Quantitative Nanofriction Characterization of Corrugated Surfaces by Atomic Force Microscopy

Atomic Force Microscopy (AFM) is a suitable tool to perform tribological characterization of materials down to the nanometer scale. An important aspect in nanofriction measurements of corrugated samples is the local tilt of the surface, which affects the lateral force maps acquired with the AFM. This is one of the most important problems of state-of-the-art nanotribology, making difficult a reliable and quantitative characterization of real corrugated surfaces. A correction of topographic spurious contributions to lateral force maps is thus needed for corrugated samples. In this paper we present a general approach to the topographic correction of AFM lateral force maps and we apply it in the case of multi-asperity adhesive contact. We describe a complete protocol for the quantitative characterization of the frictional properties of corrugated systems in the presence of surface adhesion using the AFM.Comment: 33 pages, 9 figures, RevTex 4, submitted to Journal of Applied Physic

CONSOLIDATION AND RESTORATION OF HISTORICAL HERITAGE: THE FLAVIAN AMPHITHEATER IN ROME

Abstract. The recovery and retrofitting techniques adopted for historical structures and archaeological sites face an apparent dichotomy between conservation of constructions and the safety of users. Literatures show several examples where the current day structural safety of historical constructions, gets defined by the nature of past interventions, the compatibility of materials and elements used in retrofitting. The adopted interventions were, in their time, considered innovative, but over the years their compatibility and reversibility leave the historic constructions structurally vulnerable. For these reasons, a careful understanding of the structural systems is fundamental for the implementation of appropriate retrofitting solutions. Especially for monuments and Archaeological sites the objective to be achieved has to be clear, avoiding destructive investigation tests. In this work the instabilities caused by a consolidation intervention on some travertine columns in a sector of the Flavian Amphitheatre, better known as "Colosseum" in Rome, are critically analysed. The current consolidation operations are compared to the previous one. The restoration activity involves in-depth diagnosis process: the historical analysis of the failures and restorations of that area of the Colosseum, a survey of the crack pattern and an indirect investigation on the travertine of the columns. Subsequently the various data coming from the knowledge phase are elaborated, in order to have a correct interpretation of the causes triggering the failure and guide the choice of the most correct retrofitting techniques

SIMPLIFIED PARAMETERS FOR THE EVALUATION OF SITE EFFECTS IN THE

After the 2002 earthquakes, that struck the southern Italy provinces of Campobasso (Molise) and Foggia (Apulia), the safety assessment of buildings has allowed to evaluate, for different building typologies, the damage level caused by the seismic event; in particular, the survey of the damaged cultural heritage was carried out by the Task Cultural Heritage of the Mixed Operating Centre (COM) in Larino (a village in the epicentral area), coordinated by the “Working Group for the Safeguard of the Cultural Heritage from Natural Risks” (Italy’s Gazzetta Ufficiale n. 116, 21 May 2001 - PCM-DPC Decree, 3 May 2001)”. For this survey activity, the churches were investigated with a specific form proposed by the same Working Group (Ministerial Decree n. 133, 23th January 2001), adopting different forms for other kinds of buildings. The surveyors were organized in teams, called NOPSA (Nuclei Operativi Patrimonio Storico Artistico), composed by officials of the Regional board of the Ministry of Cultural Heritage and Environmental Conservation (architects and art historians), an engineer and a Fire Brigade technician. The first phase of the safety assessment has been developed on the basis of the warnings received by the Larino COM, and most of the surveyed buildings were churches. The damage assessment of public or private buildings began, initially, near the earthquake epicentre (area 1 - IMCS between 6 and 8.5) and subsequently was carried out for all the villages from which inspection requests arrived. At the same time a vulnerability survey was carried out for the churches, using the II level form (Lagomarsino et al., 2004) proposed in the SAVE Project (“Updated Tools for the Seismic Vulnerability Evaluation of the Italian Real Estate and of Urban Systems” – http://gndt.ingv.it). The damage and vulnerability survey has allowed to verify and optimize the procedures for damage assessment immediately after a seismic event (emergency phase) and to obtain useful indications for the reconstruction phase. On the whole 379 monumental buildings in 101 Molise villages and 207 monumental buildings in 44 Apulia villages were investigated. Figure 1 shows the number of monumental buildings surveyed after the earthquakes for each Molise village, subdividing the region according to the seismic classification proposed by the recent Italian Seismic Code (OPCM n. 3274, 2003 – http://zonesismiche.mi.ingv.it)

Effetti di amplificazione topografica osservati sul patrimonio monumentale

La ricerca ha avuto l’obiettivo di indagare gli effetti di amplificazione sismica, per cause topografiche, che possono aver interessato le chiese danneggiate da alcuni terremoti storici italiani. La novità di questo studio consiste nell’aver messo a punto una metodologia di analisi che, partendo dall’osservazione degli effetti del terremoto sull’edificio, confronta il danno osservato ed il danno atteso, calcolato attraverso modelli basati su dati statisticamente affidabili, prevede una fase di rilevo delle caratteristiche geologiche, geomorfologiche, geotecniche e geofisiche dei siti di ubicazione delle chiese, arriva a quantificare, anche attraverso modellazioni numeriche della risposta sismica locale, l’influenza che la morfologia di questi siti può aver avuto nel determinare l’incremento dell’input sismico e conseguentemente del danno osservato

Correlation between local amplification effects and damage mechanism for monumental buildings

