Factores que inciden en el cumplimiento del trabajo decente y los derechos humanos en el mercado del trabajo sexual, estudio a partir de un meta análisis

Trabajo de investigaciónEl presente trabajo tiene como objetivo identificar los factores que inciden en el cumplimiento del trabajo decente y los derechos humanos en el mercado del trabajo sexual.INTRODUCCIÓN 1. GENERALIDADES 2. METODOLOGÍA 3. CONCLUSIONES BIBLIOGRAFÍA ANEXOSPregradoEconomist

SOLUCIÓN DE DOS ESCENARIOS PRESENTES EN ENTORNOS CORPORATIVOS BAJO EL USO DE TECNOLOGÍA CISCO

En el presente documento se encuentran desarrollados dos escenarios que corresponden al Diplomado de Profundización CISCO CCNP (Certificado Profesional en redes de Cisco). Cada escenario esta compuesto por una red con topología diferente, las cuales fueron desarrolladas usando el software de simulación Cisco Packet Tracer, la infraestructura electronica se componen principalmente de routers y switchs, los cuales fueron configurados en el entorno de trabajo CLI (Interfaz de Línea de Comando). En estas redes, se habilitó la conmutación entre los diferentes dispositivos que la integran, con el fin de poder enviar y recepcionar paquetes. El primer escenario, conformado por una red conmutada de cinco enrutadores, se empleó los principios de enrutamiento y los protocolos EIGRP AS y OSPF, se crearon interfaces loopback en los extremos de la red, y se configuró la redistribución de rutas del protocolo EIGRP en OSPF y viceversa. El segundo escenario, se basa en una estructura Core de una empresa de telecomunicaciones en la cual se interconectó cada dispositivo de la red, configurando los puertos troncales y Port-channels, VLAN (Red de área local y virtual), VTP (VLAN Trunking Protocol) y STP (Spanning Tree Protocol).In the present document are developed two scenarios that correspond to the CISCO CCNP (Cisco Certified Networking Professional). Each scenario is composed of a network with different topology, which were developed using Cisco Packet Tracer simulation software, the electronic infrastructure is mainly composed of routers and switches, which were configured in the CLI (Command Line Interface) work environment. In these networks, switching was enabled between the different devices that integrate it, in order to be able to send and receive packets. The first scenario, consisting of a switched network of five routers, used the principles of routing and the EIGRP AS and OSPF protocols, created loopback interfaces at the ends of the network, and configured the redistribution of EIGRP protocol routes in OSPF and vice versa. The second scenario is based on a Core structure of a telecommunications company in which each network device was interconnected, configuring the trunk ports and Port-channels, VLAN (Virtual and Local Area Network), VTP (VLAN Trunking Protocol) and STP (Spanning Tree Protocol)

Androgen Receptor and Epidermal Growth Factor Signaling in Prostate Cancer

The androgen receptor (AR) is required for prostate cancer development and contributes to tumor progression following remission in response to androgen deprivation therapy. Epidermal growth factor (EGF) increases AR transcriptional activity at low levels of androgen in the CWR-R1 prostate cancer cell line derived from the castration-recurrent CWR22 prostate cancer xenograft. Our studies indicated that EGF does not regulate TIF2 mRNA levels and that TIF2 is required for AR transactivation induced by DHT and EGF in CWR-R1 cells. Real-time RT-PCR was used to determine that hK2 is a suitable marker for androgen-regulated gene transcription in CWR-R1 cells and that DHT does not up-regulate EGF transcription. Here we report that knockdown of AR decreases EGF stimulation of prostate cancer cell growth and demonstrate a mechanistic link between EGF and AR signaling. The EGF induced increase in AR transcriptional activity is dependent on phosphorylation at MAP kinase consensus site Ser-515 in the AR NH2-terminal region and at protein kinase C consensus site Ser-578 in the AR DNA binding domain. Phosphorylation at these sites alters the nuclear-cytoplasmic shuttling of AR and AR interaction with the Ku-70/80 regulatory subunits of DNA-dependent protein kinase. Abolishing AR Ser-578 phosphorylation by introducing an S578A mutation eliminates the AR transcriptional response to EGF, increases both AR binding of Ku-70/80 and nuclear retention of AR in association with hyperphosphorylation of AR Ser-515. AR-S578A did not transactivate the MMTV-Luc reporter and we show the negative regulatory element-1 in the long terminal repeat of MMTV mediates AR-induced transcription of that promoter. The results support a model in which AR transcriptional activity increases castration-recurrent prostate cancer cell growth in response to EGF by site-specific serine phosphorylation that regulates nuclear-cytoplasmic shuttling through interactions with the Ku-70/80 regulatory complex

Formulación del Plan Institucional de Gestión Ambiental (PIGA) para la Gobernación de Boyacá.

