Università e territorio. Studi e progetti per l’ambito urbano lecchese nel decennale del corso di laurea ingegneria edile-architettura

ll volume, realizzato a integrazione e supporto dell’omonima mostra ideata e realizzata da Marco Muscogiuri e Piero Poggioli (Lecco, Scuderie di Villa Manzoni, Febbraio-Marzo 2009), raccoglie i testi redatti dai docenti del Politecnico di Milano e documenta il lavoro di studio, di analisi e di progetto, sviluppato sul territorio lecchese nell’ambito della didattica e della ricerca universitaria

Assessment of Identity Disturbance: Factor Structure and Validation of the Personality Structure Questionnaire in an Italian Sample

here are few brief measures of identity disturbance for use in clinical practice that have been subject to any cross - culturally validation . This study investigated the construct validity of the Personality Structure Questionnaire (PSQ) in Italian clinical (N=237) and community ( N=296) samples . Confirmatory factor analysis was conducted to investigate the internal structure of the PSQ. A three – factor structure (i.e., differing self - states, mood variability and behavioral loss of control) including a second - order factor provided the best fit to the data . This structure was demonstrated to be invariant across sex and clinical diagnosis , with clinical diagnosis significantly predicting increased PSQ scores . A g lobal PSQ score of between 26 - 28 was found to be an appropriate cut-off for assisting in diagnostic processes. Implications for the assessment and treatment of psychological disorders with a marked identity disturbance component are discussed

Renal Stone Formation in Patients with Inflammatory Bowel Disease

Kidney stones are more common in patients with inflammatory bowel disease (IBD) than in the general population. The main lithogenetic risk factors were evaluated in patients affected by Crohn\u27s disease and ulcerative colitis. Our results show the presence of several factors, besides hyperoxaluria, in patients with IBD although their behaviour appears different in Crohn\u27s disease and ulcerative colitis at pre- and post-operative stages. Before surgery in patients with Crohn\u27s disease we found a decreased citrate (p \u3c 0.001) and magnesium (p \u3c 0.005) excretion together with a low urinary volume (p \u3c 0.001) and pH (p \u3c 0.005). After surgery patients with Crohn\u27s disease showed a further reduction of magnesium and citrate. Patients with ulcerative colitis before surgery showed a reduced citrate excretion (p \u3c 0.05) and a more acidic pH (p \u3c 0.05) than healthy subjects. Surgical treatment of proctocolectomy with ileal pouch-anal anastomosis seems to increase the risk of stone formation; in fact, after surgery we observed a relevant decrease of urinary volume (p \u3c 0.001), pH (p \u3c 0.0001) and urinary excretion of citrate (p \u3c0.0001) as well as magnesium (p \u3c 0.005). Patients with IBD seem to be at greater risk of stone formation than patients with idiopathic calcium lithiasis; in fact, they show a lower excretion of citrate (p \u3c 0.001) and magnesium (p \u3c 0.001) together with a low urinary pH (p \u3c 0.001) and volume (p \u3c 0.001). Urinary volume reduction is probably one of the major risk factors together with the decrease of small molecular weight inhibitors that is a constant finding in all patients with IBD

Infliximab in the treatment of Crohn's disease

The recent introduction of infliximab, a chimeric monoclonal antibody against tumor necrosis factor-alpha, has greatly modified the treatment of Crohn's disease (CD). Data from the literature show encouraging results after intravenous infusion both for closure of intestinal or perianal fistulas and for induction and maintenance of remission in patients with moderate to severe intestinal disease unresponsive to other treatments. However, some contraindications such as fibrostenosing CD and sepsis have been identified. In addition, the data on long-term outcomes and safety is still limited. Our initial experience showed that in selected cases local injection of infliximab is effective in the treatment of complex perianal disease offering the possibility of using such treatment even in small bowel obstructing disease with minimal systemic effects. This paper analyzes the state of the use of both intravenous and local injection of infliximab in patients with CD

Combined carriership of TLR9-1237C and CD14-260T alleles enhances the risk of developing chronic relapsing pouchitis

AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity. METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G, TLR9 -1237T>C, TLR9+2848G>A, and IRAKM + 22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients, 35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls. RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients. However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, oddos ratio (OR) = 3.2, 95%CI = 1.2-8.6]. This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians. Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3). CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis

Weakly-Coupled Higgs Bosons and Precision Electroweak Physics

We examine the prospects for discovering and elucidating the weakly-coupled Higgs sector at future collider experiments. The Higgs search consists of three phases: (i) discovery of a Higgs candidate, (ii) verification of the Higgs interpretation of the signal, and (iii) precision measurements of Higgs sector properties. The discovery of one Higgs boson with Standard Model properties is not sufficient to expose the underlying structure of the electroweak symmetry breaking dynamics. It is critical to search for evidence for a non-minimal Higgs sector and/or new physics associated with electroweak symmetry breaking dynamics. An improvement in precision electroweak data at future colliders can play a useful role in confirming the theoretical interpretation of the Higgs search results

Energy Linearity and Resolution of the ATLAS Electromagnetic Barrel Calorimeter in an Electron Test-Beam

A module of the ATLAS electromagnetic barrel liquid argon calorimeter was exposed to the CERN electron test-beam at the H8 beam line upgraded for precision momentum measurement. The available energies of the electron beam ranged from 10 to 245 GeV. The electron beam impinged at one point corresponding to a pseudo-rapidity of eta=0.687 and an azimuthal angle of phi=0.28 in the ATLAS coordinate system. A detailed study of several effects biasing the electron energy measurement allowed an energy reconstruction procedure to be developed that ensures a good linearity and a good resolution. Use is made of detailed Monte Carlo simulations based on Geant which describe the longitudinal and transverse shower profiles as well as the energy distributions. For electron energies between 15 GeV and 180 GeV the deviation of the measured incident electron energy over the beam energy is within 0.1%. The systematic uncertainty of the measurement is about 0.1% at low energies and negligible at high energies. The energy resolution is found to be about 10% sqrt(E) for the sampling term and about 0.2% for the local constant term

Position resolution and particle identification with the ATLAS EM calorimeter

In the years between 2000 and 2002 several pre-series and series modules of the ATLAS EM barrel and end-cap calorimeter were exposed to electron, photon and pion beams. The performance of the calorimeter with respect to its finely segmented first sampling has been studied. The polar angle resolution has been found to be in the range 50-60 mrad/sqrt(E (GeV)). The neutral pion rejection has been measured to be about 3.5 for 90% photon selection efficiency at pT=50 GeV/c. Electron-pion separation studies have indicated that a pion fake rate of (0.07-0.5)% can be achieved while maintaining 90% electron identification efficiency for energies up to 40 GeV.Comment: 32 pages, 22 figures, to be published in NIM