Epidemiology, prevention and control of oral diseases in pediatric subjects

Caries and periodontal diseases are a neglected epidemic by millions of Italians who suffer unnecessarily from them. Both diseases are preventable and the combination of high prevalence, high morbidity and relative inattention from the National Health Service (NHS), makes caries and periodontal disease a significant public health problem. In this perspective, the World Health Organization and the University of Milan have promoted a national epidemiological study aimed at a sample of 4, 6 and 12-years-old students from schools in the North, Central and South of Italy. The study provides for the administration of a questionnaire to parents and a dental examination carried out at school by dentists trained by the WHO. In our town the epidemiological study planning and the survey were carried out by professors of the School of Specialization in "Pediatric Dentistry" (Prof. G. Giuliana and Prof. G. Pizzo) supported by specialist dentists from the same School, calibrated according to the WHO methodology. The survey was carried out between 2017 and 2019 involving 2701 children attending schools in the 8 districts of the town. The parents were sent a letter which explained the nature of the survey and contained a pre-printed form for the issue of informed consent to participate in the survey with a questionnaire regarding the family nuclear, the oral hygiene and eating habits of the minor and the child's previous dental experiences. The ICDAS (International Caries Detection and Assessment System) was used to detect the prevalence of carious lesions. The dentist used for each child visited a dental mirror and the CPI (Community Periodontal Index) index for periodontal assessment. Preliminary results showed that 25.3% of 12-years-old students had gingival bleeding and 41.1% had tartar. The caries index (ICDAS) shows us that as early as 4 years, 20% of children have initial carious lesions, 37% have dentine caries and that 34.38% have highly destructive caries. At 12 years, 34.95% had initial carious lesions, 46% had cavities that already affected dentin and that 42.44% had highly destructive cavities. The exigence to implement a program of prevention / early treatment of caries/gingivitis in pediatric subjects living in Palermo, since the first months of child's life, was born from the data analysis. The project "Un sorriso per 54 tutti i bambini", carried out at the U.O. of "Pediatric Dentistry" of Policlinico Paolo Giaccone in Palermo, was therefore finalised in order to 1) improve efficiency and effectiveness in the promotion of the oral health of minors, through the creation of a preventive / assistance route of significant social health impact; 2) assess the effectiveness of the preventive methodologies adopte

New radio halos and relics in clusters of galaxies

We present here new images of relics and halo sources in rich cluster of galaxies and the correlation between the halo radio surface brightness versus the cluster bolometric X-ray luminosity.Comment: 2 pages, 4 figures. To appear in the Proceedings of the International Conference: "The Origin and Evolution of Cosmic Magnetism"; Bologna 29 August - 2 September 2005; eds R. Beck, G. Brunetti, L. Feretti, and B. Gaensler (Astronomische Nachrichten, 2006

Stream dynamics between 1 AU and 2 AU: A detailed comparison of observations and theory

A radial alignment of three solar wind stream structures observed by IMP-7 and -8 (at 1.0 AU) and Voyager 1 and 2 (in the range 1.4 to 1.8 AU) in late 1977 is presented. It is demonstrated that several important aspects of the observed dynamical evolution can be both qualitatively and quantitatively described with a single-fluid 2-D MHD numerical model of quasi-steady corotating flow, including accurate prediction of: (1) the formation of a corotating shock pair at 1.75 AU in the case of a simple, quasi-steady stream; (2) the coalescence of the thermodynamic and magnetic structures associated with the compression regions of two neighboring, interacting, corotating streams; and (3) the dynamical destruction of a small (i.e., low velocity-amplitude, short spatial-scale) stream by its overtaking of a slower moving, high-density region associated with a preceding transient flow. The evolution of these flow systems is discussed in terms of the concepts of filtering and entrainment

Invariant NKT cells and rheumatic disease: Focus on primary sjogren syndrome

Primary Sjogren syndrome (pSS) is a complex autoimmune disease mainly affecting salivary and lacrimal glands. Several factors contribute to pSS pathogenesis; in particular, innate immunity seems to play a key role in disease etiology. Invariant natural killer (NK) T cells (iNKT) are a T-cell subset able to recognize glycolipid antigens. Their function remains unclear, but studies have pointed out their ability to modulate the immune system through the promotion of specific cytokine milieu. In this review, we discussed the possible role of iNKT in pSS development, as well as their implications as future markers of disease activity