Teniendo en cuenta la importancia del cumplimiento de la Normatividad Ambiental vigente (Ley 99 de 1993) por parte de las entidades públicas, la Gobernación de Boyacá implementa estrategias como el Plan Institucional de Gestión Ambiental – PIGA (Instrumento de planeación que parte del análisis de la Situación Ambiental Institucional, con el propósito de brindar información y argumentos necesarios para el planteamiento de acciones de Gestión Ambiental que garanticen primordialmente el cumplimiento de los objetivos de ecoeficiencia establecidos) para el para el uso, cuidado, conservación y preservación del Medio Ambiente. (Secretaria Distrital de Ambiente, Alcaldía mayor de Bogotá, 2014). Este proyecto parte de una Revisión Ambiental Inicial (RAI) que se realiza dentro de la entidad para conocer e identificar los Aspectos e Impactos Ambientales que la organización genera en su quehacer diario y a partir de lo analizado, se implementan estrategias de Gestión Ambiental (uso responsable del agua, energía, control y aprovechamiento de los residuos sólidos, entre otras) y de mejora continua para mitigar y prevenir la contaminación en aras de mejorar las condiciones Ambientales a nivel interno y externo, garantizando un ambiente apropiado para empleados y usuarios.Taking into account the importance of compliance with the environmental regulations in force by public entities, the Government of Boyacá implements strategies such as the Institutional Plan of Environmental Management – PIGA (Planning instrument based on the analysis of the institutional environmental situation, for the purpose of providing information and arguments necessary for the approach of environmental management actions that primarily ensure compliance with the established ecoeficiency objectives) for the use, conservation and preservation of the environment. (District environmental secretary, mayor’s office of Bogotá, 2014). This project starts from an Initial Environmental Review (RAI) that is carried out within the entity to know and identify the environmental aspects and impacts that the organization generates in its daily work and based on the analyzed, Environmental management strategies are implemented (responsible use of water, energy, control and use of solid waste, among others) and continuous improvement to mitigate and prevent pollution in order to improve environmental conditions internally and externally, ensuring an appropriate environment for employees and users

Sector-wide analysis of early childhood development and education in emergencies in Colombia and considerations to strengthen systems globally

There is an urgent need to strengthen early childhood development and education in emergencies (ECDEiE) globally. Colombia has faced protracted and acute crises for decades. Also, the country has applied a unique approach to holistic and integrated ECDE policy formulation. We argue that these characteristics offer a valuable country-case to identify barriers and levers to the operationalization of ECDEiE. We applied a sector-wide analysis protocol that harmonized components of the Humanitarian Programme Cycle by the Inter-Agency Standing Committee and of a framework to characterize the governance of ECDE systems. The study outlines how the policy and program characteristics identified may represent levers or barriers to the effective operationalization of ECDEiE in Colombia. We discuss how these attributes could be considered in the trans-sectoral dialogue between ECDE and humanitarian actors with the aim of strengthening ECDEiE systems globally

Effectiveness of a youth-led early childhood care and education programme in rural Pakistan: A cluster-randomised controlled trial

Background: The United Nation\u27s Sustainable Development Goals encompass lifelong learning from birth to youth to adulthood (Goal 4) and economic opportunities for young people (Goal 8). The targets include improving access to quality early childhood care and education (ECCE) as well as learning and training opportunities for adolescents and youth. Cross-generational models for young children and youth may offer opportunities to address the interconnections between goals and targets for the next generation. We investigated whether an ECCE programme for young children (3.5-6.5 years) delivered by female youth (18-24 years) in rural Pakistan would be effective on children\u27s school readiness.Methods: In partnership with the National Commission for Human Development in Pakistan, we implemented the \u27Youth Leaders for Early Childhood Assuring Children are Prepared for School\u27 (LEAPS) programme to train female youth to deliver ECCE. The effectiveness of the LEAPS programme on children\u27s school readiness was evaluated in a cluster-randomised controlled trial. We randomly allocated five clusters (villages) to receive the intervention (n = 170 children) and five clusters to control (n = 170 children). Children\u27s school readiness was assessed after nine months of intervention exposure using the International Development and Early Learning Assessment tool. Analyses was by intention-to-treat. The trial is registered with ClinicalTrials.gov, number NCT02645162.Findings: At endline, the intervention group had significantly higher school readiness scores (n = 166, mean percentage score 59.4, 95% CI 52.7 to 66.2) compared with the control group (n = 168, mean percentage score 45.5, 95% CI 38.8 to 52.3). The effect size (Cohen\u27s d) was 0.3.Conclusion: Trained female youth delivered an ECCE programme that was effective in benefitting young children\u27s school readiness. The cross-generational model is a promising approach to support early child development; however, further evaluation of the model is needed to assess the specific benefits to youth including their skills and economic development

Variabilidad de resultados en la modelación numérica de pisos industriales, alternando el módulo de rotura del concreto

