Product Lifecycle Management - Application of Patterning Methods to Gas Turbine Blades and Creation of Learning Materials

To compete in the global marketplace, companies need to embrace virtual design and manufacturing methods. Product Lifecycle Management (PLM) embodies both the workflow processes and tools to bring forth products from conception to design to fabrication to service to decommissioning, and to eventual recycling. In response to the growing demand for engineers and technicians with these critical skills, colleges and universities should introduce these virtual tools through seminars, software workshops, and computer laboratory sessions. Some of the opportunities in the PLM Center at Clemson University include short courses on PLM practices, focused software training sessions, hands-on exploration activities, and research projects. The participants across campus include creative inquiry students, capstone design classes, graduate researchers, and community outreach for K-12 students. Through these interactions, participants will gain insight into the challenges and opportunities with virtual engineering processes and software. The recent worldwide pandemic has demonstrated the need for engineers skilled in virtual design methods to enable the digital design, manufacturing, and support processes to occur in, and remote of, the workplace. Computer-aided design (CAD) and computer-aided engineering (CAE) methods embody the software tools that bring forth products from conception to design. A variety of packages are available, which allow for the progress of a product to be tracked and detailed changes to be made along the way. One complex product currently designed using CAE software is a natural gas fired turbine for electrical power generation. In these thermo-dynamic rotational systems, blade cooling using internal forced airflow is vital to withstand the operating temperatures in the combustion chamber. Accordingly, ribbed surface disruptors, known as turbulators, are placed inside the turbine blades to promote air mixing to help remove heat from the hot surfaces. Three CAE patterning features will be examined to create these turbulators with evaluation metrics based on the execution speed, accessibility, accuracy, adaptability, and relevance. The numerical case study results revealed that the face pattern method was the most suitable option with productivity time improvements of 5% in comparison to the feature and geometry pattern approaches. The feature pattern method proved to be viable for smaller modeling changes which require significant detail. However, the geometry patterning method did not show any indications of being a usable option over the others in any scenario tested. To prepare the next generation of engineers for these PLM processes and software tools, a PEER & WISE workshop module has been created for students to engage with these virtual concepts. In these four-day, 90-minute sessions, middle school students will learn about engineering design processes, fundamental engineering and science concepts, and CAD software. They will create virtual mechanical components using CAD software, while hands-on tasks will enable the creation of mechanical assemblies using discrete components to demonstrate the functionality of gears and drivelines. To assess the student experience, a survey was created and submitted for IRB approval. The pandemic created a unique situation for these prepared sessions as students could not participate right away, however, they will be offered in the future

Continuous-variable entanglement of two bright coherent states that never interacted

We study continuous-variable entanglement of bright quantum states in a pair of evanescently coupled nonlinear $\chi^{(2)}$ waveguides operating in the regime of degenerate down-conversion. We consider the case where only the energy of the nonlinearly generated fields is exchanged between the waveguides while the pump fields stay independently guided in each original waveguide. We show that this device, when operated in the depletion regime, entangles the two non-interacting bright pump modes due to a nonlinear cascade effect. It is also shown that two-colour quadripartite entanglement can be produced when certain system parameters are appropriately set. This device works in the traveling-wave configuration, such that the generated quantum light shows a broad spectrum. The proposed device can be easily realized with current technology and therefore stands as a good candidate for a source of bipartite or multipartite entangled states for the emerging field of optical continuous-variable quantum information processing.Comment: 10 pages, 12 figure

Squamous Cell Carcinoma Of Tongue

Introducción: el Carcinoma Epidermoide es la neoplasia maligna más frecuente que afecta el epitelio plano estratificado que puede producir proliferación destructiva local y metástasis a distancia. Representa el 90% de los canceres orales, predominando en sus localizaciones el labio inferior, bordes laterales de la lengua y piso de boca. A pesar de que el cáncer bucal se localiza en regiones accesibles a la exploración física, la mayoría de los pacientes se diagnostican en estadios avanzados cuando las posibilidades de curación son remotas, lo que dificulta el tratamiento y empeora el pronóstico de los pacientes.Introduction: Squamous Cell Carcinoma is the most frequent malignant neoplasm, it affects the stratified flat epithelium it can cause local destructive proliferation and distant metastases. This represent 90% of oral cancers, predominantly in their locations the lower lip, lateral edges of the tongue and floor of the mouth. Despite the fact the oral cancer is located in regions accessible to physical examination, the majority patients are diagnosed in advanced stages when the possibilities of cure are remote which makes treatment difficult and worsens the prognosis of patients.Facultad de Odontologí

