Silica@zirconia@poly(malic acid) nanoparticles: promising nanocarriers for theranostic applications

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Species History Masks the Effects of Human-Induced Range Loss – Unexpected Genetic Diversity in the Endangered Giant Mayfly Palingenia longicauda

Freshwater biodiversity has declined dramatically in Europe in recent decades. Because of massive habitat pollution and morphological degradation of water bodies, many once widespread species persist in small fractions of their original range. These range contractions are generally believed to be accompanied by loss of intraspecific genetic diversity, due to the reduction of effective population sizes and the extinction of regional genetic lineages. We aimed to assess the loss of genetic diversity and its significance for future potential reintroduction of the long-tailed mayfly Palingenia longicauda (Olivier), which experienced approximately 98% range loss during the past century. Analysis of 936 bp of mitochondrial DNA of 245 extant specimens across the current range revealed a surprisingly large number of haplotypes (87), and a high level of haplotype diversity (). In contrast, historic specimens (6) from the lost range (Rhine catchment) were not differentiated from the extant Rába population (, ), despite considerable geographic distance separating the two rivers. These observations can be explained by an overlap of the current with the historic (Pleistocene) refugia of the species. Most likely, the massive recent range loss mainly affected the range which was occupied by rapid post-glacial dispersal. We conclude that massive range losses do not necessarily coincide with genetic impoverishment and that a species' history must be considered when estimating loss of genetic diversity. The assessment of spatial genetic structures and prior phylogeographic information seems essential to conserve once widespread species

Rhetorical-Performative Analysis of the Urban Symbolic Landscape : Populism in Action

This chapter introduces a rhetorical-performative analysis as a tool for exploring urban symbolic landscape and populism and hence deals with relationality and materiality from the postfoundational perspective. It connects the articulation theory of cultural theorists Stuart Hall or political theorists Ernesto Laclau and Chantal Mouffe and spatial analysis of cultural geographer Doreen Massey to the study of populism. The case of Hungary shows how political frontiers have been articulated in the public space, contestable interpretations of the past are deliberately used and key symbolic urban landscapes transformed radically to articulate a political ‘us’—and ‘them.’ In the 2010s, in the Hungarian capital Budapest, the top-down process transforming urban space faced bottom-up movements which reproduce the populist logic of articulation.Peer reviewe

Nonlinear equation systems

Nonlinear equation systems may be solved by using a modified version of the Levenberg-Marquardt algorithm

Nonlinear equation systems

Nonlinear equation systems may be solved by using a modified version of the Levenberg-Marquardt algorithm.THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE. TO VIEW A LIST OF FILES AND ACCESS THE FILES IN THIS DATASET CLICK ON THE DOI-LINK ABOV

HUNGARY. Risks and Opportunities Related to Media and Journalism Studies (2000–2020). Case Study on the National Research and Monitoring Capabilities.

The Hungarian media market is relatively small, but the media policies of the 2010s have drawn attention to media regulation and market issues, so there are a large number of resources available for studying the conditions for deliberative communication in Hungary. After mapping the relevant literature from the period between 2000 and 2020, the Hungarian bibliographical database contains 650 records. Data and research are rather fragmented, there are limited, but not unprecedented longitudinal monitorings. For the study of the four domains defined in the theoretical background of the Mediadelcom project, we have information for almost every variable – some of it from quantitative, some from qualitative approaches. A decent quantity and high quality of data are available from the academic and NGO sectors, but we can also rely on useful materials from state and industry actors. There is also a strong international research focus on Hungary, with European Union bodies, international NGOs, and academic research projects regularly dealing with the Hungarian media situation. However, this does not mean that Hungary's media monitoring potential could be considered as ideal. This case study has also identified serious risks, but some of them can be counterbalanced or mitigated by some actors through good practices and by creating opportunities for monitoring the media in Hungary

HUNGARY. Critical junctures in the media transformation process.

In the research period between 2000 and 2020 several critical junctures can be determined that have universally designated the development of media not just in Hungary, but in other participating countries as well. There are some country-specific developments, too. The advent of online media thanks to the broadband Internet technologies from 2000, joining to the European Union in 2004, the rise of social media from the second half of the first decade, the world economic crises from 2008, the constitutional majority victory of Fidesz in 2010, the migration crisis, the so-called “Orbán-Simicska war” in 2015 and the coronavirus pandemic in 2020. Some of these junctures created risk and opportunities in all domains of the media system, the legal environment, the media market and the situation of journalism, the media usage habits and the field of media literacy. The Hungarian media situation is particularly complex. If we look at the variables defined in the theoretical background of the Mediadelcom project, which aims to capture the guarantees that ensure the conditions for deliberative communication, we can see that there are few areas in this respect where we cannot identify serious risks

Folate receptor targeted self-assembled chitosan-based nanoparticles for SPECT/CT imaging: demonstrating a preclinical proof of concept

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Preparation and 68Ga-radiolabeling of porous zirconia nanoparticle platform for PET/CT-imaging guided drug delivery

This paper describes the preparation of gallium-68 (68Ga) isotope labeled porous zirconia (ZrO2) nanoparticle (NP) platform of nearly 100 nm diameter and its first pharmacokinetic and biodistribution evaluation accomplished with a microPET/CT (�Pet/CT) imaging system. Objectives of the investigations were to provide a nanoparticle platform which can be suitable for specific delivery of various therapeutic drugs using surface attached specific molecules as triggering agents, and at the same time, suitable for positron emission tomography (PET) tracing of the prospective drug delivery process. Radiolabeling was accomplished using DOTA bifunctional chelator. DOTA was successfully adsorbed onto the surface of nanoparticles, while the 68Ga-radiolabeling method proved to be simple and effective. In the course of biodistribution studies, the 68Ga-labeled DOTA-ZrNPs showed proper radiolabeling stability in their original suspension and in blood serum. �Pet/CT imaging studies confirmed a RESbiodistribution profile indicating stable nano-sized labeled particles in vivo. Results proved that the new method offers the opportunity to examine further specifically targeted and drug payload carrier variants of zirconia NP systems using PET/CT imaging