The Regeneration Games: Commodities, Gifts and the Economics of London 2012

This paper considers contradictions between two concurrent and tacit conceptions of the Olympic ‘legacy’, setting out one conception that understands the games and their legacies as gifts alongside and as counterpoint to the prevailing discourse, which conceives Olympic assets as commodities. The paper critically examines press and governmental discussion of legacy, in order to locate these in the context of a wider perspective contrasting ‘gift’ and ‘commodity’ Olympics – setting anthropological conceptions of gift-based sociality as a necessary supplement to contractual and dis-embedded socioeconomic organizational assumptions underpinning the commodity Olympics. Costbenefit planning is central to modern city building and mega-event delivery. The paper considers the insufficiency of this approach as the exclusive paradigm within which to frame and manage a dynamic socio-economic and cultural legacy arising from the 2012 games

Outflow and dense gas emission from massive Infrared Dark Clouds

Infrared Dark Clouds are expected to harbor sources in different, very young evolutionary stages. To better characterize these differences, we observed a sample of 43 massive Infrared Dark Clouds, originally selected as candidate high-mass starless cores, with the IRAM 30m telescope covering spectral line tracers of low-density gas, high-density gas, molecular outflows/jets and temperature effects. The SiO(2-1) observations reveal detections toward 18 sources. Assuming that SiO is exclusively produced by sputtering from dust grains, this implies that at least in 40% of this sample star formation is on-going. A broad range of SiO line-widths is observed (between 2.2 and 65km/s), and we discuss potential origins for this velocity spread. While the low-density tracers 12CO(2-1) and 13CO(1-0) are detected in several velocity components, the high-density tracer H13CO+(1--0) generally shows only a single velocity component and is hence well suited for kinematic distance estimates of IRDCs. Furthermore, the H13CO+ line-width is on average 1.5 times larger than that of previously observed NH3(1,1). This is indicative of more motion at the denser core centers, either due to turbulence or beginning star formation activity. In addition, we detect CH3CN toward only six sources whereas CH3OH is observed toward approximately 40% of the sample. Estimates of the CH3CN and CH3OH abundances are low with average values of 1.2x10^{-10} and 4.3x10^{-10}, respectively. These results are consistent with chemical models at the earliest evolutionary stages of high-mass star formation. Furthermore, the CH3OH abundances compare well to recently reported values for low-mass starless cores.Comment: 22 pages (ApJ referee style), 7 figures, accepted for Ap

Native fish in Northland: application of the River Values Assessment System (RiVAS and RiVAS+)

The fourth application of the River Values Assessment System (RiVAS and RiVAS+) for native fisheries value was made in the Northland region. Data for nine out of ten indicators were provided from modelling undertaken by Cawthron Institute using a variety of databases including the NZFFD and FENZ. The expert panel then checked the modelling results and adjusted where appropriate based on local knowledge, and it populated the Population Stronghold indicator. Of 27 river catchment/clusters evaluated, nine were considered of national significance, namely the Bay of Islands North, Bay of Islands South, East Coast, Herekino, Hokianga, Mangamuka, Waihou, Waipoua and Wairoa. The Wairoa scored very poorly for all attributes other than presence of many at risk species. The remaining 18 are of regional significance. No river catchment/clusters were identified as being of local significance. The RIVAS+ identified work that can be done to reduce the inference on migratory fish movements caused by a barrier on the Waipoua River.This work was funded by Northland Regional Council and we gratefully acknowledge their support

Addressing the behavioral and mental health educational gap in pediatric residency training

In the study “Competency of Future Pediatricians Caring for Children With Behavioral and Mental Health Problems” in this issue of Pediatrics, Green et al describe the continued deficit in pediatric resident competence in assessing and treating behavioral and mental health (B/MH) conditions based on survey questions asked during the 2018 initial pediatrics certifying examination application. B/MH concerns in pediatric practice are rising in prevalence. Approximately 13% to 20% of children in the United States experience a mental health disorder each year, and suicide is now the second leading cause of death for children ages 10 to 14 and adolescents and young adults ages 15 to 24. Nearly 25% of pediatric primary care visits involve a concern for B/MH issues

Extracellular dsRNA induces a type I interferon response mediated via class A scavenger receptors in a novel Chinook salmon derived spleen cell line