Calibration and Stokes Imaging with Full Embedded Element Primary Beam Model for the Murchison Widefield Array

15 pages, 11 figures. Accepted for publication in PASA. © Astronomical Society of Australia 2017The Murchison Widefield Array (MWA), located in Western Australia, is one of the low-frequency precursors of the international Square Kilometre Array (SKA) project. In addition to pursuing its own ambitious science program, it is also a testbed for wide range of future SKA activities ranging from hardware, software to data analysis. The key science programs for the MWA and SKA require very high dynamic ranges, which challenges calibration and imaging systems. Correct calibration of the instrument and accurate measurements of source flux densities and polarisations require precise characterisation of the telescope's primary beam. Recent results from the MWA GaLactic Extragalactic All-sky MWA (GLEAM) survey show that the previously implemented Average Embedded Element (AEE) model still leaves residual polarisations errors of up to 10-20 % in Stokes Q. We present a new simulation-based Full Embedded Element (FEE) model which is the most rigorous realisation yet of the MWA's primary beam model. It enables efficient calculation of the MWA beam response in arbitrary directions without necessity of spatial interpolation. In the new model, every dipole in the MWA tile (4 x 4 bow-tie dipoles) is simulated separately, taking into account all mutual coupling, ground screen and soil effects, and therefore accounts for the different properties of the individual dipoles within a tile. We have applied the FEE beam model to GLEAM observations at 200 - 231 MHz and used false Stokes parameter leakage as a metric to compare the models. We have determined that the FEE model reduced the magnitude and declination-dependent behaviour of false polarisation in Stokes Q and V while retaining low levels of false polarisation in Stokes U.Peer reviewedFinal Accepted Versio

Human Bone Proteomes before and after Decomposition: Investigating the Effects of Biological Variation and Taphonomic Alteration on Bone Protein Profiles and the Implications for Forensic Proteomics

Bone proteomic studies using animal proxies and skeletonized human remains have delivered encouraging results in the search for potential biomarkers for precise and accurate post-mortem interval (PMI) and the age-at-death (AAD) estimation in medico-legal investigations. The development of forensic proteomics for PMI and AAD estimation is in critical need of research on human remains throughout decomposition, as currently the effects of both inter-individual biological differences and taphonomic alteration on the survival of human bone protein profiles are unclear. This study investigated the human bone proteome in four human body donors studied throughout decomposition outdoors. The effects of ageing phenomena (in vivo and post-mortem) and intrinsic and extrinsic variables on the variety and abundancy of the bone proteome were assessed. Results indicate that taphonomic and biological variables play a significant role in the survival of proteins in bone. Our findings suggest that inter-individual and inter-skeletal differences in bone mineral density (BMD) are important variables affecting the survival of proteins. Specific proteins survive better within the mineral matrix due to their mineral-binding properties. The mineral matrix likely also protects these proteins by restricting the movement of decomposer microbes. New potential biomarkers for PMI estimation and AAD estimation were identified. Future development of forensic bone proteomics should include standard measurement of BMD and target a combination of different biomarkers

Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma

This randomised phase III trial compared standard of care Everolimus with the anti-PD1 monoclonal antibody Nivolumab in previously treated patients with locally advanced inoperable or metastatic clear cell renal cancer. 810 patients were randomised to receive either Everolimus 10 mg orally daily or 3 mg/kg of Nivolumab intravenously every two weeks. Patients were treated until unacceptable toxicity or disease progression. Patients could be treated beyond progression if the investigator believed that the patient was gaining clinical benefit. The primary endpoint was overall survival. The median survival was 25 months for Nivolumab and 19.8 months for Everolimus (p=0.002). The objective response rate was higher for Nivolumab (25 versus 5%; p=<0.001).The median progression free survivals were 4.6 & 4.4 months (p=0.11). Grade 3 & 4 treatment related toxicities were observed in 19 & 37% of patients on Nivolumab or Everolimus respectively. In patients with previously treated renal cell carcinoma Nivolumab produced superior survival and more tolerable treatment than Everolimus

