Towards Elastic Virtual Machine Placement in Overbooked OpenStack Clouds under Uncertainty

Cloud computing datacenters currently provide millions of virtual machines in highly dynamic Infrastructure as a Service (IaaS) markets. As a first step on implementing algorithms previously proposed by the authors for Virtual Machine Placement (VMP) in a real- world IaaS middleware, this work presents an experimental comparison of these algorithms against current algorithms considered for solving VMP problems in OpenStack. Several experiments considering scenario- based simulations for uncertainty modelling demonstrate that the proposed algorithms present promising results for its implementation towards real-world operations. Next research steps are also summarized.Facultad de Informátic

Towards Elastic Virtual Machine Placement in Overbooked OpenStack Clouds under Uncertainty

Cloud computing datacenters currently provide millions of virtual machines in highly dynamic Infrastructure as a Service (IaaS) markets. As a first step on implementing algorithms previously proposed by the authors for Virtual Machine Placement (VMP) in a real- world IaaS middleware, this work presents an experimental comparison of these algorithms against current algorithms considered for solving VMP problems in OpenStack. Several experiments considering scenario- based simulations for uncertainty modelling demonstrate that the proposed algorithms present promising results for its implementation towards real-world operations. Next research steps are also summarized.Facultad de Informátic

Towards Elastic Virtual Machine Placement in Overbooked OpenStack Clouds under Uncertainty

Cloud computing datacenters currently provide millions of virtual machines in highly dynamic Infrastructure as a Service (IaaS) markets. As a first step on implementing algorithms previously proposed by the authors for Virtual Machine Placement (VMP) in a real- world IaaS middleware, this work presents an experimental comparison of these algorithms against current algorithms considered for solving VMP problems in OpenStack. Several experiments considering scenario- based simulations for uncertainty modelling demonstrate that the proposed algorithms present promising results for its implementation towards real-world operations. Next research steps are also summarized.Facultad de Informátic

Mechanical properties of reciprocating thermally treated NiTi endodontic instruments / Propriedades mecânicas de instrumentos endodônticos de NiTi reciprocantes tratados termicamente

The aim of this study was to evaluate the flexibility, buckling resistance, dynamic cyclic fatigue resistance and roughness pattern of Reciproc R25 M-Wire (R25M), Reciproc Blue R25 (R25B) and WaveOne Gold Primary (WOGP) NiTi reciprocating instruments. Thirty-three R25M, 30 R25B e 30 WOGP, all with 25mm in length, were tested. The flexibility was determined by 45° bending tests according to the standard ANSI/ADA number 101 specification. To determine the buckling resistance an increasing axial load was applied to the instruments until the file underwent an elastic displacement of 1mm. A customized machine was used to perform the dynamic cyclic fatigue test measuring the time to fracture in a metallic stainless steel canal measuring 1.4 mm of diameter, 19 mm of total length, an angle of 86 degrees and 6 mm of curvature radius. The roughness was obtained using a profilometer. Results were analyzed using one-way ANOVA and Student-Newman-Keuls post-hoc test. Analysis were performed with the significance level (?) of 5%. The instruments presented the following order of flexibility: R25B > WOGP > R25M (P < 0.05); buckling resistance: R25M > R25B > WOGP (P < 0.05); and cyclic fatigue resistance: R25B > R25M > WOGP (P < 0.05). No differences were observed regarding the roughness pattern (P > 0.05). The R25B file presented superior flexibility and performance under fatigue tests. The R25M have higher buckling resistance. Instruments demonstrated similar characteristics of surface. 