Trabajo de InvestigaciónEn esta investigación se realizó la modelación numérica de pisos industriales variando cinco módulos de rotura los cuales están en función del módulo de elasticidad (MR= 38, 40, 42, 45, 48 kg/cm2). Para dar alcance al proyecto se estableció como carga puntual, la correspondiente a un vehículo con ejes “single Wheel tándem” con una carga de (120KN), espesor de losa de 25cm, espesor de base 15cm, y modulación de losa con dimensiones de 4.6mX3.6m. Con lo cual se visualizó los esfuerzos de tensión máximos y tensión mínima, esfuerzos de compresión máximos y compresión mínima, y la ubicación de los esfuerzos máximos y minimos (x, y, z) en la losa, un plano de deformaciones de cada una de las simulaciones realizadas, encontrando como resultados que los esfuerzos de tensión se presentan en menor magnitud que los esfuerzos de compresión.PregradoIngeniero Civi

Androgen receptor phosphorylation at serine 308 and serine 791 predicts enhanced survival in castrate resistant prostate cancer patients

We previously reported that AR phosphorylation at serine 213 was associated with poor outcome and may contribute to prostate cancer development and progression. This study investigates if specific AR phosphorylation sites have differing roles in the progression of hormone naïve prostate cancer (HNPC) to castrate resistant disease (CRPC). A panel of phosphospecific antibodies were employed to study AR phosphorylation in 84 matched HNPC and CRPC tumours. Immunohistochemistry measured Androgen receptor expression phosphorylated at serine residues 94 (pAR<sub>94</sub>), 308 (pAR<sub>308</sub>), 650(pAR<sub>650</sub>) and 791(pAR<sub>791</sub>). No correlations with clinical parameters were observed for pAR<sub>94</sub> or pAR<sub>650</sub> in HNPC or CRPC tumours. In contrast to our previous observation with serine 213, high pAR<sub>308</sub> is significantly associated with a longer time to disease specific death (p= 0.011) and high pAR<sub>791</sub> expression significantly associated with a longer time to disease recurrence (p= 0.018) in HNPC tumours and longer time to death from disease recurrence (p= 0.040) in CRPC tumours. This observation in CRPC tumours was attenuated in high apoptotic tumours (p= 0.022) and low proliferating tumours (p= 0.004). These results demonstrate that understanding the differing roles of AR phosphorylation is necessary before this can be exploited as a target for castrate resistant prostate cancer

Criterios de implementación ISO 14001:2015 Caso estudio sector industria láctea.

Las industrias alimentarias especícamente las lácteas, son las que mayor impacto ambientales depositan al medio ambiente, empezando por sus proceso de elaboración de los productos, de acuerdo con esto se describe la descripción de la problemática ambiental de la empresa explicada más adelante, se relacionan a través del diagrama de ujo con las etapas de cada proceso, en este aspecto, cuando se procesa la materia prima, primordialmente la leche que es un producto perecedero, se requiere establecer periodos de almacenamiento y conservación prolongada, estos generan un gran volumen de residuos sólidos y líquidos, de los cuales están colmados de grasas, aceites, insumos químicos, y sólidos suspendidos. La presente auditoria interna, la organización se evaluó según los requerimientos de la norma ISO 14001:2015, en búsqueda de vericar el cumplimiento de las normas y principios que rigen el control, además se cuanticó los aspectos e impactos ambientales de cada actividad, estas están relacionadas con el medio ambiente. En este mismo orden de ideas se dene el alcance que la presente auditoria tiene, considerando la legislación aplicable al sector lácteo, así mismo se identica, dos aspectos e impactos ambientales mas signicativas, deniendo las acciones de mejoras que se pueden llegar a tomar en con el objetivo de; mitigar, compensar y/o disminuir los impactos generados por la actividad relacionada. Con la información recolectada y los resultados obtenidos se concretaron conclusiones y recomendaciones, además de esto se logró establecer dos preguntas basadas en la problemática ambiental y la norma aplicable, que desarrolla el sector de la industria láctea en la actual empresa.Criterios para la implementación de las normas ISO 14001:2015, 9001:2015 y 45001:2018, en la industria láctea.The food industries, specifically dairy products, have the greatest environmental impact they deposit in the environment, starting with the process of elaboration of the products, In agreement with this, the description of the environmental problems of the company is described explained below, are related through the flow diagram to the stages of each process, in this aspect, when the raw material is processed, primarily the milk that is a perishable product, it is necessary to establish periods of storage and conservation prolonged, these generate a large volume of solid and liquid waste, of which filled with fats, oils, chemical inputs, and suspended solids. The present internal audit, the organization was evaluated according to the requirements of the standard ISO 14001: 2015, seeking to verify compliance with the rules and principles that govern In addition, the environmental aspects and impacts of each activity were quantified, these they are related to the environment. In this same order of ideas, the scope is that the present audit has, considering the legislation applicable to the dairy sector, likewise identifies, two aspects and more significant environmental impacts, denoting the actions of improvements that can be made to take in order to; mitigate, compensate and / or decrease the impacts generated by the related activity. With the information collected and the results obtained conclusions and recommendations were finalized, in addition to this He was able to establish two questions based on environmental issues and the applicable standard, which develops the dairy industry sector in the current company