Committing Suicide for a Headscarf: Agency and the Feminist Subject in Orhan Pamuk’s Snow

In her book, Politics of Piety: The Islamic Revival and the Feminist Subject (2005), Saba Mahmood points out that the identification of Islam as a patriarchal, conservative religion gives rise to the contention that the Islamic woman is a victim of the constrictive patriarchy of her religion, denied access to emancipatory modes of Western feminism. Mahmood argues that while this attitude of the West engages in a process of cultural hegemonisation by dangerously downplaying the uniqueness of the spatiocultural differences between the West and the Middle-East, it also ignores the exercising of individual will by the Islamic women. In my paper I will draw upon Mahmood’s argument that the veil is not merely a symbol for faith, but an instrument in the construction of self-identity to interpret the Turkish novelist Orhan Pamuk’s engagement with the idea of women’s suicides in a remote Turkish town in his novel Snow as an expression of oppression and thwarted autonomy resulting from the failure of a modernist state to accommodate non-liberal modes of agency and thought as embodied in the sartorial choice of a woman rejecting the emancipatory Western styles of dressing in favour of a traditional Muslim attire of a headscarf

Low-Resource Text Style Transfer for Bangla: Data & Models

Text style transfer (TST) involves modifying the linguistic style of a given text while retaining its core content. This paper addresses the challenging task of text style transfer in the Bangla language, which is low-resourced in this area. We present a novel Bangla dataset that facilitates text sentiment transfer, a subtask of TST, enabling the transformation of positive sentiment sentences to negative and vice versa. To establish a high-quality base for further research, we refined and corrected an existing English dataset of 1,000 sentences for sentiment transfer based on Yelp reviews, and we introduce a new human-translated Bangla dataset that parallels its English counterpart. Furthermore, we offer multiple benchmark models that serve as a validation of the dataset and baseline for further research

Correction: Mukherjee et al. Homo and Heterotypic Cellular Cross-Talk in Epithelial Ovarian Cancer Impart Pro-Tumorigenic Properties through Differential Activation of the Notch3 Pathway. <i>Cancers</i> 2022, <i>14</i>, 3365

In the original publication [...

Homo and Heterotypic Cellular Cross-Talk in Epithelial Ovarian Cancer Impart Pro-Tumorigenic Properties through Differential Activation of the Notch3 Pathway

An active fluidic microenvironment governs peritoneal metastasis in epithelial ovarian cancer (EOC), but its critical functional/molecular cues are not fully understood. Utilizing co-culture models of NIH3T3 cells (differentially overexpressing Jagged1) and SKOV3 cells expressing a Notch3 luciferase reporter-sensor (SNFT), we showed that incremental expression of Jagged1 led to proportional Notch3 activation in SNFT. With no basal luciferase activity, this system efficiently recorded dose-dependent Notch3 activation by rh-Jag1 peptide and the non-appearance of such induction in co-culture with NIH3T3Δjag1 cells indicates its sensitivity and specificity. Similar Notch3 modulation was shown for the first time in co-cultures with HGSOC patients’ ascites-derived cancer-associated fibroblasts and Jagged1-expressing EOC cell lines. NIH3T3J1-A and OVCAR3 co-cultured SNFT cells showed maximum proliferation, invasion, and cisplatin resistance among all the heterotypic/homotypic cellular partners. VEGFA and CDKN1A are the two most upregulated genes identified across co-cultures by the gene profiler array. Co-culture induced VEGFA secretion from SNFT cells which also reduced cancer stem cell differentiation in platinum-resistant A2780 cells. rh-Jag1-peptide promoted enhanced nuclear-cytoplasmic p21 expression. Additionally, metastatic HGSOC tumors had higher VEGFA than corresponding primary tumors. This study thus demonstrates the tumoral and non-tumoral cell-mediated differential Notch3 activation imparting its tumorigenic effects through two critical molecular regulators, VEGFA and p21, during EOC progression

Lactoferrin-tethered betulinic acid nanoparticles promote rapid delivery and cell death in triple negative breast and laryngeal cancer cells

Cancer management presents multifarious problems. Triple negative breast cancer (TNBC) is associated with inaccurate prognosis and limited chemotherapeutic options. Betulinic acid (BA) prevents angiogenesis and causes apoptosis of TNBC cells. NIH recommends BA for rapid access in cancer chemotherapy because of its cell-specific toxicity. BA however faces major challenges in therapeutic practices due to its limited solubility and cellular entree. We report lactoferrin (Lf) attached BA nanoparticles (Lf-BAnp) for rapid delivery in triple negative breast (MDA-MB-231) and laryngeal (HEp-2) cancer cell types. Lf association was confirmed by SDS-PAGE and FT-IR analysis. Average hydrodynamic size of Lf-BAnp was 147.7 ± 6.20 nm with f potential of �28.51 ± 3.52 mV. BA entrapment efficiency was 75.38 ± 2.70% and the release mechanism followed non-fickian pattern. Impact of Lf-BAnp on cell cycle and cytotoxicity of triple negative breast cancer and its metastatic site laryngeal cancer cell lines were analyzed. Lf-BAnp demonstrated strong anti-proliferative and cytotoxic effects, along with increased sub-G1 population and reduced number of cells in G1 and G2/M phases of the cell cycle, confirming reduced cell proliferation and significant cell death. Speedy intracellular entry of Lf-BAnp occurred within 30 min. Lf-BAnp design was explored for the first time as safer chemotherapeutic arsenals against complex TNBC conditions

Polymeric Materials for Hemostatic Wound Healing

Hemorrhage is one of the greatest threats to life on the battlefield, accounting for 50% of total deaths. Nearly 86% of combat deaths occur within the first 30 min after wounding. While external wound injuries can be treated mostly using visual inspection, abdominal or internal hemorrhages are more challenging to treat with regular hemostatic dressings because of deep wounds and points of injury that cannot be located properly. The need to treat trauma wounds from limbs, abdomen, liver, stomach, colon, spleen, arterial, venous, and/or parenchymal hemorrhage accompanied by severe bleeding requires an immediate solution that the first responders can apply to reduce rapid exsanguinations from external wounds, including in military operations. This necessitates the development of a unique, easy-to-use, FDA-approved hemostatic treatment that can deliver the agent in less than 30 s and stop bleeding within the first 1 to 2 min at the point of injury without application of manual pressure on the wounded area