Tailoring Bi2MoO6 by Eu3+ incorporation for enhanced photoluminescence emissions

Here, an experimental study is presented on the structural, electronic, and optical properties of Bi2-xMoO6:xEu3+ (x = 0, 0.5, 1.0, 2.0, and 4.0 mol%) materials, synthesized by means of the microwave-assisted solvothermal method using ethylene glycol as a solvent. Different characterization techniques (X-ray diffraction measurements with Rietveld refinements, Raman and ultraviolet–visible diffuse reflectance spectroscopy, field emission scanning electron microscopy, and photoluminescence emissions) have been employed to examine the structural and electronic properties, energy transfer and defect evolution which control the performance of the as-synthetized materials. Present findings provide deep insights into the substitution of Eu3+ cations in Bi2MoO6, with focus on their influence on process that dictate the superior optical properties.Funding for open access charge: CRUE-Universitat Jaume

Intoxication of newly implanted coffee plants by simulated drift of the dicamba herbicide

After the release of soybean cultivars resistant to the herbicide dicamba, this product should be used more frequently in weed management programs, which may increase the risk of drift to neighboring crops, since the molecules are volatile and might cause damage in non-target plants. This work was developed to evaluate the effects of sub-doses of the herbicide dicamba on young coffee plants, simulating a drift situation. The experiment was carried out in a greenhouse, with a randomized block design of eight treatments and five replications. Each plot consisted of a 4 L pot, filled with sieved clayey soil and tanned manure (3:1 v/v), with a seedling of Catuaí IAC 144 coffee. The treatments used were: 0 (control), 0.0001, 0.001, 0.01, 0.1, 1.0, 10.0, and 100.0 g ha−1 of dicamba. Plant's percentual phytotoxicity was evaluated up to 49 days after application (DAA), SPAD index (14, 28, and 42 DAA), and dry matter biomass, at 49 DAA. In all evaluations, no differences were observed regarding phytotoxicity for dicamba sub-doses of up to 0.01 g ha−1. The highest doses of dicamba caused visual injuries of up to 31%. At 49 DAA, there were no differences regarding dry matter biomass. Leaf symptoms caused by the herbicide were observed, such as curling, wrinkling, and epinasty. No plant death was observed. Compared to other crops, coffee might be considered more tolerant to sub-doses of dicamba, with adequate recovery capacity for reduced doses of this herbicide

POU1F1 transcription factor induces metabolic reprogramming and breast cancer progression via LDHA regulation

Metabolic reprogramming is considered hallmarks of cancer. Aerobic glycolysis in tumors cells has been well-known for almost a century, but specific factors that regulate lactate generation and the effects of lactate in both cancer cells and stroma are not yet well understood. In the present study using breast cancer cell lines, human primary cultures of breast tumors, and immune deficient murine models, we demonstrate that the POU1F1 transcription factor is functionally and clinically related to both metabolic reprogramming in breast cancer cells and fibroblasts activation. Mechanistically, we demonstrate that POU1F1 transcriptionally regulates the lactate dehydrogenase A (LDHA) gene. LDHA catalyzes pyruvate into lactate instead of leading into the tricarboxylic acid cycle. Lactate increases breast cancer cell proliferation, migration, and invasion. In addition, it activates normal-associated fibroblasts (NAFs) into cancer-associated fibroblasts (CAFs). Conversely, LDHA knockdown in breast cancer cells that overexpress POU1F1 decreases tumor volume and [18F]FDG uptake in tumor xenografts of mice. Clinically, POU1F1 and LDHA expression correlate with relapse- and metastasis-free survival. Our data indicate that POU1F1 induces a metabolic reprogramming through LDHA regulation in human breast tumor cells, modifying the phenotype of both cancer cells and fibroblasts to promote cancer progressionThis study was supported by FEDER/Ministerio de Ciencia, Innovación y Universidades- Agencia Estatal de Investigación-PGC2018-100776-B-I00 and from Conselleria de Cultura, Educación e Ordenacion Universitaria (GPC2014/001), AM-O was supported by an FPU grant (Ministerio de Educación—FPU14/00548)S

Identification Of Anln As Etv6 Partner Gene In Recurrent T(7;12)(p15;p13): A Possible Role Of Deregulated Anln Expression In Leukemogenesis.

