An Econometric Analysis of the Canada - Florida Air Passenger Market

This thesis evaluates the Canada - Florida commercial air passenger market and explains fluctuations in the demand for air passenger service based on an econometric modeling process. Canada - Florida commercial air passenger traffic is segmented into those passengers flying on scheduled air services and those travelling on chartered air services. Two separate multiple regression equations are constructed to address the two segments of the Canada - Florida market. Both equations are formulated utilizing the same three independent variables. It was expected that the three chosen independent variables, Canadian GDP, a ratio of chartered air fare levels by scheduled air fare levels, and a ratio of chartered flight time by scheduled flight time, would explain the changes exhibited in air passenger enplanements and deplanements within the Canada - Florida air passenger market between 1971 and 1992. The results of the two separate multiple regression equations partially substantiated the hypothesis. The equation corresponding to chartered enplanements and deplanements proved to be highly significant while the equation corresponding to scheduled enplanements and deplanements was not as robust as the researcher anticipated

Test results of Spacelab 2 infrared telescope focal plane

The small helium cooled infrared telescope for Spacelab 2 is designed for sensitive mapping of extended, low-surface-brightness celestial sources as well as highly sensitive investigations of the shuttle contamination environment (FPA) for this mission is described as well as the design for a thermally isolated, self-heated J-FET transimpedance amplifier. This amplifier is Johnson noise limited for feedback resistances from less than 10 to the 8th power Omega to greater than 2 x 10 to the 10th power Omega at T = 4.2K. Work on the focal plane array is complete. Performance testing for qualification of the flight hardware is discussed, and results are presented. All infrared data channels are measured to be background limited by the expected level of zodiacal emission

Predicted Colors and Flux Densities of Protostars in the Herschel PACS and SPIRE Filters

Upcoming surveys with the Herschel Space Observatory will yield far-IR photometry of large samples of young stellar objects, which will require careful interpretation. We investigate the color and luminosity diagnostics based on Herschel broad-band filters to identify and discern the properties of low-mass protostars. We compute a grid of 2,016 protostars in various physical congurations, present the expected flux densities and flux density ratios for this grid of protostars, and compare Herschel observations of three protostars to the model results. These provide useful constraints on the range of colors and fluxes of protostar in the Herschel filters. We find that Herschel data alone is likely a useful diagnostic of the envelope properties of young starsComment: Part of HOPS KP papers to the Herschel special A&A issu

Modulation of polymorphonuclear neutrophil functions by astrocytes

<p>Abstract</p> <p>Background</p> <p>Neuroinflammation is a complex process involving cells from the immune system and the central nerve system (CNS). Polymorphonuclear neutrophils (PMN) are the most abundant class of white blood cells, and typically the first type of leukocyte recruited to sites of inflammation. In the CNS, astrocytes are the most abundant glial cell population and participate in the local innate immune response triggered by a variety of insults. In the present study, we investigated the impacts of astrocytes on PMN function.</p> <p>Methods</p> <p>Primary astrocyte cultures were derived from postnatal C57BL/6 mice and primary neutrophils were isolated from 8 to 12 weeks old C57BL/6 mice. PMNs respiratory burst was analyzed by H2DCFDA assay. For phagocytosis assay, neutrophils were incubated with FITC-labeled E. coli and the phagocytosis of E coli was determined by flow cytometer. PMNs degranulation was determined by myeloperoxidase assay. Cytokine expression was determined by real-time PCR. To determine the involvement of different signaling pathway, protein lysates were prepared and western blots were conducted to assess the activation of Akt, Erk1/2, and p38.</p> <p>Results</p> <p>Using ex vivo neutrophils and primary astrocyte cultures, our study demonstrated that astrocytes differentially regulate neutrophil functions, depending upon whether the interactions between the two cell types are direct or indirect. Upon direct cell-cell contact, astrocytes attenuate neutrophil apoptosis, respiratory bust, and degranulation, while enhancing neutrophil phagocytic capability and pro-inflammatory cytokine expression. Through indirect interaction with neutrophils, astrocytes attenuate apoptosis and enhance necrosis in neutrophils, augment neutrophil phagocytosis and respiratory burst, and inhibit neutrophil degranulation. In addition, astrocytes could augment Akt, Erk1/2, and p38 activation in neutrophils.</p> <p>Conclusions</p> <p>Astrocytes differentially regulate neutrophil functions through direct or indirect interactions between the two cell types. The diversified actions of astrocytes on neutrophils might provide protection against potential microbial infections given compromised blood-brain barrier integrity under certain neuropathological conditions. The complex actions of astrocytes on neutrophils could provide further insight to harness the inflammatory response to promote CNS repair.</p

A Comparison of Components of Written Expression Abilities in Learning Disabled and Non-Learning Disabled Students at Three Grade Levels

Although written language plays a critical role in academic success, little empirical evidence exists on the normal development of processes involved in producing written products. Even less is known about the writing performance of LD children. This study empirically compared the written products of LD and normal students at three grade levels on The Test of Written Language. Results showed that LD subjects scored significantly lower than normal subjects on most written expression abilities, especially in the mechanical tasks of spelling, punctuation, and word usage.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline

