Cognitive Correlates of Hippocampal Atrophy and Ventricular Enlargement in Adults with or without Mild Cognitive Impairment

We analyzed structural magnetic resonance imaging data from 58 cognitively normal and 101 mild cognitive impairment subjects. We used a general linear regression model to study the association between cognitive performance with hippocampal atrophy and ventricular enlargement using the radial distance method. Bilateral hippocampal atrophy was associated with baseline and longitudinal memory performance. Left hippocampal atrophy predicted longitudinal decline in visuospatial function. The multidomain ventricular analysis did not reveal any significant predictors

Covid-19 fear impact on Israeli and Maltese female “help” profession students

Background: The aim of this cross-sectional study was to examine the impact of COVID-19 fear on the well-being of Israeli and Maltese female “help” profession (e.g., social work and psychology) undergraduate students. This cross-national comparison includes factors of depression, anxiety, anger, loneliness, nervousness, substance use, eating behavior, burnout, and resilience. The study hypothesis is that country status, even with different social–cultural characteristics including religiosity, is not a significant factor associated with COVID-19 fear impact on select behavioral characteristics of female university students. Methods: A total of 453 female “help” profession students completed an online survey from January to July 2021. Various statistical methods of analysis including regression were used for this study. Results: The mean COVID-19 fear scores were the same among Israeli and Maltese students. Resilience was found to be higher among Israeli females; burnout was found to be higher among those from Malta. Substance use (i.e., tobacco, alcohol, cannabis, stimulants, or prescription drugs) in the last month was reported by 77.2% of the respondents. No significant differences were found for previous-month substance use based on country status. Regardless of country, respondents who reported more previous-month substance use had higher COVID-19 fear and burnout scores, as well as lower resilience. Due to COVID-19, most respondents (74.3%) reported deterioration of their psycho-emotional well-being in the last month; however, no significant differences were found based on country and religiosity statuses. Furthermore, no significant differences were found for eating behavior changes and weight increase based on country and religiosity statuses. Conclusion: Study findings showed the impact of COVID-19 fear on the well-being of Israeli and Maltese female “help” profession undergraduate students. This study examined only female students; however, additional research is needed to address male students and their experiences. Prevention and treatment intervention measures aimed to increase resilience and decrease burnout, including those that can be made available on campus, should be thought about by university administration personnel and student association leaders in consultation with mental health professionals.peer-reviewe

The amyloid fibril-forming properties of the amphibian antimicrobial peptide uperin 3.5

The amphibian skin is a vast resource for bioactive peptides, which form the basis of the animals' innate immune system. Key components of the secretions of the cutaneous glands are antimicrobial peptides (AMPs), which exert their cytotoxic effects often as a result of membrane disruption. It is becoming increasingly evident that there is a link between the mechanism of action of AMPs and amyloidogenic peptides and proteins. In this work, we demonstrate that the broad-spectrum amphibian AMP uperin 3.5, which has a random-coil structure in solution but adopts an α-helical structure in membrane-like environments, forms amyloid fibrils rapidly in solution at neutral pH. These fibrils are cytotoxic to model neuronal cells in a similar fashion to those formed by the proteins implicated in neurodegenerative diseases. The addition of small quantities of 2,2,2-trifluoroethanol accelerates fibril formation by uperin 3.5, and is correlated with a structural stabilisation induced by this co-solvent. Uperin 3.5 fibril formation and the associated cellular toxicity are inhibited by the polyphenol (-)-epigallocatechin-3-gallate (EGCG). Furthermore, EGCG rapidly dissociates fully formed uperin 3.5 fibrils. Ion mobility-mass spectrometry reveals that uperin 3.5 adopts various oligomeric states in solution. Combined, these observations imply that the mechanism of membrane permeability by uperin 3.5 is related to its fibril-forming properties.Antonio N. Calabrese, Yanqin Liu, Tianfang Wang, Ian F. Musgrave, Tara L. Pukala, Rico F. Tabor, Lisandra L. Martin, John A. Carver, John H. Bowi

Multiparametric Analysis of Urban Environmental Quality for Estimating Neighborhood Renewal Alternatives

