Morphology, biology and parasite fauna of the least cisco (Coregonus sardinella) of the Yenisei River

In the present study, we present an analysis of the morphological and ecological characteristics of the “turukhanskaja” form of the Siberian least cisco of the Yenisei River, including the characters of the size-age, sexual composition of the population, fecundity and growth. The variability of 34 morphological characters was studied. Significant differences were noted between males and females of the least cisco of the Yenisei River for 11 morphometric characters (head length, maximum body depth, caudal peduncle length, antepectoral distance, dorsal fin base length and dorsal fin depth, anal fin base length, pectoral fin length, head width, head (at nape), interorbital width). Significant differences in meristic characters were revealed in comparison of the least cisco from the Yenisei River with populations of Siberian least cisco from other water bodies. It was shown that the Yenisei least cisco is close to the European vendace Coregonus albula Linnaeus, 1758 not only according to cluster hierarchical analysis for some meristic and morphometric features but also in terms of growth and fecundity. In general, the Yenisei least cisco, as well as other populations of least cisco of the Taimyr, is characterized by heterogeneity in the structure of populations. The parasite fauna of Yenisei’s Siberian cisco, captured in the area of Dudinka town, consists of 17 species of parasites from seven systematic groups. It is dominated by Diphyllobothrium ditremum (Creplin, 1825) and Discocotyle sagittata (Leuckart, 1842). The feature of the parasite fauna of least cisco from Yenisei River in comparison with the Ob River (neighbouring water basin) is a low infection with trematodes and a high species diversity of Acanthocephala. The reason for the low infection with trematodes may be differences in the hydrological conditions of the water bodies, which in the Yenisei are unfavourable for the development of intermediate hosts of trematodes. Siberian cisco from the Yenisei River is a carrier of Diphyllobothrium dendriticum (Nitzsh, 1824), a species that can cause human disease

ЭКОЛОГО-ФАУНИСТИЧЕСКИЙ ОБЗОР ПАРАЗИТОВ ЛОСОСЕВИДНЫХ РЫБ ОЗЕРА СОБАЧЬЕ (ПЛАТО ПУТОРАНА)

Objective of research: The purpose of our research was to study parasite fauna of salmonoid fishes from thelakeSobach’e (Putorana plateau) and to report its ecological and faunistic characteristics.Material and methods: 88 specimens of salmonoid fishes (herring, siberian whitefish, round whitefish, arctic grayling and dominant species of char) were collected from thelakeSobach’e in July - August 2014. Collecting, fixation and cameral treatment were carried out using the standard method of Bykhovskaya-Pavlovskaya. Statistical treatment of the data was conducted using the Quantitative Parasitology 3.0 software.Results and discussion: Data on parasite infestation of salmonoid fishes from thelakeSobach’e is provided. 29 parasite species (Myxosporea – 3, Monogenea – 2, Cestoda – 7, Trematoda – 7, Nematoda – 3, Acanthocephala – 4, Hirudinea – 1, Crustacea – 2) were found. Analysis of parasite distribution in their fish hosts was described. The lake has been classified as oligotrophic with the features of subfamilies Orthocladiinae and Pontoporane according to the concept of the parasitological typing of lakes presented by Rumyantsev E.A.Цель исследований: Изучение паразитофауны лососевидных рыб озера Собачьего (плато Путорана) и описание ее эколого-фаунистической характеристики.Материалы и методы: Исследованы 88 экз. лососевидных видов рыб (сибирская ряпушка, сиг-пыжьян, валёк, сибирский хариус, массовые виды гольцов), отловленных в оз. Собачьем в июле-августе 2014 года. Сбор, фиксацию и камеральную обработку паразитологических проб проводили по общепринятой методике Быховской-Павловской. Статистический анализ зараженности рыб проводился с помощью программы Quantitative Parasitology 3.0.Результаты и обсуждение: Собраны данные по зараженности паразитами лососевидных рыб озера Собачьего. Обнаружено 29 видов паразитов (Myxosporea – 3, Monogenea – 2, Cestoda – 7, Trematoda – 7, Nematoda – 3, Acanthocephala – 4, Hirudinea – 1, Crustacea – 2). Проведен анализ распределения паразитов по видам рыб-хозяев. Озеро классифицировано как олиготрофное с признаками ортокладиинового и понтопорейного классов по концепции паразитологической типизации озер, описанной Е.А. Румянцевым

ECOLOGICAL-FAUNISTICAL REVIEW OF FISH PARASITES FROM THE LAKE SOBACH’E (PUTORANA PLATEAU)

Objective of research: The purpose of our research was to study parasite fauna of salmonoid fishes from thelakeSobach’e (Putorana plateau) and to report its ecological and faunistic characteristics.Material and methods: 88 specimens of salmonoid fishes (herring, siberian whitefish, round whitefish, arctic grayling and dominant species of char) were collected from thelakeSobach’e in July - August 2014. Collecting, fixation and cameral treatment were carried out using the standard method of Bykhovskaya-Pavlovskaya. Statistical treatment of the data was conducted using the Quantitative Parasitology 3.0 software.Results and discussion: Data on parasite infestation of salmonoid fishes from thelakeSobach’e is provided. 29 parasite species (Myxosporea – 3, Monogenea – 2, Cestoda – 7, Trematoda – 7, Nematoda – 3, Acanthocephala – 4, Hirudinea – 1, Crustacea – 2) were found. Analysis of parasite distribution in their fish hosts was described. The lake has been classified as oligotrophic with the features of subfamilies Orthocladiinae and Pontoporane according to the concept of the parasitological typing of lakes presented by Rumyantsev E.A

