Real-time virtual collaborative environment designed for risk management training : communication and decision making

Les facteurs humains figurent parmi les causes originelles de trop nombreux accidents, dans les transports, l'industrie ou encore dans les parcours de soins. Dans ces contextes sociotechniques complexes et dynamiques, le risque de survenue d'incidents est permanent. La formation des équipes interprofessionnelles à la gestion des risques dans un environnement reproduisant fidèlement le contexte professionnel est un enjeu majeur. La motivation de cette thèse est de proposer un environnement virtuel multi-joueurs destiné à la formation à la gestion des risques liés à des défauts de communication ou de prises de décision. Pour cela, une méthode de création de scénarios interactifs destinés à la formation à la gestion des risques a été présentée. Un système de communication, un système collaboratif de prise de décision et un modèle de description d'objectifs complexes composés d'actions, de communications et de décisions sont présentés. L'environnement multi-joueurs interactif s'appuie sur cet ensemble cohérent. Ces systèmes et modèles proposés octroient une relative liberté aux équipes pour gérer la situation professionnelle présentée au sein de l'environnement virtuel. Ils permettent aussi le contrôle de la situation pédagogique dans son ensemble. Une méthode à forte valeur d'innovation a aussi été proposée pour structurer le débriefing d'une formation à la gestion des risques. Cela permet notamment d'automatiser la production de débriefing personnalisé, individuel et collectif à l'issu des séances de formation.Many accidents in transport, industry or healthcare result from a causal chain of events where inadvertent human errors have not been corrected in time. In such socio-technical and dynamic systems where complexity and unpredictability widespread, training teams to risk management in real-life like situations is crucial. This thesis aims to provide a virtual multi-player environment designed for inter-professional team training to risk management. To that end, a method to design risk management interactive and controlled scenario has been described. A communication system, a group decision making system and a team tracing model have been created. They all together enable the virtual team to be free enough to manage the educational situations. These coherent and innovative environment allows us to control the team activity and automate the edition of a personalized, individual and corporate debriefing at the end of a team training session

Mecagenius : An Innovative Learning Game for Mechanical Engineering.

International audienceThe present paper provides a description of Mecagenius, a learning game to teach mechanical engineering at an engineering faculty. Firstly, the Mecagenius game and learning content are introduced before practical ways of integrating this application in educational activities are explored in relation to the skills the teacher seeks to transmit knowledge. This is followed by a review of the literature on the educational effectiveness of serious games. Secondly, the learning game experience of Mecagenius on a course is reported, providing evaluations from both students and teachers. Interviews with teacher and students together with the collected computer records allow for an assessment of the advantages and drawbacks of teaching and learning with this kind of tool.Through a qualitative analysis of students’ game reports, the different strategies used in this educational environment are assessed

Danse-doigts, jeu de motricité fine

International audienceCe document décrit la conception, la réalisation et l'expérimentation de « Danse-doigts », une application ludo-thérapeutique à destination d'enfants hémiparétiques. L'objectif de ce logiciel est double : permettre d'entraîner leur motricité fine sur tablette puis d'étudier l'effet de cet entraînement sur leurs compétences numériques (dénombrement, calcul.. .). La population visée, comme l'objectif d'évaluation des compé-tences de calcul, ont influencé la conception. Le développement logiciel se base sur des technologies Web standard mais repose sur une bibliothèque de programmation parallèle en javascript. Applications et bibliothèques sont disponibles gratuitement et s'installent très facilement sur la plupart des tablettes tactiles

LIF Mediates Proinvasive Activation of Stromal Fibroblasts in Cancer

SummarySignaling crosstalk between tumor cells and fibroblasts confers proinvasive properties to the tumor microenvironment. Here, we identify leukemia inhibitory factor (LIF) as a tumor promoter that mediates proinvasive activation of stromal fibroblasts independent of alpha-smooth muscle actin (α-SMA) expression. We demonstrate that a pulse of transforming growth factor β (TGF-β) establishes stable proinvasive fibroblast activation by inducing LIF production in both fibroblasts and tumor cells. In fibroblasts, LIF mediates TGF-β-dependent actomyosin contractility and extracellular matrix remodeling, which results in collective carcinoma cell invasion in vitro and in vivo. Accordingly, carcinomas from multiple origins and melanomas display strong LIF upregulation, which correlates with dense collagen fiber organization, cancer cell collective invasion, and poor clinical outcome. Blockade of JAK activity by Ruxolitinib (JAK inhibitor) counteracts fibroblast-dependent carcinoma cell invasion in vitro and in vivo. These findings establish LIF as a proinvasive fibroblast producer independent of α-SMA and may open novel therapeutic perspectives for patients with aggressive primary tumors

PP270—Computational modeling of dravet syndrome

e102 Volume 35 Number 8S clorazepate (20mg 2× /d), and pregabalin (100 mg 3× /d). Because of resurgence of severe anxio-depressive symptoms, without any change of the treatment, the patient was readmitted 2 months later. Despite increasing the dose of clomipramine up to 225 mg/d, there was no clinical improvement, and the patient finally attempted to her life by abusing drugs. She then improved after 2 weeks on clomipramine IV (50 mg/d). Compliance was estimated good and no pharmacokinetic interactions with the rest of the treatment were found. C and DC plasma levels were measured, and CYP2D6/CYP2C19 genotype analyzed. Results: The plasma levels of C and DC are given in the Table below. Measures were done at the steady state and at trough concentration for IV treatment and 10 hours after the last dose for oral treatment

Experimental designs for small randomised clinical trials: An algorithm for choice

Background: Small clinical trials are necessary when there are difficulties in recruiting enough patients for conventional frequentist statistical analyses to provide an appropriate answer. These trials are often necessary for the study of rare diseases as well as specific study populations e.g. children. It has been estimated that there are between 6,000 and 8,000 rare diseases that cover a broad range of diseases and patients. In the European Union these diseases affect up to 30 million people, with about 50% of those affected being children. Therapies for treating these rare diseases need their efficacy and safety evaluated but due to the small number of potential trial participants, a standard randomised controlled trial is ofte

A Method to Design a Multi-Player Educational Scenario to Make Interdisciplinary Teams Experiment Risk Management Situation in a Digital Collaborative Learning Game: A Case of Study in Healthcare

In recent years, there has been an increasing interest for collaborative training in risk management. One of the critical point is to create educational and entirely controlled training environments that support industrial companies (in aviation, healthcare, nuclear…) or hospitals to train (future or not) professionals. The aim is to improve their teamwork performance making them understand the importance applying or adjusting safety recommendations. In this article, we present a method to design multi-player educational scenario for risk management in a socio-technical and dynamic context. The socio-technical situations focused in this article involve non-technical skills such as teamwork, communication, leadership, decision-making and situation awareness. The method presented here has been used to design as well regular situations as well as critical situations in which deficiencies already exist or mistakes can be freely made and fixed by the team in a controlled digital environment

Learning the cell cycle with a game: Virtual experiments in cell biology

Cell Cycle Learn (CCL) is a learning game designed for undergraduate students in Biology to learn common knowledge about the cell-division cycle along with practical skills related with setting up an experiment and the scientific method in general. In CCL, learners are guided through the process of formulating hypotheses, conducting virtual experiments and analysing the results in order to validate or invalidate the hypotheses. The game has been designed in the University of Toulouse and introduced last year as part of the curriculum of a cellular biology class. This paper presents early results of an evaluation of the game enabled by questionnaires filled by the participants and game data collected during the training sessions. The results demonstrate with examples that both types of data can be used to assess the game's utility