The final publication is available at Elsevier via https://dx.doi.org/10.1016/j.dci.2018.08.010 © 2018. This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/Despite increased global interest in Chinook salmon aquaculture, little is known of their viral immune defenses. This study describes the establishment and characterization of a continuous cell line derived from Chinook salmon spleen, CHSS, and its use in innate immune studies. Optimal growth was seen at 14–18 °C when grown in Leibovitz's L-15 media with 20% fetal bovine serum. DNA analyses confirmed that CHSS was Chinook salmon and genetically different from the only other available Chinook salmon cell line, CHSE-214. Unlike CHSE-214, CHSS could bind extracellular dsRNA, resulting in the rapid and robust expression of antiviral genes. Receptor/ligand blocking assays confirmed that class A scavenger receptors (SR-A) facilitated dsRNA binding and subsequent gene expression. Although both cell lines expressed three SR-A genes: SCARA3, SCARA4, and SCARA5, only CHSS appeared to have functional cell-surface SR-As for dsRNA. Collectively, CHSS is an excellent cell model to study dsRNA-mediated innate immunity in Chinook salmon.Natural Sciences and Engineering Research Council of CanadaCanada Research Counci

The Endogenous Th17 Response in NO<inf>2</inf>-Promoted Allergic Airway Disease Is Dispensable for Airway Hyperresponsiveness and Distinct from Th17 Adoptive Transfer

Severe, glucocorticoid-resistant asthma comprises 5-7% of patients with asthma. IL-17 is a biomarker of severe asthma, and the adoptive transfer of Th17 cells in mice is sufficient to induce glucocorticoid-resistant allergic airway disease. Nitrogen dioxide (NO2) is an environmental toxin that correlates with asthma severity, exacerbation, and risk of adverse outcomes. Mice that are allergically sensitized to the antigen ovalbumin by exposure to NO2 exhibit a mixed Th2/Th17 adaptive immune response and eosinophil and neutrophil recruitment to the airway following antigen challenge, a phenotype reminiscent of severe clinical asthma. Because IL-1 receptor (IL-1R) signaling is critical in the generation of the Th17 response in vivo, we hypothesized that the IL-1R/Th17 axis contributes to pulmonary inflammation and airway hyperresponsiveness (AHR) in NO2-promoted allergic airway disease and manifests in glucocorticoid-resistant cytokine production. IL-17A neutralization at the time of antigen challenge or genetic deficiency in IL-1R resulted in decreased neutrophil recruitment to the airway following antigen challenge but did not protect against the development of AHR. Instead, IL-1R-/- mice developed exacerbated AHR compared to WT mice. Lung cells from NO2-allergically inflamed mice that were treated in vitro with dexamethasone (Dex) during antigen restimulation exhibited reduced Th17 cytokine production, whereas Th17 cytokine production by lung cells from recipient mice of in vitro Th17-polarized OTII T-cells was resistant to Dex. These results demonstrate that the IL-1R/Th17 axis does not contribute to AHR development in NO2-promoted allergic airway disease, that Th17 adoptive transfer does not necessarily reflect an endogenously-generated Th17 response, and that functions of Th17 responses are contingent on the experimental conditions in which they are generated. © 2013 Martin et al

Chemical Diversity in High-Mass Star Formation

Massive star formation exhibits an extremely rich chemistry. However, not much evolutionary details are known yet, especially at high spatial resolution. Therefore, we synthesize previously published Submillimeter Array high-spatial-resolution spectral line observations toward four regions of high-mass star formation that are in various evolutionary stages with a range of luminosities. Estimating column densities and comparing the spatially resolved molecular emission allows us to characterize the chemical evolution in more detail. Furthermore, we model the chemical evolution of massive warm molecular cores to be directly compared with the data. The four regions reveal many different characteristics. While some of them, e.g., the detection rate of CH3OH, can be explained by variations of the average gas temperatures, other features are attributed to chemical effects. For example, C34S is observed mainly at the core-edges and not toward their centers because of temperature-selective desorption and successive gas-phase chemistry reactions. Most nitrogen-bearing molecules are only found toward the hot molecular cores and not the earlier evolutionary stages, indicating that the formation and excitation of such complex nitrogen-bearing molecules needs significant heating and time to be fully developed. Furthermore, we discuss the observational difficulties to study massive accretion disks in the young deeply embedded phase of massive star formation. The general potential and limitations of such kind of dataset are discussed, and future directions are outlined. The analysis and modeling of this source sample reveals many interesting features toward a chemical evolutionary sequence. However, it is only an early step, and many observational and theoretical challenges in that field lie ahead.Comment: 14 pages, 9 figures, accepted for the Astronomical Journal, a high resolution version can be found at http://www.mpia.de/homes/beuther/papers.htm

Leveraging sponsorship to achieve consumer relationship objectives through the creation of ‘marketing spaces’: An exploratory study

