .0005) bilaterally in SI, lower and mid medullary brainstem, and inferior occipital cortex. Finally, nVNS treatment showed decreased activity in pronociceptive brainstem nuclei (e.g. the reticular nucleus and rostral ventromedial medulla) and key autonomic integration nuclei (e.g. the rostroventrolateral medulla, nucleus ambiguous, and dorsal motor nucleus of the vagus nerve). In aggregate, noninvasive vagal nerve stimulation reduced the physiological response to noxious thermal stimuli and impacted neural circuits important for pain processing and autonomic output
A New Scintillator Tile/Fiber Preshower Detector for the CDF Central Calorimeter
A detector designed to measure early particle showers has been installed in
front of the central CDF calorimeter at the Tevatron. This new preshower
detector is based on scintillator tiles coupled to wavelength-shifting fibers
read out by multi-anode photomultipliers and has a total of 3,072 readout
channels. The replacement of the old gas detector was required due to an
expected increase in instantaneous luminosity of the Tevatron collider in the
next few years. Calorimeter coverage, jet energy resolution, and electron and
photon identification are among the expected improvements. The final detector
design, together with the R&D studies that led to the choice of scintillator
and fiber, mechanical assembly, and quality control are presented. The detector
was installed in the fall 2004 Tevatron shutdown and started collecting
colliding beam data by the end of the same year. First measurements indicate a
light yield of 12 photoelectrons/MIP, a more than two-fold increase over the
design goals.Comment: 5 pages, 10 figures (changes are minor; this is the final version
published in IEEE-Trans.Nucl.Sci.
Development of FTK architecture: a fast hardware track trigger for the ATLAS detector
The Fast Tracker (FTK) is a proposed upgrade to the ATLAS trigger system that
will operate at full Level-1 output rates and provide high quality tracks
reconstructed over the entire detector by the start of processing in Level-2.
FTK solves the combinatorial challenge inherent to tracking by exploiting the
massive parallelism of Associative Memories (AM) that can compare inner
detector hits to millions of pre-calculated patterns simultaneously. The
tracking problem within matched patterns is further simplified by using
pre-computed linearized fitting constants and leveraging fast DSP's in modern
commercial FPGA's. Overall, FTK is able to compute the helix parameters for all
tracks in an event and apply quality cuts in approximately one millisecond. By
employing a pipelined architecture, FTK is able to continuously operate at
Level-1 rates without deadtime. The system design is defined and studied using
ATLAS full simulation. Reconstruction quality is evaluated for single muon
events with zero pileup, as well as WH events at the LHC design luminosity. FTK
results are compared with the tracking capability of an offline algorithm.Comment: To be published in the proceedings of DPF-2009, Detroit, MI, July
2009, eConf C09072
The Evolution of FTK, a Real-Time Tracker for Hadron Collider Experiments
We describe the architecture evolution of the highly-parallel dedicated
processor FTK, which is driven by the simulation of LHC events at high
luminosity (1034 cm-2 s-1). FTK is able to provide precise on-line track
reconstruction for future hadronic collider experiments. The processor,
organized in a two-tiered pipelined architecture, execute very fast algorithms
based on the use of a large bank of pre-stored patterns of trajectory points
(first tier) in combination with full resolution track fitting to refine
pattern recognition and to determine off-line quality track parameters. We
describe here how the high luminosity simulation results have produced a new
organization of the hardware inside the FTK processor core.Comment: 11th ICATPP conferenc
Is mindfulness Buddhist? (and why it matters).
Modern exponents of mindfulness meditation promote the therapeutic effects of "bare attention"--a sort of non-judgmental, non-discursive attending to the moment-to-moment flow of consciousness. This approach to Buddhist meditation can be traced to Burmese Buddhist reform movements of the first half of the 20th century, and is arguably at odds with more traditional Theravāda Buddhist doctrine and meditative practices. But the cultivation of present-centered awareness is not without precedent in Buddhist history; similar innovations arose in medieval Chinese Zen (Chan) and Tibetan Dzogchen. These movements have several things in common. In each case the reforms were, in part, attempts to render Buddhist practice and insight accessible to laypersons unfamiliar with Buddhist philosophy and/or unwilling to adopt a renunciatory lifestyle. In addition, these movements all promised astonishingly quick results. And finally, the innovations in practice were met with suspicion and criticism from traditional Buddhist quarters. Those interested in the therapeutic effects of mindfulness and bare attention are often not aware of the existence, much less the content, of the controversies surrounding these practices in Asian Buddhist history
Sequence determinants in human polyadenylation site selection
BACKGROUND: Differential polyadenylation is a widespread mechanism in higher eukaryotes producing mRNAs with different 3' ends in different contexts. This involves several alternative polyadenylation sites in the 3' UTR, each with its specific strength. Here, we analyze the vicinity of human polyadenylation signals in search of patterns that would help discriminate strong and weak polyadenylation sites, or true sites from randomly occurring signals. RESULTS: We used human genomic sequences to retrieve the region downstream of polyadenylation signals, usually absent from cDNA or mRNA databases. Analyzing 4956 EST-validated polyadenylation sites and their -300/+300 nt flanking regions, we clearly visualized the upstream (USE) and downstream (DSE) sequence elements, both characterized by U-rich (not GU-rich) segments. The presence of a USE and a DSE is the main feature distinguishing true polyadenylation sites from randomly occurring A(A/U)UAAA hexamers. While USEs are indifferently associated with strong and weak poly(A) sites, DSEs are more conspicuous near strong poly(A) sites. We then used the region encompassing the hexamer and DSE as a training set for poly(A) site identification by the ERPIN program and achieved a prediction specificity of 69 to 85% for a sensitivity of 56%. CONCLUSION: The availability of complete genomes and large EST sequence databases now permit large-scale observation of polyadenylation sites. Both U-rich sequences flanking both sides of poly(A) signals contribute to the definition of "true" sites. However, the downstream U-rich sequences may also play an enhancing role. Based on this information, poly(A) site prediction accuracy was moderately but consistently improved compared to the best previously available algorithm
D-branes Wrapped on Fuzzy del Pezzo Surfaces
We construct classical solutions in quiver gauge theories on D0-branes
probing toric del Pezzo singularities in Calabi-Yau manifolds. Our solutions
represent D4-branes wrapped around fuzzy del Pezzo surfaces. We study the
fluctuation spectrum around the fuzzy CP^2 solution in detail. We also comment
on possible applications of our fuzzy del Pezzo surfaces to the fuzzy version
of F-theory, dubbed F(uzz) theory.Comment: 1+42 pages, 9 figures v2: references added v3: statements on the
structure of the Yukawa couplings weakened. published versio
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