Factors Influencing Chat-Based Cultural Discussions for Learning History in a 3D Virtual World

In a fast-changing world, there is an increasingly felt need to bring what we teach and how we teach it intothe 21st Century. Learning@Europe is an attempt in this direction: a shared online virtual world where students from different European countries meet to play and learn about European history. Chat-based discussions of study material, research homework to prepare in col-laboration with remote peers on online forums, team games and a cultural com-petition are the main ingredients of this innovative experience, already tested by over 6000 high-school students and teachers from 18 European countries. This paper focuses on a particular Learning@Europe activity – chat-based cultural discussions about history – and analyzes the elements that are essential to its success. Basing on evaluation data and our 3-years experience, we describe strategies deal with the different elements to be taken into account: Technology; Content; Interaction Design; and – mostimportant of all – Social Behavior

DOMANDE E RISPOSTE SUL SISTEMA INTEGRATO DI VALUTAZIONE PREVENTIVA DELL'INQUINAMENTO ELETTROMAGNETICO AMBIENTALE A BASSISSIMA FREQUENZA PLEIA-CERT

L’ARPAT e l’IFAC-CNR collaborano ormai da oltre cinque anni allo sviluppo del Catasto degli Elettrodotti della Regione Toscana (CERT) e di un sistema integrato di applicazioni, denominato PLEIA (Power Line Electromagnetic Impact Assessment), per il suo utilizzo ai fini del calcolo del campo magnetico nello spazio circostante gli elettrodotti e, in particolare, della determinazione delle fasce di rispetto. Per rendere possibile a queste istituzioni un utilizzo corretto e consapevole degli strumenti realizzati e dei risultati da essi forniti, è stato indispensabile documentare innanzitutto i presupposti tecnici e metodologici che stanno alla base delle applicazioni sviluppate: a questo scopo, è venuto spontaneamente a crearsi un gruppo di lavoro informale tra esperti dell’ARPAT, dell’IFAC e della Regione Toscana. Il gruppo ha lavorato secondo un meccanismo virtuoso in cui, da un lato, si è cercato di formulare quesiti puntuali e ben definiti e, dall'altro, di rispondervi nel modo più chiaro ed esauriente possibile. Ne è scaturito un documento a domande e risposte che, opportunamente modificato, è riproposto in questa sede, perché mette in evidenza in modo semplice ma non banale alcuni rilevanti aspetti tecnici, e costituisce un buon documento introduttivo sulle potenzialità del sistema sviluppato. Le prime domande riguardano il sistema PLEIA-CERT in generale, mentre nella seconda parte si approfondiscono in particolare le modalità di calcolo delle fasce di rispetto che, anche alla luce di recenti sviluppi normativi, hanno assunto un ruolo di primaria importanza

Il sistema integrato di valutazione preventiva dell?inquinamento elettromagnetico ambientale a bassissima frequenza PLEIA?CERT

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Energy and angular momentum sharing in dissipative collisions

Primary and secondary masses of heavy reaction products have been deduced from kinematics and E-ToF measurements, respectively, for the direct and reverse collisions of 93Nb and 116Sn at 25 AMeV. Light charged particles have also been measured in coincidence with the heavy fragments. Direct experimental evidence of the correlation of energy-sharing with net mass transfer has been found using the information from both the heavy fragments and the light charged particles. The ratio of Hydrogen and Helium multiplicities points to a further correlation of angular momentum sharing with net mass transfer.Comment: 21 pages, 20 figures. Submitted to European Physics Journal

Circuit Complexity Meets Ontology-Based Data Access

Ontology-based data access is an approach to organizing access to a database augmented with a logical theory. In this approach query answering proceeds through a reformulation of a given query into a new one which can be answered without any use of theory. Thus the problem reduces to the standard database setting. However, the size of the query may increase substantially during the reformulation. In this survey we review a recently developed framework on proving lower and upper bounds on the size of this reformulation by employing methods and results from Boolean circuit complexity.Comment: To appear in proceedings of CSR 2015, LNCS 9139, Springe

Defective Expression and Function of the Leukocyte Associated Ig-like Receptor 1 in B Lymphocytes from Systemic Lupus Erythematosus Patients