The neighborhood renewal process is an important opportunity to update the built environment; however, major changes to the built environment might decrease spatial performance and environmental quality. In these processes, there is a need to evaluate urban renewal alternatives, especially the quality of the environment, to understand the performance of the newly designed built environment. The quality of the built environment depends on a variety of aspects (such as walkability, energy level, security, open spaces, water permeability, etc.), several of which can be assessed using diverse measurements and evaluation models. Current new technological developments, based on GIS, enable the evaluation of diverse aspects of environmental quality and promote urban renewal decision-making processes. Urban renewal needs to harness these models in the decision-making approaches to improve assessment processes of urban renewal alternative estimations that consider future performance and quality of the built environment. In this article, we present a 3D-GIS multiparametric scenario analysis for neighborhood renewal alternatives estimation to evaluate the performance and quality of the built environment as part of the decision-making process. The multiparametric approach will include an evaluation analysis of several aspects of environmental quality, including walkability, accessibility, sense of security, energy, shade, water infiltration, visibility, and more. The analysis results will indicate the level of performance for each aspect as indices for environmental quality. The multiparametric scenario analysis for neighborhood renewal will be conducted on three renewal alternatives for one neighborhood in the city of Hatzor HaGlilit, Israel.In this article, we present a 3D-GIS multiparametric scenario analysis for neighborhood renewal alternatives estimation to evaluate the performance and quality of the built environment as part of the decision-making process. The multiparametric approach will include evaluation analysis of several aspects of the environmental quality, including walkability, accessibility, sense of security, energy, shade, water infiltration, visibility, and more. The analysis results will indicate the level of performance for each aspect, as indices for environmental quality. The multiparametric scenario analysis for neighborhood renewal will be conducted on three renewal alternatives for one neighborhood in the city of Hatzor-HaGlilit, Israel

Gaming Disorder and Psycho-Emotional Wellbeing among Male University Students and Other Young Adults in Israel

The aim of this cross-sectional study was to examine the impact of gaming and gaming disorder on the wellbeing of Israeli male university students and other adults. Gaming disorder (i.e., persistent, and recurrent gaming activity associated with a lack of control that may be clinically diagnosed) was determined using the Internet Gaming Disorder Scale–Short-Form (IGDS9-SF). Survey participants were recruited from gaming associations, clubs and the gaming community using Facebook. Data were collected in June 2022. A total of 526 males completed the survey (30.9% university students and 69.1% other young adults). Various statistical methods of analysis including regression were used for this study. Significant study group differences revealed university students with more indications of gaming disorder, more burnout, less loneliness, more stimulant (i.e., Ritalin) use, a greater consumption of salt- and/or sugar-loaded foods and lower economic wellbeing. The levels of resilience (i.e., the ability to recover from stress), substance use (e.g., tobacco and alcohol) and weight gain were similar for the two groups. Regression analysis showed gaming disorder as a key predictor of burnout, economic wellbeing and resilience. This study examined only male gamers because of the small number of female respondents. However, additional research is needed about female internet gamers, including their possible exposure to online harassment and sexual degradation. Additionally, additional research should be considered to verify the present study’s findings about gamers based on demographic factors and gaming disorder levels. Prevention and treatment intervention measures, including those that can be made available on campus, should be thought about by university administration personnel and student association leaders in consultation with professionals who are experienced in reducing gaming disorder and other harmful behaviors among students

Economic Impact on Health and Well-Being: Comparative Study of Israeli and Japanese University “Help” Profession Students

Background: Deteriorating economic conditions caused by rising inflation and living expenses can have negative consequences for university students. This comparative study examined Israeli and Japanese “help” profession (e.g., medicine, nursing, social work, and psychology) students’ fear of such conditions and its impact on their health and well-being. Methods: Data were collected from a cross-sectional sample of 848 university students from Israel and Japan (78.9% female, 20.4% male, and 0.7% other) during a 3-month period of economic decline in 2022. Reliable data-collection instruments and SPSS (version 25) were used for the study. Results: Overall, Japanese students evidenced a higher level of economic well-being than their Israeli counterparts. This finding may have been a result of the lower inflation and living costs in Japan. However, most survey respondents evidenced a fear of deteriorating economic conditions that was significantly associated with psycho-emotional behavior, including increased burnout, substance use, unhealthy food intake, weight gain, and resilience regardless of gender and religiosity. Conclusions: The study findings showed the impact of deteriorating economic conditions on the health and well-being of “help” profession students. These results are preliminary; however, they do serve as an early warning of the key challenges that may need to be considered and addressed for prevention and intervention purposes. Further research should be conducted in other countries and over different time periods to substantiate present findings

Dance Experience and Associations with Cortical Gray Matter Thickness in the Aging Population

Introduction: We investigated the effect dance experience may have on cortical gray matter thickness and cognitive performance in elderly participants with and without mild cognitive impairment (MCI). Methods: 39 cognitively normal and 48 MCI elderly participants completed a questionnaire regarding their lifetime experience with music, dance, and song. Participants identified themselves as either dancers or nondancers. All participants received structural 1.5-tesla MRI scans and detailed clinical and neuropsychological evaluations. An advanced 3D cortical mapping technique was then applied to calculate cortical thickness. Results: Despite having a trend-level significantly thinner cortex, dancers performed better in cognitive tasks involving learning and memory, such as the California Verbal Learning Test-II (CVLT-II) short delay free recall (p = 0.004), the CVLT-II long delay free recall (p = 0.003), and the CVLT-II learning over trials 1-5 (p = 0.001). Discussion: Together, these results suggest that dance may result in an enhancement of cognitive reserve in aging, which may help avert or delay MCI