Diffuse radio emission in the complex merging galaxy cluster Abell 2069

Galaxy clusters with signs for a recent merger show in many cases extended diffuse radio features. This emission originates from relativistic electrons which suffer synchrotron losses due to the intra-cluster magnetic field. The mechanisms of the particle acceleration and the properties of the magnetic field are still poorly understood. We search for diffuse radio emission in galaxy clusters. Here, we study the complex galaxy cluster Abell 2069, for which X-ray observations indicate a recent merger. We investigate the cluster's radio continuum emission by deep Westerbork Synthesis Radio Telescope (WSRT) observations at 346 MHz and a Giant Metrewave Radio Telescope (GMRT) observation at 322 MHz. We find an extended diffuse radio feature roughly coinciding with the main component of the cluster. We classify this emission as a radio halo and estimate its lower limit flux density to 25 +/- 9 mJy. Moreover, we find a second extended diffuse source located at the cluster's companion and estimate its flux density to 15 +/- 2 mJy. We speculate that this is a small halo or a mini-halo. If true, this cluster is the first example of a double-halo in a single galaxy cluster.Comment: 6 pages, 3 figures, accepted for publication in A&

Absence of Ground States for a Class of Translation Invariant Models of Non-relativistic QED

We consider a class of translation invariant models of non-relativistic QED with net charge. Under certain natural assumptions we prove that ground states do not exist in the Fock space

Contributions to the Fourth Solar Wind Conference

Recent results in interplanetary physics are examined. These include observations of shock waves and post-shock magnetic fields made by Voyager 1, 2; observations of the electron temperature as a function of distance between 1.36 AU and 2.25 AU; and observations of the structure of sector boundaries observed by Helios 1. A theory of electron energy transport in the collisionless solar wind is presented, and compared with observations. Alfven waves and Alvenic fluctuations in the solar wind are also discussed

IL-17 polarization of MAIT cells is derived from the activation of two different pathways

MAIT cells are expanded in salivary glands of patients with Sjogren's syndrome and are IL-17 polarized. IL-7 and IL-23 induce IL-17 production activating two different pathways: IL-7 stimulation induces in fact a significant STAT3 and HIF1alpha upregulation, conversely, IL-23 stimulation significantly induces RORc overexpression in MAIT cells of patients with Sjogren's syndrome

Evaluation of the burden of HPV-related hospitalizations as a useful tool to increase awareness: 2007–2017 data from the sicilian hospital discharge records

In light of the implementation of human papillomavirus (HPV) prevention strategies, epidemiological studies in different geographical areas are required in order to assess the impact of HPV-related diseases. The purpose of the present study was to describe the burden of HPV-related hospitalizations in Sicily. A retrospective observational study estimated 43,531 hospitalizations attributable to HPV from 2007 to 2017. During the observed period, there was a decrease for all HPV-related conditions with a higher reduction, among neoplasms, for cervical cancer (annual percent change (APC) = −9.9%, p < 0.001). The median age for cervical cancer was 45 years old, with an increasing value from 43 to 47 years (p < 0.001). The age classes with greater decreases in hospital admissions for invasive cancers were women aged 35 years or more (APC range from −5.5 to −9.86) and 25–34 years old (APC = −11.87, p < 0.001) for women with cervical carcinoma in situ. After ten years for vaccine introduction and sixteen years for cervical cancer screening availability, a relatively large decrease in hospital admissions for cervical cancer and other HPV-related diseases in Sicily was observed. Some clinical characteristics of hospitalization, such as increasing age, are suggestive clues for the impact of preventive strategies, but further research is needed to confirm this relationship

Radio spectral study of the cluster of galaxies Abell 2255

Spectral index studies of halos, relics, and radio galaxies provide useful information on their origin and connection with merger processes. We present WSRT multi-wavelength observations of the galaxy cluster Abell 2255 at 25 cm, 85 cm, and 2 m. The spectral index images allowed us to study the integrated spectrum of halo and relic and to investigate the physical properties of the Beaver head-tail radio galaxy belonging to the cluster. In the radio halo, the spectral index is steeper at the center and flatter at the locations of the radio filaments, clearly detected at 25 cm. In the relics, the spectral index flattens, moving away from the cluster center. For the Beaver radio galaxy, the spectrum severely steepens from the head towards the end of the tail, because of the energy losses suffered by the relativistic particles. In the 2 m map, which is the first high-sensitivity image presented in the literature at such a long wavelength, a new Mpc-size emission region is detected between the known radio halo and the NW relic. Not detecting this feature in the more sensitive 85 cm observations implies that it must have a very steep spectrum (alpha <= -2.6). The observational properties of the radio halo suggest that either we are looking at a superposition of different structures (filaments in the foreground plus real halo in the background) seen in projection across the cluster center or that the halo is intrinsically peculiar. The newly detected extended region to the NW of the halo could be considered as an asymmetric extension of the halo itself. However, since radio halos are known in the literature as structures showing a regular morphology, the new feature could represent the first example of steep Mpc-size diffuse structures (MDS), detected around clusters at very low frequencies.Comment: 23 pages, 18 figures. A&A, in pres