Systemic lupus erythematosus (SLE) is characterized by the production of a wide array of autoantibodies and dysregulation of B cell function. The leukocyte associated Immunoglobulin (Ig)-like receptor (LAIR)1 is a transmembrane molecule belonging to Ig superfamily which binds to different types of collagen. Herein, we have determined the expression and function of LAIR1 on B lymphocyte from SLE patients. LAIR1 expression in peripheral blood B lymphocytes from 54 SLE, 24 mixed connective tissue disease (MCTD), 20 systemic sclerosis (SSc) patients, 14 rheumatoid arthritis (RA) and 40 sex and age matched healthy donors (HD) have been analyzed by immunofluorescence. The effect of LAIR1 ligation by specific monoclonal antibodies, collagen or collagen producing mesenchymal stromal cells from reactive lymph nodes or bone marrow on Ig production by pokeweed mitogen and B cell receptor (BCR)-mediated NF-kB activation was assessed by ELISA and TransAM assay. The percentage of CD20+ B lymphocytes lacking or showing reduced expression of LAIR1 was markedly increased in SLE and MCTD but not in SSc or RA patients compared to HD. The downregulation of LAIR1 expression was not dependent on corticosteroid therapy. Interestingly, LAIR1 engagement by collagen or collagen-producing mesenchymal stromal cells in SLE patients with low LAIR1 expression on B cells delivered a lower inhibiting signal on Ig production. In addition, NF-kB p65 subunit activation upon BCR and LAIR1 co-engagement was less inhibited in SLE patients than in HD. Our findings indicate defective LAIR1 expression and function in SLE B lymphocytes, possible contributing to an altered control of B lymphocytes behavior

The impact of columnar file formats on SQL‐on‐hadoop engine performance: A study on ORC and Parquet

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Particle and light fragment emission in peripheral heavy ion collisions at Fermi energies

A systematic investigation of the average multiplicities of light charged particles and intermediate mass fragments emitted in peripheral and semiperipheral collisions is presented as a function of the beam energy, violence of the collision and mass of the system. The data have been collected with the "Fiasco" setup in the reactions 93Nb+93Nb at 17, 23, 30, 38AMeV and 116Sn+116Sn at 30, 38AMeV. The midvelocity emission has been separated from the emission of the projectile-like fragment. This last component appears to be compatible with an evaporation from an equilibrated source at normal density, as described by the statistical code Gemini at the appropriate excitation energy. On the contrary, the midvelocity emission presents remarkable differences for what concerns both the dependence of the multiplicities on the energy deposited in the midvelocity region and the isotopic composition of the emitted light charged particles.Comment: 18 pages, 17 figures, Revtex

Fast cerebellar reflex circuitry requires synaptic vesicle priming by Munc13-3

Munc13-3 is a member of the Munc13 family of synaptic vesicle priming proteins and mainly expressed in cerebellar neurons. Munc13-3 null mutant (Munc13-3(−/−)) mice show decreased synaptic release probability at parallel fiber to Purkinje cell, granule cell to Golgi cell, and granule cell to basket cell synapses and exhibit a motor learning deficit at highest rotarod speeds. Since we detected Munc13-3 immunoreactivity in the dentate gyrus, as reported here for the first time, and current studies indicated a crucial role for the cerebellum in hippocampus-dependent spatial memory, we systematically investigated Munc13-3(−/−) mice versus wild-type littermates of both genders with respect to hippocampus-related cognition and a range of basic behaviors, including tests for anxiety, sensory functions, motor performance and balance, sensorimotor gating, social interaction and competence, and repetitive and compulsive behaviors. Neither basic behavior nor hippocampus-dependent cognitive performance, evaluated by Morris water maze, hole board working and reference memory, IntelliCage-based place learning including multiple reversals, and fear conditioning, showed any difference between genotypes. However, consistent with a disturbed cerebellar reflex circuitry, a reliable reduction in the acoustic startle response in both male and female Munc13-3(−/−) mice was found. To conclude, complete deletion of Munc13-3 leads to a robust decrease in the acoustic startle response. This readout of a fast cerebellar reflex circuitry obviously requires synaptic vesicle priming by Munc13-3 for full functionality, in contrast to other behavioral or cognitive features, where a nearly perfect compensation of Munc13-3 deficiency by related synaptic proteins has to be assumed