This paper explores the emergence of sponsorship-linked events as a strategy to leverage relational outcomes through sponsorship investment. The growing use of sponsorship-linked events reinforces the need to understand the potential of such leverage strategies, thus the findings contribute to the body of literature on effective sponsorship practices. Findings from semi-structured interviews with Sponsorship and Marketing Managers suggest a shifting orientation among sponsors towards the pursuit of relational objectives. The privileged access to consumers afforded through sponsorship allows sponsors to manufacture opportunities to create intimacy with customers through sponsorship-linked events in relaxed, comfortable environments; thus sponsorship-linked events are positioned as a rich environment to add value to consumer–brand interactions and achieve relational objectives. Hosting specifically designed events affords sponsors an increased modicum of control over consumer–brand experiences in sponsorship environments characterised by a lack of control over sponsored property actions. However, this control may be eroded by social media technologies, which facilitate consumer–consumer communication around sponsorship-linked events. Social media, however, is proposed as a useful tool to elicit consumer feedback, addressing the misalignment between current sponsorship evaluation practices and emergent relational objectives revealed in the empirical findings. Therefore, successfully activating the sponsorship-linked marketing space demands an integrated and strategic approach

Dynamic Analysis of Vascular Morphogenesis Using Transgenic Quail Embryos

Background: One of the least understood and most central questions confronting biologists is how initially simple clusters or sheet-like cell collectives can assemble into highly complex three-dimensional functional tissues and organs. Due to the limits of oxygen diffusion, blood vessels are an essential and ubiquitous presence in all amniote tissues and organs. Vasculogenesis, the de novo self-assembly of endothelial cell (EC) precursors into endothelial tubes, is the first step in blood vessel formation [1]. Static imaging and in vitro models are wholly inadequate to capture many aspects of vascular pattern formation in vivo, because vasculogenesis involves dynamic changes of the endothelial cells and of the forming blood vessels, in an embryo that is changing size and shape. Methodology/Principal Findings: We have generated Tie1 transgenic quail lines Tg(tie1:H2B-eYFP) that express H2B-eYFP in all of their endothelial cells which permit investigations into early embryonic vascular morphogenesis with unprecedented clarity and insight. By combining the power of molecular genetics with the elegance of dynamic imaging, we follow the precise patterning of endothelial cells in space and time. We show that during vasculogenesis within the vascular plexus, ECs move independently to form the rudiments of blood vessels, all while collectively moving with gastrulating tissues that flow toward the embryo midline. The aortae are a composite of somatic derived ECs forming its dorsal regions and the splanchnic derived ECs forming its ventral region. The ECs in the dorsal regions of the forming aortae exhibit variable mediolateral motions as they move rostrally; those in more ventral regions show significant lateral-to-medial movement as they course rostrally. Conclusions/Significance: The present results offer a powerful approach to the major challenge of studying the relative role(s) of the mechanical, molecular, and cellular mechanisms of vascular development. In past studies, the advantages of the molecular genetic tools available in mouse were counterbalanced by the limited experimental accessibility needed for imaging and perturbation studies. Avian embryos provide the needed accessibility, but few genetic resources. The creation of transgenic quail with labeled endothelia builds upon the important roles that avian embryos have played in previous studies of vascular development

ATCA 3mm observations of NGC6334I and I(N): dense cores, outflows and an UCHII region

Aims: Investigation of the dense gas, the outflows and the continuum emission from the massive twin cores NGC6334I and I(N) at high spatial resolution. Methods: We imaged the region with the Australia Telescope Compact Array (ATCA) at 3.4mm wavelength in continuum as well as CH3CN(5_K-4_K) and HCN(1-0) spectral line emission. Results: While the continuum emission in NGC6334I mainly traces the UCHII region, toward NGC6334I(N) we detect line emission from four of the previously identified dust continuum condensations that are of protostellar or pre-stellar nature. The CH3CN(5_K-4_K) lines are detected in all K-components up to energies of 128K above ground toward two protostellar condensations in both regions. We find line-width increasing with increasing K for all sources, which indicates a higher degree of internal motions closer to the central protostars. Toward the main mm and CH3CN source in NGC6334I we identify a velocity gradient approximately perpendicular to the large-scale molecular outflow. This may be interpreted as a signature of an accretion disk, although other scenarios, e.g., an unresolved double source, could produce a similar signature as well. No comparable signature is found toward any of the other sources. HCN does not trace the dense gas well but it is dominated by the molecular outflows. While the outflow in NGC6334I exhibits a normal Hubble-law like velocity structure, the data indicate a precessing outflow close to the plane of the sky for NGC6334I(N). Furthermore, we observe a wide (~15.4km/s) HCN absorption line, much broader than the previously observed CH3OH and NH3 absorption lines. Several explanations for the difference are discussed.Comment: 14 pages, 14 figures, accepted for A&