143 research outputs found
Spectator detection for the measurement of proton neutron interactions at ANKE
A telescope of three silicon detectors has been installed close to the
internal target position of the ANKE spectrometer, which is situated inside the
ultra-high vacuum of the COSY-Juelich light-ion storage ring. The detection and
identification of slow protons and deuterons emerging from a deuterium
cluster-jet target thus becomes feasible. A good measurement of the energy and
angle of such a spectator proton (p_sp) allows one to identify a reaction as
having taken place on the neutron in the target and then to determine the
kinematical variables of the ion-neutron system on an event-by-event basis over
a range of c.m. energies.
The system has been successfully tested under laboratory conditions. By
measuring the spectator proton in the p d to p_sp d pi^0 reaction in
coincidence with a fast deuteron in the ANKE Forward Detector, values of the p
n to d pi^0 total cross-section have been deduced. Further applications of the
telescope include the determination of the luminosity and beam polarisation
which are required for several experiments.Comment: 16 pages, 9 figure
A 2D position sensitive germanium detector for spectroscopy and polarimetry of high-energetic x-rays
We report on a first prototype 2D μ-strip germanium detector, developed at IKP-Jülich, and its performance test at the European Synchrotron Radiation Facility (ESRF) in Grenoble, France. Beside an accurate determination of the detector response function, the polarization sensitivity has been addressed in this study. For this purpose photon beams at energies of 60 keV and 210 keV have been used
Meson Production in p+d Reactions
The production of neutral and charged pions as well as eta mesons is studied
in the Delta and N* resonance region, respectively. Heavy A=3 recoils were
measured with the GEM detector. The differential cross sections covering the
full angular range are compared with model calculations.Comment: 4 pages, latex, 4 figures, talk presented at the XVIIth European
Conference on Few-Body Problems in Physics, Evora, Portugal, September 2000;
to be published in Nucl. Phys.
Relativistic quantum dynamics in strong fields: Photon emission from heavy, few-electron ions
Recent progress in the study of the photon emission from highly-charged heavy
ions is reviewed. These investigations show that high- ions provide a unique
tool for improving the understanding of the electron-electron and
electron-photon interaction in the presence of strong fields. Apart from the
bound-state transitions, which are accurately described in the framework of
Quantum Electrodynamics, much information has been obtained also from the
radiative capture of (quasi-) free electrons by high- ions. Many features in
the observed spectra hereby confirm the inherently relativistic behavior of
even the simplest compound quantum systems in Nature.Comment: Version 18/11/0
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First-Generation Hybrid Compact Compton Imager
At Lawrence Livermore National Laboratory, we are pursuing the development of a gamma-ray imaging system using the Compton effect. We have built our first generation hybrid Compton imaging system, and we have conducted initial calibration and image measurements using this system. In this paper, we present the details of the hybrid Compton imaging system and initial calibration and image measurements
Forward K+ production in subthreshold pA collisions at 1.0 GeV
K+ meson production in pA (A = C, Cu, Au) collisions has been studied using
the ANKE spectrometer at an internal target position of the COSY-Juelich
accelerator. The complete momentum spectrum of kaons emitted at forward angles,
theta < 12 degrees, has been measured for a beam energy of T(p)=1.0 GeV, far
below the free NN threshold of 1.58 GeV. The spectrum does not follow a thermal
distribution at low kaon momenta and the larger momenta reflect a high degree
of collectivity in the target nucleus.Comment: 4 pages, 3 figure
Gregor Lang-Wojtasik (2008): Schule in der Weltgesellschaft – Herausforderungen und Perspektiven einer Schultheorie jenseits der Moderne. Weinheim, München: Juventa 2008, 240 S. [Rezension]
Rezension zu: Gregor Lang-Wojtasik (2008): Schule in der Weltgesellschaft – Herausforderungen und Perspektiven einer Schultheorie jenseits der Moderne. Weinheim, München: Juventa 2008, 240 S., ISBN 978-3-7799-1267-
Decreased transcription-coupled nucleotide excision repair capacity is associated with increased p53- and MLH1-independent apoptosis in response to cisplatin
Abstract
Background
One of the most commonly used classes of anti-cancer drugs presently in clinical practice is the platinum-based drugs, including cisplatin. The efficacy of cisplatin therapy is often limited by the emergence of resistant tumours following treatment. Cisplatin resistance is multi-factorial but can be associated with increased DNA repair capacity, mutations in p53 or loss of DNA mismatch repair capacity.
Methods
RNA interference (RNAi) was used to reduce the transcription-coupled nucleotide excision repair (TC-NER) capacity of several prostate and colorectal carcinoma cell lines with specific defects in p53 and/or DNA mismatch repair. The effect of small inhibitory RNAs designed to target the CSB (Cockayne syndrome group B) transcript on TC-NER and the sensitivity of cells to cisplatin-induced apoptosis was determined.
Results
These prostate and colon cancer cell lines were initially TC-NER proficient and RNAi against CSB significantly reduced their DNA repair capacity. Decreased TC-NER capacity was associated with an increase in the sensitivity of tumour cells to cisplatin-induced apoptosis, even in p53 null and DNA mismatch repair-deficient cell lines.
Conclusion
The present work indicates that CSB and TC-NER play a prominent role in determining the sensitivity of tumour cells to cisplatin even in the absence of p53 and DNA mismatch repair. These results further suggest that CSB represents a potential target for cancer therapy that may be important to overcome resistance to cisplatin in the clinic
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