Mathematical Methods in Economics and Finance

Rivista internazionale

Competing during a pandemic? Retailers’ ups and downs during the COVID-19 outbreak

The COVID-19 pandemic (that started in early 2020) is causing several disruptions in the short- and mid-term, to which businesses have to adapt. Some retailers have reacted to the emergency immediately, displaying a plethora of different intervention types. The authors aim to synthesize the challenges that retailers are facing during the COVID-19 emergency. We do this from the perspective of both consumers and managers, with the goal of providing guidelines on and examples of how retailers can handle this unprecedented situation

Tweets to escape: intercultural differences in consumer expectations and risk behavior during the COVID-19 lockdown in three European countries

This study aims to understand the extent to which a time of emergency, (e.g. the COVID-19 pandemic), impacts consumer behaviour in terms of risk and expectations. The methodology involves the systematic content analysis of 15,000 tweets collected from three countries (UK, Italy and Spain) in April 2020. The results suggest that the top-of-mind expectation by consumers deals with escaping from home and enjoying freedom, either by having a good meal (UK), drinking alcoholic beverages (Spain), or travelling (Italy). They also suggest that the high levels of risk individuals were exposed to during the pandemic will not influence behavior in the long-term post- lockdown. Instead, they suggest consumers are willing to restore their consumption levels especially of activities that contribute to the sense of escapism. Finally, results provide evidence of the cultural differences emerging from consumers from different countries during the pandemic. Implications for international marketers and retailers are provided

Aberrant spleen simulating an adrenal mass

Indexación: Web of Science; ScieloIntroducción: El diagnóstico de los así llamados "incidentalomas" suprarrenales, cada vez más frecuente en la práctica clínica, plantea un diagnóstico diferencial importante. Caso clínico: Se presenta el caso clínico de una paciente de 69 años, hipertensa, con el hallazgo de una masa suprarrenal izquierda aparentemente funcionante, operada por vía laparoscópica y que resultó ser un bazo aberrante. Se discute el diagnóstico diferencial entre masa suprarrenal y pseudo-tumores adrenales y la embriología y presentación clínica del bazo aberrante.Introduction: The diagnosis of adrenal incidentalomas is common in current clinical practice. Clinical case: We report a 69 years-old female patient with hypertension, who underwent an abdominal CAT Scan, finding a left adrenal mass of 8 cm diameter. Subsequent studies showed elevated urinary metanephrine levels. With the suspicion of a pheochromocytoma, a laparoscopic surgery was performed. The mass resulted to be an aberrant spleen.http://ref.scielo.org/jtr4t

Multicasting Over 6G Non-Terrestrial Networks: A Softwarization-Based Approach

Multicast/broadcast delivery is a critical challenge of future 6G mobile networks where massive Internet of Things (IoT) deployment and extended reality multimedia such as teleportation are target application scenarios. Non-terrestrial networks (NTNs) are considered essential for the success of 6G, which aims to provide true 'global' services by extending mobile access worldwide, thus overcoming the coverage limit of current terrestrial networks (TNs). This article discusses how the main distinguishing features of NTNs can be effectively exploited for 6G multicasting. Furthermore, in line with the evolution of future 6G networks toward softwarized systems, we evaluate the potential of using the softwarization paradigm in the heterogeneous TN-NTN architecture to deliver multicast services

Protein kinase CK2 is widely expressed in follicular, Burkitt and diffuse large B-cell lymphomas and propels malignant B-cell growth.

