Electroweak constraints on warped models with custodial symmetry

It has been recently argued that realistic models with warped extra dimensions can have Kaluza-Klein particles accessible at the Large Hadron Collider if a custodial symmetry, SU(2)_V \times P_{LR}, is used to protect the T parameter and the coupling of the left-handed bottom quark to the Z gauge boson. In this article we emphasize that such a symmetry implies that the loop corrections to both the T parameter and the Z b_L \bar{b}_L coupling are calculable. In general, these corrections are correlated, can be sizable, and should be considered to determine the allowed parameter space region in models with warped extra dimensions and custodial symmetry, including Randall-Sundrum models with a fundamental Higgs, models of gauge-Higgs unification and Higgsless models. As an example, we derive the constraints that arise on a representative model of gauge-Higgs unification from a global fit to the precision electroweak observables. A scan over the parameter space typically leads to a lower bound on the Kaluza-Klein excitations of the gauge bosons of about 2-3 TeV, depending on the configuration. In the fermionic sector one can have Kaluza-Klein excitations with masses of a few hundred GeV. We present the constraints on these light fermions from recent Tevatron searches, and explore interesting discovery channels at the LHC.Comment: 38 pages, 8 figure

Whole Saliva has a Dual Role on the Adherence of Candida albicans to Polymethylmetacrylate

Adhesion of Candida albicans to acrylic of dental prostheses or to salivary macromolecules adsorbed on their surface is believed to be a critical event in the development of denture stomatitis. In previous studies our group has shown that adhesion of C. albicans germ tubes to polystyrene is decreased by saliva whereas C. albicans yeast cells adhesion to the same material is enhanced. The results presented in this study confirm this dual role played by whole saliva, since it decreased the adhesion of germ tubes but increased the adhesion of yeast cells to polymethylmetacrylate (PMMA). These effects mediated by whole saliva do not seem to be related to an inhibition of the germination of C. albicans, since similar levels of filamentation were observed in presence and absence of saliva. These results may give new insights into the conflicting role of saliva in the adhesion of C. albicans to acrylic resins of dental prostheses

Rotary travelling wave oscillator with differential nonlinear transmission lines

A methodology for the harmonic-balance analysis and design of rotary-traveling wave oscillator is presented. Two different implementations are compared. The first one is the standard configuration based on a distributed transmission lines. The second one is a new configuration based on a differential nonlinear transmission line (NLTL), which enables the generation of square waveforms with reduced number of stages, while still maintaining the capability to produce multiphase signals. The possible coexistence of oscillation modes is investigated with a detailed bifurcation analysis versus practical parameters such as the device bias voltage. The phase-noise spectrum is predicted from the variance of the common phase deviation. The parameters that determine this variance are identified with the conversion-matrix approach. The two prototypes, based on a distributed transmission line and a differential NLTL, have been manufactured and characterized experimentally, obtaining very good agreement between simulations and measurements.This work has been supported by the Spanish Ministry of Economy and Competitiveness through project TEC2011-29264-C03-01

Identification of protein and mannoprotein antigens of Candida albicans of relevance for the serodiagnosis of invasive candidiasis

Antigens from Candida albicans blastoconidia and germ tubes were identified by two-dimensional electrophoresis and Western blotting and characterized by microsequencing, reactivity with concanavalin A, and a panel of human sera. Antigens identified included a polydispersed area in the acidic high-molecular-mass regions of blastoconidium and germ-tube extracts, and 16 antigens varying in molecular masses and isoelectric points (pIs). The majority of the detected antigens, especially those in the polydispersed region, showed mannosyl groups, as determined by concanavalin A reactivity. Antibodies present in sera from patients with invasive candidiasis showed high reactivity with a number of antigens not detected with sera from blood donors. Eight of the 16 antigens could be identified by reactivity with monoclonal antibodies or by microsequencing. Five antigens showed homology with five enzymes previously described as antigens in C. albicans: enolase, phosphoglycerate kinase, malate dehydrogenase, and two isoforms of the fructose biphosphate aldolase. However, to our knowledge, this is the first report of the immunogenic activity of a kexin precursor, a mitochondrial complex I chaperone, and a diacylglycerol kinase catalytic domain from C. albicans. Antigens described in this study may be of potential interest for the serodiagnosis of invasive candidiasis. [Int Microbiol 2007; 10(2):103-108

Clinical significance of the detection of Candida albicans germ tube-specific antibodies in critically ill patients

AbstractThe present study, comprising a prospective multicentre study including 53 non-neutropenic patients from intensive care units (ICU) in six Spanish tertiary-care hospitals, was carried out to determine the clinical significance and influence on mortality of Candida albicans germ tube-specific antibodies (CAGTA). There were 22 patients (41.5%) for whom the CAGTA results were positive, although none of had a blood culture positive for Candida. The intra-ICU mortality rate was significantly lower (p = 0.004) in CAGTA-positive patients (61.2% vs. 22.7%). Multivariate analysis confirmed that a positive CAGTA result was the only protective factor to be independently associated with ICU mortality (β coefficient = −0.3856; 95% confidence interval = −0.648 to −0.123)

