Petrology, geochemistry, and U-Pb (zircon) age of the quartz-feldspar porphyry dyke at the Lake George antimony mine, New Brunswick: implications for origin, emplacement process, and mineralization

A steeply west-dipping, north-northwest-trending, biotite-bearing quartz-feldspar porphyry dyke is associated with the Lake George granodiorite, a cupola of the Pokiok Batholith. These Early Devonian intrusions are spatially and temporally related to W-Mo-Au and Sb-Au mineralization in the area. The porphyry dyke yielded an age of 420.8 +5.9/-4.0 Ma (U-Pb zircon) and is inferred to be coeval with or slightly older than the Lake George granodiorite (412 +5/-4 Ma, U-Pb zircon). The variably altered dyke contains subhedral to anhedral (rounded) quartz, plagioclase, and orthoclase phenocrysts (0.5 to 30 mm; 30 to 60 vol. %), and numerous angular to subrounded xenoliths of altered intrusion carapace and quenched dyke rocks, as well as local Kingsclear Formation metasedimentary rocks. The dyke is similar to the Lake George granodiorite in phenocryst population, volcanic arc (I-type) affinity, average Zr (157 ppm), TiO2 (0.54 %), La/Yb ratio (13), and REE (129 ppm). The average Au content is lower in the dyke (20 ppb) than in the granodiorite (32 ppb), the abundance of gold is related to minor magmatic hydrothermal chalcopyrite and pyrrhotite (< 2 %). Based on textural evidence, including autobrecciation, coupled with rheological and thermal modeling calculations for the 5 m-wide dyke, it is suggested that fluidization (vapour exsolution) of the magma was key to its rapid emplacement as a quenched glass-gas mixture (tuffisite). The S abundance and S isotopic signature of the dyke, relative to Au and Cu abundance, support reduced I-type magmatic volatiles involved in dyke emplacement and cogenetic autometasomatic alteration. RÉSUMÉ Un dyke de porphyre quartzo-feldspathique renfermant de la biotite, orienté vers le nord-nord-ouest et s’inclinant abruptement vers l’ouest, est associé à la granodiorite du lac George, une coupole du magmatisme du batholite de Pokiok. Ces intrusions régionales du Dévonien précoce sont spatialement et temporellement apparentées à une minéralisation de W-Mo-Au et de Sb-Au dans le secteur. Le dyke de porphyre a accusé un âge de 420,8 +5,9/-4,0 Ma (U-Pb sur zircon) et on le suppose du même âge ou légèrement plus âgé que la granodiorite du lac George (412 +5/-4 Ma, U-Pb sur zircon). Le dyke altéré de façon variable abrite des phénocristaux hypautomorphes à allotriomorphes (arrondis) de quartz, de plagioclase et d’orthoclase (0,5 à 30 mm, 30 à 60 % en vol.) ainsi que de nombreux xénolites angulaires à subsphérique d’une carapace d’intrusion altérée et de roches de dykes noyées, en plus de roches métasédimentaires locales de la Formation de Kingsclear. Le dyke s’avère analogue à la granodiorite du lac George du point de vue de la population de phénocristaux, de l’affinité avec l’arc insulaire (de type intrusif), de la concentration moyenne de Zr (157 ppm), du TiO2 (0,54 %), du ratio de La/Yb (13) et des ÉTR (129 ppm). La teneur moyenne en Au est plus faible dans le dyke (20 parties par milliard) que dans la granodiorite (32 parties par milliard); son abondance est apparentée à la présence restreinte de chalcopyrite et de pyrrhotite hydrothermales magmatiques (< 2 %). Selon les indices texturaux, notamment l’autobréchification, conjugués à des calculs de modélisation rhéologique et thermale du dyke (5 m), on peut supposer que la fluidisation (exsolution à l’état de vapeur) du magma a contribué à sa mise en place rapide sous forme d’un mélange de verre-gaz (tuffisite) noyé. L’abondance de S et la signature isotopique du S du dyke, comparativement à l’abondance d’Au et de Cu, appuient la participation réduite d’éléments volatils magmatiques de type intrusif à la mise en place du dyke et à l’altération autométasomatique cogénétique. [Traduit par la rédaction

New insights into the early evolution of horizontal spiral trace fossils and the age of the Brioverian series (Ediacaran-Cambrian) in Brittany, NW France

