3,308 research outputs found
Pressure-Induced Superconductivity in Sc to 74 GPa
Using a diamond anvil cell with nearly hydrostatic helium pressure medium we
have significantly extended the superconducting phase diagram Tc(P) of Sc, the
lightest of all transition metals. We find that superconductivity is induced in
Sc under pressure, Tc increasing monotonically to 8.2 K at 74.2 GPa. The Tc(P)
dependences of the trivalent d-electron metals Sc, Y, La, and Lu are compared
and discussed within a simple s-d charge transfer framework.Comment: to be published in Phys. Rev. B (Brief Reports
Comb-calibrated solar spectroscopy through a multiplexed single-mode fiber channel
We investigate a new scheme for astronomical spectrograph calibration using
the laser frequency comb at the Solar Vacuum Tower Telescope on Tenerife. Our
concept is based upon a single-mode fiber channel, that simultaneously feeds
the spectrograph with comb light and sunlight. This yields nearly perfect
spatial mode matching between the two sources. In combination with the absolute
calibration provided by the frequency comb, this method enables extremely
robust and accurate spectroscopic measurements. The performance of this scheme
is compared to a sequence of alternating comb and sunlight, and to absorption
lines from Earth's atmosphere. We also show how the method can be used for
radial-velocity detection by measuring the well-explored 5-minute oscillations
averaged over the full solar disk. Our method is currently restricted to solar
spectroscopy, but with further evolving fiber-injection techniques it could
become an option even for faint astronomical targets.Comment: 21 pages, 11 figures. A video abstract for this paper is available on
youtube. For watching the video, please follow
https://www.youtube.com/watch?v=oshdZgrt89I . The video abstract is also
available for streaming and download on the related article website of New
Journal of Physic
Protease inhibitors prevent plasminogen-mediated, but not pemphigus vulgaris-induced, acantholysis in human epidermis
Pemphigus is an autoimmune blistering disease of the skin and mucous membranes. It is caused by autoantibodies directed against desmosomes, which are the principal adhesion structures between epidermal keratinocytes. Binding of autoantibodies leads to the destruction of desmosomes resulting in the loss of cell-cell adhesion (acantholysis) and epidermal blisters. The plasminogen activator system has been implicated as a proteolytic effector in pemphigus. We have tested inhibitors of the plasminogen activator system with regard to their potential to prevent pemphigus-induced cutaneous pathology. In a human split skin culture system, IgG preparations of sera from pemphigus vulgaris patients caused histopathologic changes (acantholysis) similar to those observed in the original pemphigus disease. All inhibitors that were tested (active site inhibitors directed against uPA, tPA, and/or plasmin; antibodies neutralizing the enzymatic activity of uPA or tPA; substances interfering with the binding of uPA to its specific cell surface receptor uPAR) failed to prevent pemphigus vulgaris IgG-mediated acantholysis. Plasminogen-mediated acantholysis, however, was effectively antagonized by the synthetic active site serine protease inhibitor WX-UK1 or by p-aminomethylbenzoic acid. Our data argue against applying anti-plasminogen activator/anti-plasmin strategies in the management of pemphigus
A Frequency Comb calibrated Solar Atlas
The solar spectrum is a primary reference for the study of physical processes
in stars and their variation during activity cycles. In Nov 2010 an experiment
with a prototype of a Laser Frequency Comb (LFC) calibration system was
performed with the HARPS spectrograph of the 3.6m ESO telescope at La Silla
during which high signal-to-noise spectra of the Moon were obtained. We exploit
those Echelle spectra to study the optical integrated solar spectrum . The
DAOSPEC program is used to measure solar line positions through gaussian
fitting in an automatic way. We first apply the LFC solar spectrum to
characterize the CCDs of the HARPS spectrograph. The comparison of the LFC and
Th-Ar calibrated spectra reveals S-type distortions on each order along the
whole spectral range with an amplitude of +/-40 m/s. This confirms the pattern
found by Wilken et al. (2010) on a single order and extends the detection of
the distortions to the whole analyzed region revealing that the precise shape
varies with wavelength. A new data reduction is implemented to deal with CCD
pixel inequalities to obtain a wavelength corrected solar spectrum. By using
this spectrum we provide a new LFC calibrated solar atlas with 400 line
positions in the range of 476-530, and 175 lines in the 534-585 nm range. The
new LFC atlas improves the accuracy of individual lines by a significant factor
reaching a mean value of about 10 m/s. The LFC--based solar line wavelengths
are essentially free of major instrumental effects and provide a reference for
absolute solar line positions. We suggest that future LFC observations could be
used to trace small radial velocity changes of the whole solar photospheric
spectrum in connection with the solar cycle and for direct comparison with the
predicted line positions of 3D radiative hydrodynamical models of the solar
photosphere.Comment: Accept on the 15th of October 2013. 9 pages, 10 figures. ON-lINE data
A&A 201
PHL 5038: a spatially resolved white dwarf + brown dwarf binary
