Defects in memory B-cell and plasma cell subsets expressing different immunoglobulin-subclasses in patients with CVID and immunoglobulin subclass deficiencies

Background: Predominantly antibody deficiencies (PADs) are the most prevalent primary immunodeficiencies, but their B-cell defects and underlying genetic alterations remain largely unknown. Objective: We investigated patients with PADs for the distribution of 41 blood B-cell and plasma cell (PC) subsets, including subsets defined by expression of distinct immunoglobulin heavy chain subclasses. Methods: Blood samples from 139 patients with PADs, 61 patients with common variable immunodeficiency (CVID), 68 patients with selective IgA deficiency (IgAdef), 10 patients with IgG subclass deficiency with IgA deficiency, and 223 age matched control subjects were studied by using flow cytometry with EuroFlow immunoglobulin isotype staining. Patients were classified according to their B-cell and PC immune profile, and the obtained patient clusters were correlated with clinical manifestations of PADs. Results: Decreased counts of blood PCs, memory B cells (MB Cs), or both expressing distinct IgA and IgG subclasses were identified in all patients with PADs. In patients with IgAdef, B-cell defects were mainly restricted to surface membrane (sm)IgA(+) PCs and MBCs, with 2 clear subgroups showing strongly decreased numbers of smIgA(+) PCs with mild versus severe smIgA(+) MBC defects and higher frequencies of nonrespiratory tract infections, autoimmunity, and affected family members. Patients with IgG subclass deficiency with IgA deficiency and those with CVID showed defects in both smIgA(+) and smIgG(+) MBCs and PCs. Reduced numbers of switched PCs were systematically found in patients with CVID (absent in 98%), with 6 different defective MBC (and clinical) profiles: (1) profound decrease in MBC numbers; (2) defective CD27(+) MBCs with almost normal IgG(3)(+) MBCs; (3) absence of switched MBCs; and (4) presence of both unswitched and switched MBCs without and; (5) with IgG(2)(+) MBCs; and (6) with IgA(1)(+) MBCs. Conclusion: Distinct PAD defective B-cell patterns were identified that are associated with unique clinical profiles

Plan de comunicación interna y externa de la Facultad de Ciencias Sociales. Programa de Actividades Complementarias y de Difusión Cultural de la Facultad II

Memoria ID-0258. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2014-2015

Predictive Power of the "Trigger Tool" for the detection of adverse events in general surgery: a multicenter observational validation study

Background In spite of the global implementation of standardized surgical safety checklists and evidence-based practices, general surgery remains associated with a high residual risk of preventable perioperative complications and adverse events. This study was designed to validate the hypothesis that a new “Trigger Tool” represents a sensitive predictor of adverse events in general surgery. Methods An observational multicenter validation study was performed among 31 hospitals in Spain. The previously described “Trigger Tool” based on 40 specific triggers was applied to validate the predictive power of predicting adverse events in the perioperative care of surgical patients. A prediction model was used by means of a binary logistic regression analysis. Results The prevalence of adverse events among a total of 1,132 surgical cases included in this study was 31.53%. The “Trigger Tool” had a sensitivity and specificity of 86.27% and 79.55% respectively for predicting these adverse events. A total of 12 selected triggers of overall 40 triggers were identified for optimizing the predictive power of the “Trigger Tool”. Conclusions The “Trigger Tool” has a high predictive capacity for predicting adverse events in surgical procedures. We recommend a revision of the original 40 triggers to 12 selected triggers to optimize the predictive power of this tool, which will have to be validated in future studies

Derecho, género e igualdad : cambios en las estructuras jurídicas androcéntricas. Vol 2

Este libro es producto de una selección de ponencias y comunicaciones presentadas en el "I Congreso Internacional Derecho, Género e Igualdad", organizado por el Grupo Antígona de la Universidad Autónoma de Barcelona durante el año 2009

Association of Candidate Gene Polymorphisms With Chronic Kidney Disease: Results of a Case-Control Analysis in the Nefrona Cohort

Chronic kidney disease (CKD) is a major risk factor for end-stage renal disease, cardiovascular disease and premature death. Despite classical clinical risk factors for CKD and some genetic risk factors have been identified, the residual risk observed in prediction models is still high. Therefore, new risk factors need to be identified in order to better predict the risk of CKD in the population. Here, we analyzed the genetic association of 79 SNPs of proteins associated with mineral metabolism disturbances with CKD in a cohort that includes 2, 445 CKD cases and 559 controls. Genotyping was performed with matrix assisted laser desorption ionizationtime of flight mass spectrometry. We used logistic regression models considering different genetic inheritance models to assess the association of the SNPs with the prevalence of CKD, adjusting for known risk factors. Eight SNPs (rs1126616, rs35068180, rs2238135, rs1800247, rs385564, rs4236, rs2248359, and rs1564858) were associated with CKD even after adjusting by sex, age and race. A model containing five of these SNPs (rs1126616, rs35068180, rs1800247, rs4236, and rs2248359), diabetes and hypertension showed better performance than models considering only clinical risk factors, significantly increasing the area under the curve of the model without polymorphisms. Furthermore, one of the SNPs (the rs2248359) showed an interaction with hypertension, being the risk genotype affecting only hypertensive patients. We conclude that 5 SNPs related to proteins implicated in mineral metabolism disturbances (Osteopontin, osteocalcin, matrix gla protein, matrix metalloprotease 3 and 24 hydroxylase) are associated to an increased risk of suffering CKD

La legalización de la Eutanasia: seminario sobre su tratamiento Jurídico

La Sección de Málaga del Instituto Andaluz Interuniversitario de Criminología celebró los días 3 a 5 de Noviembre un Seminario jurídico internacional sobre Eutanasia. A tal efecto representantes de España (Del Rosal, Stangeland, Escohotado), Italia (Seminara), Alemania (Koch), Holanda (v. Kalmthout), Francia (Gonzálvez), Suiza (Queloz), Japón (Nakayama/Kuzuhara), Australia (Kelly), Estados Unidos (Winslade), Uruguay (Cairoli) y Canadá (Keyserlingk) presentaron ponencias donde, tras recoger un conjunto de datos criminológicos, analizaron la situación legal y las propuestas de reforma de sus respectivos países en relación con las variadas situaciones en las que se plantea la problemática de la eutanasia. El Seminario, que contó igualmente con la presencia de los profesores españoles Mu-oz Conde, Carbonell Mateu, Valle Muñiz, Mapelli Caffarena, así como de una buena parte de los profesores integrantes de la Sección de Málaga del I.A.I.C, dedicó una parte importante de su tiempo al desarrollo de intensos debates entre el restringido número de participantes. Lo que aquí sigue es un brevísimo resumen de lo que sucedió, estando prevista la publicación de un volumen con todas las ponencias, así como con una relación general de los debates que llevarán a cabo los profesores Muñoz Sánchez y Prieto del Pino

Criminal law and Seniors Rights. The case of maltreatment in the Spanish Legislation

Conferencia impartida durante la celebración del I International Simposium Challenges en Active Ageing, celebrado en Málaga entre el 23 y el 27 de abril de 2012.Este congreso fue organizado por la Facultad de Estudios Sociales y del Trabajo de la Universidad de Málaga, dentro de los actos del Año Europeo del Envejecimiento Activo y la Solidaridad Internacional. La RevistaeSalud.com ha querido apoyar este evento publicando los abstracts y resúmenes de las principales conferencias y convirtiéndose en el medio oficial de este Simposium