EXPERIENCE OF ADALIMUMAB TREATMENT IN PATIENT WITH JUVENILE ANKYLOSING SPONDYLITIS AND UVEITIS

A medical case of early onset and severe course of juvenile ankylosing spondylitis and eyes involvement resistant to routine immunosuppressive drugs is represented in this article. The successful treatment with biological agent adalimumab is described. By the 4th week of treatment the acute inflammatory changes in joints have been arrested, the motion capacity completely restored. By the 8th week of treatment the remission of uveitis has been confirmed, the laboratory indicators of active stage of disease (ESR, serum CRP) have been normalized

ОПЫТ ПРИМЕНЕНИЯ АДАЛИМУМАБА У БОЛЬНОГО ЮВЕНИЛЬНЫМ АНКИЛОЗИРУЮЩИМ СПОНДИЛИТОМ И УВЕИТОМ

A medical case of early onset and severe course of juvenile ankylosing spondylitis and eyes involvement resistant to routine immunosuppressive drugs is represented in this article. The successful treatment with biological agent adalimumab is described. By the 4th week of treatment the acute inflammatory changes in joints have been arrested, the motion capacity completely restored. By the 8th week of treatment the remission of uveitis has been confirmed, the laboratory indicators of active stage of disease (ESR, serum CRP) have been normalized.  В данной статье представлен случай раннего дебюта и тяжелого течения ювенильного спондилита с поражением глаз, рефрактерного к терапии классическими иммунодепрессантами. Описано успешное применение биологического агента — адалимумаба. Уже к 4-й нед терапии купировались островоспалительные изменения в пораженных суставах, полностью восстановился объем движений в них; к 8-й нед отмечена ремиссия увеита, нормализовались лабораторные показатели активности заболевания — СОЭ, сывороточная концентрация СРБ.

Contemporary Presentation and Management of Valvular Heart Disease The EURObservational Research Programme Valvular Heart Disease II Survey

International audienceBackground: Valvular heart disease (VHD) is an important cause of mortality and morbidity and has been subject to important changes in management. The VHD II survey was designed by the EURObservational Research Programme of the European Society of Cardiology to analyze actual management of VHD and to compare practice with guidelines. Methods: Patients with severe native VHD or previous valvular intervention were enrolled prospectively across 28 countries over a 3-month period in 2017. Indications for intervention were considered concordant if the intervention was performed or scheduled in symptomatic patients, corresponding to Class I recommendations specified in the 2012 European Society of Cardiology and in the 2014 American Heart Association/American College of Cardiology VHD guidelines. Results: A total of 7247 patients (4483 hospitalized, 2764 outpatients) were included in 222 centers. Median age was 71 years (interquartile range, 62-80 years); 1917 patients (26.5%) were >= 80 years; and 3416 were female (47.1%). Severe native VHD was present in 5219 patients (72.0%): aortic stenosis in 2152 (41.2% of native VHD), aortic regurgitation in 279 (5.3%), mitral stenosis in 234 (4.5%), mitral regurgitation in 1114 (21.3%; primary in 746 and secondary in 368), multiple left-sided VHD in 1297 (24.9%), and right-sided VHD in 143 (2.7%). Two thousand twenty-eight patients (28.0%) had undergone previous valvular intervention. Intervention was performed in 37.0% and scheduled in 26.8% of patients with native VHD. The decision for intervention was concordant with Class I recommendations in symptomatic patients with severe single left-sided native VHD in 79.4% (95% CI, 77.1-81.6) for aortic stenosis, 77.6% (95% CI, 69.9-84.0) for aortic regurgitation, 68.5% (95% CI, 60.8-75.4) for mitral stenosis, and 71.0% (95% CI, 66.4-75.3) for primary mitral regurgitation. Valvular interventions were performed in 2150 patients during the survey; of them, 47.8% of patients with single left-sided native VHD were in New York Heart Association class III or IV. Transcatheter procedures were performed in 38.7% of patients with aortic stenosis and 16.7% of those with mitral regurgitation. Conclusions: Despite good concordance between Class I recommendations and practice in patients with aortic VHD, the suboptimal number in mitral VHD and late referral for valvular interventions suggest the need to improve further guideline implementation

Chronic coronary syndromes without standard modifiable cardiovascular risk factors and outcomes: the CLARIFY registry

Background and Aims: It has been reported that patients without standard modifiable cardiovascular (CV) risk factors (SMuRFs—diabetes, dyslipidaemia, hypertension, and smoking) presenting with first myocardial infarction (MI), especially women, have a higher in-hospital mortality than patients with risk factors, and possibly a lower long-term risk provided they survive the post-infarct period. This study aims to explore the long-term outcomes of SMuRF-less patients with stable coronary artery disease (CAD). Methods: CLARIFY is an observational cohort of 32 703 outpatients with stable CAD enrolled between 2009 and 2010 in 45 countries. The baseline characteristics and clinical outcomes of patients with and without SMuRFs were compared. The primary outcome was a composite of 5-year CV death or non-fatal MI. Secondary outcomes were 5-year all-cause mortality and major adverse cardiovascular events (MACE—CV death, non-fatal MI, or non-fatal stroke). Results: Among 22 132 patients with complete risk factor and outcome information, 977 (4.4%) were SMuRF-less. Age, sex, and time since CAD diagnosis were similar across groups. SMuRF-less patients had a lower 5-year rate of CV death or non-fatal MI (5.43% [95% CI 4.08–7.19] vs. 7.68% [95% CI 7.30–8.08], P = 0.012), all-cause mortality, and MACE. Similar results were found after adjustments. Clinical event rates increased steadily with the number of SMuRFs. The benefit of SMuRF-less status was particularly pronounced in women. Conclusions: SMuRF-less patients with stable CAD have a substantial but significantly lower 5-year rate of CV death or non-fatal MI than patients with risk factors. The risk of CV outcomes increases steadily with the number of risk factors