Bilinear softening parameters and equivalent LEFM R-curve in quasibrittle failure

For composites and adhesive joints, the determination of the cohesive zone parameters from Double Cantilever Beam specimens loaded with pure moments is now well established and documented. However, for quasibrittle materials used in Civil Engineering such as concrete or wood, the difficulty to apply a pure bending moment lies inappropriated the method used for composites. Nevertheless, the one-to-one correspondence which exists between the R-curve and the softening curve is here revisited and adapted for any kind of specimen geometry and for the bilinear approximation of the softening function, well-known to successfully describe the failure of a wide group of quasibrittle materials. It is shown that even though the connections between the cohesive parameters and the ‘equivalent LEFM’ R-curve are geometry and material dependent, their trends are preserved whatever the specimen geometry and the material are. The outline of a general estimation procedure of the cohesive zone parameters funded on the equivalent LEFM R-curve is proposed

Functional output-controllability of time-invariant singular linear systems

In the space of finite-dimensional singular linear continuous-time-invariant systems described in the form \begin{equation}\label{eq1}\left . \begin{array}{rl} E \dot x(t)&= Ax(t)+Bu(t)\\ y(t)&=Cx(t)\end{array}{\kern-1mm}\right \}\end{equation} where $E,A\in M=M_{n}(\mathbb{C})$, $B\in M_{n\times m}(\mathbb{C})$, $C\in M_{p\times n}(\mathbb{C})$, functional output-controllability character is considered. A simple test based in the computation of the rank of a certain constant matrix that can be associated to the system is presentedPeer ReviewedPostprint (published version

D-Fagomine lowers postprandial blood glucose and modulates bacterial adhesion

d-Fagomine is an iminosugar originally isolated from seeds of buckwheat (Fagopyrum sculentum Moench), present in the human diet and now available as a pure crystalline product. We tested d-fagomine for activities connected to a reduction in the risk of developing insulin resistance, becoming overweight and suffering from an excess of potentially pathogenic bacteria. The activities were: intestinal sucrase inhibition in vitro (rat mucosa and everted intestine sleeves), modulation of postprandial blood glucose in rats, bacterial agglutination and bacterial adhesion to pig intestinal mucosa. When ingested together with sucrose or starch, d-fagomine lowered blood glucose in a dose-dependent manner without stimulating insulin secretion. d-Fagomine reduced the area under the curve (0-120 min) by 20 % (P < 0•01) and shifted the time to maximum blood glucose concentration (T max) by 15 min at doses of 1-2 mg/kg body weight when administered together with 1 g sucrose/kg body weight. Moreover, d-fagomine (0•14 mm) agglutinated 60 % of Enterobacteriaceae (Escherichia coli, Salmonella enterica serovar Typhimurium) populations (P < 0•01), while it did not show this effect on Bifidobacterium spp. or Lactobacillus spp. At the same concentration, d-fagomine significantly (P < 0•001) inhibited the adhesion of Enterobacteriaceae (95-99 % cells in the supernatant) and promoted the adhesion of Lactobacillus acidophilus (56 % cells in the supernatant) to intestinal mucosa. d-Fagomine did not show any effect on bacterial cell viability. Based on all this evidence, d-fagomine may be used as a dietary ingredient or functional food component to reduce the health risks associated with an excessive intake of fast-digestible carbohydrates, or an excess of potentially pathogenic bacteria. © 2011 The Authors

A record-linkage study of the development of hepatocellular carcinoma in persons with hepatitis C infection in Scotland

We investigated trends in first time hospital admissions and deaths attributable to hepatocellular carcinoma (HCC) in a large population based cohort of 22 073 individuals diagnosed with hepatitis C viral (HCV) infection through laboratory testing in Scotland in 1991 2006. We identified new cases of HCC through record linkage to the national inpatient hospital discharge database and deaths registry. A total of 172 persons diagnosed with HCV were admitted to hospital or died with first time mention of HCC. Hepatocellular carcinoma incidence increased between 1996 and 2006 (average annual change of 6.1, 95% confidence interval (CI):0.9 11.6%, P¼0.021). The adjusted relative risk of HCC was greater for males (hazard ratio¼2.7, 95% CI: 1.7 4.2), for those aged 60 years or older (hazard ratio ¼2.7, 95% CI: 1.9 4.1) compared with 50 59 years, and for those with a previous alcohol related hospital admission (hazard ratio¼2.5, 95% CI: 1.7 3.7). The risk of individuals diagnosed with HCV developing HCC was greatlyincreased compared with the general Scottish population (standardised incidence ratio¼127, 95% CI: 102 156). Owing to the advancing age of the Scottish HCV diagnosed population, the annual number of HCC cases is projected to increase, with a consequent increasing burden on the public healthcare system

Asymmetric distribution of pl10 and bruno2, new members of a conserved core of early germline determinants in cephalochordates

Molecular fingerprinting of conserved germline and somatic "stemness" markers in different taxa have been key in defining the mechanism of germline specification ("preformation" or "epigenesis"), as well as expression domains of somatic progenitors. The distribution of molecular markers for primordial germ cells (PGCs), including vasa, nanos, and piwil1, as well as Vasa antibody staining, support a determinative mechanism of germline specification in the cephalochordate Branchiostoma lanceolatum, similarly to other amphioxus species. pl10 and bruno2, but not bruno4/6, are also expressed in a pattern consistent with these other germline genes, adding to our repertoire of PGC markers in lancelets. Expression of nanos, vasa, and the remaining markers (musashi, pufA, pufB, pumilio, and piwil2) may define populations of putative somatic progenitors in the tailbud, the amphioxus posterior growth zone, or zones of proliferative activity. Finally, we also identify a novel expression domain for musashi, a classic neural stem cell marker, during notochord development in amphioxus. These results are discussed in the context of germline determination in other taxa, stem cell regulation, and regenerative capacity in adult amphioxus

