Need for standardization of the measurement of preoperative weight in bariatric surgical patients in the UK: A survey of British Obesity and Metabolic Surgery Society (BOMSS) members

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VideoAnalysis4ALL: An On-line Tool for the Automatic Fragmentation and Concept-based Annotation, and the Interactive Exploration of Videos.

This paper presents the VideoAnalysis4ALL tool that supports the automatic fragmentation and concept-based annotation of videos, and the exploration of the annotated video fragments through an interactive user interface. The developed web application decomposes the video into two different granularities, namely shots and scenes, and annotates each fragment by evaluating the existence of a number (several hundreds) of high-level visual concepts in the keyframes extracted from these fragments. Through the analysis the tool enables the identification and labeling of semantically coherent video fragments, while its user interfaces allow the discovery of these fragments with the help of human-interpretable concepts. The integrated state-of-the-art video analysis technologies perform very well and, by exploiting the processing capabilities of multi-thread / multi-core architectures, reduce the time required for analysis to approximately one third of the video’s duration, thus making the analysis three times faster than real-time processing

Developing Integrated Clinical Pathways for the Management of Clinically Severe Adult Obesity: a Critique of NHS England Policy

Purpose of the Review: Pathways for obesity prevention and treatment are well documented, yet the prevalence of obesity is rising, and access to treatment (including bariatric surgery) is limited. This review seeks to assess the current integrated clinical pathway for obesity management in England and determine the major challenges. Recent Findings: Evidence for tier 2 (community-based lifestyle intervention) and tier 3 (specialist weight management services) is limited, and how it facilitates care and improve outcomes in tier 4 remains uncertain. Treatment access, rigidity in pathways, uncertain treatment outcomes and weight stigma seems to be major barriers to improved care. Summary: More emphasis must be placed on access to effective treatments, treatment flexibility, addressing stigma and ensuring treatment efficacy including long-term health outcomes. Prevention and treatment should both receive significant focus though should be considered to be largely separate pathways. A simplified system for weight management is needed to allow flexibility and the delivery of personalized care including post-bariatric surgery care for those who need it

Decentralized cooperative scheduling of prosumer flexibility under forecast uncertainties

Scheduling of prosumer flexibility is challenging in finding an optimal allocation of energy resources for heterogeneous prosumer goals under various forecast uncertainties and operation constraints. This study addresses this challenge by introducing a bottom-up framework for cooperative flexibility scheduling that relies on a decentralized network of scheduling agents to perform a coordinated decision-making and select a subset of households’ net load schedules that fulfills the techno-socio-economic prosumer objectives in the resource operation modes and ensures the reliability of the grid. The resource flexibility in terms of alternative operation schedules is mathematically modeled with multiobjective optimization that attains economic, environmental, and energy self-sufficiency prosumer goals with respect to their relative importance. The coordination is achieved with a privacy-preserving collective learning algorithm that aims to reduce the aggregated peak demand of the households considering prosumers’ willingness to cooperate and accept a less preferred resource schedule. By utilizing the framework and real-world data, the novel case study is demonstrated for prosumers equipped with solar battery systems in a community microgrid. The findings show that the flexibility scheduling with an optimal prosumer cooperation level decreases the global costs of collective peak shaving by 83% while increasing the local prosumer costs by 28% in comparison with noncooperative scheduling. However, the forecast uncertainty in net load and parameters of the frequency containment reserve causes imbalances in the planned schedules. It is suggested that the imbalances can be decreased if the flexibility modeling takes into account variable specific levels of forecast uncertainty

SMOTEC: An Edge Computing Testbed for Adaptive Smart Mobility Experimentation

Smart mobility becomes paramount for meeting net-zero targets. However, autonomous, self-driving and electric vehicles require more than ever before an efficient, resilient and trustworthy computational offloading backbone that expands throughout the edge-to-cloud continuum. Utilizing on-demand heterogeneous computational resources for smart mobility is challenging and often cost-ineffective. This paper introduces SMOTEC, a novel open-source testbed for adaptive smart mobility experimentation with edge computing. SMOTEC provides for the first time a modular end-to-end instrumentation for prototyping and optimizing placement of intelligence services on edge devices such as augmented reality and real-time traffic monitoring. SMOTEC supports a plug-and-play Docker container integration of the SUMO simulator for urban mobility, Raspberry Pi edge devices communicating via ZeroMQ and EPOS for an AI-based decentralized load balancing across edge-to-cloud. All components are orchestrated by the K3s lightweight Kubernetes. A proof-of-concept of self-optimized service placements for traffic monitoring from Munich demonstrates in practice the applicability and cost-effectiveness of SMOTEC

Exploring colistin pharmacodynamics against Klebsiella pneumoniae: A need to revise current susceptibility breakpoints

Objectives: Because the pharmacokinetic/pharmacodynamic (PK/PD) characteristics of colistin against Enterobacteriaceae are not well explored, we studied the activity of colistin against K. pneumoniae in an in vitro PK/PD model simulating different dosing regimens. Methods: Three clinical isolates of K. pneumoniae with MICs of 0.5, 1 and 4mg/L were tested in an in vitro PK/PD model following a dose-fractionation design over a period of 24h. A high and low inoculumof 107 and 104 cfu/mL with and without a heteroresistant subpopulation, respectively, were used. PK/PD indices associated with colistin activity were explored and Monte Carlo analysis was performed in order to determine the PTA for achieving a bactericidal effect (2 log kill). Results: The fAUC/MIC (R2"0.64-0.68) followed by fCmax/MIC (R2=0.55-0.63) best described colistin's 24 h log10 cfu/mL reduction for both low and high inocula. Dosing regimens with fCmax/MIC≥6 were always associated with a bactericidal effect (P=0.0025). However, at clinically achievable concentrations, usually below fCmax/MIC=6, an fAUC/MIC ≤25 was more predictive of a bactericidal effect. Using a dosing regimen of 9 MU/ day, the PTA for this pharmacodynamic target was 100%, 5%-70%and 0%, for isolates with MICs of ≤0.5, 1 and ≥2 mg/L, respectively. Dosing regimens that aim for a trough level of 1 mg/L achieve coverage of strains up to 0.5 mg/L (target trough/MIC=2 mg/L). Conclusions: Characterization of the pharmacodynamics of colistin against Enterobacteriaceae in an in vitro model of infection indicates that a revision of current susceptibility breakpoints is needed. Therapeutic drug monitoring of colistin to achieve pharmacodynamic targets in individual patients is highly recommended

Energy governance as a commons: Engineering alternative socio-technical configurations

Transitioning into a sustainable energy system is becoming ever more pressing as the reality of an anthropogenic ecological crisis becomes difficult to ignore. Due to the complexity of the matter, proposed solutions often address the symptoms of the current socioeconomic configuration rather than its core. To conceptualise possible future energy systems, this Perspective focuses on the disconnect between science and technology and engineering studies. On the one hand, this disconnect leads to social science research that passively critiques rather than contributes to tackling societal issues in practice. On the other, it produces technical work limited by the incumbent conceptualisations of economic activity and organisational configurations around production without capturing the broader social and political dynamics. We thus propose a schema for bridging this divide that uses the “commons” as an umbrella concept. We apply this framework on the hardware aspect of a conceptual energy system, which builds on networked microgrids powered by open-source, lower cost, adaptable, socially responsible and sustainable technology. This Perspective is a call to engineers and social scientists alike to form genuine transdisciplinary collaborations for developing radical alternatives to the energy conundrum