Gundissalinus on the Angelic Creation of the Human Soul: A Peculiar Example of Philosophical Appropriation

With his original reflection—deeply influenced by many important Arabic thinkers—Gundissalinus wanted to renovate the Latin debate concerning crucial aspects of the philosophical tradition. Among the innovative doctrines he elaborated, one appears to be particularly problematic, for it touches a very delicate point of Christian theology: the divine creation of the human soul, and thus, the most intimate bond connecting the human being and his Creator. Notwithstanding the relevance of this point, Gundissalinus ascribed the creation of the human soul to the angels rather than God. He also stated that the angels create the souls from prime matter, and through a kind of causality which cannot be operated by God. What are the sources of this unusual and perilous doctrine? And what are the reasons which led Gundissalinus to hold such a problematic position? This article thoroughly examines the theoretical development and sources of Gundissalinus’s position, focusing on the correlations between this doctrine, the overall cosmological descriptions expounded by Gundissalinus in his original works, and the main sources upon which this unlikely doctrine is grounded: Avicenna and Ibn Gabirol

Gundissalinus and Avicenna: Some Remarks on an Intricate Philosophical Connection

This article analyses the peculiarities of Dominicus Gundissalinus’s reading and use of Avicenna’s writings in his original works. Gundissalinus (1120ca – post 1190) is the Latin translator of Avicenna’s De anima and Liber de philosophia prima, but also an original philosopher whose writings are precious witnesses of the very first reception of Avicennian philosophy in the Latin West. The article points out the structural bond with the Persian philosopher upon which Gundissalinus grounds his own speculation. This contribution stresses, in particular, the important role played by Avicenna’s psychology, epistemology, and metaphysics in order to provide Gundissalinus with a different set of answers to at least two main questions. On the one hand, the problem of creatural existence and cosmological causation, concerning which Gundissalinus tends to doctrinally merge Avicenna with Ibn Gabirol. On the other hand, Avicenna’s influence is crucial for Gundissalinus’s attempt at elaborating a new system of knowledge, which was supposed to be able to include the new sciences made available by the translation movement, but that also needed to be internally organised through firm epistemological principles. Beside his crucial contribution as translator, Gundissalinus’s first philosophical encounter with the Avicenna paved the road for the subsequent reception of the Persian philosopher’s works, opening a hermeneutical perspective which would be pivotal for the thirteenth-century discussions on soul, knowledge, and being

Gundissalinus and the Application of al-Fārābī's Metaphysical Programme. A Case of Philosophical Transfer

This study deals with Dominicus Gundissalinus's discussion on metaphysics as philosophical discipline. Gundissalinus's translation and re-elaboration of al-Fārābī's Iḥṣā' al-ʿulūm furnish him, in the De scientiis, a specific and detailed procedure for metaphysical analysis articulated in two different stages, an ascending and a descending one. This very same procedure is presented by Gundissalinus also in his De divisione philosophiae, where the increased number of sources –in particular, Avicenna– does not prevent Gundissalinus to quote the entire passage on the methods of metaphysical science from the Iḥṣā' al-ʿulūm, with some slight changes in his Latin translation. The analytical procedure herein proposed becomes an effective 'metaphysical programme' with regards to Gundissalinus's onto-cosmological writing, the De processione mundi. The comparative analysis of this treatise with the procedure received by al-Fārābī shows Gundissalinus's effort to follow and apply this metaphysical programme to his own reflection, in a whole different context from al-Fārābī's and presenting doctrines quite opposed to the theoretical ground on which al-Fārābī's epistemology is based, like ibn Gabirol's universal hylomorphism. Nevertheless, thanks to the application of the 'metaphysical programme', one can effectively claim that Gundissalinus's metaphysics is, at least in the author's intentions, a well-defined metaphysical system. In appendix to this article the three Latin versions of al-Fārābī's discussion on metaphysics are reported, e.g., Gundissalinus's quotations in De scientiis and De divisione philosophiae, and Gerard of Cremona's translation in his De scientiis

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Quantitation of regional ejection fractions using gated tomographic imaging with Tc-99m-sestamibi

BACKGROUND: A new oro-dispersible film (ODF) formulation of sildenafil has been developed for the treatment of erectile dysfunction (ED) to overcome the drawbacks that some patients experience when taking the conventional film-coated tablet (FCT). AIM: To assess the effectiveness and safety of sildenafil ODF formulation in patients with ED who were using the conventional FCT. METHODS: From May 2017 through July 2017, 139 patients with ED were enrolled. Data from penile color-duplex ultrasound, medical history, hormonal evaluation, and patient self-administered questionnaires were collected. All patients were administered sildenafil 100-mg FCT for 4 weeks. Thereafter, they underwent a 2-week washout period and subsequently took sildenafil 75-mg ODF for 4 weeks. OUTCOMES: The International Index of Erectile Function (IIEF-15), Hospital Anxiety and Depression Scale (HADS), Patient Global Impressions of Improvement (PGI-I), and Clinician Global Impressions of Improvement (CGI-I) questionnaires were administered and severity of ED was classified as severe (IIEF-15 score ≤ 10), moderate (IIEF-15 score 11-16), or mild (IIEF-15 score = 17-25). RESULTS: All patients completed the final protocol. Differences in mean IIEF scores for erectile function, orgasmic function, sexual desire, and intercourse satisfaction were significantly in favor of sildenafil 100-mg FCT, whereas the mean score for overall satisfaction was in favor of sildenafil 75-mg ODF. A significant difference in changes in HADS score was found from washout to final follow-up (mean difference = -0.19; P < .01). For the ODF formulation, the median CGI-I score was 3.5 (interquartile range [IQR] = 2.5-4.5) and the median PGI-I score was 3.0 (IQR = 2.0-4.0). The median action time was 20.0 minutes (IQR = 15.0-30.0) and the median mouth time was 60.0 seconds (IQR = 30.0-120.0). CLINICAL IMPLICATIONS: The ODF formulation of a widely known drug, with the same safety and effectiveness of the FCT, was better appreciated by patients in overall satisfaction. STRENGTHS AND LIMITATIONS: This is the first clinical trial to assess the efficacy of a new formulation of sildenafil in patients with ED. The limitations of the study are related to the methodology used: it was not a case-control study and the patients were not drug-naïve for ED treatment. Therefore, only the "additional" side effects of the ODF formulation compared with FCT are reported. CONCLUSION: The new ODF formulation is as efficient and safe as the FCT formulation and offers a new choice of treatment to specialists for more precisely tailored therapy. Cocci A, Capece M, Cito G, et al. Effectiveness and Safety of Oro-Dispersible Sildenafil in a New Film Formulation for the Treatment of Erectile Dysfunction: Comparison Between Sildenafil 100-mg Film-Coated Tablet and 75-mg Oro-Dispersible Film. J Sex Med 2017;X:XXX-XXX