Accurate ab initio spin densities

We present an approach for the calculation of spin density distributions for molecules that require very large active spaces for a qualitatively correct description of their electronic structure. Our approach is based on the density-matrix renormalization group (DMRG) algorithm to calculate the spin density matrix elements as basic quantity for the spatially resolved spin density distribution. The spin density matrix elements are directly determined from the second-quantized elementary operators optimized by the DMRG algorithm. As an analytic convergence criterion for the spin density distribution, we employ our recently developed sampling-reconstruction scheme [J. Chem. Phys. 2011, 134, 224101] to build an accurate complete-active-space configuration-interaction (CASCI) wave function from the optimized matrix product states. The spin density matrix elements can then also be determined as an expectation value employing the reconstructed wave function expansion. Furthermore, the explicit reconstruction of a CASCI-type wave function provides insights into chemically interesting features of the molecule under study such as the distribution of $\alpha$- and $\beta$-electrons in terms of Slater determinants, CI coefficients, and natural orbitals. The methodology is applied to an iron nitrosyl complex which we have identified as a challenging system for standard approaches [J. Chem. Theory Comput. 2011, 7, 2740].Comment: 37 pages, 13 figure

Importancia del agua en la hidratación de la población española: documento FESNAD 2010

For any healthy individual, thirst is an appropriate sign to drink water, except for babies, sportsmen, and most of ill and elderly people. In these instances, it is convenient to schedule appropriate times to drink water since great demands and the physiological mechanisms that determine thirst in these situations may condition water unbalances with important consequences for health and the physical and intellectual performance. The human body has a number of mechanisms that allow keeping constant the water content by adjusting intakes and wastes. Water balance is determined by intake (consumed water, beverages, and water contained in foods) and wastes (urine, stools, the skin, and expired air from the lungs). Failure of these mechanisms and subsequent impairments in water balance may produce severe disarrangements that may threaten somebody's life. In the present document, we analyze the evidences regarding the factors conditioning water needs in the different life stages and physiological situations, as well as the consequences of water unbalance under different situations. A proper hydration may be achieved by feeding and the use of water and other liquids. Although water is the beverage by excellence and represents the ideal way of restoring the losses and get hydrated, we should be aware that, from the very beginning, we have sought other liquid sources with hydration properties. In the last decades we have increased the consumption of different beverages, with a proliferation of sugar-containing beverages. Since excessive sugar consumption has been related to obesity and other chronic conditions, it is evident that the use of these caloric beverages should be rationalized, especially in children. In this document all the considerations regarding hydration are presented and different recommendations are expose

Definition of a list of fish diseases to aid health management in Spain

Trabajo presentado en la 14th EAFP International Conference (European Association of Fish Pathologists), celebrada en Praga (República Checa), del 14 al 19 de septiembre de 2009An expert working group used a risk ranking technique to compile a list of fish disease hazards (pathogens) of relevance to Spanish aquaculture. It was possible to divide the list into three groups: I-high national risk; II-regional risk; III-low risk. The three groups were as follows: Group I (high risk) Aphanomyces invadans (EUS)**, spring viraemia of carp virus (SVCV), koi herpes virus (KHV)¿ and infectious haematopoietic necrosis virus (IHNV)¿ Group II (regional risk) Enteromyxum spp. (leei and scophthalmi), Aquabirnaviridae (incl. IPNV), viral encephalopathy and retinopathy virus (VERV), Streptococcus iniae, Philasterides dicentrarchi and Aeromonas salmonicida (in the marine environment). Group III (low risk) Sparicotyle chrysophrii/Microcotylidae, Flavobacterium maritimus, Photobacterium piscicida, Togaviridae, Sphaerospora testicularis, Edwardsiella tarda, Birnavirus (no-EVE), Lactococcus garviae, viral haemorrhagic septicaemia virus (VHSV)¿, Tenacibaculum maritimum, epizootic haematopoietic necrosis virus (EHNV)**, Renibacterium salmoninarum (BKD) and Gyrodactylus salaris. The exercise formed part of a project concerning aquaculture health management (Jacumar-GESAC¿) in Spain and is being used to help define sampling plans for disease monitoring using epidemiological and risk-based criteria. **The diseases caused by these pathogens are notifiable and exotic according to Directive 2006/88/EC ¿The diseases caused by these pathogens are notifiable and non-exotic according to Directive 2006/88/EC ¿Plan Nacional de Cultivos Marinos; Gestión sanitaria de la acuicultura: Adaptación a la nueva normativa (GESAC) ¿ financed by the Junta Nacional Asesora de Cultivos Marinos (Jacumar

The role of SRC-3 in estrogen-dependent vasoprotection during vascular wall remodeling postinjury

Estrogen receptors are hormone-inducible transcription factors requiring coactivators such as members of the SRC/p160 family to modulate the transcription of their target genes. This perspective will examine the interplay between estrogen receptors and their coactivators in vasoprotection during vascular wall remodeling