The ETV6 gene encodes an ETS family transcription factor that is involved in a myriad of chromosomal rearrangements found in hematological malignancies and other neoplasms. A recurrent ETV6 translocation, previously described in patients with acute myeloid leukemia (AML) (Genes Chromosomes Cancer 51:328-337,2012, Leuk Res 35:e212-214, 2011), whose partner has not been identified is t(7;12)(p15;p13). We herein report that the t(7;12)(p15;p13) fuses ETV6 to ANLN, a gene not previously implicated in the pathogenesis of hematological malignancies, and we demonstrate that this translocation leads to high expression of the fusion transcript in the myeloid and lymphoid lineages.1419

Clinical, demographic, and radiographic analysis of 82 patients affected by florid osseous dysplasia: an international collaborative study

OBJECTIVE : The aim of this study was to correlate the clinical, demographic, and radiographic aspects of 82 cases of florid osseous dysplasia (FOD) from four countries assessed by five reviewers. STUDY DESIGN : Retrospective data of patients diagnosed with FOD were obtained from archives of five institutes and analyzed according to clinical and radiographic criteria. RESULTS: A total of 82 cases of FOD were included in the study. In the majority (77.5%) of FOD cases, black women were affected. The disease mainly affected the mandible (100%), and the stage of the lesion was directly correlated with the age (P &#060 .05). The rates of convergence showed confluence of assessment in the mandible (posterior), and the highest rate of divergence between the reviewers was in assessing involvement in the maxilla. There were no differences among the characteristics of the lesion provided by the five institutions, except for the variable proportion of black patients affected by the disease. CONCLUSIONS : FOD mostly affects the mandible of middle-aged black women, and its stage is correlated with patient age. Although panoramic radiography is used for diagnosis, the divergence in assessment of the maxilla might indicate that this method is not the most suitable to evaluate this area.The State of São Paulo Funding Agency (FAPESP grant: 2014/08930-0) and Carlos Chagas Filho Funding Agency of the State of Rio de Janeiro (FAPERJ).http://www.journals.elsevier.com/oral-surgery-oral-medicine-oral-pathology-and-oral-radiology/2017-08-30Oral Pathology and Oral Biolog

Role of body mass and physical activity in autonomic function modulation on Post-COVID-19 condition: an observational subanalysis of Fit-COVID study

The harmful effects of coronavirus disease 2019 (COVID-19) can reach the autonomic nervous system (ANS) and endothelial function. Therefore, the detrimental multiorgan effects of COVID-19 could be induced by deregulations in ANS that may persist after the acute SARS-CoV-2 infection. Additionally, investigating the differences in ANS response in overweight/obese, and physically inactive participants who had COVID-19 compared to those who did not have the disease is necessary. The aim of the study was to analyze the autonomic function of young adults after mild-to-moderate infection with SARS-CoV-2 and to assess whether body mass index (BMI) and levels of physical activity modulates autonomic function in participants with and without COVID-19. Patients previously infected with SARS-CoV-2 and healthy controls were recruited for this cross-sectional observational study. A general anamnesis was taken, and BMI and physical activity levels were assessed. The ANS was evaluated through heart rate variability. A total of 57 subjects were evaluated. Sympathetic nervous system activity in the post-COVID-19 group was increased (stress index; p = 0.0273). They also presented lower values of parasympathetic activity (p < 0.05). Overweight/obese subjects in the post-COVID-19 group presented significantly lower parasympathetic activity and reduced global variability compared to non-obese in control group (p < 0.05). Physically inactive subjects in the post-COVID-19 group presented significantly higher sympathetic activity than active subjects in the control group. Parasympathetic activity was significantly increased in physically active subjects in the control group compared to the physically inactive post-COVID-19 group (p < 0.05). COVID-19 promotes changes in the ANS of young adults, and these changes are modulated by overweight/obesity and physical activity levels.info:eu-repo/semantics/publishedVersio