MONITORAGGIO DI OPERE STRATEGICHE MEDIANTE TECNICHE SATELLITARI: IL CASO STUDIO DELLA DIGA “CASTELLO SUL FIUME MAGAZZOLO”

Il Global Navigation Satellite System (GNSS) e il telerilevamento sono stati utilizzati per determinare la relazione tra le deformazioni di una diga di terra e le variazioni di superficie e livello di invaso, durante il periodo di un anno. L’utilizzo di un ricevitore posto sul coronamento della diga e di una stazione permanente attivi durante l’arco della giornata ha permesso la determinazione della serie temporale degli spostamenti dell’opera nel periodo analizzato, riferiti ad un sistema di riferimento locale della diga. La componente ortogonale al coronamento è stata successivamente posta in relazione con le forze di natura idraulica che agiscono sull’opera. Per la determinazione dei livelli di invaso sono state impiegate due differenti metodologie nell’ambito del telerilevamento, sfruttando immagini satellitari (ottiche e radar) con differenti caratteristiche. Le metodologie utilizzate per l’identificazione dei livelli di invaso del bacino si basano: la prima su un processo di classificazione non controllata, al fine di utilizzare un processo quanto più possibile automatizzato, l’altra invece, sfrutta la sovrapposizione del bacino su isoipse esistenti per l’identificazione manuale dei limiti del bacino. I risultati ottenuti dalle due tecniche sono stati messi a confronto con misure in situ al fine di valutarne l’attendibilità, valutando inoltre la relazione con gli spostamenti ortogonali al coronamento, ottenuti durante il periodo di monitoraggio del bacino. Dal confronto è emerso che la relazione tra gli spostamenti e il livello di invaso è di tipo non lineare

An integrated geodetic and InSAR technique for the monitoring and detection of active faulting in southwestern Sicily

We present the results of the analysis of GNSS (Global Navigation Satellite System) and InSAR (Interferometric synthetic-aperture radar) data collected in the frame of a project financed by the “Struttura Terremoti” of INGV (Istituto Nazionale di Geofisica e Vulcanologia). Combined investigations pointed out for potential seismogenic sources for destructive earthquakes recorded in southwestern Sicily, including the 1968 Belice earthquake sequence and that supposed to have destroyed the Greek city of Selinunte which, according to geoarcheological data experienced two earthquakes in historical times. Our approach is aimed to evaluate the current deformation rate in SW Sicily and to improve the knowledge about the seismic potential of this area. The geodetic data proposed in this paper show that the Campobello di Mazara–Castelvetrano alignment (CCA) is currently deforming with a vertical and horizontal displacements of 2 mm/yr and 0.5 mm/yr respectively, according to the tectonic setting of the are

Neoadjuvant treatments in triple-negative breast cancer patients: where we are now and where we are going

Abstract: Triple-negative breast cancer (TNBC) remains the poorest-prognosis breast cancer (BC) subtype. Gene expression profiling has identified at least six different triple-negative subtypes with different biology and sensitivity to therapies. The heterogeneous nature of TN tumors may justify the difficulty in treating this BC subtype. Several targeted agents have been investigated in clinical trials without demonstrating a clear survival benefit. Therefore, systemic chemotherapy remains the cornerstone of current clinical practice. Improving the knowledge of tumor biology is mandatory for patient management. In stages II and III, neoadjuvant systemic treatment is an effective option of care. The achievement of a pathological complete response represents an optimal surrogate for survival outcome as well as a test for tumor drug sensitivity. In this review, we provide a brief description of the main predictive biomarkers for tumor response to systemic treatment. Moreover, we review the treatment strategies investigated for TNBCs in neoadjuvant settings focusing on experimental drugs such as immunotherapy and poly [ADP-ribose] polymerase inhibitors that hold promise in the treatment of this aggressive disease. Therefore, the management of TNBC represents an urgent, current, unmet need in daily clinical practice. A key recommendation is to design biology-driven clinical trials wherein TNBC patients may be treated on the basis of tumor molecular profile

Data Service Platform for Sentinel-2 Surface Reflectance and Value-Added Products: System Use and Examples

