A simple strategy to optimally design and manage a photovoltaic plant integrated with a storage system for different applications

The main goal of the present paper is that of proposing a methodology for the optimal sizing of a Photovoltaic (PV) unit and a Storage (ST) device, basing on data concerning typical load and PV production profiles. To achieve this result, a set of simple requirements to manage the charging/discharging of the storage is firstly proposed. Then, the overall cost of the whole system is deduced as a function of two variables (PV and ST sizes) and minimized in order to find the optimal sizing of the system. Finally, an economic analysis is presented to determine whether or not the investment is profitable

The Molecular and Cellular Basis of Tumor Rejection After Vaccination With Mammary Adenocarcinoma Cells Transduced With the MHC Class II Transactivator CIITA

CD8+ T cell responses are major players of tumor eradication in various vaccination protocols. However, an optimal stimulation of CD4+ T helper cells is required for both priming and maintenance of the effector CTL response against the tumor. In this study we show that the murine mammary adenocarcinoma cell line TS/A, a highly malignant MHC-II-negative tumor, is rejected in vivo if genetically engineered to express MHC-II molecules by transfer of the MHC-II transactivator CIITA. TS/ACIITA cells are fully rejected by 93% of the syngeneic recipients and have a significantly lower growth rate in the remaining 7% of animals. Rejection requires CD4+ and CD8+ cells. CD4+ T cells are fundamental in the priming phase, whereas CTLs are the major anti-tumor effectors. All tumor rejecting animals are protected against rechallenge with the parental TS/A tumor. Immunohistochemical data at day 5 post-inoculation showed an higher infiltrate of CD4+ T cells in mice bearing TS/A-CIITA, than in mice bearing the TS/A tumor. Subsequently, from day 7 trough day 10, TS/A-CIITA tumors showed higher number of both CD4+ and CD8+ cells, dendritic cells, together with massive necrosis. The frequency of IFN-αsecreting splenocytes early after inoculations was also assessed by an ex vivo ELISPOT assay. Only the rejecting TS/A-CIITA animals showed an high frequency of IFN-αsecreting cells (between 80 and 120/106 splenocytes). Importantly, CD4 and CD8 depletion experiments revealed that at the time of tumor resolution the major cell population recognizing the TS/A-CIITA cells was of CD4 origin. This is the first example of successful tumor vaccination by genetic transfer of CIITA. These results open the way to a possible use of CIITA for increasing both the inducing and the effector phase of the anti-tumor response. from 2005 International Meeting of The Institute of Human Virology Baltimore, USA, 29 August – 2 September 200

Green synthesis of privileged benzimidazole scaffolds using active deep eutectic solvent

The exploitation and use of alternative synthetic methods, in the face of classical procedures that do not conform to the ethics of green chemistry, represent an ever-present problem in the pharmaceutical industry. The procedures for the synthesis of benzimidazoles have become a focus in synthetic organic chemistry, as they are building blocks of strong interest for the development of compounds with pharmacological activity. Various benzimidazole derivatives exhibit important activities such as antimicrobial, antiviral, anti-inflammatory, and analgesic activities, and some of the already synthesized compounds have found very strong applications in medicine praxis. Here we report a selective and sustainable method for the synthesis of 1,2-disubstituted or 2-substituted benzimidazoles, starting from o-phenylenediamine in the presence of different aldehydes. The use of deep eutectic solvent (DES), both as reaction medium and reagent without any external solvent, provides advantages in terms of yields as well as in the work up procedure of the reaction.Fil: Gioia, Maria Luisa Di. Università della Calabria; ItaliaFil: Cassano, Roberta. Università della Calabria; ItaliaFil: Costanzo, Paola. Magna Græcia University. Department of Health Sciences; ItaliaFil: Herrera Cano, Natividad Carolina. Universidad Nacional de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Ciencia y Tecnología de Alimentos Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Ciencia y Tecnología de Alimentos Córdoba; ArgentinaFil: Maiuolo, Loredana. Università della Calabria; ItaliaFil: Nardi, Monica. Magna Græcia University. Department of Health Sciences; ItaliaFil: Nicoletta, Fiore Pasquale. Università della Calabria; ItaliaFil: Oliverio, Manuela. Magna Græcia University. Department of Health Sciences; ItaliaFil: Procopio, Antonio. Magna Græcia University. Department of Health Sciences; Itali

SerpinE1 drives a cell-autonomous pathogenic signaling in Hutchinson-Gilford progeria syndrome