Herschel/PACS Imaging of Protostars in the HH 1-2 Outflow Complex

We present 70 and 160 micron Herschel science demonstration images of a field in the Orion A molecular cloud that contains the prototypical Herbig-Haro objects HH 1 and 2, obtained with the Photodetector Array Camera and Spectrometer (PACS). These observations demonstrate Herschel's unprecedented ability to study the rich population of protostars in the Orion molecular clouds at the wavelengths where they emit most of their luminosity. The four protostars previously identified by Spitzer 3.6-40 micron imaging and spectroscopy are detected in the 70 micron band, and three are clearly detected at 160 microns. We measure photometry of the protostars in the PACS bands and assemble their spectral energy distributions (SEDs) from 1 to 870 microns with these data, Spitzer spectra and photometry, 2MASS data, and APEX sub-mm data. The SEDs are fit to models generated with radiative transfer codes. From these fits we can constrain the fundamental properties of the protostars. We find luminosities in the range 12-84 L_sun and envelope densities spanning over two orders of magnitude. This implies that the four protostars have a wide range of envelope infall rates and evolutionary states: two have dense, infalling envelopes, while the other two have only residual envelopes. We also show the highly irregular and filamentary structure of the cold dust and gas surrounding the protostars as traced at 160 microns.Comment: 6 pages, 4 figures, accepted for publication in the A&A Herschel special issu

Hier ist wahrhaftig ein Loch im Himmel - The NGC 1999 dark globule is not a globule

The NGC 1999 reflection nebula features a dark patch with a size of ~10,000 AU, which has been interpreted as a small, dense foreground globule and possible site of imminent star formation. We present Herschel PACS far-infrared 70 and 160mum maps, which reveal a flux deficit at the location of the globule. We estimate the globule mass needed to produce such an absorption feature to be a few tenths to a few Msun. Inspired by this Herschel observation, we obtained APEX LABOCA and SABOCA submillimeter continuum maps, and Magellan PANIC near-infrared images of the region. We do not detect a submillimer source at the location of the Herschel flux decrement; furthermore our observations place an upper limit on the mass of the globule of ~2.4x10^-2 Msun. Indeed, the submillimeter maps appear to show a flux depression as well. Furthermore, the near-infrared images detect faint background stars that are less affected by extinction inside the dark patch than in its surroundings. We suggest that the dark patch is in fact a hole or cavity in the material producing the NGC 1999 reflection nebula, excavated by protostellar jets from the V 380 Ori multiple system.Comment: accepted for the A&A Herschel issue; 7 page

Herschel/PACS Spectroscopic Survey of Protostars in Orion: The Origin of Far-infrared CO Emission

We present far-infrared (57-196 μm) spectra of 21 protostars in the Orion molecular clouds. These were obtained with the Photodetector Array Camera and Spectrometer (PACS) on board the Herschel Space observatory as part of the Herschel Orion Protostar Survey program. We analyzed the emission lines from rotational transitions of CO, involving rotational quantum numbers in the range J_(up) = 14-46, using PACS spectra extracted within a projected distance of ≾2000 AU centered on the protostar. The total luminosity of the CO lines observed with PACS (L_(CO)) is found to increase with increasing protostellar luminosity (L_(bol)). However, no significant correlation is found between L_(CO) and evolutionary indicators or envelope properties of the protostars such as bolometric temperature, T_(bol), or envelope density. The CO rotational (excitation) temperature implied by the line ratios increases with increasing rotational quantum number J, and at least 3–4 rotational temperature components are required to fit the observed rotational diagram in the PACS wavelength range. The rotational temperature components are remarkably invariant between protostars and show no dependence on L_(bol), T_(bol), or envelope density, implying that if the emitting gas is in local thermodynamic equilibrium, the CO emission must arise in multiple temperature components that remain independent of L_(bol) over two orders of magnitudes. The observed CO emission can also be modeled as arising from a single-temperature gas component or from a medium with a power-law temperature distribution; both of these require sub-thermally excited molecular gas at low densities (n(H_2) ≾ 10^6 cm^(–3)) and high temperatures (T≳2000 K). Our results suggest that the contribution from photodissociation regions, produced along the envelope cavity walls from UV-heating, is unlikely to be the dominant component of the CO emission observed with PACS. Instead, the "universality" of the rotational temperatures and the observed correlation between L_(CO) and L_(bol) can most easily be explained if the observed CO emission originates in shock-heated, hot (T≳2000 K), sub-thermally excited (n(H_2) ≾ 10^6 cm^(–3)) molecular gas. Post-shock gas at these densities is more likely to be found within the outflow cavities along the molecular outflow or along the cavity walls at radii ≳ several 100-1000 AU

The regulatory subunit of PKA-I remains partially structured and undergoes β-aggregation upon thermal denaturation

Background: The regulatory subunit (R) of cAMP-dependent protein kinase (PKA) is a modular flexible protein that responds with large conformational changes to the binding of the effector cAMP. Considering its highly dynamic nature, the protein is rather stable. We studied the thermal denaturation of full-length RIα and a truncated RIα(92-381) that contains the tandem cyclic nucleotide binding (CNB) domains A and B. Methodology/Principal Findings: As revealed by circular dichroism (CD) and differential scanning calorimetry, both RIα proteins contain significant residual structure in the heat-denatured state. As evidenced by CD, the predominantly α-helical spectrum at 25°C with double negative peaks at 209 and 222 nm changes to a spectrum with a single negative peak at 212-216 nm, characteristic of β-structure. A similar α→β transition occurs at higher temperature in the presence of cAMP. Thioflavin T fluorescence and atomic force microscopy studies support the notion that the structural transition is associated with cross-β-intermolecular aggregation and formation of non-fibrillar oligomers. Conclusions/Significance: Thermal denaturation of RIα leads to partial loss of native packing with exposure of aggregation-prone motifs, such as the B' helices in the phosphate-binding cassettes of both CNB domains. The topology of the β-sandwiches in these domains favors inter-molecular β-aggregation, which is suppressed in the ligand-bound states of RIα under physiological conditions. Moreover, our results reveal that the CNB domains persist as structural cores through heat-denaturation. © 2011 Dao et al