TeV Scale Singlet Dark Matter

It is well known that stable weak scale particles are viable dark matter candidates since the annihilation cross section is naturally about the right magnitude to leave the correct thermal residual abundance. Many dark matter searches have focused on relatively light dark matter consistent with weak couplings to the Standard Model. However, in a strongly coupled theory, or even if the coupling is just a few times bigger than the Standard Model couplings, dark matter can have TeV-scale mass with the correct thermal relic abundance. Here we consider neutral TeV-mass scalar dark matter, its necessary interactions, and potential signals. We consider signals both with and without higher-dimension operators generated by strong coupling at the TeV scale, as might happen for example in an RS scenario. We find some potential for detection in high energy photons that depends on the dark matter distribution. Detection in positrons at lower energies, such as those PAMELA probes, would be difficult though a higher energy positron signal could in principle be detectable over background. However, a light dark matter particle with higher-dimensional interactions consistent with a TeV cutoff can in principle match PAMELA data.Comment: 30 pages, 11 figures. Minor changes, references adde

Effective Lagrangians and Light Gravitino Phenomenology

We construct the low-energy effective lagrangian for a light gravitino coupled to the minimal supersymmetric standard model under the assumption that supersymmetry breaking is communicated to the observable sector dominantly through soft terms. Our effective lagrangian is written in terms of the spin-1/2 Goldstino (the longitudinal component of the gravitino) transforming under a non-linear realization of supersymmetry. In this lagrangian, the Goldstino is derivatively coupled and all couplings of the Goldstino to light fields are determined uniquely by the supersymmetry-breaking scale \sqrt{F}. This lagrangian is therefore a useful starting point for further investigation of the light gravitino in gauge-mediated supersymmetry breaking models. We show that the invisible width of the Z into Goldstinos gives the constraint \sqrt{F} > 140 GeV.Comment: 15 pages, LaTeX2e, 1 eps figure. Removed erroneous claim of coupling of photon to gravitino to photons at order M^2 E^2 / F^2. Strongest bound is from invisible Z width, giving F > (140 GeV)^

Clinical factors associated with a Candida albicans Germ Tube Antibody positive test in Intensive Care Unit patients

Background: Poor outcomes of invasive candidiasis (IC) are associated with the difficulty in establishing the microbiological diagnosis at an early stage. New scores and laboratory tests have been developed in order to make an early therapeutic intervention in an attempt to reduce the high mortality associated with invasive fungal infections. Candida albicans IFA IgG has been recently commercialized for germ tube antibody detection (CAGTA). This test provides a rapid and simple diagnosis of IC (84.4% sensitivity and 94.7% specificity). The aim of this study is to identify the patients who could be benefited by the use of CAGTA test in critical care setting. Methods: A prospective, cohort, observational multicentre study was carried out in six medical/surgical Intensive care units (ICU) of tertiary-care Spanish hospitals. Candida albicans Germ Tube Antibody test was performed twice a week if predetermined risk factors were present, and serologically demonstrated candidiasis was considered if the testing serum dilution was >= 1: 160 in at least one sample and no other microbiological evidence of invasive candidiasis was found. Results: Fifty-three critically ill non-neutropenic patients (37.7% post surgery) were included. Twenty-two patients (41.5%) had CAGTA-positive results, none of them with positive blood culture for Candida. Neither corrected colonization index nor antifungal treatment had influence on CAGTA results. This finding could corroborate that the CAGTA may be an important biomarker to distinguish between colonization and infection in these patients. The presence of acute renal failure at the beginning of the study was more frequent in CAGTA-negative patients. Previous surgery was statistically more frequent in CAGTA-positive patients. Conclusions: This study identified previous surgery as the principal clinical factor associated with CAGTA-positive results and emphasises the utility of this promising technique, which was not influenced by high Candida colonization or antifungal treatment. Our results suggest that detection of CAGTA may be important for the diagnosis of invasive candidiasis in surgical patients admitted in ICU.This study has been supported by a Pfizer research gran

Bulk Gauge Fields in Warped Space and Localized Supersymmetry Breaking

We consider five dimensional supersymmetric warped scenarios in which the Standard Model quark and lepton fields are localized on the ultraviolet brane, while the Standard Model gauge fields propagate in the bulk. Supersymmetry is assumed to be broken on the infrared brane. The relative sizes of supersymmetry breaking effects are found to depend on the hierarchy between the infrared scale and the weak scale. If the infrared scale is much larger than the weak scale the leading supersymmetry breaking effect on the visible brane is given by gaugino mediation. The gaugino masses at the weak scale are proportional to the square of the corresponding gauge coupling, while the dominant contribution to the scalar masses arises from logarithmically enhanced radiative effects involving the gaugino mass that are cutoff at the infrared scale. While the LSP is the gravitino, the NLSP which is the stau is stable on collider time scales. If however the infrared scale is close to the weak scale then the effects of hard supersymmetry breaking operators on the scalar masses can become comparable to those from gaugino mediation. These operators alter the relative strengths of the couplings of gauge bosons and gauginos to matter, and give loop contributions to the scalar masses that are also cutoff at the infrared scale. The gaugino masses, while exhibiting a more complicated dependence on the corresponding gauge coupling, remain hierarchical and become proportional to the corresponding gauge coupling in the limit of strong supersymmetry breaking. The scalar masses are finite and a loop factor smaller than the gaugino masses. The LSP remains the gravitino.Comment: 36 pages, 2 figure