Hutchinson-Gilford progeria syndrome (HGPS) is a rare, fatal disease caused by Lamin A mutation, leading to altered nuclear architecture, loss of peripheral heterochromatin and deregulated gene expression. HGPS patients eventually die by coronary artery disease and cardiovascular alterations. Yet, how deregulated transcriptional networks at the cellular level impact on the systemic disease phenotype is currently unclear. A genome-wide analysis of gene expression in cultures of primary HGPS fibroblasts identified SerpinE1, also known as Plasminogen Activator Inhibitor (PAI-1), as central gene that propels a cell-autonomous pathogenic signaling from the altered nuclear lamina. Indeed, siRNA-mediated downregulation and pharmacological inhibition of SerpinE1 by TM5441 could revert key pathological features of HGPS in patient-derived fibroblasts, including re-activation of cell cycle progression, reduced DNA damage signaling, decreased expression of pro-fibrotic genes and recovery of mitochondrial defects. These effects were accompanied by the correction of nuclear abnormalities. These data point to SerpinE1 as a novel potential effector and target for therapeutic interventions in HGPS pathogenesis

Identificacion de patrones caracteristicos de la poblacion carcelaria mediante minería de datos

La situación penitenciaria muestra números preocupantes en sobrepoblación, hacinamiento, promiscuidad, avance del sida, violencia, entre otros. Estos incrementos y cuestiones alarmantes han instalado el tema como uno de los puntos inevitables de estudio dentro de la política criminal. En este contexto, en este trabajo se presentan resultados preliminares sobre el uso de minería de datos aplicada a la población carcelaria en Argentina con fines de prevención de delitos.Eje: Ingeniería de Software y Base de DatosRed de Universidades con Carreras en Informática (RedUNCI

Identificacion de patrones caracteristicos de la poblacion carcelaria mediante minería de datos

La situación penitenciaria muestra números preocupantes en sobrepoblación, hacinamiento, promiscuidad, avance del sida, violencia, entre otros. Estos incrementos y cuestiones alarmantes han instalado el tema como uno de los puntos inevitables de estudio dentro de la política criminal. En este contexto, en este trabajo se presentan resultados preliminares sobre el uso de minería de datos aplicada a la población carcelaria en Argentina con fines de prevención de delitos.Eje: Ingeniería de Software y Base de DatosRed de Universidades con Carreras en Informática (RedUNCI

Explotación de información aplicada a inteligencia criminal en Argentina

El presente trabajo describe un Proyecto de Explotación de información en el ámbito de la información criminal, analizando homicidios dolosos, homicidios culposos en accidentes de tránsito y la población carcelaria Argentina. Los análisis se realizan a través de herramientas de explotación de información de distribución libre.Workshop de Ingeniería de Software y Bases de Datos (WISBD)Red de Universidades con Carreras en Informática (RedUNCI

Explotación de información aplicada a inteligencia criminal en Argentina

El presente trabajo describe un Proyecto de Explotación de información en el ámbito de la información criminal, analizando homicidios dolosos, homicidios culposos en accidentes de tránsito y la población carcelaria Argentina. Los análisis se realizan a través de herramientas de explotación de información de distribución libre.Workshop de Ingeniería de Software y Bases de Datos (WISBD)Red de Universidades con Carreras en Informática (RedUNCI

Timed rise from floor as a predictor of disease progression in Duchenne muscular dystrophy: An observational study

The role of timed items, and more specifically, of the time to rise from the floor, has been reported as an early prognostic factor for disease progression and loss of ambulation. The aim of our study was to investigate the possible effect of the time to rise from the floor test on the changes observed on the 6MWT over 12 months in a cohort of ambulant Duchenne boys.A total of 487 12-month data points were collected from 215 ambulant Duchenne boys. The age ranged between 5.0 and 20.0 years (mean 8.48 ±2.48 DS).The results of the time to rise from the floor at baseline ranged from 1.2 to 29.4 seconds in the boys who could perform the test. 49 patients were unable to perform the test at baseline and 87 at 12 month The 6MWT values ranged from 82 to 567 meters at baseline. 3 patients lost the ability to perform the 6mwt at 12 months. The correlation between time to rise from the floor and 6MWT at baseline was high (r = 0.6, p<0.01).Both time to rise from the floor and baseline 6MWT were relevant for predicting 6MWT changes in the group above the age of 7 years, with no interaction between the two measures, as the impact of time to rise from the floor on 6MWT change was similar in the patients below and above 350 m. Our results suggest that, time to rise from the floor can be considered an additional important prognostic factor of 12 month changes on the 6MWT and, more generally, of disease progression