Far apart but closer together:a quantitative and qualitative analysis of the career structure and organisational culture of the post-war British Diplomatic Service

A good deal has been written about the organisation and structure of the British diplomatic establishment since 1945. This paper seeks to use detailed quantitative and qualitative data to help develop an understanding of the background and career trajectories of the most senior figures in the Diplomatic Service in 1975. By tracing their careers it is possible to identify more precisely than before the changing educational and social background of these individuals when compared with previous generations of diplomats. The paper also examines certain core features of the culture of the diplomatic establishment during the post-war decades, analysing how it both shaped and was shaped by particular structures and practices. The paper argues that, despite the existence of a peripatetic career structure that dispersed members of the diplomatic establishment around the globe, there were still numerous opportunities for the kinds of personal contact necessary to maintain an integrated cultur

Correlation of the Jackson cross cylinder test and the Matsuura autocross test as to cylinder axis and power, subject preference, and administration time

The purpose of this study is to compare the efficiency of the Matsuura AutoCross with that of the Jackson Cross Cylinder (JCC) in revealing the existance of astigmatism, its axis and amount in the human eye, and to determine if the AutoCross technique was a valid one and could be a practical substitution for the Jackson Cross Cylinder test

Integration of genomic and other epidemiologic data to investigate and control a cross-institutional outbreak of Streptococcus pyogenes outbrea

Single-strain outbreaks of Streptococcus pyogenes infections are common and often go undetected. In 2013, two clusters of invasive group A Streptococcus (iGAS) infection were identified in independent but closely located care homes in Oxfordshire, United Kingdom. Investigation included visits to each home, chart review, staff survey, microbiologic sampling, and genome sequencing. S. pyogenes emm type 1.0, the most common circulating type nationally, was identified from all cases yielding GAS isolates. A tailored whole-genome reference population comprising epidemiologically relevant contemporaneous isolates and published isolates was assembled. Data were analyzed independently using whole-genome multilocus sequencing and single-nucleotide polymorphism analyses. Six isolates from staff and residents of the homes formed a single cluster that was separated from the reference population by both analytical approaches. No further cases occurred after mass chemoprophylaxis and enhanced infection control. Our findings demonstrate the ability of 2 independent analytical approaches to enable robust conclusions from nonstandardized whole-genome analysis to support public health practice

S110, a novel decitabine dinucleotide, increases fetal hemoglobin levels in baboons (P. anubis)

<p>Abstract</p> <p>Background</p> <p>S110 is a novel dinucleoside analog that could have advantages over existing DNA methyltransferase (DNMT) inhibitors such as decitabine. A potential therapeutic role for S110 is to increase fetal hemoglobin (HbF) levels to treat β-hemoglobinopathies. In these experiments the effect of S110 on HbF levels in baboons and its ability to reduce DNA methylation of the γ-globin gene promoter in vivo were evaluated.</p> <p>Methods</p> <p>The effect of S110 on HbF and γ-globin promoter DNA methylation was examined in cultured human erythroid progenitors and in vivo in the baboon pre-clinical model. S110 pharmacokinetics was also examined in the baboon model.</p> <p>Results</p> <p>S110 increased HbF and reduced DNA methylation of the γ-globin promoter in human erythroid progenitors and in baboons when administered subcutaneously. Pharmacokinetic analysis was consistent with rapid conversion of S110 into the deoxycytosine analog decitabine that binds and depletes DNA.</p> <p>Conclusion</p> <p>S110 is rapidly converted into decitabine, hypomethylates DNA, and induces HbF in cultured human erythroid progenitors and the baboon pre-clinical model.</p

Dari Trainer, Imam Ibadah Hingga Patronase Spiritual : Pelayanan Kbih Al-hikmah Kepada Calon/ Jamaah Haji di Kabupaten Brebes

Some people stated that the roles of KBIH and its services toward pil­grims are questionable. Several KBIHs have been changed to businessinstitution rather than social institution. There is a kind of comodi.ficationof it. This paper argues, based on field research, that KBIH al-Hikmahhas given satisfied services to pilgrims. The services were not only inthe preparation of pilgrimages (manasik), but also during the pilgrim­ages in Mecca and and after the pilgrimages in Indonesia. In the prepa­ration of pilgrimages, the role of KBIH was a trainer - making candi­dates of pilgrims are more understanding and capable for practicingthe ritual. In Mecca, KBIH was not only as guider of long journey. butalso the imam of various rituals of pilgrimages. The role of KBIH hasbecome spiritual patronages ( ecclesiasticum] of pilgrims in the rest oftheir lifes

OC6 Phase II: Integration and verification of a new soil–structure interaction model for offshore wind design

This paper provides a summary of the work done within the OC6 Phase II project, which was focused on the implementation and verification of an advanced soil–structure interaction model for offshore wind system design and analysis. The soil–structure interaction model comes from the REDWIN project and uses an elastoplastic, macroelement model with kinematic hardening, which captures the stiffness and damping characteristics of offshore wind foundations more accurately than more traditional and simplified soil–structure interaction modeling approaches. Participants in the OC6 project integrated this macroelement capability to coupled aero-hydro-servo-elastic offshore wind turbine modeling tools and verified the implementation by comparing simulation results across the modeling tools for an example monopile design. The simulation results were also compared to more traditional soil–structure interaction modeling approaches like apparent fixity, coupled springs, and distributed springs models. The macroelement approach resulted in smaller overall loading in the system due to both shifts in the system frequencies and increased energy dissipation. No validation work was performed, but the macroelement approach has shown increased accuracy within the REDWIN project, resulting in decreased uncertainty in the design. For the monopile design investigated here, that implies a less conservative and thus more cost-effective offshore wind design.US Department of Energy Office of Energy Efficiency and Renewable Energy Wind Energy Technologies Office, Grant/Award Number: DE-AC36-08GO2830