Serine-threonine kinase CK2 is highly expressed and pivotal for survival and proliferation in multiple myeloma, chronic lymphocytic leukemia and mantle cell lymphoma. Here, we investigated the expression of \u3b1 catalytic and \u3b2 regulatory CK2 subunits by immunohistochemistry in 57 follicular (FL), 18 Burkitt (BL), 52 diffuse large B-cell (DLBCL) non-Hodgkin lymphomas (NHL) and in normal reactive follicles. In silico evaluation of available Gene Expression Profile (GEP) data sets from patients and Western blot (WB) analysis in NHL cell-lines were also performed. Moreover, the novel, clinical-grade, ATP-competitive CK2-inhibitor CX-4945 (Silmitasertib) was assayed on lymphoma cells. CK2 was detected in 98.4% of cases with a trend towards a stronger CK2\u3b1 immunostain in BL compared to FL and DLBCL. No significant differences were observed between Germinal Center B (GCB) and non-GCB DLBCL types. GEP data and WB confirmed elevated CK2 mRNA and protein levels as well as active phosphorylation of specific targets in NHL cells. CX-4945 caused a dose-dependent growth-arresting effect on GCB, non-GCB DLBCL and BL cell-lines and it efficiently shut off phosphorylation of NF-\u3baB RelA and CDC37 on CK2 target sites. Thus, CK2 is highly expressed and could represent a suitable therapeutic target in BL, FL and DLBCL NHL

Growth and infancy in three contemporary cohorts : selection bias and other methodological issues

There is broad recognition that early life growth trajectories are important predictors for the onset of several diseases. This thesis addresses two methodological challenges that arise in life-course studies of infant growth: (i) the bias that may derive from participants’ selection in cohort studies, and (ii) the modelling of individual growth trajectories. Data from socio-economically diverse populations were used to address them: the Italian NINFEA web-based birth cohort, the Portuguese GXXI birth cohort, and the Chilean GOCS cohort. Participants’ selection affects all cohorts, but web-based designs are thought to be more affected than traditional ones. The thesis first examines possible selection mechanisms by Monte Carlo simulations and then uses population registry data to assess evidence of selection bias among NINFEA participants. The simulations show that under sensible scenarios there is only weak bias in the effects estimated from a selected sample. Comparisons of NINFEA participants with their source population (via registry data) show that the confounding patterns present in NINFEA differ from those in the source population, revealing that participants’ restriction may either increase or decrease the confounding bias in an association of interest. Studying individual early life growth data requires dealing with the quality of the growth measurements and the nonlinearity of the trajectories. Alternative models are compared in terms of their ability to address these problems while extracting salient features of weight growth. SITAR results to be the most useful model for life-course enquiries. An extension of this model, that includes explanatory variables, is fitted on the three cohorts to study the effect of prenatal exposures on different biologically defined dimensions of the growth process. This reveals some interesting mechanisms. This thesis contributes to the interpretation of results obtained from cohort studies with restricted participation, and to the implementation of advanced growth models useful for life-course research

Imaging of biliary involvement in sarcoidosis: Computed tomography, magnetic resonance cholangiopancreatography, and gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging findings

Sarcoidosis is a multisystem disease usually affecting the chest, hilar lymph nodes, and lungs, but can potentially involve any organ; therefore, its clinical presentation may vary. Hepato-biliary involvement is rare, and typically asymptomatic; however, it can lead to cirrhosis, and may require liver transplantation. In this report, we present a rare case of a patient affected by sarcoidosis with hepatobiliary involvement. He presented to our hospital complaining of dyspnea triggered by moderate efforts and oppressive thoracic discomfort. Chest X-ray showed multiple bilateral nodular opacities and enlargement of both hilar regions, confirmed by a subsequent total-body computed tomography scan and positron emission tomography, which also revealed cardiac, splenic, and hepatic involvement. Liver function was studied via gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging, and magnetic resonance cholangiopancreatography (MRCP) was also performed. The diagnosis of sarcoidosis was finally achieved via liver biopsy, revealing non-necrotizing granulomas in the periportal space. The patient was treated with prednisone per os, with regression of all lesions at all levels. Although other cases of biliary sarcoidosis have been described, this report provides a complete image set of Gd-EOB-DTPA-enhanced magnetic resonance and MRCP images that is lacking in the English literature, and which may be useful for diagnosis