In northwestern France, the Brioverian series is a thick siliciclastic succession deposited during the Cadomian cycle (c. 750-540 Ma). In the uppermost Brioverian beds, previous studies unravelled an assemblage dominated by simple horizontal trace fossils associated with microbially stabilized surfaces. Here, we report Spirodesmos trace fossils - one-way, irregular and regular horizontal spirals - from Crozon (Finistère, Brittany), Montfort-sur-Meu and St-Gonlay (Ille-et-Vilaine, Brittany). After reviewing the literature on horizontal spiral trace fossils, an Ediacaran-Fortunian Spirodesmos pool is identified from marginal-marine to shelf settings, while an Ordovician-Recent trend formed in the deep-marine realm. These results suggest that an onshore-offshore migration in Spirodesmos took place during Ediacaran-Fortunian to Ordovician time, similar to what happened in graphoglyptids. In addition, the age of the uppermost Brioverian beds (Ediacaran or early Cambrian) is still a pending question. Here, we report two new U-Pb detrital zircon datings from sandstone samples in St-Gonlay, giving maximum deposition ages of 551 ± 7 Ma and 540 ± 5 Ma. Although these results do not discard an Ediacaran age for the uppermost Brioverian beds, a Fortunian age is envisioned because the new dating corroborates previous dating from Brittany, Mayenne and Normandy. However, the intervals of error of the radiometric dating, and the dominance of non-penetrative trace fossils associated with matgrounds (an ecology more typical of the Ediacaran Period), do not allow definitive conclusions on the age of the uppermost Brioverian beds

Evidence for Archaean lamprophyre from the Kaapvaal Craton, South Africa

A suite of mafic dykes occurs as a late component in a wellcharacterized trondhjemite–tonalite–diorite–granodiorite assemblage in the Johannesburg Dome of the central Kaapvaal Craton, southern Africa. The dykes have been subdivided into two sets, based on their orientation, and major and trace element geochemistry. Set 1 dykes are characterized by elevated SiO2, Al2O3 and TiO2, and particularly by enriched LILE and HSFE (e.g. Zr > 200 ppm, Nb > 20 ppm, Ba > 300 ppm), higher than in any of the accompanying felsic rocks. REE and trace element values for Set 1 dykes are similar to those for calc-alkaline lamprophyres. The Set 2 dykes have similar trace element distributions, but are significantly less enriched in general, and are broadly tholeiitic in composition, with enriched MgO (>11 wt. percentage) indicative of an olivine–phyric tholeiitic basaltic protolith. Field relationships and available U–Pb zircon geochronology indicate that the dykes are contemporaneous with components of the trondhjemitic host rocks, and with late granodiorites. The geochemical, geochronological and field petrological setting indicates partial melting of basaltic and eclogitic lithosphere at c. 3120 Myr ago in the basal Kaapvaal Craton, and subsequent emplacement into pre-existing c. 3430 Myr tonalitic to dioritic crust

Magmatic and hydrothermal behavior of uranium in syntectonic leucogranites: The uranium mineralization associated with the Hercynian Guérande granite (Armorican Massif, France)