A near-infrared excess is detected at the white dwarf PHL 5038 in UKIDSS photometry, consistent with the presence of a cool, substellar companion. We have obtained H- and K-grism spectra and images of PHL 5038 using NIRI on Gemini North. The target is spatially and spectrally resolved into two components: an 8000 K DA white dwarf, and a likely L8 brown dwarf companion, separated by 0.94\arcsec. The spectral type of the secondary was determined using standard spectral indices for late L and T dwarfs. The projected orbital separation of the binary is 55 AU, so it becomes only the second known wide WD+dL binary to be found after GD 165AB. This object could potentially be used as a benchmark for testing substellar evolutionary models at intermediate to older ages
In vitro antischistosomal activity of Artemisia annua and Artemisia afra extracts
Background Schistosomiasis, a neglected tropical disease, imposes substantial health and economic burdens on impoverished groups living in predominantly rural areas. Praziquantel (PZQ) is the only drug available for treatment, and it is not completely efficacious. Artemisia annua and Artemisia afra infusions were proposed to possess antischistosomal activities in a recently retracted publication of a clinical trial, leading to our investigation in vitro. Objective The objective was to identify the main components of the infusions and evaluate the in vitro antischistosomal activities of traditionally prepared infusions as well as hexane and dichloromethane (DCM) extracts of the infusions of A. afra and A. annua. Methods Infusions of A. afra and A. annua were submitted to liquid-liquid partitioning with n-hexane and DCM to provide samples for in vitro bioassays using newly transformed schistosomulas (NTS) and adult Schistosoma mansoni worms obtained from infected mice. The viability of the NTS and adult S. mansoni was visually scored via microscopic readout. Results Nine phytochemicals comprising coumarins and organic acids were identified. A. afra and A. annua infusions and extracts possess potent in vitro antischistosomal activities against NTS, at 100 ÎĽg/ml. However, the A. afra infusions exhibited better activities against NTS than the A. annua infusion. The A. afra hexane- and DCM extracts presented IC50 values that are similar to PZQ (1.5 ÎĽg/ml) and approximately five times lower than the comparison drug artesunate (11.6 ÎĽg/ml) against NTS. Low IC50 values for both these extracts were also obtained in phenotypic assays with adult S. mansoni. Conclusion A. afra shows greater antischistosomal potential than A. annua. Thus, further studies are necessary to identify the active molecule(s) responsible for the notable antischistosomal activity of A. afra
Metastable anions of dinitrobenzene: resonances for electron attachment and kinetic energy release
Attachment of free, low-energy electrons to dinitrobenzene (DNB) in the gas phase leads to DNB as well as several fragment anions. DNB, (DNB-H), (DNB-NO), (DNB-2NO), and (DNB-NO(2)) are found to undergo metastable (unimolecular) dissociation. A rich pattern of resonances in the yield of these metastable reactions versus electron energy is observed; some resonances are highly isomer-specific. Most metastable reactions are accompanied by large average kinetic energy releases (KER) that range from 0.5 to 1.32 eV, typical of complex rearrangement reactions, but (1,3-DNB-H)(-) features a resonance with a KER of only 0.06 eV for loss of NO. (1,3-DNB-NO)(-) offers a rare example of a sequential metastable reaction, namely, loss of NO followed by loss of CO to yield C(5)H(4)O(-) with a large KER of 1.32 eV. The G4(MP2) method is applied to compute adiabatic electron affinities and reaction energies for several of the observed metastable channels. (C) 2010 American Institute of Physics. [doi:10.1063/1.3514931
The Sun's position in the sky
We express the position of the Sun in the sky as a function of time and the
observer's geographic coordinates. Our method is based on applying rotation
matrices to vectors describing points on the celestial sphere. We also derive
direct expressions, as functions of date of the year and geographic latitude,
for the duration of daylight, the maximum and minimum altitudes of the Sun, and
the cardinal directions to sunrise and sunset. We discuss how to account for
the eccentricity of the earth's orbit, the precessions of the equinoxes and the
perihelion, the size of the solar disk, and atmospheric refraction. We
illustrate these results by computing the dates of "Manhattanhenge" (when
sunset aligns with the east-west streets on the main traffic grid for
Manhattan, in New York City), by plotting the altitude of the Sun over
representative cities as a function of time, and by showing plots ("analemmas")
for the position of the Sun in the sky at a given hour of the day.Comment: 19 pages, 16 figures. v3: Replaced to match published version and to
re-package Mathematica notebook as an ancillary fil
Materials for engine applications above 3000 deg F: An overview
Materials for future generations of aeropropulsion systems will be required to perform at ever-increasing temperatures and have properties superior to the current state of the art. Improved engine efficiency can reduce specific fuel consumption and thus increase range and reduce operating costs. The ultimate payoff gain is expected to come when materials are developed which can perform without cooling at gas temperatures to 2200 C (4000 F). An overview is presented of materials for applications above 1650 C (3000 F), some pertinent physical property data, and the rationale used: (1) to arrive at recommendations of material systems that qualify for further investigation, and (2) to develop a proposed plan of research. From an analysis of available thermochemical data it was included that such materials systems must be composed of oxide ceramics. The required structural integrity will be achieved by developing these materials into fiber-reinforced ceramic composites
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