Inter-Laboratory Reproducibility of Inducible HIV-1 Reservoir Quantification by TILDA

Substantial efforts to eliminate or reduce latent HIV-1 reservoirs are underway in clinical trials and have created a critical demand for sensitive, accurate, and reproducible tools to evaluate the efficacy of these strategies. Alternative reservoir quantification assays have been developed to circumvent limitations of the quantitative viral outgrowth assay. One such assay is tat/rev induced limiting dilution assay (TILDA), which measures the frequency of CD4+ T cells harboring inducible latent HIV-1 provirus. We modified pre-amplification reagents and conditions (TILDA v2.0) to improve assay execution and first internally validated assay performance using CD4+ T cells obtained from cART-suppressed HIV-1-infected individuals. Detection of tat/rev multiply spliced RNA was not altered by modifying pre-amplification conditions, confirming the robustness of the assay, and supporting the technique’s amenability to limited modifications to ensure better implementation for routine use in clinical studies of latent HIV-1 reservoirs. Furthermore, we cross-validated results of TILDA v2.0 and the original assay performed in two separate laboratories using samples from 15 HIV-1-infected individuals. TILDA and TILDA v2.0 showed a strong correlation (Lin’s Concordance Correlation Coefficient = 0.86). The low inter-laboratory variability between TILDAs performed at different institutes further supports use of TILDA for reservoir quantitation in multi-center interventional HIV-1 Cure trials

Comparing Redundant and Sky-model-based Interferometric Calibration: A First Look with Phase II of the MWA

© 2018. The American Astronomical Society. All rights reserved.. Interferometric arrays seeking to measure the 21 cm signal from the epoch of reionization (EOR) must contend with overwhelmingly bright emission from foreground sources. Accurate recovery of the 21 cm signal will require precise calibration of the array, and several new avenues for calibration have been pursued in recent years, including methods using redundancy in the antenna configuration. The newly upgraded Phase II of Murchison Widefield Array (MWA) is the first interferometer that has large numbers of redundant baselines while retaining good instantaneous UV coverage. This array therefore provides a unique opportunity to compare redundant calibration with sky-model-based algorithms. In this paper, we present the first results from comparing both calibration approaches with MWA Phase II observations. For redundant calibration, we use the package OMNICAL and produce sky-based calibration solutions with the analysis package Fast Holographic Deconvolution (FHD). There are three principal results: (1) We report the success of OMNICAL on observations of ORBComm satellites, showing substantial agreement between redundant visibility measurements after calibration. (2) We directly compare OMNICAL calibration solutions with those from FHD and demonstrate that these two different calibration schemes give extremely similar results. (3) We explore improved calibration by combining OMNICAL and FHD. We evaluate these combined methods using power spectrum techniques developed for EOR analysis and find evidence for marginal improvements mitigating artifacts in the power spectrum. These results are likely limited by the signal-to-noise ratio in the 6 hr of data used, but they suggest future directions for combining these two calibration schemes

Low-Frequency Spectral Energy Distributions of Radio Pulsars Detected with the Murchison Widefield Array

We present low-frequency spectral energy distributions of 60 known radio pulsars observed with the Murchison Widefield Array telescope. We searched the GaLactic and Extragalactic All-sky Murchison Widefield Array survey images for 200-MHz continuum radio emission at the position of all pulsars in the Australia Telescope National Facility (ATNF) pulsar catalogue. For the 60 confirmed detections, we have measured flux densities in 20 × 8 MHz bands between 72 and 231 MHz. We compare our results to existing measurements and show that the Murchison Widefield Array flux densities are in good agreement

The Murchison Widefield Array Commissioning Survey : A Low-Frequency Catalogue of 14,110 Compact Radio Sources over 6,100 Square Degrees

22 pages, 18 figures, accepted to PASAWe present the results of an approximately 6,100 square degree 104--196MHz radio sky survey performed with the Murchison Widefield Array during instrument commissioning between 2012 September and 2012 December: the Murchison Widefield Array Commissioning Survey (MWACS). The data were taken as meridian drift scans with two different 32-antenna sub-arrays that were available during the commissioning period. The survey covers approximately 20.5 hPeer reviewedFinal Accepted Versio