Most of the hydrothermal uranium (U) deposits from the European Hercynian belt (EHB) are spatially associated with Carboniferous peraluminous leucogranites. In the southern part of the Armorican Massif (French part of the EHB), the Guérande peraluminous leucogranite was emplaced in an extensional deformation zone at ca. 310 Ma and is spatially associated with several U deposits and occurrences. The apical zone of the intrusion is structurally located below the Pen Ar Ran U deposit, a perigranitic vein-type deposit where mineralization occurs at the contact between black shales and Ordovician acid metavolcanics. In the Métairie-Neuve intragranitic deposit, uranium oxide-quartz veins crosscut the granite and a metasedimentary enclave. Airborne radiometric data and published trace element analyses on the Guérande leucogranite suggest significant uranium leaching at the apical zone of the intrusion. The primary U enrichment in the apical zone of the granite likely occurred during both fractional crystallization and the interaction with magmatic fluids. The low Th/U values (18Owhole rock = 9.7–11.6‰ for deformed samples and δ18Owhole rock = 12.2–13.6‰ for other samples) indicate that the deformed facies of the apical zone underwent sub-solidus alteration at depth with oxidizing meteoric fluids. Fluid inclusion analyses on a quartz comb from a uranium oxide-quartz vein of the Pen Ar Ran deposit show evidence of low-salinity fluids (1–6 wt.% NaCl eq.), in good agreement with the contribution of meteoric fluids. Fluid trapping temperatures in the range of 250–350 °C suggest an elevated geothermal gradient, probably related to regional extension and the occurrence of magmatic activity in the environment close to the deposit at the time of its formation. U-Pb dating on uranium oxides from the Pen Ar Ran and Métairie-Neuve deposits reveals three different mineralizing events. The first event at 296.6 ± 2.6 Ma (Pen Ar Ran) is sub-synchronous with hydrothermal circulations and the emplacement of late leucogranitic dykes in the Guérande leucogranite. The two last mineralizing events occur at 286.6 ± 1.0 Ma (Métairie-Neuve) and 274.6 ± 0.9 Ma (Pen Ar Ran), respectively. Backscattered uranium oxide imaging combined with major elements and REE geochemistry suggest similar conditions of mineralization during the two Pen Ar Ran mineralizing events at ca. 300 Ma and ca. 275 Ma, arguing for different hydrothermal circulation phases in the granite and deposits. Apatite fission track dating reveals that the Guérande granite was still at depth and above 120 °C when these mineralizing events occurred, in agreement with the results obtained on fluid inclusions at Pen Ar Ran. Based on this comprehensive data set, we propose that the Guérande leucogranite is the main source for uranium in the Pen Ar Ran and Métairie-Neuve deposits. Sub-solidus alteration via surface-derived low-salinity oxidizing fluids likely promoted uranium leaching from magmatic uranium oxides within the leucogranite. The leached out uranium may then have been precipitated in the reducing environment represented by the surrounding black shales or graphitic quartzites. As similar mineralizing events occurred subsequently until ca. 275 Ma, meteoric oxidizing fluids likely percolated during the time when the Guérande leucogranite was still at depth. The age of the U mineralizing events in the Guérande region (300–275 Ma) is consistent with that obtained on other U deposits in the EHB and could suggest a similar mineralization condition, with long-term upper to middle crustal infiltration of meteoric fluids likely to have mobilized U from fertile peraluminous leucogranites during the Late Carboniferous to Permian crustal extension events

Intra-Host Evolution Analyses in an Immunosuppressed Patient Supports SARS-CoV-2 Viral Reservoir Hypothesis.

Throughout the SARS-CoV-2 pandemic, several variants of concern (VOCs) have been identified, many of which share recurrent mutations in the spike glycoprotein's receptor-binding domain (RBD). This region coincides with known epitopes and can therefore have an impact on immune escape. Protracted infections in immunosuppressed patients have been hypothesized to lead to an enrichment of such mutations and therefore drive evolution towards VOCs. Here, we present the case of an immunosuppressed patient that developed distinct populations with immune escape mutations throughout the course of their infection. Notably, by investigating the co-occurrence of substitutions on individual sequencing reads in the RBD, we found quasispecies harboring mutations that confer resistance to known monoclonal antibodies (mAbs) such as S:E484K and S:E484A. These mutations were acquired without the patient being treated with mAbs nor convalescent sera and without them developing a detectable immune response to the virus. We also provide additional evidence for a viral reservoir based on intra-host phylogenetics, which led to a viral substrain that evolved elsewhere in the patient's body, colonizing their upper respiratory tract (URT). The presence of SARS-CoV-2 viral reservoirs can shed light on protracted infections interspersed with periods where the virus is undetectable, and potential explanations for long-COVID cases

Evaluation of endothelial function and subclinical atherosclerosis in association with hepatitis C virus in HIV-infected patients: a cross-sectional study

<p>Abstract</p> <p>Background</p> <p>Relationship of hepatitis C virus (HCV) infection with an increased risk of cardiovascular disease (CVD) in HIV-infected patients remains controversial. We evaluated endothelial function and subclinical atherosclerosis in HIV-infected patients with and without HCV.</p> <p>Methods</p> <p>Flow-mediated dilatation (FMD) of the brachial artery and circulating levels of cell adhesion molecules (CAM) were measured in HCV/HIV-coinfected and HIV-monoinfected patients. Subclinical atherosclerosis was assessed by carotid intima-media thickness (cIMT).</p> <p>Results</p> <p>63 (31%) HCV/HIV-coinfected and 138 (69%) HIV-monoinfected patients were included. Median soluble vascular CAM-1 (sVCAM-1) and intercellular CAM-1 (sICAM-1) levels were significantly higher in HIV/HCV-coinfected patients (P < 0.001 for both cases). Median (interquartile range) FMD was 6.21% (2.86-9.62) in HCV/HIV-coinfected and 5.54% (2.13-9.13) in HIV-monoinfected patients (P = 0.37). Adjustment for variables associated with HCV and FMD disclosed similar results. FMD correlated inversely with cIMT and age. Carotid IMT did not differ between HCV/HIV-coinfected and HIV-monoinfected patients in unadjusted (0.61 [0.55-0.65] mm vs 0.60 [0.53-0.72] mm; P = 0.39) or adjusted analyses.</p> <p>Conclusion</p> <p>HCV infection was associated with higher levels of sICAM-1 and sVCAM-1, but no evidence of increased subclinical atherosclerosis was found when endothelial function was evaluated through FMD, or when assessing the cIMT.</p

