Die Bibliothek als Erfolgsfaktor:

Im Jahr 2012 konnte die Universitätsbibliothek ihr 50. Jubiläum feiern. Aus diesem Anlass hat die Bibliothek eine Festschrift herausgegeben. Es findet keine Rückschau auf die Vergangenheit statt. Hingegen wird in drei Themenbereichen "Die Universitätsbibliothek - professionelle Partnerin für Lehre , Studium und Forschung", "Innovationen für die campusweiten Dienstleistungen der Universitätsbibliothek" und "Ein scharfes Profil für die Ruhr-Universität Bochum - der Beitrag der Universitätsbibliothek" auf die Rolle und Funktion der Universitätsbibliothek Bochum bis hin zu aktuellen Veränderungen bei Arbeitsabläufen in der Universitätsbibliothek im Jahr 2012 eingegangen

Refined histopathological predictors of BRCA1 and BRCA2 mutation status: A large-scale analysis of breast cancer characteristics from the BCAC, CIMBA, and ENIGMA consortia

Introduction: The distribution of histopathological features of invasive breast tumors in BRCA1 or BRCA2 germline mutation carriers differs from that of individuals with no known mutation. Histopathological features thus have utility for mutation prediction, including statistical modeling to assess pathogenicity of BRCA1 or BRCA2 variants of uncertain clinical significance. We analyzed large pathology datasets accrued by the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) and the Breast Cancer Association Consortium (BCAC) to reassess histopathological predictors of BRCA1 and BRCA2 mutation status, and provide robust likelihood ratio (LR) estimates for statistical modeling. Methods: Selection criteria for study/center inclusion were estrogen receptor (ER) status or grade data available for invasive breast cancer diagnosed younger than 70 years. The dataset included 4,477 BRCA1 mutation carriers, 2,565 BRCA2 mutation carriers, and 47,565 BCAC breast cancer cases. Country-stratified estimates of the

Refined histopathological predictors of BRCA1 and BRCA2 mutation status : a large-scale analysis of breast cancer characteristics from the BCAC, CIMBA, and ENIGMA consortia

Abstract Introduction The distribution of histopathological features of invasive breast tumors in BRCA1 or BRCA2 germline mutation carriers differs from that of individuals with no known mutation. Histopathological features thus have utility for mutation prediction, including statistical modeling to assess pathogenicity of BRCA1 or BRCA2 variants of uncertain clinical significance. We analyzed large pathology datasets accrued by the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA) and the Breast Cancer Association Consortium (BCAC) to reassess histopathological predictors of BRCA1 and BRCA2 mutation status, and provide robust likelihood ratio (LR) estimates for statistical modeling. Methods Selection criteria for study/center inclusion were estrogen receptor (ER) status or grade data available for invasive breast cancer diagnosed younger than 70 years. The dataset included 4,477 BRCA1 mutation carriers, 2,565 BRCA2 mutation carriers, and 47,565 BCAC breast cancer cases. Country-stratified estimates of the likelihood of mutation status by histopathological markers were derived using a Mantel-Haenszel approach. Results ER-positive phenotype negatively predicted BRCA1 mutation status, irrespective of grade (LRs from 0.08 to 0.90). ER-negative grade 3 histopathology was more predictive of positive BRCA1 mutation status in women 50 years or older (LR = 4.13 (3.70 to 4.62)) versus younger than 50 years (LR = 3.16 (2.96 to 3.37)). For BRCA2, ER-positive grade 3 phenotype modestly predicted positive mutation status irrespective of age (LR = 1.7-fold), whereas ER-negative grade 3 features modestly predicted positive mutation status at 50 years or older (LR = 1.54 (1.27 to 1.88)). Triple-negative tumor status was highly predictive of BRCA1 mutation status for women younger than 50 years (LR = 3.73 (3.43 to 4.05)) and 50 years or older (LR = 4.41 (3.86 to 5.04)), and modestly predictive of positive BRCA2 mutation status in women 50 years or older (LR = 1.79 (1.42 to 2.24)). Conclusions These results refine likelihood-ratio estimates for predicting BRCA1 and BRCA2 mutation status by using commonly measured histopathological features. Age at diagnosis is an important variable for most analyses, and grade is more informative than ER status for BRCA2 mutation carrier prediction. The estimates will improve BRCA1 and BRCA2 variant classification and inform patient mutation testing and clinical management

2023-2024 Master Class - Gary Hoffman (Cello)

https://spiral.lynn.edu/conservatory_masterclasses/1253/thumbnail.jp

2023-2024 Celebration of the Classics: Friends of the Conservatory Concert and Friendship Tea

https://spiral.lynn.edu/foc-events/1047/thumbnail.jp

2023-2024 Master Class - Philip Setzer (Violin)

https://spiral.lynn.edu/conservatory_masterclasses/1263/thumbnail.jp

Lynn Chamber Music Competition 2023

Competition Coordinator Chauncey Patterson Juries Luciano Magnanini - Former Bassoon Professor at Frost School of Music and Former Principal Bassoonist of the Florida Grand Opera Ralph Evans - First Violinist of the Fine Arts String Quartet Santiago Rodriguez - Piano Professor at Frost School of Music Schedule Preliminary round - Tuesday, December 12, 2023 at 4:00 p.m. Final round - Wednesday, December 13, 2023 at 6:00 p.m. Winners First Place (Prize: Performance at Lyric Chamber Music Society of New York) Marcando Quartet (Miriam Smith, violin; Lillian Platte, viola; Megan Hagel, cello; Elizabeth Thomashoff, piano) Second Place (Prize: Performance at St. Paul\u27s Episcopal Church in Delray Beach) Aurora Quartet (Mable Lecrone and Ruvit Bracho Marquez, violins; Rosa Ortega Iannelli, viola; Joel Osinga, cello) Third Place (Prize: Performance at St. Paul\u27s Episcopal Church in Delray Beach) Zelena Quartet (Angela Fiedler and Adriana Fernandez, violins; Lauren Swartz, viola; Jon Cruz Cruz, cello) Alternate Lacerta Sextet (Youbeen Cho, flute; Kari Jenks, oboe; Noah Suarez, clarinet; Graydon Howard, bassoon; Baran Zolfaghari, horn; Caroline Dratnal, piano)https://spiral.lynn.edu/conservatory_chamber-music-competition/1009/thumbnail.jp

2023-2024 Harmony Across Cultures, Bridging Tradition: Friends of the Conservatory of Musi Concert

https://spiral.lynn.edu/foc-events/1044/thumbnail.jp