Does a Computer have an Arrow of Time?

In [Sch05a], it is argued that Boltzmann's intuition, that the psychological arrow of time is necessarily aligned with the thermodynamic arrow, is correct. Schulman gives an explicit physical mechanism for this connection, based on the brain being representable as a computer, together with certain thermodynamic properties of computational processes. [Haw94] presents similar, if briefer, arguments. The purpose of this paper is to critically examine the support for the link between thermodynamics and an arrow of time for computers. The principal arguments put forward by Schulman and Hawking will be shown to fail. It will be shown that any computational process that can take place in an entropy increasing universe, can equally take place in an entropy decreasing universe. This conclusion does not automatically imply a psychological arrow can run counter to the thermodynamic arrow. Some alternative possible explana- tions for the alignment of the two arrows will be briefly discussed.Comment: 31 pages, no figures, publication versio

Simulating the Atmospheric Entry of Micrometeorites Using a Two Stage Light Gas Gun

We present our work on the use of A Light Gas Gun to simulate atmospheric entry of micrometeorites

Dynamically generated resonances from the vector octet-baryon decuplet interaction

We study the interaction of the octet of vector mesons with the decuplet of baryons using Lagrangians of the hidden gauge theory for vector interactions. The unitary amplitudes in coupled channels develop poles that can be associated with some known baryonic resonances, while there are predictions for new ones at the energy frontier of the experimental research. The work offers guidelines on how to search for these resonances

Reconstruction of Black Hole Metric Perturbations from Weyl Curvature

Perturbation theory of rotating black holes is usually described in terms of Weyl scalars $\psi_4$ and $\psi_0$, which each satisfy Teukolsky's complex master wave equation and respectively represent outgoing and ingoing radiation. On the other hand metric perturbations of a Kerr hole can be described in terms of (Hertz-like) potentials $\Psi$ in outgoing or ingoing {\it radiation gauges}. In this paper we relate these potentials to what one actually computes in perturbation theory, i.e $\psi_4$ and $\psi_0$. We explicitly construct these relations in the nonrotating limit, preparatory to devising a corresponding approach for building up the perturbed spacetime of a rotating black hole. We discuss the application of our procedure to second order perturbation theory and to the study of radiation reaction effects for a particle orbiting a massive black hole.Comment: 6 Pages, Revtex

Renal cyst growth is attenuated by a combination treatment of tolvaptan and pioglitazone, while pioglitazone treatment alone is not effective

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is one of the most common monogenic disorders, characterized by the progressive formation of fluid-filled cysts. Tolvaptan is an approved drug for ADPKD patients, but is also associated with multiple side effects. The peroxisome proliferator-activator receptor gamma (PPAR gamma) agonist pioglitazone slows disease progression in the PCK rat model for PKD. Here, we tested whether a combination treatment of relevant doses of tolvaptan and pioglitazone leads to improved efficacy in an adult-onset PKD mouse model. Tolvaptan indeed slowed PKD progression, but the combination treatment was not more effective than tolvaptan alone. In addition, although pioglitazone raised plasma levels of its surrogate drug marker adiponectin, the drug unexpectedly failed to slow PKD progression. The pioglitazone target PPAR. was expressed at surprisingly low levels in mouse, rat and human kidneys. Other pioglitazone targets were more abundantly expressed, but this pattern was comparable across various species. The data suggest that several potential pharmacokinetic and pharmacodynamic (PK/PD) differences between different species may underlie whether or not pioglitazone is able to slow PKD progression. The ongoing phase II clinical trial with low-dose pioglitazone treatment (NCT02697617) will show whether pioglitazone is a suitable drug candidate for ADPKD treatment.Functional Genomics of Systemic Disorder

Gravitational radiation from a particle in circular orbit around a black hole. V. Black-hole absorption and tail corrections

A particle of mass $\mu$ moves on a circular orbit of a nonrotating black hole of mass $M$. Under the restrictions $\mu/M \ll 1$ and $v \ll 1$, where $v$ is the orbital velocity, we consider the gravitational waves emitted by such a binary system. We calculate $\dot{E}$, the rate at which the gravitational waves remove energy from the system. The total energy loss is given by $\dot{E} = \dot{E}^\infty + \dot{E}^H$, where $\dot{E}^\infty$ denotes that part of the gravitational-wave energy which is carried off to infinity, while $\dot{E}^H$ denotes the part which is absorbed by the black hole. We show that the black-hole absorption is a small effect: $\dot{E}^H/\dot{E} \simeq v^8$. We also compare the wave generation formalism which derives from perturbation theory to the post-Newtonian formalism of Blanchet and Damour. Among other things we consider the corrections to the asymptotic gravitational-wave field which are due to wave-propagation (tail) effects.Comment: ReVTeX, 17 page

Optimal low-thrust trajectories to asteroids through an algorithm based on differential dynamic programming

In this paper an optimisation algorithm based on Differential Dynamic Programming is applied to the design of rendezvous and fly-by trajectories to near Earth objects. Differential dynamic programming is a successive approximation technique that computes a feedback control law in correspondence of a fixed number of decision times. In this way the high dimensional problem characteristic of low-thrust optimisation is reduced into a series of small dimensional problems. The proposed method exploits the stage-wise approach to incorporate an adaptive refinement of the discretisation mesh within the optimisation process. A particular interpolation technique was used to preserve the feedback nature of the control law, thus improving robustness against some approximation errors introduced during the adaptation process. The algorithm implements global variations of the control law, which ensure a further increase in robustness. The results presented show how the proposed approach is capable of fully exploiting the multi-body dynamics of the problem; in fact, in one of the study cases, a fly-by of the Earth is scheduled, which was not included in the first guess solution

Second order gauge invariant gravitational perturbations of a Kerr black hole

We investigate higher than the first order gravitational perturbations in the Newman-Penrose formalism. Equations for the Weyl scalar $\psi_4,$ representing outgoing gravitational radiation, can be uncoupled into a single wave equation to any perturbative order. For second order perturbations about a Kerr black hole, we prove the existence of a first and second order gauge (coordinates) and tetrad invariant waveform, $\psi_I$, by explicit construction. This waveform is formed by the second order piece of $\psi_4$ plus a term, quadratic in first order perturbations, chosen to make $\psi_I$ totally invariant and to have the appropriate behavior in an asymptotically flat gauge. $\psi_I$ fulfills a single wave equation of the form ${\cal T}\psi_I=S,$ where ${\cal T}$ is the same wave operator as for first order perturbations and $S$ is a source term build up out of (known to this level) first order perturbations. We discuss the issues of imposition of initial data to this equation, computation of the energy and momentum radiated and wave extraction for direct comparison with full numerical approaches to solve Einstein equations.Comment: 19 pages, REVTEX. Some misprints corrected and changes to improve presentation. Version to appear in PR

Effects of pseudoscalar-baryon channels in the dynamically generated vector-baryon resonances

We study the interaction of vector mesons with the octet of stable baryons in the framework of the local hidden gauge formalism using a coupled channels unitary approach, including also the pseudoscalar-baryon channels which couple to the same quantum numbers. We examine the scattering amplitudes and their poles, which can be associated to known $J^P=1/2^-,3/2^-$ baryon resonances, and determine the role of the pseudoscalar-baryon channels, changing the width and eventually the mass of the resonances generated with only the basis of vector-baryon states