The tree that hides the forest: cryptic diversity and phylogenetic relationships in the Palaearctic vector Obsoletus/Scoticus Complex (Diptera: Ceratopogonidae) at the European level

Abstract Background Culicoides obsoletus is an abundant and widely distributed Holarctic biting midge species, involved in the transmission of bluetongue virus (BTV) and Schmallenberg virus (SBV) to wild and domestic ruminants. Females of this vector species are often reported jointly with two morphologically very close species, C. scoticus and C. montanus, forming the Obsoletus/Scoticus Complex. Recently, cryptic diversity within C. obsoletus was reported in geographically distant sites. Clear delineation of species and characterization of genetic variability is mandatory to revise their taxonomic status and assess the vector role of each taxonomic entity. Our objectives were to characterize and map the cryptic diversity within the Obsoletus/Scoticus Complex. Methods Portion of the cox1 mitochondrial gene of 3763 individuals belonging to the Obsoletus/Scoticus Complex was sequenced. Populations from 20 countries along a Palaearctic Mediterranean transect covering Scandinavia to Canary islands (North to South) and Canary islands to Turkey (West to East) were included. Genetic diversity based on cox1 barcoding was supported by 16S rDNA mitochondrial gene sequences and a gene coding for ribosomal 28S rDNA. Species delimitation using a multi-marker methodology was used to revise the current taxonomic scheme of the Obsoletus/Scoticus Complex. Results Our analysis showed the existence of three phylogenetic clades (C. obsoletus clade O2, C. obsoletus clade dark and one not yet named and identified) within C. obsoletus. These analyses also revealed two intra-specific clades within C. scoticus and raised questions about the taxonomic status of C. montanus. Conclusions To our knowledge, our study provides the first genetic characterization of the Obsoletus/Scoticus Complex on a large geographical scale and allows a revision of the current taxonomic classification for an important group of vector species of livestock viruses in the Palaearctic region

Correction to: The tree that hides the forest : cryptic diversity and phylogenetic relationships in the Palaearctic vector Obsoletus/Scoticus complex (Diptera: Ceratopogonidae) at the European level

An amendment to this paper has been published and can be accessed via the original article

ABO Blood Group and the Risk of Hepatocellular Carcinoma: A Case-Control Study in Patients with Chronic Hepatitis B

BACKGROUND: Studies have observed an association between the ABO blood group and risk of certain malignancies. However, no studies of the association with hepatocellular carcinoma (HCC) risk are available. We conducted this hospital-based case-control study to examine the association with HCC in patients with chronic hepatitis B (CHB). METHODS: From January 2004 to December 2008, a total of 6275 consecutive eligible patients with chronic hepatitis B virus (HBV) infection were recruited. 1105 of them were patients with HBV-related HCC and 5,170 patients were CHB without HCC. Multivariate logistic regression models were used to investigate the association between the ABO blood group and HCC risk. RESULTS: Compared with subjects with blood type O, the adjusted odds ratio (AOR) for the association of those with blood type A and HCC risk was 1.39 [95% confidence interval (CI), 1.05-1.83] after adjusting for age, sex, type 2 diabetes, cirrhosis, hepatitis B e antigen, and HBV DNA. The associations were only statistically significant [AOR (95%CI) = 1.56(1.14-2.13)] for men, for being hepatitis B e antigen positive [AOR (95%CI) = 4.92(2.83-8.57)], for those with cirrhosis [AOR (95%CI), 1.57(1.12-2.20)], and for those with HBV DNA≤10(5)copies/mL [AOR (95%CI), 1.58(1.04-2.42)]. Stratified analysis by sex indicated that compared with those with blood type O, those with blood type B also had a significantly high risk of HCC among men, whereas, those with blood type AB or B had a low risk of HCC among women. CONCLUSIONS: The ABO blood type was associated with the risk of HCC in Chinese patients with CHB. The association was gender-related