This technical note presents the first Sentinel-2 data service platform for obtaining atmospherically-corrected images and generating the corresponding value-added products for any land surface on Earth. Using the European Space Agency’s (ESA) Sen2Cor algorithm, the platform processes ESA’s Level-1C top-of-atmosphere reflectance to atmospherically-corrected bottom-of-atmosphere (BoA) reflectance (Level-2A). The processing runs on-demand, with a global coverage, on the Earth Observation Data Centre (EODC), which is a public-private collaborative IT infrastructure in Vienna (Austria) for archiving, processing, and distributing Earth observation (EO) data. Using the data service platform, users can submit processing requests and access the results via a user-friendly web page or using a dedicated application programming interface (API). Building on the processed Level-2A data, the platform also creates value-added products with a particular focus on agricultural vegetation monitoring, such as leaf area index (LAI) and broadband hemispherical-directional reflectance factor (HDRF). An analysis of the performance of the data service platform, along with processing capacity, is presented. Some preliminary consistency checks of the algorithm implementation are included to demonstrate the expected product quality. In particular, Sentinel-2 data were compared to atmospherically-corrected Landsat-8 data for six test sites achieving a R2 = 0.90 and Root Mean Square Error (RMSE) = 0.031. LAI was validated for one test site using ground estimations. Results show a very good agreement (R2 = 0.83) and a RMSE of 0.32 m2/m2 (12% of mean value)

Curcumin and Andrographolide Co-Administration Safely Prevent Steatosis Induction and ROS Production in HepG2 Cell Line

Non-alcoholic fatty liver disease (NAFLD) is an emerging chronic liver disease worldwide. Curcumin and andrographolide are famous for improving hepatic functions, being able to reverse oxidative stress and release pro-inflammatory cytokines, and they are implicated in hepatic stellate cell activation and in liver fibrosis development. Thus, we tested curcumin and andrographolide separately and in combination to determine their effect on triglyceride accumulation and ROS production, identifying the differential expression of genes involved in fatty liver and oxidative stress development. In vitro steatosis was induced in HepG2 cells and the protective effect of curcumin, andrographolide, and their combination was observed evaluating cell viability, lipid and triglyceride content, ROS levels, and microarray differential gene expression. Curcumin, andrographolide, and their association were effective in reducing steatosis, triglyceride content, and ROS stress, downregulating the genes involved in lipid accumulation. Moreover, the treatments were able to protect the cytotoxic effect of steatosis, promoting the expression of survival and anti-inflammatory genes. The present study showed that the association of curcumin and andrographolide could be used as a therapeutic approach to counter high lipid content and ROS levels in steatosis liver, avoiding the possible hepatotoxic effect of curcumin. Furthermore, this study improved our understanding of the antisteatosis and hepatoprotective properties of a curcumin and andrographolide combination

Influence of antisynthetase antibodies specificities on antisynthetase syndrome clinical spectrum time course

Antisynthetase syndrome (ASSD) is a rare clinical condition that is characterized by the occurrence of a classic clinical triad, encompassing myositis, arthritis, and interstitial lung disease (ILD), along with specific autoantibodies that are addressed to different aminoacyl tRNA synthetases (ARS). Until now, it has been unknown whether the presence of a different ARS might affect the clinical presentation, evolution, and outcome of ASSD. In this study, we retrospectively recorded the time of onset, characteristics, clustering of triad findings, and survival of 828 ASSD patients (593 anti-Jo1, 95 anti-PL7, 84 anti-PL12, 38 anti-EJ, and 18 anti-OJ), referring to AENEAS (American and European NEtwork of Antisynthetase Syndrome) collaborative group's cohort. Comparisons were performed first between all ARS cases and then, in the case of significance, while using anti-Jo1 positive patients as the reference group. The characteristics of triad findings were similar and the onset mainly began with a single triad finding in all groups despite some differences in overall prevalence. The "ex-novo" occurrence of triad findings was only reduced in the anti-PL12-positive cohort, however, it occurred in a clinically relevant percentage of patients (30%). Moreover, survival was not influenced by the underlying anti-aminoacyl tRNA synthetase antibodies' positivity, which confirmed that antisynthetase syndrome is a heterogeneous condition and that antibody specificity only partially influences the clinical presentation and evolution of this condition

Influence of Antisynthetase Antibodies Specificities on Antisynthetase Syndrome Clinical Spectrum TimeCourse

Introduction: Increased cardiovascular (CV) morbidity and mortality is observed in inflammatory joint diseases (IJDs) such as rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis. However, the management of CV disease in these conditions is far from being well established.Areas covered: This review summarizes the main epidemiologic, pathophysiological, and clinical risk factors of CV disease associated with IJDs. Less common aspects on early diagnosis and risk stratification of the CV disease in these conditions are also discussed. In Europe, the most commonly used risk algorithm in patients with IJDs is the modified SCORE index based on the revised recommendations proposed by the EULAR task force in 2017.Expert opinion: Early identification of IJD patients at high risk of CV disease is essential. It should include the use of complementary noninvasive imaging techniques. A multidisciplinary approach aimed to improve heart-healthy habits, including strict control of classic CV risk factors is crucial. Adequate management of the underlying IJD is also of main importance since the reduction of disease activity decreases the risk of CV events. Non-steroidal anti-inflammatory drugs may have a lesser harmful effect in IJD than in the general population, due to their anti-inflammatory effects along with other potential beneficial effects.This research was partially funded by FOREUM—Foundation for Research in Rheumatolog