The damage and vulnerability survey of the monumental buildings, damaged by the 2002 earthquake in the Molise Region, has allowed singling out of a correlation between the observed damage of the churches and their morphological site conditions. The vulnerability model connected to the survey methodology provides an evaluation of the expected mean damage. Comparison with the observed damage determined the introduction of a local morphological behaviour modifier, able to take into account the vulnerability increase due to the site effects. In order to validate the previous results, a numerical 2-D analysis of the seismic local response has been performed. In particular, a numerical code, working with boundary elements, has been applied to the analyzed situations. The results, in terms of pseudo-acceleration response spectra and amplification factors, allow one to compare the numerical and the observed analyses. This comparison shows good agreement and allows one to find some correlations between the geometric characteristics of the sites, the values of the amplification coefficients and the damage mechanism activated

Correlation between local amplification effects and damage mechanisms for monumental buildings

The damage and vulnerability survey of the monumental buildings, damaged by the 2002 earthquake in the Molise Region, has allowed singling out of a correlation between the observed damage of the churches and their morphological site conditions. The vulnerability model connected to the survey methodology provides an evaluation of the expected mean damage. Comparison with the observed damage determined the introduction of a local morphological behaviour modifier, able to take into account the vulnerability increase due to the site effects. In order to validate the previous results, a numerical 2-D analysis of the seismic local response has been performed. In particular, a numerical code, working with boundary elements, has been applied to the analyzed situations. The results, in terms of pseudo-acceleration response spectra and amplification factors, allow one to compare the numerical and the observed analyses. This comparison shows good agreement and allows one to find some correlations between the geometric characteristics of the sites, the values of the amplification coefficients and the damage mechanism activated

Haploidentical α/β T-cell and B-cell Depleted Stem Cell Transplantation in Severe Mevalonate Kinase Deficiency

Objective: Mevalonic aciduria represents the most severe form of mevalonate kinase deficiency (MKD). Patients with mevalonic aciduria have an incomplete response even to high doses of anti-cytokine drugs such as anakinra or canakinumab and stem cell transplantation (SCT) represents a possible therapy for this severe disease. Methods: We report the first two children affected by severe MKD who received haploidentical α/β T-cell and B-cell depleted SCT. Both patients received a treosulfan-based conditioning regimen and one received a second haploidentical-SCT for secondary rejection of the first. Results: Both patients obtained a stable full donor engraftment with a complete regression of clinical and biochemical inflammatory signs, without acute organ toxicity or acute and chronic GvHD. In both, the urinary excretion of mevalonic acid remained high post-transplant in the absence of any inflammatory signs. Conclusion: Haploidentical α/β T-cell and B-cell depleted SCT represents a potential curative strategy in patients affected by MKD. The persistence of urinary excretion of mevalonic acid after SCT, probably related to the ubiquitous expression of MVK enzyme, suggests that these patients should be carefully monitored after SCT to exclude MKD clinical recurrence. Prophylaxis with anakinra in the acute phase after transplant could represent a safe and effective approach. Further biological studies are required to clarify the pathophysiology of inflammatory attacks in MKD in order to better define the therapeutic role of SCT.info:eu-repo/semantics/publishedVersio

Nothing is as it seems: genetic analyses on stranded fin whales unveil the presence of a fin-blue whale hybrid in the Mediterranean Sea (Balaenopteridae)

The fin whale Balaenoptera physalus is a large rorqual species occurring worldwide, mainly in temperate and subpolar zones. In contrast to many baleen whales, not all the fin whale populations show the same model of migration. In fact, migratory behaviours of this latter species range from long seasonal migration between high and low latitudes to a complete nonmigratory behaviour. A resident fin whale population was described in the Mediterranean Sea, which is also frequented by North Atlantic individuals entering through the Strait of Gibraltar in winter to feed. Between 2020 and 2021 three individuals initially identified as fin whales died along the Tyrrhenian coasts (Mediterranean Sea, Italy). Their mitochondrial DNA control region (mtDNA CR) was analysed and compared to fin whale haplotypes previously described in North Atlantic Ocean and Mediterranean Sea to identify their geographical origin. Our results show that two individuals most likely belong to the Mediterranean fin whale population, while an individual was recognised as a putative fin-blue whale hybrid (Balaenoptera physalus x Balaenoptera musculus) with a North Atlantic origin. The discovery of the first fin-blue whale hybrid in the Mediterranean Sea was confirmed by the analysis of a biparentally inherited marker, the α-lactalbumin (α-lac) nuclear gene, demonstrating that the morphological analysis alone does not allow to correctly identify hybrids, especially if intermediate characters of both parental species are not clearly distinguishable

2002 Molise earthquake: the run of the reconstruction

The job illustrates the activities, the normative and procedural dispositions of the reconstruction in Molise that has been on its way after the 2002 earthquake. The individualized run has been characterized by numerous technical innovations, consequent to the emanation of the new seismic code (OPCM n. 3274/2003). The President of the Region, Delegated Commissioner for the reconstruction after-earthquake 2002, has programmed and coordinated all the activities, using structures of consultation, of address and of technical support. Particularly, the Scientific Technical Committee (CTS) has taken care of the containing directives, the criterions and the general norms for the trial of the reconstruction, emanate through the Ordinance of the Delegated Commissioner n. 13/2003. The Committee for the Microzonation (CMS) has predisposed indications and guidelines, while the CNR Institute for the Technologies of the Construction, in collaboration with the University of Basilicata and Dicat-University of Genoa, has up the guidelines for the investigations of vulnerability and for the interventions on the scholastic buildings, on the churches and on the monumental buildings. Finally, the Delegated Commissioner has ordered that the Local Corporate Bodies were made themselves responsible for the reconstruction realization. In the Campobasso province , with exception of the S.Giuliano diPuglia common, have been compiled about 16.200 preliminary projects (PPS). It is esteemed a general economic requirement of about 1.800 million of Euros for the residential buildings and of about 900 million of Euros for the public works. The reconstruction is in advanced realization and involves the buildings affected by an evacuation measure (Priority A).PublishedPisa, Italia4.2. Scenari e mappe di pericolosità sismica e dannoope